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Table 1 Demographic of patient who underwent virtual challenge

From: Virtually supported penicillin allergy de-labelling during COVID-19

Age

Sex

Comorbidities

Inciting medication

Index reaction

Risk of reactiona

Rationale for virtually supervised challenge based on patient–physician shared decision making

Reactions—immediate or delayedb

3

M

Multiple food allergies

Amoxicillin

Generalized urticaria

Intermediate

Convenience–distance

None

3

F

 

Amoxicillin

Maculopapular rash

Intermediate

Convenience–distance

None

4

M

Cystic fibrosis

Amoxicillin clavulanic acid

Maculopapular rash

Intermediate

Convenience–distance

None

4

M

Asthma, atopic dermatitis

Amoxicillin

Maculopapular rash

Intermediate

Convenience–distance

None

6

F

Recurrent urinary tract infections, allergic rhinoconjuctivitis

Amoxicillin

Generalized urticaria

Intermediate

Convenience–distance

None

6

F

Atopic dermatitis

Amoxicillin

Maculopapular rash

Intermediate

Convenience–distance

None

6

F

 

Amoxicillin clavulanic acid

Urticaria

Intermediate

Convenience–distance

None

8

F

 

Amoxicillin

Generalized urticaria and facial angioedema

Intermediate

Convenience–distance

None

8

M

NSAID allergy

Amoxicillin

Urticaria and angioedema

Intermediate

Convenience–distance

None

8

M

Cystic fibrosis

Amoxicillin

Urticaria

Intermediate

Convenience

None

11

F

 

Amoxicillin

Generalized urticaria

Intermediate

Convenience

None

12

M

Food allergy (peanut), asthma, allergic rhinoconjunctivitis

Penicillin

Maculopapular rash

Intermediate

Convenience, less missed school days

None

12

F

 

Amoxicillin

Generalized urticaria

Intermediate

Convenience

None

12

M

 

Amoxicillin

Maculopapular rash

Intermediate

Convenience

None

14

M

Allergic rhinitis, food allergy, asthma

Amoxicillin

Urticaria

Intermediate

Convenience

None

19

F

Asthma

Amoxicillin

Generalized urticaria

Intermediate

Convenience, less missed school days

None

37

M

Relapsing Hodgkin lymphoma, thyroiditis, previous stem cell transplant

Amoxicillin

Rash

Intermediate

Reduce hospital/infectious risk exposure

None

54

F

Interstitial lung disease on oxygen (end stage)

Amoxicillin

Localized rash on arm

Intermediate

Reduce hospital/infectious risk exposure in patient-high risk for severe COVID19 outcomes

None

65

F

Myelodysplastic syndrome, dyslipidemia, hypertension, diabetes

Piperacillin tazobactam

Petechial macules/thin papules coalescing into larger purpuric patches on her upper and lower extremities and including trunk, patient also thrombocytopenic

Intermediate

Reduce hospital/infectious risk exposure in immunosuppressed patient

None

66

F

Multiple myeloma awaiting stem cell transplant, hypertension, diabetes

Amoxicillin

Local rash to chest

Intermediate

 

None

70

F

Locally advanced thymic tumour, hypertension, diabetes

Penicillin

Urticaria

Intermediate

Reduce hospital/infectious risk exposure in patient-high risk for severe COVID19 outcomes

None

70

F

Diffuse large B-cell lymphoma awaiting bone marrow transplant

Penicillin

Unknown

Intermediate

Convenience

None

71

M

Interstitial lung disease (end stage) awaiting transplant, emphysema, hypothyroidism, hypertension, dyslipidemia

Penicillin

Local rash

Intermediate

Reduce hospital/infectious risk exposure in patient-high risk for severe COVID19 outcomes

None

  1. All patients underwent a one-step oral challenge with 250–500 mg of oral amoxicillin (or weight-based dose if pediatric) at their physician’s discretion. Majority of patients lived over 2 h from the centre and/or had co-morbidities putting them at high risk of severe COVID, thus wishing for limited healthcare interaction
  2. aRisk of reaction for proposed oral challenge determined as per the algorithm recommended in reference 3
  3. bReactions—immediate or delayed after the oral challenge took place