Fig. 1

Experimental protocol for allergic rhinitis (AR) mouse model and effect of BLAB on nasal symptoms. A Time schedule of the OVA-induced AR mouse model and treatment with BLAB. B The frequency of total sneezing numbers during 10 min after the OVA challenge on day 42. C The frequency of total rubbing numbers during 10 min after the OVA challenge on day 42. Mice were sensitized on days 0, 4, 7, 10, 14, 18, and 21, and challenged on days 28 to 42 with OVA. Mice in the BLAB or Dex group were administered orally once daily at 100, 200, 400 mg/mL BLAB or 2.5 mg/kg dexamethasone on day 22 to 42 for 21 continuously days, respectively. The values represent the mean ± SE (n = 6/group). Significant differences at ^##P < 0.01 compared with the control group. *P < 0.05, **P < 0.01 compared with the OVA group