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  1. Kimura disease (KD) is a rare chronic idiopathic condition of unknown etiology that is prevalent in Asian males. It often causes subcutaneous lumps and enlarged lymph nodes, especially in head and neck region....

    Authors: Ruiyun Fan, Guopeng Xu, Ying Chen, Jinghuan Lv and Zhongwei Zhang
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:58
  2. The mechanism of action behind anaphylactic reactions to the mRNA COVID-19 vaccines remains unknown, but the excipient polyethylene glycol, PEG-2000, has been implicated. Initial recommendations were made for ...

    Authors: Daniel H. Li, Erika Lee and Christine Song
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:57
  3. Air pollution may induce or reinforce nasal inflammation regardless of allergy status. There is limited direct clinical evidence informing the treatment of airborne pollution-related rhinitis.

    Authors: Yuan Zhang, Chunguang Shan, Weiwei Liu, Yaozhong Han, Guanggang Shi, Yongjian Ma, Kerstin Wagner, Xiaoyan Tian, Lili Zhang, Allan Joseph Larona, Steven Sacavage, Kathleen Franklin, Chengshuo Wang and Luo Zhang
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:56
  4. The microtubule-dependent molecular motor protein Kinesin Family Member 2A (KIF2A) is down-regulated in asthmatic human airway epithelium. However, little is known about the roles of KIF2A as well as the possi...

    Authors: Zhengxia Wang, Jingjing Wu, Jingxian Jiang, Qiyun Ma, Meijuan Song, Tingting Xu, Yanan Liu, Zhongqi Chen, Yanmin Bao, Mao Huang, Mingshun Zhang and Ningfei Ji
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:55
  5. Food protein-induced enterocolitis syndrome is a non-IgE-mediated reaction to food that is poorly understood, and underdiagnosed. Trigger foods can belong to any food group, but are most commonly milk, soy, ri...

    Authors: Samantha Wong, Lucy Duan, Alana Galper, Adelle Atkinson, Julia Upton and Thomas Eiwegger
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:54
  6. Public health measures to mitigate the COVID-19 pandemic have altered health care for chronic conditions. The impact of the COVID-19 pandemic on paediatric asthma, the most common chronic respiratory cause of ...

    Authors: Nusrat Homaira, Nan Hu, Louisa Owens, Mei Chan, Melinda Gray, Philip N Britton, Hiran Selvadurai, Raghu Lingam and Adam Jaffe
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:53
  7. Platelet-activating factor (PAF) has been suggested to be a potent inflammatory mediator in Allergic rhinitis (AR) pathogenesis. Vitamin E, an essential nutrient that comprises tocopherol and tocotrienol, is k...

    Authors: Cheryl Wei Ling Teo, Stephanie Jia Ying Png, Yee Wei Ung and Wei Ney Yap
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:52
  8. A food ladder is a form of home-based dietary advancement therapy that gradually increases exposure to an allergenic food through the gradual introduction of egg or milk containing food with increasing quantit...

    Authors: Gilbert T. Chua, Edmond S. Chan, Joanne Yeung, Scott B. Cameron, Lianne Soller, Brock A. Williams, Alanna Chomyn, Timothy K. Vander Leek, Elissa M. Abrams, Raymond Mak and Tiffany Wong
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:51
  9. 22q11.2 Deletion Syndrome (22q11.2DS) can result in array of congenital abnormalities including immune dysfunction. International guidelines recommend immune evaluation of 22q11.2DS patients prior to live vacc...

    Authors: Sophie McGregor, Matthew Boroditsky, Geraldine Blanchard-Rohner, Christine Loock and Kyla Jade Hildebrand
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:50
  10. The Rosaceae family includes fruits, such as peach, apple, Japanese apricot, cherry (Prunoideae subfamily), and strawberry (Rosoideae subfamily). The allergens responsible for Rosaceae fruit allergies have bee...

    Authors: Chisato Inuo, Fumiko Okazaki, Rie Shiraki, Yutaka Tanaka, Keiko Momma, Yasuto Kondo and Hiroshi Narita
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:49
  11. Patients with asthma frequently over rely on short-acting beta-agonists (SABA) to treat acute symptoms. This can adversely impact quality of life and increase the risk of exacerbations. SABA overuse is also as...

    Authors: Anne K. Ellis, Vanessa Foran, Alan Kaplan and Patrick D. Mitchell
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:48
  12. The entire school community contributes to the safety of students with food allergy. We sought to determine the food allergy perceptions and education needs of parents, students and school staff, with the goal...

    Authors: Nancy Ross, Sandra Dalke, Shauna Filuk, Bev Kulbaba, Diane Marks, Jo-Anne St-Vincent and Elinor Simons
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:47
  13. Human inborn errors of immunity (IEI) are a group of inherited genetic disorders of the immune system. IEI Patients suffer from severe repeated infections, autoimmunity, lymphadenopathy and/or increased suscep...

    Authors: Safa Meshaal, Rabab EI Hawary, Alia Eldash, Aya Erfan, Dalia Abd Elaziz, Radwa Alkady, Sohilla Lotfy, Nermeen Galal, Jeannette Boutros and Aisha Elmarsafy
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:45
  14. Specific immunotherapy for patients with honey bee hypersensitivity is commonly applied. Re-challenge with venom is performed to prove protection in individual cases.

    Authors: Sara Micaletto, Kurt Ruetzler, Martin Bruesch and Peter Schmid-Grendelmeier
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:44
  15. One of the main barriers to vaccination against SARS-CoV-2 is the fear of developing hypersensitivity reactions to any of its components. Although these reactions are very rare, it is necessary to establish an...

    Authors: Vicente Jover Cerdá, Ramón Rodríguez Pacheco, Joan Doménech Witek, Sonia Alonso Hernández, Rafael Durán García, Marina Real Panisello and Francisco Manuel Marco de la Calle
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:43
  16. Globally, a small proportion (5–12%) of asthma patients are estimated to have severe disease. However, severe asthma accounts for disproportionately high healthcare resource utilization. The Global Initiative ...

    Authors: William J. Calhoun and Geoffrey L. Chupp
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:42
  17. The present narrative review provides a comprehensive update of the current knowledge on urticaria, both in adult and pediatric populations, and on the safety and efficacy of fexofenadine hydrochloride (HCl) a...

    Authors: Ignacio J. Ansotegui, Jonathan A. Bernstein, Giorgio W. Canonica, Sandra N. Gonzalez-Diaz, Bryan L. Martin, Mario Morais-Almeida, Margarita Murrieta-Aguttes and Mario Sanchez Borges
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:41

    The Correction to this article has been published in Allergy, Asthma & Clinical Immunology 2022 18:65

  18. More and more studies had suggested that dyslipidemia was closely related to allergic diseases. High density lipoprotein (HDL) often plays anti-inflammatory and anti-oxidative roles by suppressing immune cell ...

    Authors: Shengli Gao, Qingxiang Zeng, Yinhui Zeng, Yiquan Tang and Wenlong Liu
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:40
  19. Bronchial thermoplasty (BT) is an effective treatment in severe asthma. How to select patients who more likely benefit from BT is an unmet clinical need. Moreover, mechanisms of BT efficacy are still largely u...

    Authors: Nicola Facciolongo, Martina Bonacini, Carla Galeone, Patrizia Ruggiero, Francesco Menzella, Giulia Ghidoni, Roberto Piro, Chiara Scelfo, Chiara Catellani, Alessandro Zerbini and Stefania Croci
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:39
  20. Patients with primary immunodeficiency (PID) are at increased risk for infections such as SARS-CoV-2 (COVID-19), due to the nature of their diseases and being immunocompromised. At this time, four vaccines aga...

    Authors: Babak Aberumand, Whitney Ayoub Goulstone and Stephen Betschel
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:38
  21. Shared learnings from the early use of novel therapies can aid in their optimization. The recent introduction of peanut oral immunotherapy (peanut OIT; Palforzia [Peanut (Arachis hypogaea) Allergen Powder-dnfp]) ...

    Authors: Jay Portnoy, Christina E. Ciaccio, Janet Beausoleil, George Du Toit, Stanley Fineman, Stephen A. Tilles, June Zhang, Claire Lawrence, Mohamed Yassine and S Shahzad Mustafa
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:37
  22. Infants at high risk for developing a food allergy have either an atopic condition (such as eczema) themselves or an immediate family member with such a condition. Breastfeeding should be promoted and supporte...

    Authors: Elissa M. Abrams, Wade Watson, Timothy K. Vander Leek, Adelle Atkinson, Marie-Noel Primeau, Marie-Josee Francoeur, Mary McHenry, Elana Lavine, Julia Orkin, Carl  Cummings, Becky Blair and Edmond S. Chan
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:36
  23. Biologics dramatically improve symptoms of severe asthma; however, various exacerbating factors may induce flare-up. Pneumocystis spp. have not been reported as a cause of asthma exacerbation during biologic use,...

    Authors: Kazuya Takeda, Toshiyuki Sumi, Yuta Nagahisa, Keigo Matsuura, Motoki Sekikawa, Hiroki Watanabe, Yuichi Yamada and Hirofumi Chiba
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:35
  24. The determinants of tolerance to food allergens are not fully understood. We aimed to elucidate the longitudinal association between oropharyngeal symptoms without systemic reactions (OSw/oS) and tolerance to ...

    Authors: Masaaki Hamada, Keigo Saeki and Yoshihiko Sakurai
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:34
  25. The prevalence of allergic diseases is increasing in Zimbabwe and the data relate to local as well as exotic allergen sources. As entomophagy, the practice of eating insects, is a recognised source of local al...

    Authors: Vuyelwa Ndlovu, Moses Chimbari, Pisirai Ndarukwa and Elopy Sibanda
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:33
  26. Safety and effectiveness concerns may preclude physicians from recommending vaccination in mild/moderate inborn errors of immunity (IEI). This study describes attitudes and practices regarding vaccination amon...

    Authors: Sneha Suresh, Joseline Zafack, Anne Pham-Huy, Beata Derfalvi, Manish Sadarangani, Athena McConnell, Bruce Tapiéro, Scott A. Halperin, Gaston De Serres, Jeffrey M Pernica and Karina A. Top
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:32
  27. Common variable immunodeficiency (CVID) is a primary immunodeficiency disorder associated with a broad symptom presentation that is still being characterized. We report a rare case of recurrent mycoplasma skin...

    Authors: David X. Gao, Habiba Hussain, Brianna Bobber and Peter Phan
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:31
  28. Erythritol is widely used as an additive in foods and pharmaceuticals. We present the case of a 6-year-old boy who developed an allergy to erythritol. He showed a positive skin prick test result and a negative...

    Authors: Satomi Mori, Kazuyuki Kurihara and Chisato Inuo
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:28
  29. Penicillin allergy labels frequently impede guideline-directed treatment with a penicillin or other β-lactam antibiotics. Despite presumed allergy, targeted questioning may indicate a low probability of sensit...

    Authors: Philipp Schrüfer, Johanna Stoevesandt and Axel Trautmann
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:26
  30. Hypereosinophilic syndrome (HES) is an extremely uncommon group of disorders. It rarely presents with coagulopathy without cardiac involvement.

    Authors: Kestutis Aukstuolis, Jocelyn J. Cooper, Katherine Altman, Anna Lang and Andrew G. Ayars
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:25
  31. Allergic rhinitis is a risk factor for asthma development. In asthma, fibroblast progenitors, fibrocytes, are increased in the blood and bronchial mucosa following allergen exposure. These cells may play a rol...

    Authors: Marie-Ève Côté, Marie-Ève Boulay, Sophie Plante, Andréanne Côté, Jamila Chakir and Louis-Philippe Boulet
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:24
  32. Intravenous immunoglobulin (IVIG) is increasingly used as a treatment for recurrent pregnancy loss (RPL) despite lack of clear evidence on efficacy. Recent data suggest IVIG might be more effective in a subgro...

    Authors: Denise H. J. Habets, Kim Pelzner, Lotte Wieten, Marc E. A. Spaanderman, Eduardo Villamor and Salwan Al-Nasiry
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:23
  33. Immediate hypersensitivity reactions to COVID-19 vaccines have been postulated to be linked to their excipients, such as polyethylene glycol (PEG) in Pfizer Comirnaty, or polysorbate 80 and ethylenediaminetetr...

    Authors: Syed B. Ali, Griffith Perkins, Dongjae Ryoo, Maverick Lee, Matthew Tunbridge, Chino Yuson, William Smith, Pravin Hissaria and Thanh-Thao Le
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:22
  34. Non-infectious complications have become a major cause of morbidity and mortality in patients with Common Variable Immunodeficiency (CVID). The monitoring of patients with CVID prior to the development of non-...

    Authors: Erika Yue Lee, Stephen Betschel and Eyal Grunebaum
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:21
  35. Allergic rhinitis (AR) is an upper respiratory tract inflammation disease caused by IgE-mediated reactions against inhaled allergens. The incidence of AR is significantly increasing throughout the world. Hence...

    Authors: Yun Hao, Boqian Wang, Jinming Zhao, Ping Wang, Yali Zhao, Xiangdong Wang, Yan Zhao and Luo Zhang
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:20
  36. Primary immunodeficiencies (PI), which include more than 450 single-gene inborn errors of immunity and may affect up to 1% of the population, are genetic disorders that impair the immune system. If not properly i...

    Authors: Jessica Quinn, Vicki Modell, Jordan S. Orange and Fred Modell
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:19
  37. Eosinophilic granulomatosis with polyangiitis (EGPA) is characterized by a necrotizing vasculitis with tissue and peripheral blood eosinophilia affecting small and medium-sized arteries, capillaries, and veins...

    Authors: Sei Adachi, Chiyako Oshikata, Takeshi Kaneko and Naomi Tsurikisawa
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:18
  38. Prolidase deficiency (PD) is an autosomal recessive inborn multisystemic disease caused by mutations in the PEPD gene encoding the enzyme prolidase D, leading to defects in turnover of proline-containing proteins...

    Authors: Nora Alrumayyan, Drew Slauenwhite, Sarah M. McAlpine, Sarah Roberts, Thomas B. Issekutz, Adam M. Huber, Zaiping Liu and Beata Derfalvi
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:17
  39. In the era of COVID-19, utilization of telemedicine has dramatically increased. In addition to reduced travel times, patient expenses, and work or school days missed, telemedicine allows clinicians to provide ...

    Authors: Sarah Edgerley, Rongbo Zhu, Ariba Quidwai, Harold Kim and Samira Jeimy
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:16
  40. Activated phosphoinositide 3-kinase (PI3K) δ syndrome (APDS) is a rare form of primary immunodeficiency with 243 known cases reported in the literature. Known findings associated with the condition include rec...

    Authors: Megan Craig, Bob Geng, Kristen Wigby, Susan A. Phillips, Christine Bakhoum, John Naheedy and Mateja Cernelc-Kohan
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:15
  41. Eosinophilic granulomatosis with polyangiitis (EGPA) is a vasculitis characterized by abnormally high eosinophils and frequent peripheral neuropathy. Mepolizumab is an approved therapy for EGPA, but its effica...

    Authors: Yoshiro Kai, Masanori Yoshikawa, Masayuki Matsuda, Kentaro Suzuki, Hiroya Ohara, Naohiko Iguchi, Takehito Kasamatsu, Kenji Uno, Nobuhiro Fujioka, Yukio Fujita and Shigeo Muro
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:14
  42. Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare vasculitis. Although glucocorticoid therapy with or without immunosuppressants leads to remission in the majority of cases, most EGPA patients rem...

    Authors: Danxu Ma, Yuting Xue, Rong Shi, Yinan Yang, Huili Li, Xuhua Shi, Li Wang and Yun Wang
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:13
  43. Epidemiological studies have revealed a link between atopic dermatitis (AD) and asthma. AS1517499, a selective signal transducer and activation of transcription 6 (STAT6) inhibitor, has been shown to effective...

    Authors: Xueying Li, Zhaoqing Han, Feng Wang and Jianou Qiao
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:12
  44. Allergic rhinitis (AR) and allergic contact dermatitis (ACD) are prevalent allergic diseases and have significant impacts on patients’ daily life. Despite many studies on AR or ACD have been conducted separate...

    Authors: Wenjia Chai, Xuyi Zhang, Meixiong Lin, Zhuo Chen, Xiaolin Wang, Changqing Wang, Aoyan Chen, Caisheng Wang, Hongwu Wang, Honghong Yue and Jingang Gui
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:10
  45. Atopic dermatitis is a common chronic skin disease that can occur in pregnancy. Current treatments include topical and systemic glucocorticoids and cyclosporine. Presently, the only biologic approved for atopi...

    Authors: Nabeel H. Akhtar, Touraj Khosravi-Hafshejani, Daud Akhtar, Gurbir Dhadwal and Amin Kanani
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:9

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