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Table 3 Pharmacokinetics of fexofenadine in children

From: Fexofenadine: review of safety, efficacy and unmet needs in children with allergic rhinitis

Fexofenadine dose and frequency Age, years Number of patients Mean maximum plasma concentration, ng/mL Mean area under the plasma concentration curve, ng hour/mL Drug clearance References
15 mg BID Infants < 2 55 130 15.6 L/h [16]
30 mg BID  > 2– < 7 80 157 29.9 L/h [16]
30 mg, single dose 2–5 50 224* 898 [18]
30 mg, single dose 6–12 14 178 ± 22 1090 ± 125 14.4 ± 2.0 ml/min/kg [17]
60 mg, single dose 6–12 14 286 ± 34 1892 ± 129 18.4 ± 2.4 ml/min/kg [17]
  1. BID, twice daily; QD, once daily
  2. *24 h post dose
  3. 2.4 ± 0.2 h post dose
  4. Day 8, 3 h and 3–9 h post dose