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Table 2 Clinical characteristics and HAE therapy history of case series patients

From: Impact of lanadelumab in hereditary angioedema: a case series of 12 patients in Canada

Case Type of attacks Most debilitating attacks Pre-lana LTP Pre-lana acute treatment Lana transition date Lana dosage Post-lana acute treatment
1 Extremity swelling
Abdominal pain
Laryngeal swelling
Laryngeal swelling C1-INH 2000U IV q3-4d Icatibant 30 mg SC January 2020 300 mg SC q2w Icatibant 30 mg SC
2 Abdominal pain
Lip swelling
Abdominal pain C1-INH 3000U IV q3d C1-INH 3000U IV July 2019 300 mg SC q2w C1-INH 3000U IV
3 Extremity swelling
Laryngeal swelling
Laryngeal swelling C1-INH 1500U IV q5d Icatibant 30 mg SC January 2020 300 mg SC q2w Icatibant 30 mg SC
4 Extremity swelling
Abdominal pain
Abdominal pain C1-INH 1500U IV q3-4d Icatibant 30 mg SC October 2019 300 mg SC q4w Icatibant 30 mg SC
5 Extremity swelling
Abdominal pain
Lip swelling
Headaches
Abdominal pain C1-INH 1500U IV q3-4d C1-INH 3000U IV April 2020 300 mg SC q2w C1-INH 1500U IV
6 Abdominal pain
Extremity swelling
Laryngeal swelling
Abdominal pain C1-INH 1500U IV q3d Icatibant 30 mg SC April 2019 300 mg SC q2w Icatibant 30 mg SC
7 Abdominal pain
Extremity swelling
Laryngeal swelling
Abdominal pain None None October 2020 300 mg SC q2w Icatibant 30 mg SC
8 Abdominal pain
Extremity swelling
Abdominal pain C1-INH 4500U SC q3-4d Icatibant 30 mg SC February 2020 300 mg SC q2w Icatibant 30 mg SC
9 Extremity swelling Extremity swelling None Prednisonea February 2020 300 mg SC q2w Icatibant 30 mg SC
10 Abdominal pain
Extremity swelling
Laryngeal swelling
Abdominal attacks Danazol C1-INH 4500U SC q3-4d C1-INH IV May 2019 300 mg SC q2w C1-INH IV
11 Lip swelling
Abdominal pain
Laryngeal swelling
Laryngeal swelling TXA C1-INH 1500U IV q2-3d Icatibant or C1-INH IV January 2020 300 mg SC q2w Icatibant or C1-INH IV
12 Abdominal pain
Laryngeal swelling
Abdominal, Laryngeal Danazol C1-INH 2000U IV q3-4d Icatibant or C1-INH IV October 2020 300 mg SC q2w Icatibant
  1. All data was extracted from patient chart review
  2. LTP long-term prophylaxis, C1-INH plasma-derived C1 esterase inhibitor enzyme, TXA tranexamic acid
  3. aPrednisone was given to this patient as acute treatment prior to HAE diagnosis and was ineffective at treating attacks