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Table 5 HAE attack rates during follow-up, overall and by country

From: A multicenter chart review of patient characteristics, treatment, and outcomes in hereditary angioedema: unmet need for more effective long-term prophylaxis

 

Overall (N = 131)

US (n = 34)

Canada (n = 42)

Germany (n = 17)

Australia (n = 19)

UK (n = 12)

Italy (n = 7)

Annual attack rate

 Mean ± SD

20.2 ± 16.9

21.8 ± 17.5

17.4 ± 17.0

25.6 ± 13.5

17.8 ± 14.8

23.4 ± 24.7

17.5 ± 9.7

 Median (range)

14.1 (0, 84.1)

15.9 (0, 72.0)

11.9 (0.3, 79.3)

24.0 (4.0, 52.2)

14.0 (2.0, 52.2)

11.8 (0.3, 84.1)

13.8 (6.0, 33.2)

Received LTPa

79 (60.3)

22 (64.7)

28 (66.7)

6 (35.3)

11 (57.9)

11 (91.7)

1 (14.3)

Annual attack rate

 Mean ± SD

20.8 ± 18.9

26.9 ± 19.1

14.6 ± 13.2

35.4 ± 13.8

12.9 ± 15.2

25.0 ± 28.3

9.7 ± 

 Median (range)

13.9 (0, 84.1)

20.7 (0, 72.0)

11.6 (0.3, 52.2)

30.0 (24.0, 52.2)

5.6 (1.1, 52.2)

12.0 (0.3, 84.1)

9.7 (9.7, 9.7)

Did not receive LTPa

52 (39.7)

12 (35.3)

14 (33.3)

11 (64.7)

8 (42.1)

1 (8.3)

6 (85.7)

Annual attack rate

 Mean ± SD

20.3 ± 16.8

14.1 ± 14.7

23.4 ± 24.4

20.2 ± 10.3

22.9 ± 14.3

43.0 ± 

18.7 ± 10.1

 Median (range)

15.7 (0.3, 79.3)

9.4 (0.9, 48.2)

15.7 (0.3, 79.3)

24.0 (4.0, 36.0)

23.8 (2.0, 52.2)

43.0 (43.0, 43.0)

18.9 (6.0, 33.2)

  1. Only patients with information on frequency of HAE attacks are included
  2. HAE hereditary angioedema, LTP long-term prophylaxis, SD standard deviation
  3. aLTP was or was not received during the period(s) in which frequency of HAE attacks was reported