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  1. Content type: Review

    Oral H1-antihistamines (AHs) are the most commonly used therapy to treat allergic rhinitis and chronic urticaria. Older, first-generation AHs (e.g. diphenhydramine, hydroxyzine) have significant and common side e...

    Authors: Michael N. Fein, David A. Fischer, Andrew W. O’Keefe and Gord L. Sussman

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:61

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  2. Content type: Short report

    To assess the safety and efficacy of an oral immunotherapy regimen in patients with allergy to lipid transfer proteins (LTPs).

    Authors: Begoña Navarro, Eladia Alarcón, Ángela Claver, Mariona Pascal, Araceli Díaz-Perales and Anna Cisteró-Bahima

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:60

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  3. Content type: Review

    Despite advances in treating Systemic lupus erythematosus (SLE), a proportion of patients continue to face significant morbidity and mortality. Haemopoietic stem cell transplant (HSCT) has been recognized as a...

    Authors: Nipun Lakshitha de Silva and Suranjith L. Seneviratne

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:59

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  4. Content type: Research

    Allergic rhinitis (AR) is one of the most common diseases globally and usually persists throughout life. In the present study, we aimed to determine whether the expression of inflammatory biomarkers has a rela...

    Authors: Myung Woul Han, Song Hee Kim, Inbo Oh, Yang Ho Kim and Jiho Lee

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:58

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  5. Content type: Letter to the editor

    Associations between allergic disease and puberty amongst females have been widely studied. However, this association has received less attention in multigenerational populations. To this end, we sought to exa...

    Authors: Jennifer Lisa Penner Protudjer, Elissa Michelle Abrams, Anita Luba Kozyrskyj and Allan Barry Becker

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:57

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  6. Content type: Case report

    The incidence of chronic rhinosinusitis with nasal polyps has recently increased in Japan and other East Asian countries, and this disease is called eosinophilic chronic sinusitis (ECRS) in Japan. ECRS usually...

    Authors: Yasuho Shoda, Misa Watanabe, Kota Wada, Takehiko Soutome, Yumiko Komine, Tetsuo Mikami, Tetsuo Nemoto and Akira Ohara

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:55

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  7. Content type: Research

    Compared to non-allergic individuals, food allergic individuals have impaired health-related quality of life (HRQL). However, effects of gender and age are unclear. The objective of our study was to describe a...

    Authors: Jennifer Lisa Penner Protudjer, Roelinde Middelveld, Sven-Erik Dahlén and Staffan Ahlstedt

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:54

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  8. Content type: Letter to the editor

    Adolescents (12–17 years of age) with severe eosinophilic asthma experience frequent exacerbations and reduced lung function leading to poor health-related quality of life. Mepolizumab is approved for add-on m...

    Authors: Steven W. Yancey, Hector G. Ortega, Oliver N. Keene and Eric S. Bradford

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:53

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  9. Content type: Research

    Increasing prevalence of childhood allergic diseases including asthma is a global health concern, and we aimed to investigate prenatal risk factors for childhood asthma and to address the potential shared pren...

    Authors: Ching-Heng Lin, Jiun-Long Wang, Hsin-Hua Chen, Jeng-Yuan Hsu and Wen-Cheng Chao

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:52

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  10. Content type: Case report

    The full range of allergic reactions to Total Parenteral Nutrition (TPN) remains unknown. Additionally, beyond individual allergens, there may be other factors contributing to TPN hypersensitivity reactions.

    Authors: Steph A. Pang, Shaun Eintracht, Jesse M. Schwartz, Belinda Lobo and Elizabeth MacNamara

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:51

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  11. Content type: Research

    There is interest in better understanding vessel pathology in asthma, given the findings of loss of peripheral vasculature associated with disease severity by imaging and altered markers of endothelial activat...

    Authors: Renata Calciolari Rossi, Raquel Anonni, Diogenes Seraphim Ferreira, Luiz Fernando Ferraz da Silva and Thais Mauad

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:50

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  12. Content type: Research

    Hereditary angioedema (HAE) is a debilitating disorder resulting from C1-esterase inhibitor (C1-INH) deficiency. In the COMPACT phase 3 study the prophylactic use of a subcutaneous C1 inhibitor (C1-INH [SC], H...

    Authors: H. Henry Li, Bruce Zuraw, Hilary J. Longhurst, Marco Cicardi, Konrad Bork, James Baker, William Lumry, Jonathan Bernstein, Michael Manning, Donald Levy, Marc A. Riedl, Henrike Feuersenger, Subhransu Prusty, Ingo Pragst, Thomas Machnig and Timothy Craig

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:49

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  13. Content type: Case report

    Asthma is often accompanied by peripheral eosinophilia and eosinophilic airway inflammation. This article explores the relationship between asthma and short-term pulmonary infiltrate with eosinophilia, which r...

    Authors: Min Song, Shan Cai, Hong Luo, Yi Jiang, Min Yang, Yan Zhang, Hong Peng and Ping Chen

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:48

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  14. Content type: Case report

    The lymphohematopoietic cells originating from feto-maternal trafficking during pregnancy may cause microchimerism and lead to materno-fetal graft versus host disease (GVHD) in severe combined immunodeficiency...

    Authors: Zahra Shahbazi, Nima Parvaneh, Shirin Shahbazi, Hamzeh Rahimi, Mohammad Hamid, Davoud Shahbazi, Samaneh Delavari, Hassan Abolhassani, Asghar Aghamohammadi and Reza Mahdian

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:47

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  15. Content type: Research

    Asthma is a chronic disease that seriously harms the health of patients. Oxidative stress is involved in asthma. As an oxidative stress-inducible protein, sestrin2 is elevated in oxidative stress-related disea...

    Authors: Yanfang Kang, Chen Chen, Xiaotian Hu, Xiaohua Du, Huifen Zhai, Yan Fang, Xiulin Ye, Weimin Yang and Shibo Sun

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:46

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  16. Content type: Research

    Neutrophils play an important role in the pathogenesis of rheumatoid arthritis (RA). It has recently been reported that in addition to T helper (Th) 17 cells, other cells, including neutrophils, produce IL-17A...

    Authors: Maria Gonzalez-Orozco, Rosa E. Barbosa-Cobos, Paola Santana-Sanchez, Lizbeth Becerril-Mendoza, Leonardo Limon-Camacho, Ana I. Juarez-Estrada, Gustavo E. Lugo-Zamudio, Jose Moreno-Rodriguez and Vianney Ortiz-Navarrete

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:44

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  17. Content type: Research

    To identify novel epigenetic markers of adolescent asthma and replicate findings in an independent cohort, then explore whether such markers are detectable at birth, predictive of early-life wheeze, and associ...

    Authors: Todd M. Everson, Hongmei Zhang, Gabrielle A. Lockett, Akhilesh Kaushal, Melinda Forthofer, Susan L. Ewart, Kimberley Burrows, Caroline L. Relton, Gemma C. Sharp, A. John Henderson, Veeresh K. Patil, Faisal I. Rezwan, S. Hasan Arshad, John W. Holloway and Wilfried Karmaus

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:43

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  18. Content type: Research

    Allergic diseases are increasing yearly. We aimed to evaluate the difference in allergen sensitization pattern between adults and children in southern China by analyzing a large sample size of real-life data, ...

    Authors: Wenting Luo, Haisheng Hu, Wangbing Tang, Xiangwei Zou, Huimin Huang, Zhifeng Huang, Yong Liu and Baoqing Sun

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:42

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  19. Content type: Research

    It is known that small airway disease is present across all asthma severities; however, its prevalence and clinical characteristics in cough variant asthma (CVA) have not been fully illuminated.

    Authors: Honglei Yuan, Xiaojing Liu, Li Li, Gang Wang, Chunfang Liu, Yuzhen Zeng, Ruolin Mao, Chunling Du and Zhihong Chen

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:41

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  20. Content type: Research

    Consumption of certain foods during pregnancy has been shown to have beneficial effects on childhood asthma and allergic disease development and aggravation. However, most studies provide conflicting results a...

    Authors: Nour Baïz, Jocelyne Just, Julie Chastang, Anne Forhan, Blandine de Lauzon-Guillain, Anne-Marie Magnier and Isabella Annesi-Maesano

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:40

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  21. Content type: Research

    The pathogenesis and etiology of antrochoanal polyps (ACPs) remains obscure. This study aimed to characterize the inflammatory profiles and investigate the effect of atopy on the pathogenesis of pediatric ACPs.

    Authors: Huiwen Zheng, Lixing Tang, Beibei Song, Xiaojian Yang, Ping Chu, Shujing Han, Pengpeng Wang, Jie Lu, Wentong Ge and Xin Ni

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:39

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  22. Content type: Research

    Nearly all the investigations into the risk factors for wheezing and asthma were conducted in developed countries with a high prevalence rate of asthma and allergy, but the studies in developing countries are ...

    Authors: Jing Guo, Wenjing Zhu, Huimin Wang, Patrick G. Holt, Guicheng Zhang and Chuanhe Liu

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:38

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  23. Content type: Letter to the editor

    Limited information is available on the clinical course of patients with severe asthma following discontinuation of biologic treatment. Therefore, a post hoc analysis was conducted in patients with severe eosi...

    Authors: Hector Ortega, Catherine Lemiere, Jean-Pierre Llanos, Mark Forshag, Robert Price, Frank Albers, Steven Yancey and Mario Castro

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:37

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  24. Content type: Case report

    Allergic bronchopulmonary aspergillosis (ABPA) and allergic fungal rhinosinusitis (AFRS) are characterized by hyper-responsiveness of the respiratory tract and the nasal cavity and paranasal sinuses, respectiv...

    Authors: Eisuke Mochizuki, Shun Matsuura, Tsutomu Kubota, Yasutaka Mochizuka, Kyohei Oishi, Hyogo Naoi, Masahiro Uehara, Shinichiro Mikura, Miyuki Nagaoka, Masaru Tsukui, Naoki Koshimizu and Ichirota Nameki

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:35

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  25. Content type: Case report

    Idiopathic systemic capillary leak syndrome (ISCLS), is a rare disorder characterized by recurrent attacks of varying severity of hypovolemic shock and generalized edema in association with hemoconcentration a...

    Authors: Ahmed M. Alkhunaizi, Abdullah H. Kabbani and Mohamed A. ElTigani

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:34

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  26. Content type: Review

    MicroRNA-21 (miR-21), probably one of the most studied miRNAs to date, is found pleiotropic in various biological events. Its emerging role in pulmonary remodeling has attracted extensive attention. This revie...

    Authors: Congshan Jiang, Yuanxu Guo, Hongchuan Yu, Shemin Lu and Liesu Meng

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:33

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  27. Content type: Case report

    Hereditary angioedema (HAE) is a potentially life-threatening group of conditions that is often underdiagnosed or misdiagnosed. As HAE is typically diagnosed by detecting C1 inhibitor deficiency, there is a cr...

    Authors: Dale L. Bodian, Thierry Vilboux and Natalie S. Hauser

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:32

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  28. Content type: Research

    Asthma is a complex disease with variable course. Efforts to identify biomarkers to predict asthma severity, the course of disease and response to treatment have not been very successful so far. We have previo...

    Authors: Nami Shrestha Palikhe, Ana-Maria Bosonea, Cheryl Laratta, Vivek Dipak Gandhi, Drew Nahirney, Angela Hillaby, Miranda Bowen, Mohit Bhutani, Irvin Mayers, Lisa Cameron and Harissios Vliagoftis

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:30

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  29. Content type: Research

    Asthma is a complex disorder with multiple phenotypes which can influence its severity and response to treatment. The TH17 lymphocytes producing IL-17A and IL17-F cytokines, may have a role on asthma inflammation...

    Authors: Milca de J. Silva, Maria B. R. de Santana, Bruna R. Tosta, Roberta P. Espinheira, Neuza Maria Alcantara-Neves, Maurício L. Barreto, Camila Alexandrina Figueiredo and Ryan dos S. Costa

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:28

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  30. Content type: Research

    A cost-minimization analysis (CMA) was performed to estimate the economic impact of introducing the SQ house dust mite sublingual immunotherapy (SQ HDM SLIT)-tablet marketed as ACARIZAX™ (regulatory approval M...

    Authors: Anne K. Ellis, Rémi Gagnon, Eva Hammerby and Andrea Lau

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:27

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  31. Content type: Letter to the editor

    Little is known about the association of urticarial vasculitis (UV) with thyroid autoimmunity. The latter has been mostly described in the setting of patients with chronic spontaneous urticaria (CSU). In this ...

    Authors: Ivan Cherrez-Ojeda, Emanuel Vanegas, Valeria L. Mata, Miguel Felix, German D. Ramon, Sofia Cherrez and Annia Cherrez

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:25

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  32. Content type: Review

    Allergic rhinitis (AR) poses a global health problem and can be challenging to treat. Many of the current symptomatic treatments for AR have been available for decades, yet there has been little improvement in...

    Authors: Leif Bjermer, Marit Westman, Mats Holmström and Magnus C. Wickman

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:24

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  33. Content type: Short report

    Obstructive sleep apnea (OSA) is a risk factor for cardiovascular disease, metabolic disorders, and cognitive dysfunction. Current thinking links chronic intermittent hypoxia (CIH) with oxidative stress and sy...

    Authors: Danbing Ke, Yuji Kitamura, Duncan Lejtenyi, Bruce Mazer, Robert T. Brouillette and Karen Brown

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:23

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  34. Content type: Correction

    Eosinophilic esophagitis (EoE) is an atopic condition of the esophagus that has become increasingly recognized over the last 15 years. Diagnosis of the disorder is dependent on the patient’s clinical manifesta...

    Authors: Stuart Carr, Edmond S. Chan and Wade Watson

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:22

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    The original article was published in Allergy, Asthma & Clinical Immunology 2018 14:58

  35. Content type: Letter to the editor

    Omalizumab, a recombinant humanized monoclonal antibody targeting the IgE molecule, is the first biologic approved for moderate-to-severe allergic asthmatics, who remain uncontrolled despite high dose inhaled ...

    Authors: Manali Mukherjee, Melanie Kjarsgaard, Katherine Radford, Chynna Huang, Richard Leigh, Delbert R. Dorscheid, Catherine Lemiere, Louis-Philippe Boulet, Susan Waserman, James Martin and Parameswaran Nair

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:21

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  36. Content type: Research

    Immunoglobulin E (IgE) is the treatment target of omalizumab, a monoclonal antibody indicated in the treatment of severe allergic asthma. Long-term variability of serum total IgE (sIgEtot) in asthmatics remains p...

    Authors: Renaud Louis, Charles Pilette, Olivier Michel, Alain Michils, Guy Brusselle, Antoine Poskin, Jan Van Schoor, Kris Denhaerynck, Stefaan Vancayzeele, Ivo Abraham and Sandra Gurdain

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:20

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  37. Content type: Case report

    Natural rubber latex and chlorhexidine have previously been identified as causative substances in perioperative anaphylaxis. A pelvic examinations is generally considered noninvasive, however, this procedure i...

    Authors: Mongkhon Sompornrattanaphan, Piyawut Kreetapirom, Yuttana Srinoulprasert, Duangjit Kanistanon, Anchalika Klinniyom, Chamard Wongsa and Torpong Thongngarm

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:19

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  38. Content type: Letter to the editor

    Amyopathic dermatomyositis has been associated with the exposure to several drugs: the article by Jeimy et al. described the onset of this uncommon disease in a patient treated with omalizumab. Paradoxically, ...

    Authors: Dimitri Poddighe, Zaure Mukusheva and Maikesh Assylbekova

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:18

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  39. Content type: Research

    There is increasing evidence pointing to the important role of tumor necrosis factor-alpha (TNF-α), a key inflammatory and apoptotic mediator in urticarial inflammation. However, the role of the TNF-α system a...

    Authors: R. Grzanka, A. Damasiewicz-Bodzek and A. Kasperska-Zajac

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:15

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  40. Content type: Research

    Early accurate diagnosis and sustainable availability of affordable medicines and diagnostic tests is fundamental in optimal management of asthma and chronic obstructive pulmonary disease (COPD). We systematic...

    Authors: Davis Kibirige, Richard E. Sanya, Rebecca Nantanda, William Worodria and Bruce Kirenga

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:14

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  41. Content type: Research

    For prophylaxis of hereditary angioedema (HAE) attacks, replacement therapy with human C1-inhibitor (C1-INH) treatment is approved and available as intravenous [C1-INH(IV)] (Cinryze®) and subcutaneous [C1-INH(SC)...

    Authors: Jonathan A. Bernstein, Huamin Henry Li, Timothy J. Craig, Michael E. Manning, John-Philip Lawo, Thomas Machnig, Girishanthy Krishnarajah and Moshe Fridman

    Citation: Allergy, Asthma & Clinical Immunology 2019 15:13

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