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Table 4 Subgroup analysis by mode of administration and indication for IGRT

From: Transitioning subcutaneous immunoglobulin 20% therapies in patients with primary and secondary immunodeficiencies: Canadian real-world study

  Mode of administration Indication for IGRT
Infusion pump Manual PID SID
Patient characteristics at baseline n = 71 n = 54 n = 61a n = 64b
 Age, median (range) 66 (28–83) 63 (19–82) 57 (19–79) 69 (48–83)
 Sex, n (%)     
  Female 44 (62.0) 39 (72.2) 47 (77.0) 36 (56.3)
  Male 27 (38.0) 15 (27.8) 14 (23.0) 28 (43.8)
 Mode of administration, n (%)     
  Infusion pump 71 (100) 0 33 (54.1) 38 (59.4)
  Manual 0 54 (100) 28 (45.9) 26 (40.6)
 Indication for IGRT, n (%)     
  PIDa 33 (46.5) 28 (51.9) 61 (100) 0
  SIDb 38 (53.5) 26 (48.1) 0 64 (100)
Infusion and dosing parameters at 12 monthsc n = 65 n = 42d n = 52 n = 55
 Infusion volume/infusion, median (IQR), ml 43 (40–60) 30 (20–40) 40 (25–50) 40 (35–50)
 Infusion duration, median (IQR), minutes 60 (45–73) 24 (10–40) 43 (20–65) 60 (40–65)
 Number of infusion sites/infusion, median (IQR) 2 (2–3) 2 (1–2) 2 (2–4) 2 (2–3)
  1 site, n (%) 1 (1.7) 9 (33.3) 8 (18.6) 2 (4.5)
  2 sites, n (%) 32 (53.3) 17 (63.0) 21 (48.8) 28 (63.6)
  3 sites, n (%) 16 (26.7) 0 3 (7.0) 13 (29.5)
  > 3 sites, n (%) 11 (18.3) 1 (3.7) 11 (25.6) 1 (2.3)
 Number of infusions/month/patient, median (IQR) 4 (4–4) 4 (4–8) 4 (4–8) 4 (4–4)
 Maximal infusion rate/site, median (IQR), (ml/h)e 40.0 (34.0–59.0) 33.5 (25.7–40.0) 40.0 (35.0–60.0)
 Weekly dose, median (IQR), g 8.0 (6.0–10.0) 8.0 (6.0–8.0) 9.0 (7.0–12.0) 8.0 (6.0–10.0)
 Dosing interval, n (%)     
  Daily 0 0 0 0
  2–6 times/week 2 (3.1) 17 (40.5) 15 (28.8) 4 (7.4)
  Once weekly 56 (87.5) 25 (59.5) 34 (65.4) 47 (87.0)
  Every 2 weeks 4 (6.3) 2 (3.8) 2 (3.7)
  Other 2 (3.1) 1 (1.9) 1 (1.9)
 IgG trough levels, g/l     
  Median (IQR) 8.6 (7.9–10.6) 9.1 (8.3–11.0) 9.9 (8.6–11.8) 8.3 (7.9–9.0)
  Range 3.6–14.5 5.6–13.4 3.6–13.4 5.6–14.5
  1. a Includes one patient with PID and SID
  2. b SID only
  3. c n value for each parameter is presented based on available data and percentages are calculated as a proportion of those values
  4. d One patient in this group used an infusion pump at 12 months
  5. e Maximal infusion rate per site can only be analyzed for patients using pump administration and is the same for all sites in that infusion