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Table 2 Reaction history and characteristics of patients who underwent the virtually supervised oral amoxicillin challenge

From: Virtually supported penicillin allergy de-labelling during COVID-19

Reaction history and characteristics

Proportion of patients

Symptoms concerning for cytopenia, serum sickness-like reactions, severe cutaneous adverse reactions

None

Timing to reaction from first dose

 • Immediate (< 6 h)

1 (4.3%)

 • Delayed (> 24 h)

16 (69.6)

 • Unknown

6 (26.1%)

Cutaneous involvement onlya

19 (83%)

 • Generalized urticaria

7 (30.4%)

 • Non-urticarial exanthem

11(47.8%)

 • Angioedema

1 (4.3%)

 • Remote, unknown

1 (4.3%)

Index reaction prior to age 18

15 (65.2%)

Time elapsed since index reaction

 • > 1 year

21 (91.3%)

 • < 1 year

2 (8.7%)

  1. aWith no history of severe cutaneous adverse reactions