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Table 1 Clinical and immunological characteristics of 3 newborns presenting with abnormal TREC copy number

From: Neonatal abstinence syndrome is a potential cause of low TREC copy number

  GA (weeks) Sex Mode of delivery Birth weight (g) Antenatal exposures Medical history TREC (number/µL) T cell countsa (× 109/L)
Initial Repeat
1 36 M CS 2961 Methadone
Marijuana
Neonatal abstinence syndrome 66 385 CD3 + 3.22
CD3 + CD4 + 2.53
CD3 + CD8 + 0.78
2 37 F CS 1590 Methadone
Heroin
Neonatal abstinence syndrome
Symmetrical IUGR
46 299 CD3 + 6.64
CD3 + CD4 + 3.85
CD3 + CD8 + 2.79
3 36 + 6 F CS 2000 Methadone
Heroin
Neonatal abstinence syndrome
Symmetrical
IUGR
51 253 CD3 + 7.74
CD3 + CD4 + 5.93
CD3 + CD8 + 1.69
  1. Patients 2 and 3 were diachorionic diamnionic twins. All 3 newborns had their second TREC copy number and T cell counts measured on the 13th day of life
  2. CS caesarean section, GA gestational age at birth, IUGR intrauterine growth restriction, SVD spontaneous vaginal delivery, TREC T cell receptor excision circle
  3. aNormal values for T cell counts: CD3 + 1.5–5.0 × 109/L, CD3 + CD4 + 0.90–3.60 × 109/L, CD3 + CD8 + 0.30–1.40 × 109/L