Articles

Reproducibility of serum IgE, Ara h2 skin prick testing and fraction of exhaled nitric oxide for predicting clinical peanut allergy in children

Ara h2 sIgE serum levels improve the diagnostic accuracy for predicting peanut allergy, but the use of Ara h2 purified protein as a skin prick test (SPT), has not been substantially evaluated. The fraction of ...

Authors: Elizabeth Percival, Rani Bhatia, Kahn Preece, Patrick McElduff, Mark McEvoy, Adam Collison and Joerg Mattes

Patient engagement and patient support programs in allergy immunotherapy: a call to action for improving long-term adherence

Allergy immunotherapy (AIT) is acknowledged to produce beneficial mid- and long-term clinical and immunologic effects and increased quality of life in patients with allergic respiratory diseases (such as aller...

Authors: Pascal Demoly, Giovanni Passalacqua, Oliver Pfaar, Joaquin Sastre and Ulrich Wahn

Clinical and immuno-proteomic approach on Lantana camara pollen allergy—a major health hazard

The incidence of allergic diseases is increasing gradually and is a global burden affecting the socio-economic quality of life. Identification of allergens is the first step towards paving the way for therapeu...

Authors: Kavita Ghosal, Bodhisattwa Saha and Swati Gupta Bhattacharya

Clinical Experience with Octagam® 10 %, a solvent detergent virus inactivated intravenous immunoglobulin: a Canadian retrospective review of utilization

In Canada, intravenous immune globulin (IVIg) products are licensed for six disease indications, however it has been demonstrated that patients with a number of other conditions also benefit from IVIg. Here we...

Authors: Stephen D. Betschel, Richard J. Warrington and Robert Schellenberg

Filaggrin gene mutations and new SNPs in asthmatic patients: a cross-sectional study in a Spanish population

Several null-mutations in the FLG gene that produce a decrease or absence of filaggrin in the skin and predispose to atopic dermatitis and ichthyosis vulgaris have been described. The relationship with asthma is ...

Authors: José Luis Cubero, María Isidoro-García, Nieves Segura, David Benito Pescador, Catalina Sanz, Félix Lorente, Ignacio Dávila and Carlos Colás

Retrospective analysis on the agreement between skin prick test and serum food specific IgE antibody results in adults with suspected food allergy

Food allergy is a common clinical problem in adults. Given logistical barriers to conducting food challenges, the use of skin prick test (SPT) and specific IgE (sIgE) are important in establishing the diagnosi...

Authors: Ling Ling, Maria B. Ospina, Kyriaki Sideri and Harissios Vliagoftis

Comparison of ImmunoCAP and Immulite serum specific IgE assays for the assessment of egg allergy

Egg specific IgE levels are frequently used in combination with skin-prick tests to guide clinical decisions and to monitor egg allergy evolution in children. We compared both Immulite and ImmunoCAP egg specif...

Authors: François Graham, Philippe Bégin, Louis Paradis, Jonathan Lacombe-Barrios, Jean Paradis and Anne Des Roches

Erratum to: Safety and feasibility of oral immunotherapy to multiple allergens for food allergy

Authors: Philippe Bégin, Lisa C. Winterroth, Tina Dominguez, Shruti P. Wilson, Liane Bacal, Anjuli Mehrotra, Bethany Kausch, Anthony Trela, Elisabeth Hoyte, Gerri O’Riordan, Scott Seki, Alanna Blakemore, Margie Woch, Robert G. Hamilton and Kari C. Nadeau

Primary immunodeficiencies associated with eosinophilia

Eosinophilia is not an uncommon clinical finding. However, diagnosis of its cause can be a dilemma once common culprits, namely infection, allergy and reactive causes are excluded. Primary immunodeficiency dis...

Authors: Behdad Navabi and Julia Elizabeth Mainwaring Upton

Persistence of respiratory and inflammatory responses after dermal sensitization to persulfate salts in a mouse model of non-atopic asthma

Exposure to ammonium persulfate (AP) has been reported to be the main cause of occupational asthma in hairdressers. The aim of this study is to assess how long the asthmatic response to AP can be induced after...

Authors: M. J. Cruz, M. Olle-Monge, J. A. Vanoirbeek, A. Assialioui, S. Gomez-Olles and X. Muñoz

Maternal serum but not breast milk IL-5, IL-6, and IL-13 immune markers are associated with scratching among infants

Scratching in infants is considered to be related to early development of eczema. Little is known about the effects of maternal immune markers on scratching among infants. The objective is to compare the risks...

Authors: Nelís Soto-Ramírez, Keith Boyd, Hongmei Zhang, Venugopal Gangur, Laura Goetzl and Wilfried Karmaus

Allergen inhalation challenge, refractoriness and the effects of ibuprofen

Bronchoprovocation challenges use direct or indirect acting stimuli to induce airflow obstruction. Indirect stimuli either non-allergic/non-IgE mediated (e.g. exercise, mannitol) or allergic/IgE mediated (i.e....

Authors: Shawn Nomani, Donald W. Cockcroft and Beth E. Davis

Anaphylaxis to IGIV in immunoglobulin-naïve common variable immunodeficiency patient in the absence of IgG anti-IgA antibodies: successful administration of low IgA-containing immunoglobulin

Although severe reactions to immunoglobulin preparations have been frequently reported, IgE antibodies against IgA are usually not investigated; and occur predominantly in previously sensitized patients. The p...

Authors: Asal Gharib, Caroline Caperton and Sudhir Gupta

Multisystem reactions during egg oral food challenges may be associated with less severe reactions on initial presentation

In this study, we assessed whether multisystem reactions to egg and extensively-heated (EH) egg during OFCs were associated with a history of multisystem reactions. Records of children, who underwent OFC to eg...

Authors: Girish Vitalpur, Ann Esquivel, Kirsten M. Kloepfer, James E. Slaven and Frederick E. Leickly

Diagnostic accuracy of skin-prick testing for allergic rhinitis: a systematic review and meta-analysis

Allergic rhinitis is the most common form of allergy worldwide. The accuracy of skin testing for allergic rhinitis is still debated. Our primary objective was to evaluate the diagnostic accuracy of skin-prick ...

Authors: Immaculate F. Nevis, Karen Binkley and Conrad Kabali

Cytokine patterns in nasal secretion of non-atopic patients distinguish between chronic rhinosinusitis with or without nasal polys

Being one of the most common nasal diseases, chronic rhinosinusitis (CRS) is subdivided into CRS with nasal polyps (NP) and CRS without nasal polyps (CRSsNP). CRSsNP presents itself with a T_H1 milieu and neutroph...

Authors: Katrin König, Christine Klemens, Mareike Haack, Marion San Nicoló, Sven Becker, Matthias F. Kramer and Moritz Gröger

IgE serum concentration against airborne fungi in children with respiratory allergies

To evaluate total and specific E immunoglobulin (IgE) antibody concentrations in underage subjects with respiratory allergic diseases.

Authors: Geusa Felipa de Barros Bezerra, Denise Maria Costa Haidar, Marcos Antonio Custódio Neto da Silva, Walbert Edson Muniz Filho, Ramon Moura dos Santos, Ivone Garros Rosa, Graça Maria de Castro Viana, Luís Zaror and Maria do Desterro Soares Brandão Nascimento

Evaluation of circulating vascular endothelial growth factor and its soluble receptors in patients suffering from persistent allergic rhinitis

Overexpression and enhanced release of vascular endothelial growth factor (VEGF) have been detected in various types of allergic inflammation, including asthma.

Authors: E. Koczy-Baron, A. Grzanka, J. Jochem, R. Gawlik and A. Kasperska-Zajac

Exposure to bisphenol A enhanced lung eosinophilia in adult male mice

Bisphenol A (BPA) is useful in many manufacturing processes and is also found in commonly used consumer products. Previous experimental studies have reported that perinatal exposure to BPA promotes the develop...

Authors: Miao He, Takamichi Ichinose, Seiichi Yoshida, Hirohisa Takano, Masataka Nishikawa, Takayuki Shibamoto and Guifan Sun

Severity and disease control before house dust mite immunotherapy initiation: ANTARES a French observational survey

Allergen immunotherapy (AIT) may be prescribed for patients with allergic rhinitis (AR) induced by house dust mites (HDM) whether asthma is present or not. Current guidelines provide insufficient support for t...

Authors: Pascal Demoly, Anne Broué-Chabbert, François Wessel and Antoine Chartier

A rare nonsynonymous variant in the lipid metabolic gene HELZ2 related to primary biliary cirrhosis in Chinese Han

Several genome-wide association studies of primary biliary cirrhosis (PBC) in European and Japanese origins have shown significant association of dozens of genetic loci contributive to the susceptibility of PB...

Authors: Ping Li, Guanting Lu, Li Wang, Ying Cui, Ziyan Wu, Si Chen, Jing Li, Xiaoting Wen, Haoze Zhang, Shijie Mu, Fengchun Zhang and Yongzhe Li

Reviewer acknowledgement 2015

Authors: Richard Warrington

Allergen extracts and recombinant proteins: comparison of efficiency of in vitro allergy diagnostics using multiplex assay on a biological microchip

Immunological test systems for diagnostics of type I hypersensitivity involve the following types of antigens: whole allergen extracts, individual highly purified proteins and their recombinant analogues. The ...

Authors: Olga Smoldovskaya, Guzel Feyzkhanova, Alla Arefieva, Sergei Voloshin, Olga Ivashkina, Yuriy Reznikov and Alla Rubina

Asthma in the elderly: the effect of choline supplementation

Asthma in the elderly is poorly understood as very few studies have included these patients. DNA methylation can affect the expression of asthma susceptibility genes. Methyl groups can be produced through a ch...

Authors: Michele Columbo and Albert S. Rohr

Do epinephrine auto-injectors have an unsuitable needle length in children and adolescents at risk for anaphylaxis from food allergy?

Food allergy is the most common cause of anaphylaxis in children. Intramuscular delivery of epinephrine auto-injectors (EAI) is the standard of care for the treatment of anaphylaxis. We examined if children an...

Authors: Sten Dreborg, Xia Wen, Laura Kim, Gina Tsai, Immaculate Nevis, Ryan Potts, Jack Chiu, Arunmozhi Dominic and Harold Kim

T-cell receptor phenotype pattern in atopic children using commercial fluorescently labeled antibodies against 21 human class-specific v segments for the tcrβ chain (vβ) of peripheral blood: a cross sectional study

T-cell receptor (TCR) repertoire development is an integral part of the adaptive immune response. T-cell activation requires recognition of appropriately processed antigens by the TCR. Development of a diverse...

Authors: Gassem Gohal, Christine McCusker, Bruce Mazer, Reza Alizadehfar, Duncan Lejtenyi and Moshe Ben-shoshan

Angiopoietin-2 concentration in serum is associated with severe asthma phenotype

Several proangiogenic molecules have been implicated in the pathogenies of asthmatic inflammation and remodeling. The aim of the study was to compare the concentration of proangiogenic factors in the sera of a...

Authors: Joanna S. Makowska, Małgorzata Cieślak, Marzanna Jarzębska, Anna Lewandowska-Polak and Marek L. Kowalski

Role of specific IgE to β-lactoglobulin in the gastrointestinal phenotype of cow’s milk allergy

The prevalence of many phenotypes of food allergy is increasing. Specific gastrointestinal (GI) phenotype of food allergy (GI allergy) is also increasing but it is difficult to know the prevalence because of m...

Authors: Paloma Poza-Guedes, Yvelise Barrios, Ruperto González-Pérez, Inmaculada Sánchez-Machín, Andres Franco and Víctor Matheu

Post-vaccination myositis and myocarditis in a previously healthy male

The immunological literature has been redefining clinical phenomena as hypotheses emerge regarding causal links between triggers, immunologic manifestations, and their specific inflammatory cascades. Of late, ...

Authors: Matthew P. Cheng, Michael G. Kozoriz, Amir A. Ahmadi, John Kelsall, Katryn Paquette and Jake M. Onrot

Association between allergic rhinitis and metabolic conditions: a nationwide survey in Korea

Accumulating evidence indicates a strong correlation between allergic disease and cardiovascular risks. In spite of this, the data concerning the association between allergic rhinitis (AR) and cardiovascular r...

Authors: In Cheol Hwang, Yong Joo Lee, Hong Yup Ahn and Sang Min Lee

The role of cytokines in the pathogenesis and staging of Trypanosoma brucei rhodesiense sleeping sickness

Human African trypanosomiasis due to Trypanosoma brucei rhodesiense is invariably fatal if untreated with up to 12.3 million people at a risk of developing the disease in Sub-Saharan Africa. The disease is charac...

Authors: Charles D. Kato, Enock Matovu, Claire. M. Mugasa, Ann Nanteza and Vincent P. Alibu

Anaphylaxis following a transvaginal ultrasound

Polyethylene glycol is a ubiquitous, water-soluble, organic compound found in a wide variety of commercially available products. While generally a benign substance, in rare instances, it can induce hypersensit...

Authors: Baruch D. Jakubovic, Corey Saperia and Gordon L. Sussman

Management of the polyallergic patient with allergy immunotherapy: a practice-based approach

The great majority (60–80 %) of patients consulting specialist physicians for allergic respiratory disease are polysensitized and thus may be potentially clinically polyallergic. However, management approaches...

Authors: Pascal Demoly, Giovanni Passalacqua, Oliver Pfaar, Joaquin Sastre and Ulrich Wahn

Sensitization to common aeroallergens in a population of young adults in a sub-Saharan Africa setting: a cross-sectional study

Sensitization to aeroallergens increases the risk of developing asthma or allergic rhinitis. Data on sensitization to airborne allergens in the general population in sub-Saharan Africa are lacking. The aim of ...

Authors: Bertrand Hugo Mbatchou Ngahane, Diane Noah, Malea Nganda Motto, Yacouba Mapoure Njankouo and Louis Richard Njock

Powder milk: a user-friendly and safe product for heated-milk food challenge?

Previous studies have reported that up to 75 % of milk allergic subjects tolerate heated milk products. However, the food used for heated milk challenge is often prepared in a non-standardized manner by the pa...

Authors: Sabrine Cherkaoui, Philippe Bégin, Louis Paradis, Jean Paradis and Anne Des Roches

The human microbiome, asthma, and allergy

The human microbiome can be defined as the microorganisms that reside within and on our bodies and how they interact with the environment. Recent research suggests that numerous mutually beneficial interaction...

Authors: Amund Riiser

Marked improvement of neuropsychiatric symptoms following control of allergy symptoms with the use of humanized murine anti-IgE antibody (omalizumab) in 2 patients with severely limited expressive language

Flare-up of allergic rhinitis has been implicated in worsening neuropsychiatric symptoms such as hyperactivity and anxiety in the general population, mostly supported by epidemiological data. However, it is un...

Authors: Harumi Jyonouchi

TNF up-regulates Pentraxin3 expression in human airway smooth muscle cells via JNK and ERK1/2 MAPK pathways

Long pentraxin 3 (PTX3) is a novel candidate marker for inflammation in many chronic diseases. As a soluble pattern recognition receptor, PTX3 is involved in amplification of inflammatory reactions and regulat...

Authors: Jingbo Zhang, Latifa Koussih, Lianyu Shan, Andrew J. Halayko, Ben-Kuen Chen and Abdelilah S. Gounni

The gender, age and risk factor distribution differs in self-reported allergic and non-allergic rhinitis: a cross-sectional population-based study

Few population-based studies have assessed the prevalence and the risk factors of non-allergic rhinitis (NAR) in comparison to allergic rhinitis (AR). Moreover, epidemiologic data on rhinitis in the elderly su...

Authors: Lucia Cazzoletti, Marcello Ferrari, Mario Olivieri, Giuseppe Verlato, Leonardo Antonicelli, Roberto Bono, Lucio Casali, Isa Cerveri, Pierpaolo Marchetti, Pietro Pirina, Andrea Rossi, Simona Villani and Roberto de Marco

A retrospective comparison of false negative skin test rates in penicillin allergy, using pencilloyl-poly-lysine and minor determinants or Penicillin G, followed by open challenge

A history of penicillin allergy in patients is common, but only 10–15 % are truly allergic. While the gold standard for diagnosing penicillin allergy is challenge, it is not recommended that this be done witho...

Authors: Lana Rosenfield, Chrystyna Kalicinsky and Richard Warrington

T-cell phenotypes in chronic rhinosinusitis with nasal polyps in Japanese patients

Chronic rhinosinusitis with nasal polyps is characterized by local inflammation and is categorized into two subtypes in Japan: eosinophilic chronic rhinosinusitis, and non-eosinophilic chronic rhinosinusitis....

Authors: Shintaro Baba, Ryoji Kagoya, Kenji Kondo, Maho Suzukawa, Ken Ohta and Tatsuya Yamasoba

Peanut sensitization pattern in Norwegian children and adults with specific IgE to peanut show age related differences

Peanuts contain potent food allergens and the prevalence of allergy is reported to increase, especially in children. Since peanut sensitization may differ between different geographical regions, we wanted to i...

Authors: Ellen Namork and Berit A. Stensby

Allergen immunotherapy in pregnancy

Allergic diseases such as asthma and allergic rhinitis constitute a significant burden of disease among women of childbearing age and those who are pregnant. Adequately managing these conditions is paramount i...

Authors: Paul Oykhman, Harold L. Kim and Anne K. Ellis

Tropomyosin, the major tropical oyster Crassostrea belcheri allergen and effect of cooking on its allergenicity

Many types of shellfish including oysters are sometime cooked before ingestion and it has been demonstrated that cooking may affect the allergenicity of food. Therefore, the aim of our present study is to iden...

Authors: Zailatul Hani Mohamad Yadzir, Rosmilah Misnan, Faizal Bakhtiar, Noormalin Abdullah and Shahnaz Murad

Monoclonal antibody desensitization in a patient with a generalized urticarial reaction following denosumab administration

Denosumab is a human monoclonal antibody indicated for the treatment of osteoporosis in postmenopausal women with a high risk of fractures. To our knowledge, no cases of desensitization to this drug have been ...

Authors: D. Gutiérrez-Fernández, María-Jesús Cruz, A. Foncubierta-Fernández, A. Moreno-Ancillo, M. J. Fernández-Anguita, F. Medina-Varo and J. A. Andres-García

Epinephrine auto-injector prescriptions to food-allergic patients in primary care in The Netherlands

The knowledge of general practitioner(s) (GPs) regarding food allergy and anaphylaxis and practices in the prescription of epinephrine auto-injector(s) (EAIs) among GPs has previously only been studied using q...

Authors: Jacquelien Saleh-Langenberg, A. E. J. Dubois, F. Groenhof, J. W. H. Kocks, T. van der Molen and B. M. J. Flokstra-de Blok

Health-related quality of life in patients with primary immunodeficiency disease

Primary immunodeficiency disease (PIDD) with hypogammaglobulinemia is characterized by recurrent and severe bacterial infections and IgG replacement is the standard of care in many of these patients. Health-re...

Authors: Fonda Jiang, Troy R. Torgerson and Andrew G. Ayars

Cytokine profiles in nasal fluid of patients with seasonal or persistent allergic rhinitis

New therapeutic approaches with biologic agents such as anti-cytokine antibodies are currently on trial for the treatment of asthma, rhinosinusitis or allergic diseases necessitating patient selection by bioma...

Authors: Katrin König, Christine Klemens, Katharina Eder, Marion San Nicoló, Sven Becker, Matthias F. Kramer and Moritz Gröger

Prevention of pruritus with ethyl-chloride in skin prick test: a double-blind placebo-controlled prospective study

Ethyl-chloride (EC) spray was recently shown to be an effective antipruritic agent, when given 15 min after histamine skin-prick test (SPT), without changing the wheal and flare reaction. We aimed to investiga...

Authors: Amir Gal-Oz, Shmuel Kivity, Yacov Shacham, Elisheva Fiszer, Ori Rogowsky and Gil Chernin

Risk factors associated with asthma, atopic dermatitis and rhinoconjunctivitis in a rural Senegalese cohort

The World Allergy Organization estimates that 40 % of the world’s population is affected by allergic diseases. The International Study of Asthma and Allergies in Childhood has completed Phase III and it has no...

Authors: Magali Herrant, Cheikh Loucoubar, Sabah Boufkhed, Hubert Bassène, Fatoumata Diene Sarr, Laurence Baril, Odile Mercereau-Puijalon, Salaheddine Mécheri, Anavaj Sakuntabhai and Richard Paul