Articles

Th₁₇ responses are not altered by natural exposure to seasonal allergens in pollen-sensitive patients

Allergic rhinitis affects 10–30 % of the global population and this number is likely to increase in the forthcoming years. Moreover, it commonly co-exists with allergic asthma as a chronic allergic respiratory...

Authors: Agata Schramm, Barbara Jasiewicz-Honkisz, Grzegorz Osmenda, Grzegorz Wilk, Mateusz Siedlinski, Agnieszka Sagan, Pawel T. Matusik, Joanna Maciag, Tomasz Sliwa, Marta Czesnikiewicz-Guzik and Tomasz P. Mikolajczyk

Predictors of allergen sensitization in Singapore children from birth to 3 years

Immune responses in allergic diseases begin with allergen sensitization, which usually occurs in childhood. Allergen sensitization involves a complex interplay of genetic and environmental factors, and sensiti...

Authors: Evelyn Xiu Ling Loo, Jordan Zheng Ting Sim, Anne Goh, Oon Hoe Teoh, Yiong Huak Chan, Seang Mei Saw, Kenneth Kwek, Peter D. Gluckman, Keith M. Godfrey, Hugo Van Bever, Yap Seng Chong, Bee Wah Lee, Michael S. Kramer and Lynette Pei-chi Shek

Prospective evaluation of testing with baked milk to predict safe ingestion of baked milk in unheated milk-allergic children

Cow’s milk allergy is one of the most common food allergies affecting young children. A subset of milk-allergic individuals can eat baked milk without allergic symptoms which is beneficial in terms of prognost...

Authors: Allison Kwan, Maria Asper, Sasson Lavi, Elana Lavine, David Hummel and Julia E. Upton

Interacting effects of obesity, race, ethnicity and sex on the incidence and control of adult-onset asthma

To improve care and control for patients with adult-onset asthma, a better understanding of determinants of their risk and outcomes is important. We investigated how associations between asthma, asthma control...

Authors: Corinna Koebnick, Heidi Fischer, Matthew F. Daley, Assiamira Ferrara, Michael A. Horberg, Beth Waitzfelder, Deborah Rohm Young and Michael K. Gould

Air pollution, epigenetics, and asthma

Exposure to traffic-related air pollution (TRAP) has been implicated in asthma development, persistence, and exacerbation. This exposure is highly significant as large segments of the global population resides...

Authors: Hong Ji, Jocelyn M. Biagini Myers, Eric B. Brandt, Cole Brokamp, Patrick H. Ryan and Gurjit K. Khurana Hershey

Genetic and epigenetic studies of atopic dermatitis

Atopic dermatitis (AD) is a chronic inflammatory disease caused by the complex interaction of genetic, immune and environmental factors. There have many recent discoveries involving the genetic and epigenetic ...

Authors: Lianghua Bin and Donald Y. M. Leung

Clinical validation of controlled exposure to birch pollen in the Environmental Exposure Unit (EEU)

The Environmental Exposure Unit (EEU) in Kingston, Ontario, Canada is a controlled allergen challenge facility (CACF) that has been previously clinically validated for the use of ragweed and grass pollen in cl...

Authors: Anne K. Ellis, Mena Soliman, Lisa M. Steacy, Daniel E. Adams, Barnaby Hobsbawn and Terry J. B. Walker

Co-exposure to zymosan A and heat-inactivated Asian sand dust exacerbates ovalbumin-induced murine lung eosinophilia

Epidemiological studies have implicated Asian sand dust (ASD) in the increased prevalence of respiratory disorders, including asthma. It has been observed that fungal elements such as β-glucan can be adsorbed ...

Authors: Kaori Sadakane, Takamichi Ichinose, Masataka Nishikawa, Hirohisa Takano and Takayuki Shibamoto

Adrenal suppression in children treated with swallowed fluticasone and oral viscous budesonide for eosinophilic esophagitis

Adrenal suppression (AS), a glucocorticoid (GC) side effect associated with significant morbidity, is well described related to inhaled corticosteroid therapy for asthma. Swallowed topical glucocorticoid thera...

Authors: Alexandra Ahmet, Eric I. Benchimol, Ellen B. Goldbloom and Janice L. Barkey

Genetic susceptibility to allergic bronchopulmonary aspergillosis in asthma: a genetic association study

In patients with asthma, the fungus Aspergillus fumigatus can cause allergic bronchopulmonary aspergillosis (ABPA). Familial ABPA is reported, and some genetic factors have been associated with the disease, howev...

Authors: Nicola L. D. Overton, David W. Denning, Paul Bowyer and Angela Simpson

A novel combination of an IgE mediated adult onset food allergy and a suspected mast cell activation syndrome presenting as anaphylaxis

Adult onset food allergy is a rare, but increasingly recognized phenomenon. Mast cell activation syndromes present an ongoing diagnostic and classification challenge. The combination of the two has been rarely...

Authors: Colin Barber and Chrystyna Kalicinsky

Systematic review of outcome measures in pediatric eosinophilic esophagitis treatment trials

Heterogeneity has been noted in the selection and reporting of disease-specific, pediatric outcomes in randomized controlled trials (RCTs). The consequence is invalid results or difficulty comparing results ac...

Authors: Tamar Rubin, Jacqueline Clayton, Denise Adams, Rabin Persad and Sunita Vohra

Two-weeks-sustained unresponsiveness by oral immunotherapy using microwave heated cow’s milk for children with cow’s milk allergy

Several studies have reported that oral immunotherapy (OIT) is effective for children with cow’s milk (CM) allergy. These studies reported the efficacy of OIT in terms of desensitization, but did not describe ...

Authors: Masaya Takahashi, Shoichiro Taniuchi, Kazuhiko Soejima, Yasuko Hatano, Sohsaku Yamanouchi and Kazuanri Kaneko

Proceedings of the Canadian society of allergy and clinical immunology annual scientific meeting 2015

A1 Role of fibrocytes in allergic rhinitis

Authors: Marie-Ève Côté, Marie-Ève Boulay, Sophie Plante, Jamila Chakir, Louis-Philippe Boulet, Hanan Ahmed, Maria-Beatriz Ospina, Kyriaki Sideri, Harissios Vliagoftis, Sara F. Johnson, Roberta L. Woodgate, Guilhem Cros, Pierre Teira, Sonia Cellot, Henrique Bittencourt, Helene Decaluwe…

Potential factors involved in the causation of rhabdomyolysis following status asthmaticus

Rhabdomyolysis is a rare but potentially fatal complication of status asthmaticus. Since the first case was reported in 1978, only a few dozen cases have been described till date. We performed a literature rev...

Authors: Hongmei Qiao, Huanji Cheng, Li Liu and Jianing Yin

Antibiotic prescription and food allergy in young children

To assess the relationship between any systemic antibiotic prescription within the first year of life and the presence of an ICD-9-CM diagnosis code for food allergy (FA).

Authors: Bryan L. Love, Joshua R. Mann, James W. Hardin, Z. Kevin Lu, Christina Cox and David J. Amrol

Investigation of anti-asthmatic potential of dried fruits of Vitis vinifera L. in animal model of bronchial asthma

Fruits of Vitis vinifera L., commonly known as grapes, are largely consumed worldwide because of their high nutritional and medicinal benefits.

Authors: Poonam Arora, S. H. Ansari, Abul Kalam Najmi, Varisha Anjum and Sayeed Ahmad

Reduced work/academic performance and quality of life in patients with allergic rhinitis and impact of allergen immunotherapy

Allergic rhinitis (AR) is characterised by burdensome nasal and/or ocular symptoms. This inflammatory disease can be debilitating and thus result in considerable health-related and economic consequences.

Authors: A. Roger, E. Arcalá Campillo, M. C. Torres, C. Millan, I. Jáuregui, E. Mohedano, S. Liñan, P. Verdu, N. Rubira, M. Santaolalla, P. González, A. Orovitg and E. Villarrubia

Association between cancer and allergies

The prevalence of allergies and the incidence of cancer are both increasing worldwide. It has been hypothesized that atopy may affect the risk of some cancers.

Authors: Renata Kozłowska, Andrzej Bożek and Jerzy Jarząb

Reproducibility of serum IgE, Ara h2 skin prick testing and fraction of exhaled nitric oxide for predicting clinical peanut allergy in children

Ara h2 sIgE serum levels improve the diagnostic accuracy for predicting peanut allergy, but the use of Ara h2 purified protein as a skin prick test (SPT), has not been substantially evaluated. The fraction of ...

Authors: Elizabeth Percival, Rani Bhatia, Kahn Preece, Patrick McElduff, Mark McEvoy, Adam Collison and Joerg Mattes

Specific immunotherapy ameliorates ulcerative colitis

Hypersensitivity reaction to certain allergens plays a role in the pathogenesis of inflammatory bowel disease (IBD). This study aims to observe the effect of specific immunotherapy in a group of IBD patients.

Authors: Min Cai, Lu Zeng, Lin-Jing Li, Li-Hua Mo, Rui-Di Xie, Bai-Sui Feng, Peng-Yuan Zheng, Zhi-Gang Liu, Zhan-Ju Liu and Ping-Chang Yang

A role for auto-immunity in chronic rhinosinusitis? Lessons learned from sub-epidermal bullous disorders of the skin

Chronic rhinosinusitis (CRS) is a frequent chronic condition, which has origins in complex interactions between genetic, immunological and microbial factors. The role of auto-immunity in CRS remains unclear, a...

Authors: Philippe Lefrançois, Hugo Chapdelaine, Benoît Côté and Martin Desrosiers

Prevalence and clinical features of adverse food reactions in Portuguese adults

Only one previous study, via telephone call, on the prevalence of self-reported food allergies has been performed in Portugal, in a small sample of adults. The objective of this study was to determine the prev...

Authors: Carlos Lozoya-Ibáñez, Sara Morgado-Nunes, Alexandra Rodrigues, Cláudia Lobo and Luis Taborda-Barata

Patient engagement and patient support programs in allergy immunotherapy: a call to action for improving long-term adherence

Allergy immunotherapy (AIT) is acknowledged to produce beneficial mid- and long-term clinical and immunologic effects and increased quality of life in patients with allergic respiratory diseases (such as aller...

Authors: Pascal Demoly, Giovanni Passalacqua, Oliver Pfaar, Joaquin Sastre and Ulrich Wahn

Clinical and immuno-proteomic approach on Lantana camara pollen allergy—a major health hazard

The incidence of allergic diseases is increasing gradually and is a global burden affecting the socio-economic quality of life. Identification of allergens is the first step towards paving the way for therapeu...

Authors: Kavita Ghosal, Bodhisattwa Saha and Swati Gupta Bhattacharya

Clinical Experience with Octagam® 10 %, a solvent detergent virus inactivated intravenous immunoglobulin: a Canadian retrospective review of utilization

In Canada, intravenous immune globulin (IVIg) products are licensed for six disease indications, however it has been demonstrated that patients with a number of other conditions also benefit from IVIg. Here we...

Authors: Stephen D. Betschel, Richard J. Warrington and Robert Schellenberg

Filaggrin gene mutations and new SNPs in asthmatic patients: a cross-sectional study in a Spanish population

Several null-mutations in the FLG gene that produce a decrease or absence of filaggrin in the skin and predispose to atopic dermatitis and ichthyosis vulgaris have been described. The relationship with asthma is ...

Authors: José Luis Cubero, María Isidoro-García, Nieves Segura, David Benito Pescador, Catalina Sanz, Félix Lorente, Ignacio Dávila and Carlos Colás

Retrospective analysis on the agreement between skin prick test and serum food specific IgE antibody results in adults with suspected food allergy

Food allergy is a common clinical problem in adults. Given logistical barriers to conducting food challenges, the use of skin prick test (SPT) and specific IgE (sIgE) are important in establishing the diagnosi...

Authors: Ling Ling, Maria B. Ospina, Kyriaki Sideri and Harissios Vliagoftis

Comparison of ImmunoCAP and Immulite serum specific IgE assays for the assessment of egg allergy

Egg specific IgE levels are frequently used in combination with skin-prick tests to guide clinical decisions and to monitor egg allergy evolution in children. We compared both Immulite and ImmunoCAP egg specif...

Authors: François Graham, Philippe Bégin, Louis Paradis, Jonathan Lacombe-Barrios, Jean Paradis and Anne Des Roches

Primary immunodeficiencies associated with eosinophilia

Eosinophilia is not an uncommon clinical finding. However, diagnosis of its cause can be a dilemma once common culprits, namely infection, allergy and reactive causes are excluded. Primary immunodeficiency dis...

Authors: Behdad Navabi and Julia Elizabeth Mainwaring Upton

Allergen inhalation challenge, refractoriness and the effects of ibuprofen

Bronchoprovocation challenges use direct or indirect acting stimuli to induce airflow obstruction. Indirect stimuli either non-allergic/non-IgE mediated (e.g. exercise, mannitol) or allergic/IgE mediated (i.e....

Authors: Shawn Nomani, Donald W. Cockcroft and Beth E. Davis

Maternal serum but not breast milk IL-5, IL-6, and IL-13 immune markers are associated with scratching among infants

Scratching in infants is considered to be related to early development of eczema. Little is known about the effects of maternal immune markers on scratching among infants. The objective is to compare the risks...

Authors: Nelís Soto-Ramírez, Keith Boyd, Hongmei Zhang, Venugopal Gangur, Laura Goetzl and Wilfried Karmaus

Persistence of respiratory and inflammatory responses after dermal sensitization to persulfate salts in a mouse model of non-atopic asthma

Exposure to ammonium persulfate (AP) has been reported to be the main cause of occupational asthma in hairdressers. The aim of this study is to assess how long the asthmatic response to AP can be induced after...

Authors: M. J. Cruz, M. Olle-Monge, J. A. Vanoirbeek, A. Assialioui, S. Gomez-Olles and X. Muñoz

Erratum to: Safety and feasibility of oral immunotherapy to multiple allergens for food allergy

Authors: Philippe Bégin, Lisa C. Winterroth, Tina Dominguez, Shruti P. Wilson, Liane Bacal, Anjuli Mehrotra, Bethany Kausch, Anthony Trela, Elisabeth Hoyte, Gerri O’Riordan, Scott Seki, Alanna Blakemore, Margie Woch, Robert G. Hamilton and Kari C. Nadeau

Anaphylaxis to IGIV in immunoglobulin-naïve common variable immunodeficiency patient in the absence of IgG anti-IgA antibodies: successful administration of low IgA-containing immunoglobulin

Although severe reactions to immunoglobulin preparations have been frequently reported, IgE antibodies against IgA are usually not investigated; and occur predominantly in previously sensitized patients. The p...

Authors: Asal Gharib, Caroline Caperton and Sudhir Gupta

Multisystem reactions during egg oral food challenges may be associated with less severe reactions on initial presentation

In this study, we assessed whether multisystem reactions to egg and extensively-heated (EH) egg during OFCs were associated with a history of multisystem reactions. Records of children, who underwent OFC to eg...

Authors: Girish Vitalpur, Ann Esquivel, Kirsten M. Kloepfer, James E. Slaven and Frederick E. Leickly

Cytokine patterns in nasal secretion of non-atopic patients distinguish between chronic rhinosinusitis with or without nasal polys

Being one of the most common nasal diseases, chronic rhinosinusitis (CRS) is subdivided into CRS with nasal polyps (NP) and CRS without nasal polyps (CRSsNP). CRSsNP presents itself with a T_H1 milieu and neutroph...

Authors: Katrin König, Christine Klemens, Mareike Haack, Marion San Nicoló, Sven Becker, Matthias F. Kramer and Moritz Gröger

Diagnostic accuracy of skin-prick testing for allergic rhinitis: a systematic review and meta-analysis

Allergic rhinitis is the most common form of allergy worldwide. The accuracy of skin testing for allergic rhinitis is still debated. Our primary objective was to evaluate the diagnostic accuracy of skin-prick ...

Authors: Immaculate F. Nevis, Karen Binkley and Conrad Kabali

IgE serum concentration against airborne fungi in children with respiratory allergies

To evaluate total and specific E immunoglobulin (IgE) antibody concentrations in underage subjects with respiratory allergic diseases.

Authors: Geusa Felipa de Barros Bezerra, Denise Maria Costa Haidar, Marcos Antonio Custódio Neto da Silva, Walbert Edson Muniz Filho, Ramon Moura dos Santos, Ivone Garros Rosa, Graça Maria de Castro Viana, Luís Zaror and Maria do Desterro Soares Brandão Nascimento

Evaluation of circulating vascular endothelial growth factor and its soluble receptors in patients suffering from persistent allergic rhinitis

Overexpression and enhanced release of vascular endothelial growth factor (VEGF) have been detected in various types of allergic inflammation, including asthma.

Authors: E. Koczy-Baron, A. Grzanka, J. Jochem, R. Gawlik and A. Kasperska-Zajac

Exposure to bisphenol A enhanced lung eosinophilia in adult male mice

Bisphenol A (BPA) is useful in many manufacturing processes and is also found in commonly used consumer products. Previous experimental studies have reported that perinatal exposure to BPA promotes the develop...

Authors: Miao He, Takamichi Ichinose, Seiichi Yoshida, Hirohisa Takano, Masataka Nishikawa, Takayuki Shibamoto and Guifan Sun

Severity and disease control before house dust mite immunotherapy initiation: ANTARES a French observational survey

Allergen immunotherapy (AIT) may be prescribed for patients with allergic rhinitis (AR) induced by house dust mites (HDM) whether asthma is present or not. Current guidelines provide insufficient support for t...

Authors: Pascal Demoly, Anne Broué-Chabbert, François Wessel and Antoine Chartier

A rare nonsynonymous variant in the lipid metabolic gene HELZ2 related to primary biliary cirrhosis in Chinese Han

Several genome-wide association studies of primary biliary cirrhosis (PBC) in European and Japanese origins have shown significant association of dozens of genetic loci contributive to the susceptibility of PB...

Authors: Ping Li, Guanting Lu, Li Wang, Ying Cui, Ziyan Wu, Si Chen, Jing Li, Xiaoting Wen, Haoze Zhang, Shijie Mu, Fengchun Zhang and Yongzhe Li

Reviewer acknowledgement 2015

Authors: Richard Warrington

Allergen extracts and recombinant proteins: comparison of efficiency of in vitro allergy diagnostics using multiplex assay on a biological microchip

Immunological test systems for diagnostics of type I hypersensitivity involve the following types of antigens: whole allergen extracts, individual highly purified proteins and their recombinant analogues. The ...

Authors: Olga Smoldovskaya, Guzel Feyzkhanova, Alla Arefieva, Sergei Voloshin, Olga Ivashkina, Yuriy Reznikov and Alla Rubina

Asthma in the elderly: the effect of choline supplementation

Asthma in the elderly is poorly understood as very few studies have included these patients. DNA methylation can affect the expression of asthma susceptibility genes. Methyl groups can be produced through a ch...

Authors: Michele Columbo and Albert S. Rohr

Do epinephrine auto-injectors have an unsuitable needle length in children and adolescents at risk for anaphylaxis from food allergy?

Food allergy is the most common cause of anaphylaxis in children. Intramuscular delivery of epinephrine auto-injectors (EAI) is the standard of care for the treatment of anaphylaxis. We examined if children an...

Authors: Sten Dreborg, Xia Wen, Laura Kim, Gina Tsai, Immaculate Nevis, Ryan Potts, Jack Chiu, Arunmozhi Dominic and Harold Kim

T-cell receptor phenotype pattern in atopic children using commercial fluorescently labeled antibodies against 21 human class-specific v segments for the tcrβ chain (vβ) of peripheral blood: a cross sectional study

T-cell receptor (TCR) repertoire development is an integral part of the adaptive immune response. T-cell activation requires recognition of appropriately processed antigens by the TCR. Development of a diverse...

Authors: Gassem Gohal, Christine McCusker, Bruce Mazer, Reza Alizadehfar, Duncan Lejtenyi and Moshe Ben-shoshan

Angiopoietin-2 concentration in serum is associated with severe asthma phenotype

Several proangiogenic molecules have been implicated in the pathogenies of asthmatic inflammation and remodeling. The aim of the study was to compare the concentration of proangiogenic factors in the sera of a...

Authors: Joanna S. Makowska, Małgorzata Cieślak, Marzanna Jarzębska, Anna Lewandowska-Polak and Marek L. Kowalski

Role of specific IgE to β-lactoglobulin in the gastrointestinal phenotype of cow’s milk allergy

The prevalence of many phenotypes of food allergy is increasing. Specific gastrointestinal (GI) phenotype of food allergy (GI allergy) is also increasing but it is difficult to know the prevalence because of m...

Authors: Paloma Poza-Guedes, Yvelise Barrios, Ruperto González-Pérez, Inmaculada Sánchez-Machín, Andres Franco and Víctor Matheu