Table 3 Pharmacokinetics of fexofenadine in children
From: Fexofenadine: review of safety, efficacy and unmet needs in children with allergic rhinitis
Fexofenadine dose and frequency | Age, years | Number of patients | Mean maximum plasma concentration, ng/mL | Mean area under the plasma concentration curve, ng hour/mL | Drug clearance | References |
|---|---|---|---|---|---|---|
15 mg BID | Infants < 2 | 55 | 130‡ | – | 15.6 L/h | [16] |
30 mg BID |  > 2– < 7 | 80 | 157‡ | – | 29.9 L/h | [16] |
30 mg, single dose | 2–5 | 50 | 224* | 898 | – | [18] |
30 mg, single dose | 6–12 | 14 | 178 ± 22†| 1090 ± 125 | 14.4 ± 2.0 ml/min/kg | [17] |
60 mg, single dose | 6–12 | 14 | 286 ± 34†| 1892 ± 129 | 18.4 ± 2.4 ml/min/kg | [17] |