Table 2 Clinical characteristics and HAE therapy history of case series patients
From: Impact of lanadelumab in hereditary angioedema: a case series of 12 patients in Canada
Case | Type of attacks | Most debilitating attacks | Pre-lana LTP | Pre-lana acute treatment | Lana transition date | Lana dosage | Post-lana acute treatment |
|---|---|---|---|---|---|---|---|
1 | Extremity swelling Abdominal pain Laryngeal swelling | Laryngeal swelling | C1-INH 2000U IV q3-4d | Icatibant 30 mg SC | January 2020 | 300 mg SC q2w | Icatibant 30 mg SC |
2 | Abdominal pain Lip swelling | Abdominal pain | C1-INH 3000U IV q3d | C1-INH 3000U IV | July 2019 | 300 mg SC q2w | C1-INH 3000U IV |
3 | Extremity swelling Laryngeal swelling | Laryngeal swelling | C1-INH 1500U IV q5d | Icatibant 30 mg SC | January 2020 | 300 mg SC q2w | Icatibant 30 mg SC |
4 | Extremity swelling Abdominal pain | Abdominal pain | C1-INH 1500U IV q3-4d | Icatibant 30 mg SC | October 2019 | 300 mg SC q4w | Icatibant 30 mg SC |
5 | Extremity swelling Abdominal pain Lip swelling Headaches | Abdominal pain | C1-INH 1500U IV q3-4d | C1-INH 3000U IV | April 2020 | 300 mg SC q2w | C1-INH 1500U IV |
6 | Abdominal pain Extremity swelling Laryngeal swelling | Abdominal pain | C1-INH 1500U IV q3d | Icatibant 30 mg SC | April 2019 | 300 mg SC q2w | Icatibant 30 mg SC |
7 | Abdominal pain Extremity swelling Laryngeal swelling | Abdominal pain | None | None | October 2020 | 300 mg SC q2w | Icatibant 30 mg SC |
8 | Abdominal pain Extremity swelling | Abdominal pain | C1-INH 4500U SC q3-4d | Icatibant 30 mg SC | February 2020 | 300 mg SC q2w | Icatibant 30 mg SC |
9 | Extremity swelling | Extremity swelling | None | Prednisonea | February 2020 | 300 mg SC q2w | Icatibant 30 mg SC |
10 | Abdominal pain Extremity swelling Laryngeal swelling | Abdominal attacks | Danazol C1-INH 4500U SC q3-4d | C1-INH IV | May 2019 | 300 mg SC q2w | C1-INH IV |
11 | Lip swelling Abdominal pain Laryngeal swelling | Laryngeal swelling | TXA C1-INH 1500U IV q2-3d | Icatibant or C1-INH IV | January 2020 | 300 mg SC q2w | Icatibant or C1-INH IV |
12 | Abdominal pain Laryngeal swelling | Abdominal, Laryngeal | Danazol C1-INH 2000U IV q3-4d | Icatibant or C1-INH IV | October 2020 | 300 mg SC q2w | Icatibant |