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Table 2 On-demand treatments used for unique attacks, overall and by country

From: A multicenter chart review of patient characteristics, treatment, and outcomes in hereditary angioedema: unmet need for more effective long-term prophylaxis

n (%)

Overall (N = 545)

US (n = 140)

Canada (n = 112)

Germany (n = 74)

Australia (n = 103)

UK (n = 116)

Yes

421 (77.2)

112 (80.0)

58 (51.8)

45 (60.8)

90 (87.4)

116 (100)

 C1-INH: Berinert®

257 (61.0)

20 (17.9)

55 (94.8)

42 (93.3)

52 (57.8)

88 (75.9)

  Intravenous

249 (96.9)

20 (100)

47 (85.5)

42 (100)

52 (100)

88 (100)

  Subcutaneousa

8 (3.1)

0

8 (14.5)

0

0

0

 Icatibant

99 (23.5)

60 (53.6)

1 (1.7)

3 (6.7)

33 (36.7)

2 (1.7)

 C1-INH: Cinryze®

51 (12.1)

24 (21.4)

0

0

1 (1.1)

26 (22.4)

 Androgens

7 (1.7)

2 (1.8)

2 (3.4)

0

3 (3.3)

0

 Ecallantide

4 (1.0)

4 (3.6)

0

0

0

0

 Fresh frozen plasma

3 (0.7)

2 (1.8)

0

0

1 (1.1)

0

No

54 (9.9)

11 (7.9)

6 (5.4)

27 (36.5)

10 (9.7)

0

Unknown

70 (12.8)

17 (12.1)

48 (42.9)

2 (2.7)

3 (2.9)

0

  1. C1-INH C1 inhibitor, HAE hereditary angioedema
  2. aBerinert is approved for intravenous administration to treat acute attacks of HAE in pediatric and adult patients. Subcutaneous administration for on-demand treatment of attacks is unapproved