Articles

Impact of lanadelumab in hereditary angioedema: a case series of 12 patients in Canada

Hereditary angioedema (HAE) is a rare autosomal dominant disease resulting in recurring episodes of swelling, leading to considerable patient morbidity and mortality. Lanadelumab is a plasma kallikrein inhibit...

Authors: Aled Iaboni, Amin Kanani, Gina Lacuesta, Christine Song, Manstein Kan and Stephen D. Betschel

BMI trajectory in childhood is associated with asthma incidence at young adulthood mediated by DNA methylation

Body mass index (BMI) is associated with asthma but associations of BMI temporal patterns with asthma incidence are unclear. Previous studies suggest that DNA methylation (DNAm) is associated with asthma statu...

Authors: Rutu Rathod, Hongmei Zhang, Wilfried Karmaus, Susan Ewart, Latha Kadalayil, Caroline Relton, Susan Ring, S. Hasan Arshad and John W. Holloway

Assessment of TSLP, IL 25 and IL 33 in patients with shrimp allergy

Shrimp allergy is a growing problem among the European population. TSLP, IL-25 and IL-33 are involved in the pathophysiology of allergic diseases, including asthma and atopic dermatitis, as they activate the T...

Authors: Natalia Ukleja-Sokołowska, Magdalena Żbikowska-Gotz, Kinga Lis, Rafał Adamczak and Zbigniew Bartuzi

Immediate hypersensitivity reaction followed by successful oral desensitization to ursodiol

Immediate hypersensitivity reaction to ursodiol is rare and there is no previously published protocol on ursodiol desensitization.

Authors: Erika Yue Lee and Christine Song

CD8⁺ Tregs ameliorate inflammatory reactions in a murine model of allergic rhinitis

CD8⁺CD25⁺fork-head box transcription factor (Foxp3)⁺ regulatory T cells (CD8⁺ Tregs) play a role in immune tolerance. However, the role of these cells in allergic rhinitis (AR) has not been elucidated. The study ...

Authors: Lin Lin, Fei Dai, Jinjin Wei and Zheng Chen

Transcutaneous penetration of a single-chain variable fragment (scFv) compared to a full-size antibody: potential tool for atopic dermatitis (AD) treatment

Currently, several biologics are used for the treatment of cutaneous pathologies such as atopic dermatitis (AD), psoriasis or skin cancers. The main administration routes are subcutaneous and intravenous injec...

Authors: Audrey Baylet, Raoul Vyumvuhore, Marine Laclaverie, Laëtitia Marchand, Carine Mainzer, Sylvie Bordes, Brigitte Closs-Gonthier and Laurent Delpy

Demographic characteristics associated with food allergy in a Nationwide Canadian Study

We conducted a nationwide Canadian telephone survey on food allergy prevalence between February 2016 and January 2017, targeting vulnerable populations (New, Indigenous, and lower-income Canadians).

Authors: Ann E. Clarke, Susan J. Elliott, Yvan St. Pierre, Lianne Soller, Sebastien La Vieille and Moshe Ben-Shoshan

Allergic reactions to emerging food allergens in Canadian children

Most Canadian food allergy data has focused on Health Canada’s priority food allergens. This study describes which non-priority (emerging) food allergens were most commonly reported by Canadian parents and cat...

Authors: Lianne Soller, Sebastien La Vieille, Scott B. Cameron, Raymond Mak, Victoria E. Cook, Jennifer Gerdts and Edmond S. Chan

Methylprednisolone-induced anaphylaxis diagnosed by intradermal skin test: a case report

Glucocorticoids rarely cause anaphylaxis. Common methods for the determination of allergens include in vivo skin prick test (SPT) and intradermal skin test (IDST) and the in vitro basophil activation test (BAT...

Authors: Hitomi Amano, Yoshiro Kitagawa, Tomohito Hayakawa, Taichiro Muto, Akihisa Okumura and Hideyuki Iwayama

Gene–gene and gene-environment interactions on cord blood total IgE in Chinese Han children

IL13, IL4, IL4RA, FCER1B and ADRB2 are susceptible genes of asthma and atopy. Our previous study has found gene–gene interactions on asthma between these genes in Chinese Han children. Whether the interactions be...

Authors: Li Hua, Quanhua Liu, Jing Li, Xianbo Zuo, Qian Chen, Jingyang Li, Yuwei Wang, Haipei Liu, Zhaobo Shen, Yi Li, Zenan Ma, Shengdong Dong, Ruoxu Ji, Dingzhu Fang, Yi Chen, Wenwei Zhong…

Improvement of skin lesions in corticosteroid withdrawal-associated severe eczema by multicomponent traditional Chinese medicine therapy

We recently showed that multicomponent traditional Chinese medicine (TCM) therapy had steroid-sparing effects in moderate-to-severe eczema. We sought to evaluate TCM effects in severe eczema in a 7-year-old ma...

Authors: Serife Uzun, Zixi Wang, Tory A. McKnight, Paul Ehrlich, Erin Thanik, Anna Nowak-Wegrzyn, Nan Yang and Xiu-Min Li

Pre-existing asthma as a comorbidity does not modify cytokine responses and severity of COVID-19

A significant portion of COVID-19 sufferers have asthma. The impacts of asthma on COVID-19 progression are still unclear but a modifying effect is plausible as respiratory viruses are acknowledged to be an imp...

Authors: Jian Luo, Yi-Ling Chen, Wentao Chen, David A. Duncan, Alexander Mentzer, Julian C. Knight, Graham Ogg, Paul Klenerman, Ian D. Pavord and Luzheng Xue

Sublingual immunotherapy tablet: a cost-minimizing alternative in the treatment of tree pollen-induced seasonal allergic rhinitis in Canada

A cost-minimization analysis (CMA) was performed to evaluate the economic implications of introducing the SQ Tree sublingual immunotherapy (SLIT)-tablets marketed as ITULATEK® (Health Canada regulatory approva...

Authors: Anne K. Ellis, Rémi Gagnon, Eva Hammerby, Julia Shen and Sheena Gosain

Systemic reactions to subcutaneous allergen immunotherapy: real-world cause and effect modelling

Subcutaneous immunotherapy (SCIT) is an effective treatment for allergic rhinoconjunctivitis. However, adverse events, including life-threatening systemic reactions, may occur. The purpose of this project is t...

Authors: Adam Aue, Joella Ho, Rongbo Zhu, Harold Kim and Samira Jeimy

Increased levels of serum IL-17 and induced sputum neutrophil percentage are associated with severe early-onset asthma in adults

Differences between adult patients with severe early-onset and late-onset asthma have not been well studied.

Authors: Dandan Chen, Yu Zhang, Can Yao, Binbin Li, Sinian Li, Wenwen Liu, Rongchang Chen and Fei Shi

Underestimation of airway luminal eosinophilia by quantitative sputum cytometry

On Wright-stained sputum cytospins, eosinophil differential of ≥ 1.2% is considered abnormal, and ≥ 2.3% identifies an eosinophilic endotype. We hypothesized that failure to consider free eosinophil granules (...

Authors: Melanie Kjarsgaard, Adil Adatia, Anurag Bhalla, Nicola LaVigne, Katherine Radford, Chynna Huang, Manali Mukherjee and Parameswaran Nair

Management of allergic rhinitis with leukotriene receptor antagonists versus selective H1-antihistamines: a meta-analysis of current evidence

Inconsistencies remain regarding the effectiveness and safety of leukotriene receptor antagonists (LTRAs) and selective H1-antihistamines (SAHs) for allergic rhinitis (AR). A meta-analysis of randomized contro...

Authors: Yan Feng, Ya-Ping Meng, Ying-Ying Dong, Chang-Yu Qiu and Lei Cheng

Psychosocial burden of type 1 and 2 hereditary angioedema: a single-center Canadian cohort study

Hereditary angioedema (HAE) is a rare but serious disorder associated with a multifaceted burden of illness including a high prevalence of psychiatric symptoms and impaired health-related quality of life (HRQo...

Authors: Julia Hews-Girard and Marilyn Dawn Goodyear

Letting the patients speak: an in-depth, qualitative research-based investigation of factors relevant to health-related quality of life in real-world patients with hereditary angioedema using subcutaneous C1 inhibitor replacement therapy

While many studies of effective hereditary angioedema (HAE) therapy have demonstrated improved health-related quality of life (HRQoL) using validated instruments, specific reasons behind the improved scores ha...

Authors: John Anderson, Donald S. Levy, William Lumry, Patricia Koochaki, Sally Lanar and H. Henry Li

Taurine promotes the production of CD4⁺CD25⁺FOXP3⁺ Treg cells through regulating IL-35/STAT1 pathway in a mouse allergic rhinitis model

Allergic rhinitis (AR) is one of the most widespread immune conditions worldwide. However, common treatments often present with significant side effects or are cost-prohibitive for much of the population. A pl...

Authors: Jing Zhou, Yi Lu, Wei Wu and Yunhai Feng

Effect of omalizumab for autoimmune progesterone dermatitis refractory to bilateral oophorectomy: a case report

Autoimmune progesterone dermatitis (APD) is a rare skin condition caused by sensitivity to high levels of progesterone secreted during the luteal phase of the menstrual cycle. This may be due to various pathop...

Authors: Akshay Varghese, Terri Paul, Harold Kim, Stan Van Uum, Peter Vadas and Alescia Azzola

Primary prescription adherence for obstructive lung disease in a primary care population

The objective of this study was to determine primary prescription adherence for obstructive lung diseases (e.g., asthma, COPD) in an adult primary care patient population over a 3-year period.

Authors: Alexander G. Singer, Alan Katz, Lisa LaBine, Lisa M. Lix, Marina Yogendran, Ian Sinha and Elissa M. Abrams

A case of lymphocytic esophagitis in a woman with multiple allergies

Lymphocytic esophagitis is a newly recognized entity of unknown origin. Dysphagia is defined as difficulty swallowing and represents a common symptom in the general population with a prevalence of approximatel...

Authors: O. Wojas, M. Żalikowska-Gardocka, E. Krzych-Fałta, B. Szczepankiewicz, P. Samel-Kowalik, B. Samoliński and A. Przybyłkowski

HealthSWEDE: costs with sublingual immunotherapy—a Swedish questionnaire study

The aim of this cross-sectional survey was to compare the health-economic consequences for allergic rhinitis (AR) patients treated with sublingual Immunotherapy (SLIT) in terms of direct and indirect costs wit...

Authors: Petter Olsson, Carl Skröder, Lars Ahlbeck, Frida Hjalte, Karl-Olof Welin, Ulla Westin, Morgan Andersson, Cecilia Ahlström-Emanuelsson and Lars-Olaf Cardell

A case report: anaphylaxis to cefazolin during renal transplant surgery

While there exist case reports of anaphylaxis occurring during renal transplant surgery, descriptions of continuing transplant surgery post-anaphylaxis have been scarce. Anaphylactic reactions that present sol...

Authors: Kaveh Hemati, Shelley Gierat, Garrett R. Roll and Odmara L. Barreto Chang

Anti-ganglioside antibodies and celiac disease

Authors: Alessandro Granito, Francesco Tovoli, Alberto Raiteri and Umberto Volta

Assessment of changes in genetic transcriptome in nasal epithelial cells exposed to ozone-aged black carbon and pollen allergen by high-throughput transcriptomics

Air pollution may be associated with increased airway responsiveness to allergens in allergic rhinitis (AR). Ozone-aged environmental black carbon (O₃BC) is an important constituent of atmospheric particulate mat...

Authors: Yuhui Ouyang, Ying Li, Zhaojun Xu, Yusan An and Luo Zhang

Expression levels of plasma exosomal miR-124, miR-125b, miR-133b, miR-130a and miR-125b-1-3p in severe asthma patients and normal individuals with emphasis on inflammatory factors

Identification of molecular markers, such as miRNAs is promising for the diagnosis of asthma and its clinical phenotypes. The aim of this study was to examine the changes in the expression of selected microRNA...

Authors: Mostafa Atashbasteh, Esmaeil Mortaz, Seyed Alireza Mahdaviani, Hamidreza Jamaati and Abdolamir Allameh

Clinical and demographic pattern of chronic granulomatous disease (CGD) from a multicenter perspective: Malaysia’s experience over 26 years

A retrospective review of clinical manifestations and demographic pattern of patients diagnosed as chronic granulomatous disease (CGD) from 7 hospitals in Malaysia. An analysis of the available database would ...

Authors: Lokman Mohd Noh, Amir Hamzah Abdul Latiff, Intan Hakimah Ismail, Rahim Md Noah, Asrul Abdul Wahab, Intan Juliana Abd. Hamid, Adiratna Mat Ripen, Nasuruddin B. Abdullah, Kamarul Azhar Razali, Norzila Zainudin, Florence Bakon, Long Juan Kok, Adli Ali, Bilkis Banu SAbd Aziz, Hasniah Abdul Latif, Siti Mardhiana Mohamad…

Selective cannabis strain allergy in a patient presenting with a local allergic reaction

Cannabis use is growing domestically due to recent legalization in many jurisdictions. There are two main species of cannabis, Cannabis sativa and Cannabis indica, and thousands of different commercially availabl...

Authors: Peter Stepaniuk and Amin Kanani

Kimura’s disease with recurrent bilateral lacrimal gland involvement in a male Japanese child successfully treated with cyclosporine A

Kimura’s disease (KD) is a rare chronic inflammatory disease of unknown etiology. Clinically, KD is characterized by nodular subcutaneous masses, that are typically localized to the neck and head. Involvement ...

Authors: Keisuke Sugimoto, Takuji Enya, Yuichi Morimoto, Rina Oshima, Kohei Miyazaki and Mitsuru Okada

Characteristics of inflammatory phenotypes among patients with asthma: relationships of blood count parameters with sputum cellular phenotypes

There is a need to identify the asthma inflammatory phenotypes of patients to facilitate personalized asthma treatment. Sputum induction is time-consuming and requires expert clinical technique. This study aim...

Authors: Bingqing Shi, Wei Li, Yuqiu Hao, Hongna Dong, Wenjing Cao, Jie Guo and Peng Gao

Sensitisation patterns and allergy outcomes in pregnant women living in the urban area

Worldwide, allergy affects more than one billion people, with particularly rising prevalence in industrialised areas. Specifically, young adults appear to be predominantly targeted for an allergy diagnosis. Al...

Authors: Hanna Danielewicz, Anna Dębińska, Grzegorz Myszczyszyn, Anna Myszkal, Lidia Hirnle, Anna Drabik-Chamerska, Danuta Kalita and Andrzej Boznański

Classification of non-acute bronchial asthma according to allergy and eosinophil characteristics: a retrospective study

Investigating the endotypes of the different asthma phenotypes would help disease monitoring, prognosis determination, and improving asthma management standardization. This study aimed to classify asthma into ...

Authors: Yi Jiang, Ruoli An, Li Cheng, Qianru Yue, Hanwei Zhang, Yali Zhang, Xiaomei Kong, Hongxia Ma, Fang Chen and Yufeng Guo

Interaction between early-life pet exposure and methylation pattern of ADAM33 on allergic rhinitis among children aged 3–6 years in China

Recent research has pointed out the important roles of epigenetic modifications in the development and persistence of allergic rhinitis (AR), especially in relation to DNA methylation of disease-associated gen...

Authors: Yu Zhang, Meiyu Tan, Xiaoqiong Qian, Cong Li, Lei Yue, Yuehong Liu and Song Shi

Intestinal helminthic infection and allergic disorders among school children enrolled in mass deworming program, Sululta, Ethiopia

Intestinal helminths have been proposed to have a protective role against allergic sensitization and atopic diseases. However, consistent data demonstrating this are lacking in Sub-Saharan countries. We aimed ...

Authors: Dessie Abera, Moges Wordofa, Abiyot Mesfin, Gemechu Tadesse, Mistire Wolde, Kassu Desta, Aster Tsegaye and Bineyam Taye

Trained immunity induced by in vivo peptide-based STAT6 inhibition prevents ragweed allergy in mice

Trained immunity is the ability of the innate immune system to form immune memory responses to provide support the formation of appropriate adaptive responses. Allergic airways disease (AAD) is a maladapted im...

Authors: Husheem Michael, Yuanyi Li, Yufa Wang and Christine T. McCusker

Leveraging unstructured data to identify hereditary angioedema patients in electronic medical records

The epidemiologic impact of hereditary angioedema (HAE) is difficult to quantify, due to misclassification in retrospective studies resulting from non-specific diagnostic coding. The aim of this study was to i...

Authors: Emily S. Brouwer, Emily W. Bratton, Aimee M. Near, Lynn Sanders and Christina D. Mack

Assessment and management of disease burden and quality of life in patients with hereditary angioedema: a consensus report

Hereditary angioedema (HAE) is a rare disease characterized by unpredictable, potentially life-threatening attacks, resulting in significant physical and emotional burdens for patients and families. To optimiz...

Authors: Konrad Bork, John T. Anderson, Teresa Caballero, Timothy Craig, Douglas T. Johnston, H. Henry Li, Hilary J. Longhurst, Cristine Radojicic and Marc A. Riedl

Adjunct therapy with probiotics for chronic urticaria in children: randomised placebo-controlled trial

Chronic urticaria is a common disorder of the skin, characterised by recurrent skin wheals and angioedema. Recent reports have shown that altered diversity and composition of the gut microbiota may lead to imb...

Authors: Xiao-Dong Bi, Bao-Zhen Lu, Xin-Xin Pan, Sha Liu and Jiu-Yao Wang

Interleukin-35 inhibited the production of histamine and pro-inflammatory cytokines through suppression MAPKs pathway in HMC-1 cells

IL-35 is a newly anti-inflammatory cytokine that belongs to the IL-12 family. Mast cells, as one of the major effector cells in the immune response system, plays an important role in the pathogenesis of chroni...

Authors: Li-xin Fu, Tao Chen, Qiao-mei Sun, Pei-mei Zhou and Zai-pei Guo

DRESS induced by amoxicillin-clavulanate in two pediatric patients confirmed by lymphocyte toxicity assay

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but serious delayed hypersensitivity reaction that can be caused by antibiotic exposure. The reaction typically develops in 2 to 6 weeks....

Authors: Arun Dhir, Hasandeep Kular, Abdelbaset A. Elzagallaai, Bruce Carleton, Michael J. Rieder, Raymond Mak and Tiffany Wong

A case of hand urticaria, lip angioedema, and oropharyngeal pruritus induced by Japanese radish through IgE-mediated immediate allergic reaction

Although Japanese radish (Raphanus sativus L.) is a common Japanese ingredient, there are few reports of IgE-mediated immediate food allergy caused by Japanese radish.

Authors: Sumiko Abe, Jun Ito, Sonoko Harada, Hitoshi Sasano, Shoko Ueda, Yuuki Sandhu, Tomohito Takeshige, Yoko Katsura, Norihiro Harada and Kazuhisa Takahashi

Autoantibodies to speckled protein family in primary biliary cholangitis

The autoantibody profile of primary biliary cholangitis (PBC) includes antinuclear antibodies (ANA) which are detectable by indirect immunofluorescence in more than 50% of PBC patients. One of the two immunofl...

Authors: Alessandro Granito, Luigi Muratori, Francesco Tovoli and Paolo Muratori

Proceedings of the Canadian Society of Allergy and Clinical Immunology Annual Scientific Meeting 2020

Authors:

Clinical validation of controlled exposure to house dust mite in the environmental exposure unit (EEU)

The Environmental Exposure Unit (EEU), a controlled allergen exposure model of allergic rhinitis (AR), has traditionally utilized seasonal allergens. We sought to clinically validate the use of house dust mite...

Authors: Lubnaa Hossenbaccus, Sophia Linton, Jenny Thiele, Lisa Steacy, Terry Walker, Crystal Malone and Anne K. Ellis

The effect of Co-Q10 on allergic rhinitis and allergic asthma

Allergic asthma is an inflammatory disease resulting from continued or intermittent allergen exposure, and allergic rhinitis can be trigger of asthma. The main mechanism of these disease is allergic reaction a...

Authors: Qixue Du, Wei Meng, Seyyed Shamsadin Athari and Renzhong Wang

Practical challenges in oral immunotherapy resolved through patient-centered care

Oral immunotherapy (OIT) is now widely recognized as a valid option for the management of IgE-mediated food allergies. However, in real-life practice, OIT can lead to a variety of unique situations where the b...

Authors: François Graham, Douglas P. Mack and Philippe Bégin

Early intervention of atopic dermatitis as a preventive strategy for progression of food allergy

Atopic diseases, such as atopic dermatitis (AD) and food allergy (FA), have increased in prevalence in industrialized countries during the past few decades and pose a significant health burden. They appear to ...

Authors: Alyssa Sweeney, Vanitha Sampath and Kari C. Nadeau

COVID-19 vaccine testing & administration guidance for allergists/immunologists from the Canadian Society of Allergy and Clinical Immunology (CSACI)

Safe and effective vaccines provide the first hope for mitigating the devastating health and economic impacts resulting from coronavirus disease 2019 (COVID-19) and related public health orders. Recent case re...

Authors: Timothy K. Vander Leek, Edmond S. Chan, Lori Connors, Beata Derfalvi, Anne K. Ellis, Julia E. M. Upton and Elissa M. Abrams