Table 2 Clinical outcome comparison between subjects with low vs normal IgG
From: Low immunoglobulin levels affect the course of COPD in hospitalized patients
Low IgG (N = 14) | Normal IgG (N = 35) | p | |
|---|---|---|---|
Demographics | |||
Age years (median{IQR}) | 73 (65–79) | 66 (58–73) | 0.132 |
Sex—female (n {%}) | 7 (50%) | 19 (54.3%) | 1.000 |
BMI* (kg/m2) (median {IQR}) | 22.2 (19.8–24.0) | 29.2/34 (21.8–34.2) | 0.009 |
FEV1** (% predicted) (median. {IQR}) | 37.5 (23.6–66.4) | 37.4 (22.4–50.0) | 0.799 |
FEV1/FVC** (%) (median {IQR}) | 39.8 (36.9–52.9) | 43.0 (35.1–48.5) | 0.879 |
Current Smoking* (n {%}) | 4 (30.8%) | 8 (22.9%) | 0.710 |
Number of pack years***(median {IQR}) | 50.0 (24.8–57.5) | 45.0 (21.0–50.0) | 0.500 |
Subjects taking systemic corticosteroid (%) | 13 (92.9%) | 33 (94.3%) | 1.000 |
Subjects taking antibiotics (%) | 13 (92.9%) | 31 (88.6%) | 1.000 |
Immunoglobulin levels | |||
IgG (median {IQR}) | 6.00 (5.3–6.1) | 9.34 (7.6–10.5) | < 0.0001 |
IgA (median {IQR}) | 1.46 (0.9–1.8) | 2.32 (1.7–2.9) | < 0.0001 |
IgM (median {IQR}) | 0.69 (0.4–1.1) | 0.91 (0.5–1.4) | 0.192 |
Clinical outcomes | |||
Length of hospital stay (median {IQR}) | 2.5 (2.0–5.3) | 4.0 (3.0–6.0) | 0.245 |
Emergency department visits (median {IQR}) | 2.0 (0.7–4.7) | 1.0 (0.0–4.0) | 0.297 |
Readmissions (median {IQR}) | 1.5 (0.0–3.0) | 0.0 (0.0–2.0) | 0.320 |
AECOPD related readmissions (median {IQR}) | 1.0 (0.0–2.0) | 0.0 (0.0–1.0) | 0.195 |