Association between interleukin-6-174G/C gene polymorphism and asthma severity: exploring the role of total serum IgE, blood eosinophils, and FeNO as markers of type 2 inflammation

Table 1 Comparing the demographic characters and the frequency of IL-6 gene (-174G/C) polymorphism in control versus mild and severe asthma subgroups

Factors	Control (n = 121)		Mild asthma (n = 98)		Severe asthma (n = 116)		P1	P2	P3
	Mean	SD	Mean	SD	Mean	SD
Age (Years)	37.5	16.1	38.3	16.6	52.8	11.5	0.73	< 0.001^†	< 0.001^†
Female-sex	83	68.6	66	67.35	80	68.97	0.84	0.95	0.81
BMI	29.91	8.92	30.19	6.95	31.46	5.75	0.62	0.09	0.15

IL-6 polymorphisms	N	%	N	%	N	%	OR	95% CI		OR	95% CI		OR	95% CI
CC	77	63.64	56	57.14	62	53.45	1.313	(0.761–2.264)	0.32	1.524	(0.906–2.563)	0.11	0.898	(0.523–1.541)	0.69
GC	32	26.45	10	10.2	42	36.21	0.316	(0.147–0.682)	0.002*	1.579	(0.907–2.746)	0.12	4.995	(2.346–10.635)	< 0.001*
GG	12	9.92	32	32.65	12	10.34	4.404	(2.121–9.143)	< 0.001*	1.048	(0.451–2.438)	0.91	4.4	(2.121–9.128)	< 0.001*
C allele	186/242	76.85	122/196	62.24	166/232	71.55	0.41	(0.29, 0.59)	0.001*	0.57	(0.435, 2.834)	0.54	1.53	(1.017–2.289)	0.05*
G allele	56/242	23.14	74/196	37.75	66/232	28.44	1.67	(1.15, 2.44)	0.006*	1.13	(0.874–1.996)	0.22	0.65	(0.437–0.984)	0.05*

Dominant pattern	N	%	N	%	N	%	OR	95% CI		OR	95% CI		OR	95% CI
CC + CG	109	90.08	66	67.35	104	89.66	4.404	(2.121–9.143)	< 0.001*	1.04	(0.451–2.438)	0.91	4.4	(2.121–9.128)	< 0.001*
GG	12	9.92	32	32.65	12	10.34	Reference			Reference

Recessive pattern	N	%	N	%	N	%	OR	95% CI		OR	95% CI		OR	95% CI
CC	77	63.64	56	57.14	62	53.45	Reference		0.32	Reference		0.11
CG + GG	44	36.36	42	42.86	54	46.55	1.313	(0.761–2.264)		1.52	(0.906–2.563)		0.898	(0.523–1.541)	0.65

N number, SD standard deviation, OR odd ratio, CI Confidence interval
Numerical data represented as mean and standard deviation and categorical data as number and percentage, p1: Control versus mild asthma, p2: control versus severe asthma, p3, mild asthma versus severe asthma, the test of significant: ^†: Independent t-test, *: Chi square test
Text with Bold represents a significant p value; p < 0.05

ISSN: 1710-1492