Articles

Real-world outcomes in hereditary angioedema: first experience from the Icatibant Outcome Survey in the United Kingdom

Hereditary angioedema (HAE) is a potentially life-threatening, bradykinin-mediated disease, often misdiagnosed and under-treated, with long diagnostic delays. There are limited real-world data on best-practice...

Authors: Hilary J. Longhurst, John Dempster, Lorena Lorenzo, Matthew Buckland, Sofia Grigoriadou, Christine Symons, Claire Bethune, Vincent Fabien, Catherine Bangs and Tomaz Garcez

Serum periostin levels following small bone fractures, long bone fractures and joint replacements: an observational study

In asthma, serum periostin may potentially be used as a biomarker in the management of patients with Type-2 eosinophilic airway inflammation. However, serum periostin may be influenced by factors other than Ty...

Authors: Rachel Varughese, Ruth Semprini, Claire Munro, James Fingleton, Cecile Holweg, Mark Weatherall, Richard Beasley and Irene Braithwaite

Interplay between acute phase response and coagulation/fibrinolysis in chronic spontaneous urticaria

Chronic spontaneous urticaria (CSU) is associated with activation of systemic inflammatory response and coagulation/fibrinolysis.

Authors: R. Grzanka, A. Damasiewicz-Bodzek and A. Kasperska-Zajac

Regular follow-up visits reduce the risk for asthma exacerbation requiring admission in Korean adults with asthma

Asthma requires regular follow-up visits and sustained medication use. Although several studies have reported the importance of adherence to medication and compliance with the treatment, none to date have repo...

Authors: Hye Jung Park, Min Kwang Byun, Hyung Jung Kim, Chul Min Ahn, Chin Kook Rhee, Kyungjoo Kim, Bo Yeon Kim, Hye Won Bae and Kwang-Ha Yoo

Frequency of CD4⁺ and CD8⁺ T cells in Iranian chronic rhinosinusitis patients

Chronic Rhinosinusitis (CRS) is a persistent inflammatory disease affecting paranasal sinuses. CRS is categorized into two distinct subgroups defined as CRS with nasal polyps (CRSwNP) and CRS without nasal pol...

Authors: Farhad Seif, Babak Ghalehbaghi, Hossein Aazami, Alireza Mohebbi, Aslan Ahmadi, Reza Falak, Pegah Babaheidarian, Mohammad Najafi, Majid Khoshmirsafa, Sahand Ghalehbaghi and Mehdi Shekarabi

A population-based epidemiological study of anaphylaxis using national big data in Korea: trends in age-specific prevalence and epinephrine use in 2010–2014

Previous reports on anaphylaxis in Asia are limited to relatively small-scale studies. We performed this study to identify the nationwide prevalence of anaphylaxis and epinephrine prescription rates by age gro...

Authors: Kyunguk Jeong, Jung-Dong Lee, Dae Ryong Kang and Sooyoung Lee

Heat-induced necrosis after bronchial thermoplasty: a new concern?

Bronchial thermoplasty (BT) is an endoscopic procedure for the treatment of severe refractory asthma, based on the local airways delivery of radio-frequency at 65 °C. Several controlled clinical studies demons...

Authors: Francesco Menzella, Mirco Lusuardi, Carla Galeone, Gloria Montanari, Alberto Cavazza and Nicola Facciolongo

Prevalence of food allergens sensitization and food allergies in a group of allergic Honduran children

Food allergy is a public health problem that has increased in the last decade. Despite the increasing rates in children, quality data on the burden of these diseases is lacking particularly in developing count...

Authors: Victoria Alejandra Gonzales-González, Adolfo Martin Díaz, Karla Fernández and María Félix Rivera

Effect of artemisinin and neurectomy of pterygoid canal in ovalbumin-induced allergic rhinitis mouse model

Allergic rhinitis (AR), characterized by sneezing, nasal itching and rhinorrhea, affects a large number of population. This study aimed to explore the effects of artemisinin alone or combined with neurectomy o...

Authors: Jian Li, Bin Wang, Yingying Luo, Yajie Bian and Ruipei Wang

Case report presenting the diagnostic challenges in a patient with recurrent acquired angioedema, antiphospholipid antibodies and undetectable C2 levels

Angioedema secondary to acquired C1 inhibitor deficiency (AAE) is a rare disease. It usually is associated with lymphoproliferative disorders. We present a case of AAE in a patient with antiphospholipid syndro...

Authors: Arturo J. Bonnin, Charles DeBrosse, Terri Moncrief and G. Wendell Richmond

Histone modifications and their role in epigenetics of atopy and allergic diseases

This review covers basic aspects of histone modification and the role of posttranslational histone modifications in the development of allergic diseases, including the immune mechanisms underlying this develop...

Authors: Bilal Alaskhar Alhamwe, Razi Khalaila, Johanna Wolf, Verena von Bülow, Hani Harb, Fahd Alhamdan, Charles S. Hii, Susan L. Prescott, Antonio Ferrante, Harald Renz, Holger Garn and Daniel P. Potaczek

Association between fractional exhaled nitric oxide, sputum induction and peripheral blood eosinophil in uncontrolled asthma

The fractional exhaled nitric oxide (FeNO) and blood eosinophils are biomarkers of eosinophilic airway inflammation used in the diagnosis and management of asthma, although induced sputum is the gold standard ...

Authors: Jie Gao and Feng Wu

The association between sexual dysfunctions and severity of symptoms in patients with chronic spontaneous urticaria

Authors: Agnieszka Skrzypulec-Frankel, Katarzyna Bieniek and Alicja Kasperska-Zając

Loss of bronchoprotection to Salbutamol during sputum induction with hypertonic saline: implications for asthma therapy

Sputum induction with hypertonic saline in obstructive airway diseases is generally safe. However, saline induces bronchoconstriction in some patients despite pre-medication with Salbutamol. Our objectives wer...

Authors: Hongyu Wang, Melanie Kjarsgaard, Terence Ho, John D. Brannan and Parameswaran Nair

New onset colitis in an adult patient with chronic granulomatous disease treated with hematopoietic stem cell transplantation: a diagnostic dilemma

Chronic granulomatous disease (CGD) is a rare primary immunodeficiency characterized by recurrent life-threatening bacterial and fungal infections, granuloma formation and intestinal disease. This disease is c...

Authors: Kara Robertson, Stephen Couban, Desmond Leddin, Imran Ahmad and Lori Connors

Investigating the effectiveness of the Trigonella foenum-graecum L. (fenugreek) seeds in mild asthma: a randomized controlled trial

Asthma is one of the important chronic diseases. The asthma prevalence is increasing in last decades. Despite the presence of good controller drugs like corticosteroids, about 60% of asthmatic patients use alt...

Authors: Majid Emtiazy, Laleh Oveidzadeh, Minoo Habibi, Leila Molaeipour, Daryush Talei, Zahra jafari, Mahmoud Parvin and Mohammad Kamalinejad

Severe, eosinophilic asthma in primary care in Canada: a longitudinal study of the clinical burden and economic impact based on linked electronic medical record data

Stratification of patients with severe asthma by blood eosinophil counts predicts responders to anti-interleukin (IL)-5 (mepolizumab and reslizumab) and anti-IL-5 receptor α (benralizumab) therapies. This stud...

Authors: Don Husereau, Jason Goodfield, Richard Leigh, Richard Borrelli, Michel Cloutier and Alain Gendron

The course of asthma during pregnancy in a recent, multicase–control study on respiratory health

Over the years it has been widely stated that approximately one-third of asthmatic women experience worsening of the disease during pregnancy. However, the literature has not been reviewed systematically and t...

Authors: A. Grosso, F. Locatelli, E. Gini, F. Albicini, C. Tirelli, I. Cerveri and A. G. Corsico

An update on molecular cat allergens: Fel d 1 and what else? Chapter 1: Fel d 1, the major cat allergen

Cats are the major source of indoor inhalant allergens after house dust mites. The global incidence of cat allergies is rising sharply, posing a major public health problem. Ten cat allergens have been identif...

Authors: B. Bonnet, K. Messaoudi, F. Jacomet, E. Michaud, J. L. Fauquert, D. Caillaud and B. Evrard

Critical view of anaphylaxis epidemiology: open questions and new perspectives

In contrast to the majority of allergic or hypersensitivity conditions, worldwide anaphylaxis epidemiological data remain sparse with low accuracy, which hampers comparable morbidity statistics. Data can diffe...

Authors: Luciana Kase Tanno, Ana Luiza Bierrenbach, F. Estelle R. Simons, Victoria Cardona, Bernard Yu-Hor Thong, Nicolas Molinari, Moises A. Calderon, Margitta Worm, Yoon-Seok Chang, Nikolaos G. Papadopoulos, Thomas Casale and Pascal Demoly

Immediate type hypersensitivity and late phase reaction occurred consecutively in a patient receiving ethambutol and levofloxacin

We experienced a rare case of immediate type hypersensitivity and late phase reaction to anti-tubercular therapy consisting of ethambutol and levofloxacin, which occurred in close succession, giving the appear...

Authors: Yukihiko Kato, Yu Sato, Miho Nakasu and Ryoji Tsuboi

Proceedings of the Canadian Society of Allergy and Clinical Immunology Annual Scientific Meeting 2017

Authors:

Tuberculosis induced autoimmune haemolytic anaemia: a systematic review to find out common clinical presentations, investigation findings and the treatment options

Tuberculosis induced autoimmune haemolytic anaemia is a rare entity. The aim of this study was to explore its common presentations, investigation findings and treatment options through a systematic review of p...

Authors: Devarajan Rathish and Sisira Siribaddana

Cytokine profiles among patients co-infected with Plasmodium falciparum malaria and soil borne helminths attending Kampala International University Teaching Hospital, in Uganda

Malaria and helminths share the same geographical distribution in tropical Africa. Studies of the interaction of helminth and malaria co-infection in humans have been few and are mainly epidemiological, with l...

Authors: Richard Bwanika, Charles D. Kato, Johnson Welishe and Daniel C. Mwandah

A novel outpatient desensitization protocol for recombinant human erythropoietin allergy in a pediatric patient

Recombinant human erythropoietin, such as epoetin alfa and darbepoetin alfa, is an important therapy for anemia due to chronic renal failure. Allergy to recombinant human erythropoietin and the need for desens...

Authors: Jaime S. Rosa, Van B. Vuong, Orly Haskin and Anne Y. Liu

Clinical implications of CD4⁺ T cell subsets in adult atopic asthma patients

T cells play a central role in chronic inflammation in asthma. However, the roles of individual subsets of T cells in the pathology of asthma in patients remain to be better understood.

Authors: Matthew Wiest, Katherine Upchurch, Wenjie Yin, Jerome Ellis, Yaming Xue, Bobby Lanier, Mark Millard, HyeMee Joo and SangKon Oh

Evaluation of eczema, asthma, allergic rhinitis and allergies among the Grade-1 children of Iqaluit

Little is known about the prevalence of asthma, allergic rhinitis, eczema and allergies among Canadian Inuit children, especially those living in the arctic and subarctic areas.

Authors: Ahmed Ahmed, Amir Hakim and Allan Becker

Seasonal variation in circulating group 2 innate lymphoid cells in mugwort-allergic asthmatics during and outside pollen season

Group 2 innate lymphoid cells (ILC2s) are a newly identified cell population with the potent capability to produce Th2-type cytokines in a non-antigen specific manner. Previous study demonstrated that enhanced...

Authors: Qing Miao, Yan Wang, Yong-ge Liu, Yi-xin Ren, Hui Guan, Zhen Li, Wei Xu and Li Xiang

Atopy and related clinical symptoms among Swiss medical students from 2007 to 2015

Atopic allergy is a widespread disease with increasing prevalence in the second half of the twentieth century and is most often associated with clinical symptoms, like rhinoconjunctivitis, asthma or eczema. Th...

Authors: Lukas Steinegger, Stephan Regenass, Lucas M. Bachmann, Elsbeth Probst and Urs C. Steiner

Self-reported questionnaire survey on the prevalence and symptoms of adverse food reactions in patients with chronic inhalant diseases in Tangshan city, China

The prevalence of adverse food reactions in patients with chronic inhalant diseases has seldom been studied in China. This study is to investigate the prevalence of adverse food reactions and the symptoms caus...

Authors: Guodong Hao, Xuxin Lai, Zhijing Song, Zhixing Wang, Xing-ai Kong, Haifeng Zhong, Sui Fu Hui and Yiwu Zheng

Onset of action for loratadine tablets for the symptomatic control of seasonal allergic rhinitis in adults challenged with ragweed pollen in the Environmental Exposure Unit: a post hoc analysis of total symptom score

Loratadine is a second-generation, non-sedating antihistamine used for the relief of allergic rhinitis symptoms. Previous studies reported that when loratadine was encapsulated, the onset of action for symptom...

Authors: Mark W. Tenn, Lisa M. Steacy, Charlene C. Ng and Anne K. Ellis

CSACI position statement: prescribing sublingual immunotherapy tablets for aeroallergens

Authors: J. Quirt, R. Gagnon, A. K. Ellis and H. L. Kim

Positive correlation of airway resistance and serum asymmetric dimethylarginine (ADMA) in bronchial asthma patients lacking evidence for systemic inflammation

Contribution of nitric-oxide (NO) pathway to the pathogenesis of bronchial asthma (asthma) is ambiguous as NO may confer both protective and detrimental effects depending on the NO synthase (NOS) isoforms, tis...

Authors: Gabor Tajti, Csaba Papp, Laszlo Kardos, Sandor Keki, Krisztian Pak, Magdolna Emma Szilasi, Rudolf Gesztelyi, Angela Mikaczo, Andrea Fodor, Maria Szilasi and Judit Zsuga

Feasibility of sustained response through long-term dosing in food allergy immunotherapy

Clinical trials using oral immunotherapy (OIT) for the treatment of food allergies have shown promising results. We previously demonstrated the feasibility of desensitization for up to 5 food allergens simulta...

Authors: Sandra Andorf, Monali Manohar, Tina Dominguez, Whitney Block, Dana Tupa, Rohun A. Kshirsagar, Vanitha Sampath, R. Sharon Chinthrajah and Kari C. Nadeau

Observational long-term follow-up study of rapid food oral immunotherapy with omalizumab

A number of clinical studies focused on treating a single food allergy through oral immunotherapy (OIT) with adjunctive omalizumab treatment have been published. We previously demonstrated safety and tolerabil...

Authors: Sandra Andorf, Monali Manohar, Tina Dominguez, Whitney Block, Dana Tupa, Rohun A. Kshirsagar, Vanitha Sampath, R. Sharon Chinthrajah and Kari C. Nadeau

MPO-ANCA associated vasculitis with mononeuritis multiplex following influenza vaccination

Although influenza vaccines are generally safe and effective, a variety of autoimmune phenomena have been reported after vaccination over the past years, such as Guillain–Barre syndrome, rheumatoid arthritis, ...

Authors: Stefanie Eindhoven, Jolien Levels, Margriet Huisman, Koos Ruizeveld de Winter, Virgil Dalm and Rehmat Alwani

Initial intravenous immunoglobulin doses should be based on adjusted body weight in obese patients with primary immunodeficiency disorders

Immunoglobulin therapy plays a critical role in the treatment of immunodeficiency disorders as well as autoimmune and inflammatory conditions. In immunodeficient patients, there has been controversy whether in...

Authors: Rohan Ameratunga

Anaphylactic shock following castor bean contact: a case report

The castor bean plant, Ricinus communis, is known to have allergenic and toxic properties. Castor bean allergy has been described mainly as an occupational inhalation allergy in laboratory workers, in persons wor...

Authors: Y. Coattrenec, D. Jaques, P. Jandus, T. Harr and D. Spoerl

Asthma biomarkers in the age of biologics

The heterogeneous nature of asthma has been understood for decades, but the precise categorization of asthma has taken on new clinical importance in the era of specific biologic therapy. The simple categories ...

Authors: Harold Kim, Anne K. Ellis, David Fischer, Mary Noseworthy, Ron Olivenstein, Kenneth R. Chapman and Jason Lee

Adherence with epinephrine autoinjector prescriptions in primary care

The aim of this study was to estimate primary adherence for epinephrine autoinjector (EA) prescriptions in primary care practices in Manitoba, Canada.

Authors: Elissa M. Abrams, Alexander G. Singer, Lisa Lix, Alan Katz, Marina Yogendran and F. Estelle R. Simons

Response to case report: Airway autoimmune responses in severe eosinophilic asthma following low-dose Mepolizumab therapy

Authors: I. J. Pouliquen, P. Howarth, D. Austin, G. Gunn, E. Meyer, R. G. Price and E. Bradford

Adult reference intervals for IgG subclasses with Siemens immunonephelometric assays in Chinese population

To determine the adult reference intervals for the Siemens IgG subclass reagents.

Authors: Ping Li, Zhongjuan Liu, Ziyan Wu, Xiaoting Wen, Liubing Li, Shulan Zhang, Yingchun Xu and Yongzhe Li

Are food allergic consumers ready for informative precautionary allergen labelling?

Precautionary allergen labelling (PAL) has resulted in consumer confusion. Previous research has shown that interpretive labels (using graphics, symbols, or colours) are better understood than the traditional ...

Authors: Giovanni A. Zurzolo, Rachel L. Peters, Jennifer J. Koplin, Maximilian de Courten, Michael L. Mathai and Katrina J. Allen

Oral food challenge outcomes in a pediatric tertiary care center

Oral food challenges are the clinical standard for diagnosis of food allergy. Little data exist on predictors of oral challenge failure and reaction severity.

Authors: Elissa M. Abrams and Allan B. Becker

Passive blood anaphylaxis: subcutaneous immunoglobulins are a cause of ongoing passive anaphylactic reaction

Allergic, especially anaphylactic, reactions during immunoglobulin replacement therapy are rare, but their pathophysiology and classification remain ambiguous. Recent findings show positive results of skin tes...

Authors: Przemyslaw Zdziarski, Andrzej Gamian, Jacek Majda and Agnieszka Korzeniowska-Kowal

Prevalence and clinical features of adverse food reactions in Portuguese children

The prevalence of adverse food reactions (AFR) has been increasing in the western world. Clinical manifestations are diversified and it may not be possible to clinically discriminate between IgE and non-IgE me...

Authors: Arminda Jorge, Elisa Soares, Emanuel Sarinho, Felix Lorente, Jorge Gama and Luís Taborda-Barata

Serum free IgE guided dose reduction of omalizumab: a case report

Omalizumab is a human IgG1 antibody against IgE used as a therapy for sever asthmatic patients with asthma. According to the guidelines of the Global Initiative for Asthma, omalizumab is an add-on drug at trea...

Authors: Yasuhiro Gon, Reiko Ito, Shuichiro Maruoka, Kenji Mizumura, Yutaka Kozu, Hisato Hiranuma, Yuko Iida, Sotaro Shikano and Shu Hashimoto

Management of chronic spontaneous urticaria (CSU): a treat to target approach using a patient reported outcome

Treat-to-target therapy approaches are established for chronic diseases such as diabetes, hypertension, and more recently rheumatoid arthritis, resulting in improved patient outcomes. These approaches do not u...

Authors: Hermenio Lima, Melinda Gooderham, Jan Dutz, Charles Lynde, Hugo Chapdelaine, Anne Ellis, Martin Gilbert, Vincent Ho, Kim Papp, Yves Poulin and Gordon Sussman

Poor sleep is highly associated with house dust mite allergic rhinitis in adults and children

Sleep disorders are often underreported to physicians by patients with allergies. This study aimed to characterize the sleep disorders associated with respiratory allergy to house dust mites (HDM) at the time ...

Authors: Damien Leger, Bénédicte Bonnefoy, Bernard Pigearias, Bertrand de La Giclais and Antoine Chartier

Protective barrier properties of Rhinosectan^® spray (containing xyloglucan) on an organotypic 3D airway tissue model (MucilAir): results of an in vitro study

To evaluate barrier protective properties of Rhinosectan^® spray, a medical device containing xyloglucan, on nasal epithelial cells (MucilAir).

Authors: Barbara De Servi, Francesco Ranzini and Núria Piqué