Fig. 1

Study protocols. A murine model of allergic rhinitis (AR) was prepared by intraperitoneal immunization of ovalbumin on days 1, 8, and 15 (priming) followed by daily intranasal ovalbumin challenge on days 22 to 29. This group of mice was used as allergic models (AR group). As a negative control, another group of mice received the challenge treatment of normal saline alone (normal group). A group of allergic mice received the adoptive transfer of CD8⁺CD25⁺fork-head box transcription factor (Foxp3)⁺ regulatory T cells (CD8⁺ Tregs) from normal mice (normal CD8⁺ Tregs group) or allergic mice (AR CD8⁺ Tregs group) intravenously in the tail vein on challenging days