Fig. 10

Pathology variety in mouse lungs from different groups acquired immunotherapy with TCM-1217A or 1217B after sensitization with mite allergen. A Pathology images of each group are presented respectively. Lung tissue cut at 5 μm thickness and stained with hematoxylin–eosin (100X and 40X magnification). Representative photomicrographs from mice treated with Naïve and immunotherapy with saline, DEX, 1217A, and 1217B. B 5-μm thick lung tissue sections were stained with Masson’s Trichrome of the collagen-rich fibrotic region present in blue for fibrosis detection (100X magnification). C The histologic score for each field is shown in terms of tracheal thickness, inflammatory cell count, and tracheal rupture. D Semiquantitative evaluation of lung pathology based on hematoxylin–eosin stain and evaluated with tracheal thickness, inflammatory cell count, and tracheal rupture. Ten visual fields of each mouse were observed, and the pathological features in the lung among different groups were presented as histological scores. #: p < 0.05 compared to the Naïve group; *: p < 0.05 compared to the saline group