Articles

Loss of bronchoprotection to Salbutamol during sputum induction with hypertonic saline: implications for asthma therapy

Sputum induction with hypertonic saline in obstructive airway diseases is generally safe. However, saline induces bronchoconstriction in some patients despite pre-medication with Salbutamol. Our objectives wer...

Authors: Hongyu Wang, Melanie Kjarsgaard, Terence Ho, John D. Brannan and Parameswaran Nair

New onset colitis in an adult patient with chronic granulomatous disease treated with hematopoietic stem cell transplantation: a diagnostic dilemma

Chronic granulomatous disease (CGD) is a rare primary immunodeficiency characterized by recurrent life-threatening bacterial and fungal infections, granuloma formation and intestinal disease. This disease is c...

Authors: Kara Robertson, Stephen Couban, Desmond Leddin, Imran Ahmad and Lori Connors

Investigating the effectiveness of the Trigonella foenum-graecum L. (fenugreek) seeds in mild asthma: a randomized controlled trial

Asthma is one of the important chronic diseases. The asthma prevalence is increasing in last decades. Despite the presence of good controller drugs like corticosteroids, about 60% of asthmatic patients use alt...

Authors: Majid Emtiazy, Laleh Oveidzadeh, Minoo Habibi, Leila Molaeipour, Daryush Talei, Zahra jafari, Mahmoud Parvin and Mohammad Kamalinejad

Severe, eosinophilic asthma in primary care in Canada: a longitudinal study of the clinical burden and economic impact based on linked electronic medical record data

Stratification of patients with severe asthma by blood eosinophil counts predicts responders to anti-interleukin (IL)-5 (mepolizumab and reslizumab) and anti-IL-5 receptor α (benralizumab) therapies. This stud...

Authors: Don Husereau, Jason Goodfield, Richard Leigh, Richard Borrelli, Michel Cloutier and Alain Gendron

The course of asthma during pregnancy in a recent, multicase–control study on respiratory health

Over the years it has been widely stated that approximately one-third of asthmatic women experience worsening of the disease during pregnancy. However, the literature has not been reviewed systematically and t...

Authors: A. Grosso, F. Locatelli, E. Gini, F. Albicini, C. Tirelli, I. Cerveri and A. G. Corsico

An update on molecular cat allergens: Fel d 1 and what else? Chapter 1: Fel d 1, the major cat allergen

Cats are the major source of indoor inhalant allergens after house dust mites. The global incidence of cat allergies is rising sharply, posing a major public health problem. Ten cat allergens have been identif...

Authors: B. Bonnet, K. Messaoudi, F. Jacomet, E. Michaud, J. L. Fauquert, D. Caillaud and B. Evrard

Critical view of anaphylaxis epidemiology: open questions and new perspectives

In contrast to the majority of allergic or hypersensitivity conditions, worldwide anaphylaxis epidemiological data remain sparse with low accuracy, which hampers comparable morbidity statistics. Data can diffe...

Authors: Luciana Kase Tanno, Ana Luiza Bierrenbach, F. Estelle R. Simons, Victoria Cardona, Bernard Yu-Hor Thong, Nicolas Molinari, Moises A. Calderon, Margitta Worm, Yoon-Seok Chang, Nikolaos G. Papadopoulos, Thomas Casale and Pascal Demoly

Immediate type hypersensitivity and late phase reaction occurred consecutively in a patient receiving ethambutol and levofloxacin

We experienced a rare case of immediate type hypersensitivity and late phase reaction to anti-tubercular therapy consisting of ethambutol and levofloxacin, which occurred in close succession, giving the appear...

Authors: Yukihiko Kato, Yu Sato, Miho Nakasu and Ryoji Tsuboi

Proceedings of the Canadian Society of Allergy and Clinical Immunology Annual Scientific Meeting 2017

Authors:

Tuberculosis induced autoimmune haemolytic anaemia: a systematic review to find out common clinical presentations, investigation findings and the treatment options

Tuberculosis induced autoimmune haemolytic anaemia is a rare entity. The aim of this study was to explore its common presentations, investigation findings and treatment options through a systematic review of p...

Authors: Devarajan Rathish and Sisira Siribaddana

Cytokine profiles among patients co-infected with Plasmodium falciparum malaria and soil borne helminths attending Kampala International University Teaching Hospital, in Uganda

Malaria and helminths share the same geographical distribution in tropical Africa. Studies of the interaction of helminth and malaria co-infection in humans have been few and are mainly epidemiological, with l...

Authors: Richard Bwanika, Charles D. Kato, Johnson Welishe and Daniel C. Mwandah

A novel outpatient desensitization protocol for recombinant human erythropoietin allergy in a pediatric patient

Recombinant human erythropoietin, such as epoetin alfa and darbepoetin alfa, is an important therapy for anemia due to chronic renal failure. Allergy to recombinant human erythropoietin and the need for desens...

Authors: Jaime S. Rosa, Van B. Vuong, Orly Haskin and Anne Y. Liu

Clinical implications of CD4⁺ T cell subsets in adult atopic asthma patients

T cells play a central role in chronic inflammation in asthma. However, the roles of individual subsets of T cells in the pathology of asthma in patients remain to be better understood.

Authors: Matthew Wiest, Katherine Upchurch, Wenjie Yin, Jerome Ellis, Yaming Xue, Bobby Lanier, Mark Millard, HyeMee Joo and SangKon Oh

Evaluation of eczema, asthma, allergic rhinitis and allergies among the Grade-1 children of Iqaluit

Little is known about the prevalence of asthma, allergic rhinitis, eczema and allergies among Canadian Inuit children, especially those living in the arctic and subarctic areas.

Authors: Ahmed Ahmed, Amir Hakim and Allan Becker

Seasonal variation in circulating group 2 innate lymphoid cells in mugwort-allergic asthmatics during and outside pollen season

Group 2 innate lymphoid cells (ILC2s) are a newly identified cell population with the potent capability to produce Th2-type cytokines in a non-antigen specific manner. Previous study demonstrated that enhanced...

Authors: Qing Miao, Yan Wang, Yong-ge Liu, Yi-xin Ren, Hui Guan, Zhen Li, Wei Xu and Li Xiang

Atopy and related clinical symptoms among Swiss medical students from 2007 to 2015

Atopic allergy is a widespread disease with increasing prevalence in the second half of the twentieth century and is most often associated with clinical symptoms, like rhinoconjunctivitis, asthma or eczema. Th...

Authors: Lukas Steinegger, Stephan Regenass, Lucas M. Bachmann, Elsbeth Probst and Urs C. Steiner

Self-reported questionnaire survey on the prevalence and symptoms of adverse food reactions in patients with chronic inhalant diseases in Tangshan city, China

The prevalence of adverse food reactions in patients with chronic inhalant diseases has seldom been studied in China. This study is to investigate the prevalence of adverse food reactions and the symptoms caus...

Authors: Guodong Hao, Xuxin Lai, Zhijing Song, Zhixing Wang, Xing-ai Kong, Haifeng Zhong, Sui Fu Hui and Yiwu Zheng

Onset of action for loratadine tablets for the symptomatic control of seasonal allergic rhinitis in adults challenged with ragweed pollen in the Environmental Exposure Unit: a post hoc analysis of total symptom score

Loratadine is a second-generation, non-sedating antihistamine used for the relief of allergic rhinitis symptoms. Previous studies reported that when loratadine was encapsulated, the onset of action for symptom...

Authors: Mark W. Tenn, Lisa M. Steacy, Charlene C. Ng and Anne K. Ellis

CSACI position statement: prescribing sublingual immunotherapy tablets for aeroallergens

Authors: J. Quirt, R. Gagnon, A. K. Ellis and H. L. Kim

Positive correlation of airway resistance and serum asymmetric dimethylarginine (ADMA) in bronchial asthma patients lacking evidence for systemic inflammation

Contribution of nitric-oxide (NO) pathway to the pathogenesis of bronchial asthma (asthma) is ambiguous as NO may confer both protective and detrimental effects depending on the NO synthase (NOS) isoforms, tis...

Authors: Gabor Tajti, Csaba Papp, Laszlo Kardos, Sandor Keki, Krisztian Pak, Magdolna Emma Szilasi, Rudolf Gesztelyi, Angela Mikaczo, Andrea Fodor, Maria Szilasi and Judit Zsuga

Feasibility of sustained response through long-term dosing in food allergy immunotherapy

Clinical trials using oral immunotherapy (OIT) for the treatment of food allergies have shown promising results. We previously demonstrated the feasibility of desensitization for up to 5 food allergens simulta...

Authors: Sandra Andorf, Monali Manohar, Tina Dominguez, Whitney Block, Dana Tupa, Rohun A. Kshirsagar, Vanitha Sampath, R. Sharon Chinthrajah and Kari C. Nadeau

Observational long-term follow-up study of rapid food oral immunotherapy with omalizumab

A number of clinical studies focused on treating a single food allergy through oral immunotherapy (OIT) with adjunctive omalizumab treatment have been published. We previously demonstrated safety and tolerabil...

Authors: Sandra Andorf, Monali Manohar, Tina Dominguez, Whitney Block, Dana Tupa, Rohun A. Kshirsagar, Vanitha Sampath, R. Sharon Chinthrajah and Kari C. Nadeau

MPO-ANCA associated vasculitis with mononeuritis multiplex following influenza vaccination

Although influenza vaccines are generally safe and effective, a variety of autoimmune phenomena have been reported after vaccination over the past years, such as Guillain–Barre syndrome, rheumatoid arthritis, ...

Authors: Stefanie Eindhoven, Jolien Levels, Margriet Huisman, Koos Ruizeveld de Winter, Virgil Dalm and Rehmat Alwani

Initial intravenous immunoglobulin doses should be based on adjusted body weight in obese patients with primary immunodeficiency disorders

Immunoglobulin therapy plays a critical role in the treatment of immunodeficiency disorders as well as autoimmune and inflammatory conditions. In immunodeficient patients, there has been controversy whether in...

Authors: Rohan Ameratunga

Anaphylactic shock following castor bean contact: a case report

The castor bean plant, Ricinus communis, is known to have allergenic and toxic properties. Castor bean allergy has been described mainly as an occupational inhalation allergy in laboratory workers, in persons wor...

Authors: Y. Coattrenec, D. Jaques, P. Jandus, T. Harr and D. Spoerl

Asthma biomarkers in the age of biologics

The heterogeneous nature of asthma has been understood for decades, but the precise categorization of asthma has taken on new clinical importance in the era of specific biologic therapy. The simple categories ...

Authors: Harold Kim, Anne K. Ellis, David Fischer, Mary Noseworthy, Ron Olivenstein, Kenneth R. Chapman and Jason Lee

Adherence with epinephrine autoinjector prescriptions in primary care

The aim of this study was to estimate primary adherence for epinephrine autoinjector (EA) prescriptions in primary care practices in Manitoba, Canada.

Authors: Elissa M. Abrams, Alexander G. Singer, Lisa Lix, Alan Katz, Marina Yogendran and F. Estelle R. Simons

Response to case report: Airway autoimmune responses in severe eosinophilic asthma following low-dose Mepolizumab therapy

Authors: I. J. Pouliquen, P. Howarth, D. Austin, G. Gunn, E. Meyer, R. G. Price and E. Bradford

Adult reference intervals for IgG subclasses with Siemens immunonephelometric assays in Chinese population

To determine the adult reference intervals for the Siemens IgG subclass reagents.

Authors: Ping Li, Zhongjuan Liu, Ziyan Wu, Xiaoting Wen, Liubing Li, Shulan Zhang, Yingchun Xu and Yongzhe Li

Are food allergic consumers ready for informative precautionary allergen labelling?

Precautionary allergen labelling (PAL) has resulted in consumer confusion. Previous research has shown that interpretive labels (using graphics, symbols, or colours) are better understood than the traditional ...

Authors: Giovanni A. Zurzolo, Rachel L. Peters, Jennifer J. Koplin, Maximilian de Courten, Michael L. Mathai and Katrina J. Allen

Oral food challenge outcomes in a pediatric tertiary care center

Oral food challenges are the clinical standard for diagnosis of food allergy. Little data exist on predictors of oral challenge failure and reaction severity.

Authors: Elissa M. Abrams and Allan B. Becker

Passive blood anaphylaxis: subcutaneous immunoglobulins are a cause of ongoing passive anaphylactic reaction

Allergic, especially anaphylactic, reactions during immunoglobulin replacement therapy are rare, but their pathophysiology and classification remain ambiguous. Recent findings show positive results of skin tes...

Authors: Przemyslaw Zdziarski, Andrzej Gamian, Jacek Majda and Agnieszka Korzeniowska-Kowal

Prevalence and clinical features of adverse food reactions in Portuguese children

The prevalence of adverse food reactions (AFR) has been increasing in the western world. Clinical manifestations are diversified and it may not be possible to clinically discriminate between IgE and non-IgE me...

Authors: Arminda Jorge, Elisa Soares, Emanuel Sarinho, Felix Lorente, Jorge Gama and Luís Taborda-Barata

Serum free IgE guided dose reduction of omalizumab: a case report

Omalizumab is a human IgG1 antibody against IgE used as a therapy for sever asthmatic patients with asthma. According to the guidelines of the Global Initiative for Asthma, omalizumab is an add-on drug at trea...

Authors: Yasuhiro Gon, Reiko Ito, Shuichiro Maruoka, Kenji Mizumura, Yutaka Kozu, Hisato Hiranuma, Yuko Iida, Sotaro Shikano and Shu Hashimoto

Management of chronic spontaneous urticaria (CSU): a treat to target approach using a patient reported outcome

Treat-to-target therapy approaches are established for chronic diseases such as diabetes, hypertension, and more recently rheumatoid arthritis, resulting in improved patient outcomes. These approaches do not u...

Authors: Hermenio Lima, Melinda Gooderham, Jan Dutz, Charles Lynde, Hugo Chapdelaine, Anne Ellis, Martin Gilbert, Vincent Ho, Kim Papp, Yves Poulin and Gordon Sussman

Poor sleep is highly associated with house dust mite allergic rhinitis in adults and children

Sleep disorders are often underreported to physicians by patients with allergies. This study aimed to characterize the sleep disorders associated with respiratory allergy to house dust mites (HDM) at the time ...

Authors: Damien Leger, Bénédicte Bonnefoy, Bernard Pigearias, Bertrand de La Giclais and Antoine Chartier

Protective barrier properties of Rhinosectan^® spray (containing xyloglucan) on an organotypic 3D airway tissue model (MucilAir): results of an in vitro study

To evaluate barrier protective properties of Rhinosectan^® spray, a medical device containing xyloglucan, on nasal epithelial cells (MucilAir).

Authors: Barbara De Servi, Francesco Ranzini and Núria Piqué

Expression of intelectin-1 in bronchial epithelial cells of asthma is correlated with T-helper 2 (Type-2) related parameters and its function

Intelectin-1 (ITLN-1) is secreted by intestinal goblet cells and detectable in blood. Its expression is increased in IL-13-overexpressing mouse airways. However, its expression and function in human airways is...

Authors: Taiji Watanabe, Kazuyuki Chibana, Taichi Shiobara, Rinna Tei, Ryosuke Koike, Yusuke Nakamura, Ryo Arai, Yukiko Horigane, Yasuo Shimizu, Akihiro Takemasa, Takeshi Fukuda, Sally E. Wenzel and Yoshiki Ishii

4-month omalizumab efficacy outcomes for severe allergic asthma: the Dutch National Omalizumab in Asthma Registry

Omalizumab is licensed as add-on therapy for patients with severe allergic asthma. Response is in most studies scored by the physician’s global evaluation of treatment effectiveness (GETE). A good clinical and...

Authors: S. M. Snelder, E. J. M. Weersink and G. J. Braunstahl

Safety of 100 µg venom immunotherapy rush protocols in children compared to adults

There is a paucity of studies examining the safety of venom immunotherapy (VIT) in children. We aimed to assess the incidence of anaphylactic side effects during rush VIT in a cohort of pediatric patients and ...

Authors: Johanna Stoevesandt, Christine Hosp, Andreas Kerstan and Axel Trautmann

Erratum to: Do epinephrine auto-injectors have an unsuitable needle length in children and adolescents at risk for anaphylaxis from food allergy?

Authors: Sten Dreborg, Xia Wen, Laura Kim, Gina Tsai, Immaculate Nevis, Ryan Potts, Jack Chiu, Arunmozhi Dominic and Harold Kim

Breakthrough attacks in patients with hereditary angioedema receiving long-term prophylaxis are responsive to icatibant: findings from the Icatibant Outcome Survey

Patients with hereditary angioedema (HAE) due to C1-inhibitor deficiency (C1-INH-HAE) experience recurrent attacks of cutaneous or submucosal edema that may be frequent and severe; prophylactic treatments can ...

Authors: Werner Aberer, Marcus Maurer, Laurence Bouillet, Andrea Zanichelli, Teresa Caballero, Hilary J. Longhurst, Amandine Perrin and Irmgard Andresen

Asthma pressurised metered dose inhaler performance: propellant effect studies in delivery systems

Current pressurised metered dose asthma inhaler (pMDI) propellants are not inert pharmacologically as were previous chlorofluorocarbons, have smooth muscle relaxant‚ partial pressure effects in the lungs and i...

Authors: William F. S. Sellers

Abstracts from the 10th C1-inhibitor deficiency workshop

Authors: Alvin H. Schmaier, Marco Cicardi, Avner Reshef, Dumitru Moldovan, Attila Mócsai, Margarita López-Trascasa, Alberto López Lera, Nancy J. Brown, Anastasios E. Germenis, Rafael Filippelli-Silva, Diego A. Duarte, Renan P. Martin, Camila L. Veronez, Michel Bouvier, Michael Bader, Claudio M. Costa-Neto…

Angioedema suppressed by a combination of anti-histamine and leukotriene modifier

Angioedema without co-existent urticaria is due to a limited number of causes, including hereditary and acquired C1 esterase inhibitor deficiency, drug-induced angioedema or idiopathic histaminergic or non-his...

Authors: Brendan N. Wong and Peter Vadas

A case series evaluating the serological response of adult asthma patients to the 23-valent pneumococcal polysaccharide vaccine

Asthma is an independent risk factor for invasive pneumococcal disease; however, the immune response of adult asthma patients to pneumococcal vaccination is unknown. We explore the serologic response of patien...

Authors: C. R. Laratta, K. Williams, D. Vethanayagam, M. Ulanova and H. Vliagoftis

Maternal sensitivity and social support protect against childhood atopic dermatitis

Many studies have identified associations between qualities of maternal–child relationships and childhood asthma, but few have examined associations with childhood atopic dermatitis (AD), a common precursor to...

Authors: Nicole L. Letourneau, Anita L. Kozyrskyj, Nela Cosic, Henry N. Ntanda, Lubna Anis, Martha J. Hart, Tavis S. Campbell and Gerald F. Giesbrecht

The relationship between circulating concentrations of interleukin 17 and C reactive protein in chronic spontaneous urticaria

Up-regulation of interleukin 17 (IL-17) family cytokines and acute phase response have been observed in patients with chronic spontaneous urticaria (CSU). It has been demonstrated that IL-17 stimulates C-react...

Authors: A. Grzanka, A. Damasiewicz-Bodzek and A. Kasperska-Zajac

Visual analogue scale (VAS) as a monitoring tool for daily changes in asthma symptoms in adolescents: a prospective study

Success in asthma management hinges on patients’ competency to detect and respond to ever-changing symptom severity. Thus, it is crucial to have reliable, simple, and sustainable methods of symptom monitoring ...

Authors: Hyekyun Rhee, Michael Belyea and Jennifer Mammen

Systemic mastocytosis with KIT V560G mutation presenting as recurrent episodes of vascular collapse: response to disodium cromoglycate and disease outcome

Mastocytosis are rare diseases characterized by an accumulation of clonal mast cells (MCs) in one or multiple organs or tissues. Patients with systemic mastocytosis (SM), whose MCs frequently arbor the activat...

Authors: Iolanda Conde-Fernandes, Rita Sampaio, Filipa Moreno, José Palla-Garcia, Maria dos Anjos Teixeira, Inês Freitas, Esmeralda Neves, Maria Jara-Acevedo, Luis Escribano and Margarida Lima