Fig. 1

Patient distribution of annualized HAE attack frequency, based on interview data. Index = initiation of long-term prophylaxis with C1INH(SC). ^†One outlier patient with particularly burdensome disease reported experiencing a pre-index annualized frequency of ~ 198 attacks per year (15–18 attacks per month). Post-index, the annualized rate decreased to 78 attacks per year (6–7 per month). C1INH(SC) subcutaneous C1-inhibitor, HAE hereditary angioedema