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  1. Direct inhalation challenges (e.g. methacholine) are stated to be more sensitive and less specific for a diagnosis of asthma than are indirect challenges (e.g. exercise, non-isotonic aerosols, mannitol, etc.)....

    Authors: Donald W. Cockcroft, Beth E. Davis and Christianne M. Blais

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:14

    Content type: Review

    Published on:

  2. The first and corresponding author was unfortunately presented as Mercedes Rodriguez Romano. The correct author name is Mercedes Romano.

    Authors: Mercedes Romano, Stephanie James, Emily Farrington, Richard Perry and Lisa Elliott

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:12

    Content type: Correction

    Published on:

    The original article was published in Allergy, Asthma & Clinical Immunology 2019 15:81

  3. To evaluate the effects of fluticasone furoate on the hypothalamic–pituitary–adrenocortical axis, and the safety and tolerability of fluticasone furoate treatment in children with asthma.

    Authors: Philippe Bareille, Susan Tomkins, Varsha Imber, Mohammed Tayob, Karen Dunn, Rashmi Mehta and Sanjeev Khindri

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:11

    Content type: Research

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  4. The management of the reversible airways obstruction forms the cornerstone of quality asthma management. The aim of this study was to assess the level of control for asthma in adult patients, using a cross sec...

    Authors: Pisirai Ndarukwa, Moses John Chimbari and Elopy Sibanda

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:10

    Content type: Research

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  5. Acute generalized exanthematous pustulosis (AGEP) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse reactions. These rare conditions differ in clinical presentation, pathological features, trea...

    Authors: Ana-Maria Copaescu, Danielle Bouffard and Marie-Soleil Masse

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:9

    Content type: Case report

    Published on:

  6. Women with hereditary angioedema due to C1-inhibitor deficiency (HAE-C1INH) experience more frequent and severe angioedema attacks compared with men. Fluctuations in female sex hormones can influence HAE attac...

    Authors: Donald S. Levy, Henriette Farkas, Marc A. Riedl, Florence Ida Hsu, Joel P. Brooks, Marco Cicardi, Henrike Feuersenger, Ingo Pragst and Avner Reshef

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:8

    Content type: Research

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  7. Sudan red or 1-[(2-methoxyphenyl)azo]-2-naphthol is a low molecular weight azoic agent widely used in industry, particularly in the production of hair dyes. The use of this product in the food industry is proh...

    Authors: David Clofent, Miquel de Homdedeu, Mariana Muñoz-Esquerre, María Jesús Cruz and Xavier Muñoz

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:7

    Content type: Case report

    Published on:

  8. Studies have shown the discrepancy between self-reported antibiotic allergies and true allergies. Inaccurate reporting of antibiotic hypersensitivities can limit treatment options and result in use of more exp...

    Authors: Anthony Jourdan, Brijit Sangha, Eric Kim, Sohrab Nawaz, Vikram Malik, Radhika Vij and Sudhir Sekhsaria

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:6

    Content type: Research

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  9. Allergic eye disease is common, yet often overlooked in North America. In the U.S., up to 40% of the population is deemed to be affected and this number is growing. Symptoms and signs of ocular allergy can lea...

    Authors: Pascale Dupuis, C. Lisa Prokopich, Alexander Hynes and Harold Kim

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:5

    Content type: Review

    Published on:

  10. Little is known about the epidemiology and associated factors of childhood AD in the markedly different, low-income, tropical environment like Madagascar.

    Authors: F. A. Sendrasoa, I. M. Ranaivo, N. H. Razanakoto, M. Andrianarison, O. Raharolahy, V. T. Ratovonjanahary, M. Sata, M. F. Rakotoarisaona, L. S. Ramarozatovo and F. Rapelanoro Rabenja

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:4

    Content type: Research

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  11. Cystic fibrosis (CF) is characterized by inflammation, progressive lung disease, and respiratory failure. Although the relationship is not well understood, patients with CF are thought to have a higher prevale...

    Authors: Lijia Zhang, Larry Borish, Anna Smith, Lindsay Somerville and Dana Albon

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:3

    Content type: Case report

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  12. Oral mite anaphylaxis (OMA) is a condition characterized by severe allergic reactions after ingesting food containing dust mite-contaminated flour. Physical exertion is recognized as a common trigger factor in...

    Authors: Mongkhon Sompornrattanaphan, Yanisa Jitvanitchakul, Nat Malainual, Chamard Wongsa, Aree Jameekornrak, Orathai Theankeaw and Torpong Thongngarm

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:2

    Content type: Case report

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  13. Cutis laxa is a connective tissue disease characterized by loose, wrinkled, and redundant skin. It is either inherited or acquired. In most cases, acquired cutis laxa is associated with neoplasms, drugs, and a...

    Authors: Amelia Nabatanzi, Siqi Da, Musa Male, Siyuan Chen and Changzheng Huang

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:1

    Content type: Short report

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  14. Kimura’s disease (KD) is a rare chronic inflammatory disease with unknown etiology. It usually manifests as a painless soft tissue mass or subcutaneous nodule on one side of the patient’s head and/or neck and ...

    Authors: Bo Yu, Guoxing Xu, Xiaofan Liu, Wen Yin, Hao Chen and Baoqing Sun

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:84

    Content type: Case report

    Published on:

  15. Aspirin exacerbated respiratory disease (AERD) is a disease of the upper and lower airways. It is characterized by severe asthma, chronic sinusitis with nasal polyps (CRSwNP) and intolerance towards nonsteroid...

    Authors: Monique Vorsprach, Christoph Arens, Stephan Knipping, Dörte Jechorek, Sabine Stegemann-Koniszewski, Eva Lücke and Jens Schreiber

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:83

    Content type: Research

    Published on:

  16. Lipopolysaccharide (LPS) often presents in high concentrations in particulate matter (PM), few studies have reported the enhancing effects of both LPS and PM on airway inflammation in mice and the role of toll...

    Authors: Yahao Ren, Takamichi Ichinose, Miao He, Seiichi Youshida, Masataka Nishikawa and Guifan Sun

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:82

    Content type: Research

    Published on:

  17. Allergic respiratory diseases such as allergic rhinitis (AR) and allergic asthma (AA) are common conditions that can influence sleep and daytime functioning. However, the significance of this impact is unclear...

    Authors: Mercedes Rodriguez Romano, Stephanie James, Emily Farrington, Richard Perry and Lisa Elliott

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:81

    Content type: Research

    Published on:

    The Correction to this article has been published in Allergy, Asthma & Clinical Immunology 2020 16:12

  18. Allergy to Vespa affinis venom is common in the Asia Pacific region. Venom preparations for diagnosis are not commercially available for this species.

    Authors: Peshala Gunasekara, S. M. Handunnetti, Sunil Premawansa, Pradeep Kaluarachchi, Chandima Karunatilake, Indra P. Ratnayake, R. K. S. Dias, G. A. S. Premakumara, W. M. D. K. Dasanayake, Suranjith L. Seneviratne and Rajiva de Silva

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:80

    Content type: Research

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  19. We showed previously that allergic reactivity to ovalbumin (OVA) could be regulated in mice following perturbation of immune networks using combinations of an immune Ig along with anti-idiotypic Ig. We have ex...

    Authors: R. M. Gorczynski, T. Maqbool and G. Hoffmann

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:79

    Content type: Research

    Published on:

  20. Common variable immunodeficiency disorders (CVID) are a rare group of primary immune defects, where the underlying cause is unknown. Approximately 10–20% of patients with typical CVID have a granulomatous vari...

    Authors: Rohan Ameratunga, Yeri Ahn, Dominic Tse, See-Tarn Woon, Jennifer Pereira, Sinead McCarthy and Hilary Blacklock

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:78

    Content type: Case report

    Published on:

  21. Hymenoptera venom allergy is one of the most frequent causes of anaphylaxis. In its most severe form, the reaction to wasp and honey bee stings may be life-threatening. Therefore, immediate and proper diagnosis o...

    Authors: Eliza Matuszewska, Joanna Matysiak, Anna Bręborowicz, Katarzyna Olejniczak, Zdzisława Kycler, Zenon J. Kokot and Jan Matysiak

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:77

    Content type: Research

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  22. There are numerous biologics for treating patients with severe asthma. A cost-effective method for selecting the most appropriate biologic therapy for a patient is thus important. Bronchoscopy-guided bronchial...

    Authors: Chin-Wei Kuo, Xin-Min Liao, Yi-Ching Huang, Han-Yu Chang and Chi-Chang Shieh

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:76

    Content type: Case report

    Published on:

  23. The concept of the unified allergic airway disease (UAD) recognises the association between allergic inflammation in the upper and lower airways. Patients with asthma and concomitant allergic rhinitis experien...

    Authors: Chris RuiWen Kuo, Rory Chan and Brian Lipworth

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:75

    Content type: Letter to the editor

    Published on:

  24. This study examined whether infants aged 0–3 months exhibited long-term effects of using a moisturizer skincare intervention and whether a short-term skin problem resulted in the subsequent development of food...

    Authors: Kaori Yonezawa and Megumi Haruna

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:74

    Content type: Research

    Published on:

  25. Allergen inhalation tests are a valuable research tool. The allergen dose producing an early asthmatic response (EAR) can be predicted from methacholine responsiveness and allergen skin test endpoint (STE). Th...

    Authors: Donald W. Cockcroft, Beth E. Davis, Christianne M. Blais, Louis-Philippe Boulet, Marie-Éve Boulay, Hélène Villeneuve, Gail M. Gauvreau, Paul M. O’Byrne, Karen J. Howie and Caitlin D. Obminski

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:73

    Content type: Research

    Published on:

  26. This is an update to the 2014 Canadian Hereditary Angioedema Guideline with an expanded scope to include the management of hereditary angioedema (HAE) patients worldwide. It is a collaboration of Canadian and ...

    Authors: Stephen Betschel, Jacquie Badiou, Karen Binkley, Rozita Borici-Mazi, Jacques Hébert, Amin Kanani, Paul Keith, Gina Lacuesta, Susan Waserman, Bill Yang, Emel Aygören-Pürsün, Jonathan Bernstein, Konrad Bork, Teresa Caballero, Marco Cicardi, Timothy Craig…

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:72

    Content type: Review

    Published on:

    The Correction to this article has been published in Allergy, Asthma & Clinical Immunology 2020 16:33

  27. This study was performed to determine whether there was any association between abnormal DNA methylation of a thymic stromal lymphopoietin (TSLP) locus and pathogenesis of chronic rhinosinusitis (CRS).

    Authors: Jingyun Li, Jian Jiao, Yunbo Gao, Yuan Zhang and Luo Zhang

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:71

    Content type: Research

    Published on:

  28. The National Review of Asthma Deaths UK highlighted that 46% of deaths could be avoided and recommended that all sufferers receive a structured asthma annual review which assess asthma control. In primary care...

    Authors: Raj Gill and E. Mark Williams

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:70

    Content type: Research

    Published on:

  29. In this paper, we review methodological approaches used in studies that evaluated the association between occupational exposure to quaternary ammonium compounds (quats) and occupational asthma. This associatio...

    Authors: Judy S. LaKind and Michael Goodman

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:69

    Content type: Review

    Published on:

  30. Chronic granulomatous disease (CGD) is a rare primary immunodeficiency disorder caused by a defect in the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex. The disease primarily presents wit...

    Authors: Suzan AlKhater

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:68

    Content type: Case report

    Published on:

  31. Blood has proven to be a useful resource for molecular analysis in numerous biomedical studies, with peripheral blood mononuclear cells (PBMCs) and whole blood being the major specimen types. However, comparat...

    Authors: Daniel He, Chen Xi Yang, Basak Sahin, Amrit Singh, Casey P. Shannon, John-Paul Oliveria, Gail M. Gauvreau and Scott J. Tebbutt

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:67

    Content type: Research

    Published on:

  32. Hereditary angioedema with normal C1 inhibitor (HAE-nC1 INH) is a rare, underappreciated condition characterized by recurrent subcutaneous angioedema. The underlying pathophysiology and diagnostic criteria con...

    Authors: Lundy McKibbin, Colin Barber, Chrystyna Kalicinsky and Richard Warrington

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:66

    Content type: Research

    Published on:

  33. Gender differences in asthma perception and control have been reported. The PROXIMA observational study assessed these outcomes in a cohort of Italian severe allergic asthma (SAA) patients. This post hoc analy...

    Authors: Delia Colombo, Emanuela Zagni, Fabio Ferri and Giorgio Walter Canonica

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:65

    Content type: Research

    Published on:

  34. Monocytes play an important role in immune and inflammatory diseases and monocyte subsets are predictors of disease in certain conditions. Expression of the chemokine receptors, CCR2 and CX3CR1 on monocyte subset...

    Authors: Reem Al-Rashoudi, Gillian Moir, Mohamed S. Al-Hajjaj, Monther M. Al-Alwan, Heather M. Wilson and Isabel J. Crane

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:64

    Content type: Research

    Published on:

  35. Immunological Human African Trypanosomiasis (HAT) studies often exclude malaria, although both infections overlap in specific endemic areas. During this co-infection, it is not known whether this parasitic int...

    Authors: Julius Nsubuga, Charles Drago Kato, Ann Nanteza, Enock Matovu and Vincent Pius Alibu

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:63

    Content type: Research

    Published on:

  36. Investigating the association between caesarean section (SC) and childhood asthma has shown contradictory results in different studies. The present study was conducted to determine the association between SC a...

    Authors: Behzad Darabi, Shoboo Rahmati, Mohammad Reza HafeziAhmadi, Gholamreza Badfar and Milad Azami

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:62

    Content type: Review

    Published on:

  37. Oral H1-antihistamines (AHs) are the most commonly used therapy to treat allergic rhinitis and chronic urticaria. Older, first-generation AHs (e.g. diphenhydramine, hydroxyzine) have significant and common side e...

    Authors: Michael N. Fein, David A. Fischer, Andrew W. O’Keefe and Gord L. Sussman

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:61

    Content type: Review

    Published on:

  38. To assess the safety and efficacy of an oral immunotherapy regimen in patients with allergy to lipid transfer proteins (LTPs).

    Authors: Begoña Navarro, Eladia Alarcón, Ángela Claver, Mariona Pascal, Araceli Díaz-Perales and Anna Cisteró-Bahima

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:60

    Content type: Short report

    Published on:

  39. Despite advances in treating Systemic lupus erythematosus (SLE), a proportion of patients continue to face significant morbidity and mortality. Haemopoietic stem cell transplant (HSCT) has been recognized as a...

    Authors: Nipun Lakshitha de Silva and Suranjith L. Seneviratne

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:59

    Content type: Review

    Published on:

  40. Allergic rhinitis (AR) is one of the most common diseases globally and usually persists throughout life. In the present study, we aimed to determine whether the expression of inflammatory biomarkers has a rela...

    Authors: Myung Woul Han, Song Hee Kim, Inbo Oh, Yang Ho Kim and Jiho Lee

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:58

    Content type: Research

    Published on:

  41. Associations between allergic disease and puberty amongst females have been widely studied. However, this association has received less attention in multigenerational populations. To this end, we sought to exa...

    Authors: Jennifer Lisa Penner Protudjer, Elissa Michelle Abrams, Anita Luba Kozyrskyj and Allan Barry Becker

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:57

    Content type: Letter to the editor

    Published on:

  43. The incidence of chronic rhinosinusitis with nasal polyps has recently increased in Japan and other East Asian countries, and this disease is called eosinophilic chronic sinusitis (ECRS) in Japan. ECRS usually...

    Authors: Yasuho Shoda, Misa Watanabe, Kota Wada, Takehiko Soutome, Yumiko Komine, Tetsuo Mikami, Tetsuo Nemoto and Akira Ohara

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:55

    Content type: Case report

    Published on:

  44. Compared to non-allergic individuals, food allergic individuals have impaired health-related quality of life (HRQL). However, effects of gender and age are unclear. The objective of our study was to describe a...

    Authors: Jennifer Lisa Penner Protudjer, Roelinde Middelveld, Sven-Erik Dahlén and Staffan Ahlstedt

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:54

    Content type: Research

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  45. Adolescents (12–17 years of age) with severe eosinophilic asthma experience frequent exacerbations and reduced lung function leading to poor health-related quality of life. Mepolizumab is approved for add-on m...

    Authors: Steven W. Yancey, Hector G. Ortega, Oliver N. Keene and Eric S. Bradford

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:53

    Content type: Letter to the editor

    Published on:

  46. Increasing prevalence of childhood allergic diseases including asthma is a global health concern, and we aimed to investigate prenatal risk factors for childhood asthma and to address the potential shared pren...

    Authors: Ching-Heng Lin, Jiun-Long Wang, Hsin-Hua Chen, Jeng-Yuan Hsu and Wen-Cheng Chao

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:52

    Content type: Research

    Published on:

  47. The full range of allergic reactions to Total Parenteral Nutrition (TPN) remains unknown. Additionally, beyond individual allergens, there may be other factors contributing to TPN hypersensitivity reactions.

    Authors: Steph A. Pang, Shaun Eintracht, Jesse M. Schwartz, Belinda Lobo and Elizabeth MacNamara

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:51

    Content type: Case report

    Published on:

  48. There is interest in better understanding vessel pathology in asthma, given the findings of loss of peripheral vasculature associated with disease severity by imaging and altered markers of endothelial activat...

    Authors: Renata Calciolari Rossi, Raquel Anonni, Diogenes Seraphim Ferreira, Luiz Fernando Ferraz da Silva and Thais Mauad

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:50

    Content type: Research

    Published on:

    The Correction to this article has been published in Allergy, Asthma & Clinical Immunology 2020 16:91

  49. Hereditary angioedema (HAE) is a debilitating disorder resulting from C1-esterase inhibitor (C1-INH) deficiency. In the COMPACT phase 3 study the prophylactic use of a subcutaneous C1 inhibitor (C1-INH [SC], H...

    Authors: H. Henry Li, Bruce Zuraw, Hilary J. Longhurst, Marco Cicardi, Konrad Bork, James Baker, William Lumry, Jonathan Bernstein, Michael Manning, Donald Levy, Marc A. Riedl, Henrike Feuersenger, Subhransu Prusty, Ingo Pragst, Thomas Machnig and Timothy Craig

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:49

    Content type: Research

    Published on:

  50. Asthma is often accompanied by peripheral eosinophilia and eosinophilic airway inflammation. This article explores the relationship between asthma and short-term pulmonary infiltrate with eosinophilia, which r...

    Authors: Min Song, Shan Cai, Hong Luo, Yi Jiang, Min Yang, Yan Zhang, Hong Peng and Ping Chen

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:48

    Content type: Case report

    Published on:

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