Articles

Exposure to bisphenol A enhanced lung eosinophilia in adult male mice

Bisphenol A (BPA) is useful in many manufacturing processes and is also found in commonly used consumer products. Previous experimental studies have reported that perinatal exposure to BPA promotes the develop...

Authors: Miao He, Takamichi Ichinose, Seiichi Yoshida, Hirohisa Takano, Masataka Nishikawa, Takayuki Shibamoto and Guifan Sun

Severity and disease control before house dust mite immunotherapy initiation: ANTARES a French observational survey

Allergen immunotherapy (AIT) may be prescribed for patients with allergic rhinitis (AR) induced by house dust mites (HDM) whether asthma is present or not. Current guidelines provide insufficient support for t...

Authors: Pascal Demoly, Anne Broué-Chabbert, François Wessel and Antoine Chartier

A rare nonsynonymous variant in the lipid metabolic gene HELZ2 related to primary biliary cirrhosis in Chinese Han

Several genome-wide association studies of primary biliary cirrhosis (PBC) in European and Japanese origins have shown significant association of dozens of genetic loci contributive to the susceptibility of PB...

Authors: Ping Li, Guanting Lu, Li Wang, Ying Cui, Ziyan Wu, Si Chen, Jing Li, Xiaoting Wen, Haoze Zhang, Shijie Mu, Fengchun Zhang and Yongzhe Li

Reviewer acknowledgement 2015

Authors: Richard Warrington

Allergen extracts and recombinant proteins: comparison of efficiency of in vitro allergy diagnostics using multiplex assay on a biological microchip

Immunological test systems for diagnostics of type I hypersensitivity involve the following types of antigens: whole allergen extracts, individual highly purified proteins and their recombinant analogues. The ...

Authors: Olga Smoldovskaya, Guzel Feyzkhanova, Alla Arefieva, Sergei Voloshin, Olga Ivashkina, Yuriy Reznikov and Alla Rubina

Asthma in the elderly: the effect of choline supplementation

Asthma in the elderly is poorly understood as very few studies have included these patients. DNA methylation can affect the expression of asthma susceptibility genes. Methyl groups can be produced through a ch...

Authors: Michele Columbo and Albert S. Rohr

Do epinephrine auto-injectors have an unsuitable needle length in children and adolescents at risk for anaphylaxis from food allergy?

Food allergy is the most common cause of anaphylaxis in children. Intramuscular delivery of epinephrine auto-injectors (EAI) is the standard of care for the treatment of anaphylaxis. We examined if children an...

Authors: Sten Dreborg, Xia Wen, Laura Kim, Gina Tsai, Immaculate Nevis, Ryan Potts, Jack Chiu, Arunmozhi Dominic and Harold Kim

T-cell receptor phenotype pattern in atopic children using commercial fluorescently labeled antibodies against 21 human class-specific v segments for the tcrβ chain (vβ) of peripheral blood: a cross sectional study

T-cell receptor (TCR) repertoire development is an integral part of the adaptive immune response. T-cell activation requires recognition of appropriately processed antigens by the TCR. Development of a diverse...

Authors: Gassem Gohal, Christine McCusker, Bruce Mazer, Reza Alizadehfar, Duncan Lejtenyi and Moshe Ben-shoshan

Angiopoietin-2 concentration in serum is associated with severe asthma phenotype

Several proangiogenic molecules have been implicated in the pathogenies of asthmatic inflammation and remodeling. The aim of the study was to compare the concentration of proangiogenic factors in the sera of a...

Authors: Joanna S. Makowska, Małgorzata Cieślak, Marzanna Jarzębska, Anna Lewandowska-Polak and Marek L. Kowalski

Role of specific IgE to β-lactoglobulin in the gastrointestinal phenotype of cow’s milk allergy

The prevalence of many phenotypes of food allergy is increasing. Specific gastrointestinal (GI) phenotype of food allergy (GI allergy) is also increasing but it is difficult to know the prevalence because of m...

Authors: Paloma Poza-Guedes, Yvelise Barrios, Ruperto González-Pérez, Inmaculada Sánchez-Machín, Andres Franco and Víctor Matheu

Post-vaccination myositis and myocarditis in a previously healthy male

The immunological literature has been redefining clinical phenomena as hypotheses emerge regarding causal links between triggers, immunologic manifestations, and their specific inflammatory cascades. Of late, ...

Authors: Matthew P. Cheng, Michael G. Kozoriz, Amir A. Ahmadi, John Kelsall, Katryn Paquette and Jake M. Onrot

Association between allergic rhinitis and metabolic conditions: a nationwide survey in Korea

Accumulating evidence indicates a strong correlation between allergic disease and cardiovascular risks. In spite of this, the data concerning the association between allergic rhinitis (AR) and cardiovascular r...

Authors: In Cheol Hwang, Yong Joo Lee, Hong Yup Ahn and Sang Min Lee

The role of cytokines in the pathogenesis and staging of Trypanosoma brucei rhodesiense sleeping sickness

Human African trypanosomiasis due to Trypanosoma brucei rhodesiense is invariably fatal if untreated with up to 12.3 million people at a risk of developing the disease in Sub-Saharan Africa. The disease is charac...

Authors: Charles D. Kato, Enock Matovu, Claire. M. Mugasa, Ann Nanteza and Vincent P. Alibu

Anaphylaxis following a transvaginal ultrasound

Polyethylene glycol is a ubiquitous, water-soluble, organic compound found in a wide variety of commercially available products. While generally a benign substance, in rare instances, it can induce hypersensit...

Authors: Baruch D. Jakubovic, Corey Saperia and Gordon L. Sussman

Management of the polyallergic patient with allergy immunotherapy: a practice-based approach

The great majority (60–80 %) of patients consulting specialist physicians for allergic respiratory disease are polysensitized and thus may be potentially clinically polyallergic. However, management approaches...

Authors: Pascal Demoly, Giovanni Passalacqua, Oliver Pfaar, Joaquin Sastre and Ulrich Wahn

Sensitization to common aeroallergens in a population of young adults in a sub-Saharan Africa setting: a cross-sectional study

Sensitization to aeroallergens increases the risk of developing asthma or allergic rhinitis. Data on sensitization to airborne allergens in the general population in sub-Saharan Africa are lacking. The aim of ...

Authors: Bertrand Hugo Mbatchou Ngahane, Diane Noah, Malea Nganda Motto, Yacouba Mapoure Njankouo and Louis Richard Njock

Powder milk: a user-friendly and safe product for heated-milk food challenge?

Previous studies have reported that up to 75 % of milk allergic subjects tolerate heated milk products. However, the food used for heated milk challenge is often prepared in a non-standardized manner by the pa...

Authors: Sabrine Cherkaoui, Philippe Bégin, Louis Paradis, Jean Paradis and Anne Des Roches

The human microbiome, asthma, and allergy

The human microbiome can be defined as the microorganisms that reside within and on our bodies and how they interact with the environment. Recent research suggests that numerous mutually beneficial interaction...

Authors: Amund Riiser

Marked improvement of neuropsychiatric symptoms following control of allergy symptoms with the use of humanized murine anti-IgE antibody (omalizumab) in 2 patients with severely limited expressive language

Flare-up of allergic rhinitis has been implicated in worsening neuropsychiatric symptoms such as hyperactivity and anxiety in the general population, mostly supported by epidemiological data. However, it is un...

Authors: Harumi Jyonouchi

TNF up-regulates Pentraxin3 expression in human airway smooth muscle cells via JNK and ERK1/2 MAPK pathways

Long pentraxin 3 (PTX3) is a novel candidate marker for inflammation in many chronic diseases. As a soluble pattern recognition receptor, PTX3 is involved in amplification of inflammatory reactions and regulat...

Authors: Jingbo Zhang, Latifa Koussih, Lianyu Shan, Andrew J. Halayko, Ben-Kuen Chen and Abdelilah S. Gounni

The gender, age and risk factor distribution differs in self-reported allergic and non-allergic rhinitis: a cross-sectional population-based study

Few population-based studies have assessed the prevalence and the risk factors of non-allergic rhinitis (NAR) in comparison to allergic rhinitis (AR). Moreover, epidemiologic data on rhinitis in the elderly su...

Authors: Lucia Cazzoletti, Marcello Ferrari, Mario Olivieri, Giuseppe Verlato, Leonardo Antonicelli, Roberto Bono, Lucio Casali, Isa Cerveri, Pierpaolo Marchetti, Pietro Pirina, Andrea Rossi, Simona Villani and Roberto de Marco

A retrospective comparison of false negative skin test rates in penicillin allergy, using pencilloyl-poly-lysine and minor determinants or Penicillin G, followed by open challenge

A history of penicillin allergy in patients is common, but only 10–15 % are truly allergic. While the gold standard for diagnosing penicillin allergy is challenge, it is not recommended that this be done witho...

Authors: Lana Rosenfield, Chrystyna Kalicinsky and Richard Warrington

T-cell phenotypes in chronic rhinosinusitis with nasal polyps in Japanese patients

Chronic rhinosinusitis with nasal polyps is characterized by local inflammation and is categorized into two subtypes in Japan: eosinophilic chronic rhinosinusitis, and non-eosinophilic chronic rhinosinusitis....

Authors: Shintaro Baba, Ryoji Kagoya, Kenji Kondo, Maho Suzukawa, Ken Ohta and Tatsuya Yamasoba

Peanut sensitization pattern in Norwegian children and adults with specific IgE to peanut show age related differences

Peanuts contain potent food allergens and the prevalence of allergy is reported to increase, especially in children. Since peanut sensitization may differ between different geographical regions, we wanted to i...

Authors: Ellen Namork and Berit A. Stensby

Allergen immunotherapy in pregnancy

Allergic diseases such as asthma and allergic rhinitis constitute a significant burden of disease among women of childbearing age and those who are pregnant. Adequately managing these conditions is paramount i...

Authors: Paul Oykhman, Harold L. Kim and Anne K. Ellis

Tropomyosin, the major tropical oyster Crassostrea belcheri allergen and effect of cooking on its allergenicity

Many types of shellfish including oysters are sometime cooked before ingestion and it has been demonstrated that cooking may affect the allergenicity of food. Therefore, the aim of our present study is to iden...

Authors: Zailatul Hani Mohamad Yadzir, Rosmilah Misnan, Faizal Bakhtiar, Noormalin Abdullah and Shahnaz Murad

Monoclonal antibody desensitization in a patient with a generalized urticarial reaction following denosumab administration

Denosumab is a human monoclonal antibody indicated for the treatment of osteoporosis in postmenopausal women with a high risk of fractures. To our knowledge, no cases of desensitization to this drug have been ...

Authors: D. Gutiérrez-Fernández, María-Jesús Cruz, A. Foncubierta-Fernández, A. Moreno-Ancillo, M. J. Fernández-Anguita, F. Medina-Varo and J. A. Andres-García

Epinephrine auto-injector prescriptions to food-allergic patients in primary care in The Netherlands

The knowledge of general practitioner(s) (GPs) regarding food allergy and anaphylaxis and practices in the prescription of epinephrine auto-injector(s) (EAIs) among GPs has previously only been studied using q...

Authors: Jacquelien Saleh-Langenberg, A. E. J. Dubois, F. Groenhof, J. W. H. Kocks, T. van der Molen and B. M. J. Flokstra-de Blok

Health-related quality of life in patients with primary immunodeficiency disease

Primary immunodeficiency disease (PIDD) with hypogammaglobulinemia is characterized by recurrent and severe bacterial infections and IgG replacement is the standard of care in many of these patients. Health-re...

Authors: Fonda Jiang, Troy R. Torgerson and Andrew G. Ayars

Cytokine profiles in nasal fluid of patients with seasonal or persistent allergic rhinitis

New therapeutic approaches with biologic agents such as anti-cytokine antibodies are currently on trial for the treatment of asthma, rhinosinusitis or allergic diseases necessitating patient selection by bioma...

Authors: Katrin König, Christine Klemens, Katharina Eder, Marion San Nicoló, Sven Becker, Matthias F. Kramer and Moritz Gröger

Prevention of pruritus with ethyl-chloride in skin prick test: a double-blind placebo-controlled prospective study

Ethyl-chloride (EC) spray was recently shown to be an effective antipruritic agent, when given 15 min after histamine skin-prick test (SPT), without changing the wheal and flare reaction. We aimed to investiga...

Authors: Amir Gal-Oz, Shmuel Kivity, Yacov Shacham, Elisheva Fiszer, Ori Rogowsky and Gil Chernin

Risk factors associated with asthma, atopic dermatitis and rhinoconjunctivitis in a rural Senegalese cohort

The World Allergy Organization estimates that 40 % of the world’s population is affected by allergic diseases. The International Study of Asthma and Allergies in Childhood has completed Phase III and it has no...

Authors: Magali Herrant, Cheikh Loucoubar, Sabah Boufkhed, Hubert Bassène, Fatoumata Diene Sarr, Laurence Baril, Odile Mercereau-Puijalon, Salaheddine Mécheri, Anavaj Sakuntabhai and Richard Paul

Consensus communication on early peanut introduction and the prevention of peanut allergy in high-risk infants

The purpose of this brief communication is to highlight emerging evidence to existing guidelines regarding potential benefits of supporting early, rather than delayed, peanut introduction during the period of ...

Authors: David M. Fleischer, Scott Sicherer, Matthew Greenhawt, Dianne Campbell, Edmond S. Chan, Antonella Muraro, Susanne Halken, Yitzhak Katz, Motohiro Ebisawa, Lawrence Eichenfield and Hugh Sampson

Food dependant exercise induced anaphylaxis a retrospective study from 2 allergy clinics in Colombo, Sri Lanka

The aetiology of anaphylaxis ranges from food, insect venom, drugs and various chemicals. Some individuals do not develop anaphylaxis with the offending agent unless ingestion is related temporally to physical...

Authors: Nilhan Rajiva de Silva, Wasala Mudiyanselage Dhanushka Kumari Dasanayake, Chandima Karunatilleke and Gathsauri Neelika Malavige

Retrospective case note review of chronic spontaneous urticaria outcomes and adverse effects in patients treated with omalizumab or ciclosporin in UK secondary care

Omalizumab is approved in the UK as add-on treatment for chronic spontaneous urticaria (CSU) in patients with inadequate response to H₁-antihistamines. Ciclosporin is an established but unlicensed 3rd line optio...

Authors: Sinisa Savic, Alexander Marsland, David McKay, Michael R Ardern-Jones, Tabi Leslie, Olivier Somenzi, Laura Baldock and Clive Grattan

CSACI position statement: epinephrine auto-injectors and children < 15 kg

Epinephrine (adrenaline) is the treatment of choice for anaphylaxis. While other medications, including H₁-antihistamines, H₂-antihistamines, corticosteroids, and inhaled beta-2 agonists are often used to treat a...

Authors: Michelle Halbrich, Douglas P. Mack, Stuart Carr, Wade Watson and Harold Kim

Allergy immunotherapy prescribing trends for grass pollen-induced allergic rhinitis in Germany: a retrospective cohort analysis

Allergy immunotherapy is an effective treatment for patients with allergic rhinitis whose symptoms are unresolved with pharmacotherapy. Allergy immunotherapy for grass pollen-induced allergic rhinitis is avail...

Authors: Amanda L. McDonell, Ulrich Wahn, Dirk Demuth, Catrina Richards, Charlie Hawes, Jakob Nørgaard Andreasen and Felicia Allen-Ramey

Successful desensitization in a boy with severe cow’s milk allergy by a combination therapy using omalizumab and rush oral immunotherapy

Rush oral immunotherapy (OIT) combined with omalizumab (OMB) has been reported to be an effective and safe treatment for severe milk allergies. However, no report has described long-term follow-up observations...

Authors: Masaya Takahashi, Shoichiro Taniuchi, Kazuhiko Soejima, Yasuko Hatano, Sohsaku Yamanouchi and Kazunari Kaneko

The effect of a new communication template on anticipated willingness to initiate or resume allergen immunotherapy: an internet-based patient survey

A patient’s knowledge of his/her allergic condition and treatment is a key factor in adherence and effectiveness.

Authors: Moises A. Calderon, Linda Cox, Thomas B. Casale, Ralph Mösges, Oliver Pfaar, Hans-Jørgen Malling, Joaquin Sastre, Musa Khaitov and Pascal Demoly

The Allergic Rhinitis – Clinical Investigator Collaborative (AR-CIC): nasal allergen challenge protocol optimization for studying AR pathophysiology and evaluating novel therapies

The Nasal Allergen Challenge (NAC) model allows the study of Allergic Rhinitis (AR) pathophysiology and the proof of concept of novel therapies. The Allergic Rhinitis – Clinical Investigator Collaborative (AR-...

Authors: Anne K Ellis, Mena Soliman, Lisa Steacy, Marie-Ève Boulay, Louis-Philippe Boulet, Paul K Keith, Harissios Vliagoftis, Susan Waserman and Helen Neighbour

Retraction Note: Meeting Abstract: A post-hoc qualitative analysis of real time heads-up pollen counting versus traditional microscopy counting in the environmental exposure unit (EEU)

Authors: Lisa M Steacy, Terry JB Walker, Barnaby Hobsbawn, Jenny Thiele and Anne K Ellis

Therapeutic potential of anti-IL-6 therapies for granulocytic airway inflammation in asthma

Determining the cellular and molecular phenotypes of inflammation in asthma can identify patient populations that may best benefit from targeted therapies. Although elevated IL-6 and polymorphisms in IL-6 sign...

Authors: Derek K Chu, Amal Al-Garawi, Alba Llop-Guevara, Regina A Pillai, Katherine Radford, Pamela Shen, Tina D Walker, Susanna Goncharova, William J Calhoun, Parameswaran Nair and Manel Jordana

Sensitization to workplace respiratory allergens among bakery workers in Douala, Cameroon: a cross-sectional study

Sensitization to flour or fungal alpha-amylase is a prerequisite for the development of respiratory allergy in bakers. The knowledge of occupational allergen sensitization among bakery workers will facilitate ...

Authors: Bertrand Hugo Mbatchou Ngahane, Francis Nde, Eliane Ngomo and Emmanuel Afane Ze

Central obesity and other factors associated with uncontrolled asthma in women

Asthma remains an uncontrolled disease. The Comorbidities, particularly obesity, and several other factors have been identified as being individually associated with asthma control, and these factors vary amon...

Authors: Albertina Varandas Capelo, Vania Matos de Fonseca, Maria Virgínia Marques Peixoto, Sonia Regina de Carvalho and Larissa Garcia Guerino

The role of flavor and fragrance chemicals in TRPA1 (transient receptor potential cation channel, member A1) activity associated with allergies

TRPA1 has been proposed to be associated with diverse sensory allergic reactions, including thermal (cold) nociception, hearing and allergic inflammatory conditions. Some naturally occurring compounds are know...

Authors: Satoru Mihara and Takayuki Shibamoto

Allergy to cooked, but not raw, peas: a case series and review

Allergic reactions to legumes are common.Food allergy to cooked, but not raw, pea has been rarely reported in the literature. This case series describes five children who had various IgE-mediated symptoms upon...

Authors: Elissa M Abrams and Thomas V Gerstner

CSACI position statement: systemic effect of inhaled corticosteroids on adrenal suppression in the management of pediatric asthma

Asthma is a chronic inflammatory disease of the airways that affects a growing number of children and adolescents. Inhaled corticosteroids (ICS) are the mainstay of treatment in persistent asthma, with a stepw...

Authors: Karine Issa-El-Khoury, Harold Kim, Edmond S Chan, Tim Vander Leek and Francisco Noya

Evaluation of patients’ expectations and benefits in the treatment of allergic rhinitis with a new tool: the patient benefit index – the benefica study

Symptoms of allergic rhinitis (AR) have a detrimental effect on quality of life. The AR-Patient Benefit Index (AR-PBI), a specific self-assessment tool has been developed to assess treatment-related benefit in...

Authors: Pascal Demoly, Michel Aubier, Frédéric de Blay, François Wessel, Pierre Clerson and Pascal Maigret

Insights and advances in chronic urticaria: a Canadian perspective

In the past few years there have been significant advances which have changed the face of chronic urticaria. In this review, we aim to update physicians about clinically relevant advances in the classification...

Authors: Gordon Sussman, Jacques Hébert, Wayne Gulliver, Charles Lynde, Susan Waserman, Amin Kanani, Moshe Ben-Shoshan, Spencer Horemans, Carly Barron, Stephen Betschel, William H Yang, Jan Dutz, Neil Shear, Gina Lacuesta, Peter Vadas, Kenneth Kobayashi…

Reviewer acknowledgement 2014

The editors of Allergy, Asthma & Clinical Immunology would like to thank all of our reviewers who have contributed to the journal in Volume 10 (2014).

Authors: Richard Warrington