Fig. 1

FHL1 expresses highly in mice with asthma-like airway inflammation. A The Venn map showing intersection of the top 200 DEGs obtained from asthma-related gene expression datasets GSE27066 and GSE6858. B The heatmap of the top 30 DEGs obtained from the GSE6858 dataset. The X axis represents the sample number, and the Y axis represents the DEGs; the upper right histogram is the color grade, where each rectangle corresponds to a sample expression value; the red indicates the high expression, and the green indicates the low expression. C The expression of FHL1 in asthma in the GSE27066 dataset. D Determination of airway responsiveness in mice with asthma-like airway inflammation. E HE staining images of bronchial cavities of similar diameter in lung tissues from normal and asthmatic mice. F The number of total cells and percentage of eosinophils in BALF of normal and asthmatic mouse lung tissues. G Levels of IL-4, IL-5, IL-13, and IFN-γ in BALF supernatant of normal and asthmatic mouse lung tissues measured by ELISA. H Immunohistochemical images and quantitative analysis of FHL1 and VEGF positive expression in normal and asthmatic mouse lung tissues. * p < 0.05 compared with normal mice. n = 10 mice for each treatment