Fig. 1
From: Virtually supported penicillin allergy de-labelling during COVID-19
(Figure adapted from Mack et al. [8]. JACI: In Practice)
A flow chart and checklist of a virtually supported penicillin oral challenge. A Visit 1: virtual consultation and preparation. B Visit 2: virtually supported home amoxicillin oral provocation challenge. (1) Immediate reaction is defined as Type I hypersensitivity reaction that is IgE mediated and occurs within 2 h of the first dose of medication and lasts < 24 h. (2) Delayed hypersensitivity reaction are defined as Type II–IV reactions that typically take > 24 h to develop and raise concern for end organ involvement (cytopenias, renal/hepatic dysfunction, serum sickness), or severe cutaneous adverse reactions (skin desquamation, purpura, mucosal lesions, SJS/TEN, DRESS, AGEP)