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  1. Chronic urticaria is a common disorder of the skin, characterised by recurrent skin wheals and angioedema. Recent reports have shown that altered diversity and composition of the gut microbiota may lead to imb...

    Authors: Xiao-Dong Bi, Bao-Zhen Lu, Xin-Xin Pan, Sha Liu and Jiu-Yao Wang

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:39

    Content type: Research

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  2. IL-35 is a newly anti-inflammatory cytokine that belongs to the IL-12 family. Mast cells, as one of the major effector cells in the immune response system, plays an important role in the pathogenesis of chroni...

    Authors: Li-xin Fu, Tao Chen, Qiao-mei Sun, Pei-mei Zhou and Zai-pei Guo

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:38

    Content type: Research

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  3. Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but serious delayed hypersensitivity reaction that can be caused by antibiotic exposure. The reaction typically develops in 2 to 6 weeks....

    Authors: Arun Dhir, Hasandeep Kular, Abdelbaset A. Elzagallaai, Bruce Carleton, Michael J. Rieder, Raymond Mak and Tiffany Wong

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:37

    Content type: Case Report

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  4. Although Japanese radish (Raphanus sativus L.) is a common Japanese ingredient, there are few reports of IgE-mediated immediate food allergy caused by Japanese radish.

    Authors: Sumiko Abe, Jun Ito, Sonoko Harada, Hitoshi Sasano, Shoko Ueda, Yuuki Sandhu, Tomohito Takeshige, Yoko Katsura, Norihiro Harada and Kazuhisa Takahashi

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:36

    Content type: Case Report

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  5. The autoantibody profile of primary biliary cholangitis (PBC) includes antinuclear antibodies (ANA) which are detectable by indirect immunofluorescence in more than 50% of PBC patients. One of the two immunofl...

    Authors: Alessandro Granito, Luigi Muratori, Francesco Tovoli and Paolo Muratori

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:35

    Content type: Letter to the Editor

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  6. The Environmental Exposure Unit (EEU), a controlled allergen exposure model of allergic rhinitis (AR), has traditionally utilized seasonal allergens. We sought to clinically validate the use of house dust mite...

    Authors: Lubnaa Hossenbaccus, Sophia Linton, Jenny Thiele, Lisa Steacy, Terry Walker, Crystal Malone and Anne K. Ellis

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:34

    Content type: Research

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  7. Allergic asthma is an inflammatory disease resulting from continued or intermittent allergen exposure, and allergic rhinitis can be trigger of asthma. The main mechanism of these disease is allergic reaction a...

    Authors: Qixue Du, Wei Meng, Seyyed Shamsadin Athari and Renzhong Wang

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:32

    Content type: Research

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  8. Atopic diseases, such as atopic dermatitis (AD) and food allergy (FA), have increased in prevalence in industrialized countries during the past few decades and pose a significant health burden. They appear to ...

    Authors: Alyssa Sweeney, Vanitha Sampath and Kari C. Nadeau

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:30

    Content type: Review

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  9. Safe and effective vaccines provide the first hope for mitigating the devastating health and economic impacts resulting from coronavirus disease 2019 (COVID-19) and related public health orders. Recent case re...

    Authors: Timothy K. Vander Leek, Edmond S. Chan, Lori Connors, Beata Derfalvi, Anne K. Ellis, Julia E. M. Upton and Elissa M. Abrams

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:29

    Content type: Guidelines

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  10. The impact of childhood food allergy on household costs has not been examined in Canada. The current study sought to examine differences in direct, indirect, and intangible costs among Canadian families with a...

    Authors: Michael A. Golding, Elinor Simons, Elissa M. Abrams, Jennifer Gerdts and Jennifer L. P. Protudjer

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:28

    Content type: Research

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  11. There has been research about the prevalence and risk factors of eczema, hay fever, and asthma in children, but little is known about these conditions in adults in China.

    Authors: Xiaoyan Wang, Yan Zhuang, Yanlei Chen, Hongtian Wang and Xueyan Wang

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:27

    Content type: Research

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  12. Increasingly, social media is a source for information about health and disease self-management. We conducted a content analysis of promotional asthma-related posts on Instagram to understand whether promoted ...

    Authors: Brent Heineman, Marcella Jewell, Michael Moran, Kolbi Bradley, Kerry A. Spitzer and Peter K. Lindenauer

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:26

    Content type: Letter to the Editor

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  13. For a century, epinephrine has been the drug of choice for acute treatment of systemic allergic reactions/anaphylaxis. For 40 years, autoinjectors have been used for the treatment of anaphylaxis. Over the last...

    Authors: Sten Dreborg and Harold Kim

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:25

    Content type: Review

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  14. Studies on the association between vitamin D levels and allergen sensitization have reported conflicting results. We aimed to evaluate the association between low vitamin D levels and sensitization to 59 aeroa...

    Authors: Jee Hye Wee, Sung Woo Cho, Jeong-Whun Kim and Chae-Seo Rhee

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:23

    Content type: Research

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  15. Anaphylactic sting reactions need a prompt management. A structured educational intervention for patients with insect sting allergy has not been implemented so far. The purpose of this study was to analyze the...

    Authors: Lisa-Sophie Schoeben, Nicole Mohr, Corinna Bubak, Astrid Schmieder and Marthe-Lisa Schaarschmidt

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:22

    Content type: Research

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  16. Adolescence, as a transition between childhood and adulthood, is a critical stage for the long-term control of atopic diseases. We aim to determine if sleep characteristics are involved in the increased risk o...

    Authors: Yiting Chen, Qian Yang, Kena Zhao, Zengqiang Wu, Xiaoming Shen and Shenghui Li

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:21

    Content type: Research

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  17. Cefaclor, a second-generation oral cephalosporin, is widely prescribed to treat infectious diseases. Immediate hypersensitivity (HS) reactions to cefaclor have continuously been reported and are expected to in...

    Authors: Hyo-In Rhyou, Go-Eun Doo, Jiwon Yoon, Chae-Yeon Ha, Hee-Joo Nam, Sung-Dae Woo, Youngsoo Lee, Young-Hee Nam and Young-Min Ye

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:20

    Content type: Research

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  18. We conducted a systematic review and meta-analysis to determine the effectiveness of comprehensive community-based interventions with ≥ 2 components in improving asthma outcomes in children.

    Authors: Mei Chan, Melinda Gray, Christine Burns, Louisa Owens, Susan Woolfenden, Raghu Lingam, Adam Jaffe and Nusrat Homaira

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:19

    Content type: Review

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  19. Angiotensin Converting Enzyme Inhibitors (ACEI) are a common cause of Emergency Room presentation for angioedema. Although no treatment guidelines exist, C1 esterase inhibitor concentrate (C1-INH) is used on a...

    Authors: Uliana Kovaltchouk, Boyang Zhang, Vipul Jain and Chrystyna Kalicinsky

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:18

    Content type: Letter to the Editor

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  20. Erythema multiforme (EM) is an acute, immune-mediated mucocutaneous disease, most often preceded by herpes simplex virus (HSV) infection or reactivation. Mycoplasma pneumoniae (Mp) is considered the second major ...

    Authors: Sarah M. Volkers, Christian Meisel, Dorothea Terhorst-Molawi, Guido J. Burbach, Dirk Schürmann, Norbert Suttorp and Leif E. Sander

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:17

    Content type: Case Report

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  21. Asthma is one of the most common diseases amongst children. Blood eosinophil count and neutrophil–lymphocyte ratio (NLR) are known as markers for phenotyping asthma. This study was performed to investigate blo...

    Authors: Hossein Esmaeilzadeh, Fatemeh Nouri, Seyed Hesamodin Nabavizadeh, Soheila Alyasin and Negar Mortazavi

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:16

    Content type: Research

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  22. Common variable immunodeficiency is the most prevalent symptomatic primary immunodeficiency in adults. Affected patients fail to mount an appropriate humoral response against community acquired infectious dise...

    Authors: Luciana C. Ribeiro, Bruno Deltreggia Benites, Raisa G. Ulaf, Thyago A. Nunes, Carolina Costa-Lima, Marcelo Addas-Carvalho, José Luiz Proenca-Modena, Fabiana Granja, Vitor Antonio da Costa, Adriana da Silva Santos Duarte, Audrey Basso Zangirolami, Emerson Clayton Amaro, Eli Mansour, Ricardo L. Zollner and Licio A. Velloso

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:14

    Content type: Case Report

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  23. Although the relationship between allergic sensitization and increased respiratory symptoms of chronic obstructive pulmonary disease (COPD) has been suggested, which allergen has a significant effect on COPD p...

    Authors: Hikaru Toyota, Naoya Sugimoto, Konomi Kobayashi, Yuki Suzuki, Yuri Takeshita, Ayaka Ito, Mariko Ujino, Fuminori Tomyo, Hirokazu Sakasegawa, Yuta Koizumi, Michio Kuramochi, Masao Yamaguchi and Hiroyuki Nagase

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:13

    Content type: Research

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  24. Pediatric food allergy is associated with direct, indirect and intangible costs. However, it remains unclear if intangible costs of pediatric food allergy influence parental career choices. Using data from 63 ...

    Authors: Tara Lynn Mary Frykas, Michael Golding, Elissa M. Abrams, Elinor Simons and Jennifer Lisa Penner Protudjer

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:12

    Content type: Letter to the editor

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  25. Because atopic dermatitis does not heal completely, associated severe atopic keratoconjunctivitis (AKC) and vernal keratoconjunctivitis (VKC) often require long-term treatment. This study aims to evaluate the ...

    Authors: Hiroyuki Yazu, Kazumi Fukagawa, Eisuke Shimizu, Yasunori Sato and Hiroshi Fujishima

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:11

    Content type: Research

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  26. Polyvalent Mechanical Bacterial Lysate (PMBL®) contains antigens of bacteria responsible for respiratory infections. PMBL® has been proven to reduce the number of respiratory infections, and in its use, immuno...

    Authors: Małgorzata Bartkowiak-Emeryk, Andrzej Emeryk, Jacek Roliński, Ewelina Wawryk-Gawda and Ewa Markut-Miotła

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:10

    Content type: Research

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  27. X-linked hypohidrotic ectodermal dysplasia (XLHED) is the most common form of ectodermal dysplasia. Clinical and genetic heterogeneity between different ectodermal dysplasia types and evidence of incomplete pe...

    Authors: Bhavi P. Modi, Kate L. Del Bel, Susan Lin, Mehul Sharma, Phillip A. Richmond, Clara D. M. van Karnebeek, Edmond S. Chan, Vishal Avinashi, Wingfield E. Rehmus, Catherine M. Biggs, Wyeth W. Wasserman and Stuart E. Turvey

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:9

    Content type: Letter to the editor

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  28. Severe coronavirus disease-19 (COVID-19) presents with progressive dyspnea, which results from acute lung inflammatory edema leading to hypoxia. As with other infectious diseases that affect the respiratory tr...

    Authors: Natália F. Mendes, Carlos P. Jara, Eli Mansour, Eliana P. Araújo and Licio A. Velloso

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:5

    Content type: Short report

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  29. The pathogenetic mechanisms of neutrophilic asthma are not well understood now. Whether T helper (Th)17-mediated immunity contributes to the pathogenesis of neutrophilic asthma in human is still under investig...

    Authors: Qing Wei, Jing Liao, Min Jiang, Jing Liu, Xiuan Liang and Guangmin Nong

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:4

    Content type: Research

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  30. Mepolizumab and benralizumab are biologics approved for severe eosinophilic asthma. Mepolizumab is an anti-interlukin-5 (IL-5) antibody while benralizumab is an anti-interleukin-5 receptor alpha (IL-5Rα) antib...

    Authors: Arian Ghassemian, Jane Jiyoon Park, Michael W. Tsoulis and Harold Kim

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:3

    Content type: Letter to the editor

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  31. Egg allergy is one of the most common food allergies in children. To date, oral immunotherapy (OIT) has been considered as a promising treatment option for egg allergy. However, safety issues remain concerning...

    Authors: Nagatoshi Sagara, Satoshi Fujita, Ryohei Suzuki, Akiko Aota, Kenichi Akashi and Toshio Katsunuma

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:2

    Content type: Case report

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  32. Beta-lactam allergy is reported in 5–10% of children in North America, but up to 94–97% of patients are deemed not allergic after allergist assessment. The utility of standardized skin testing for penicillin a...

    Authors: Hannah Roberts, Lianne Soller, Karen Ng, Edmond S. Chan, Ashley Roberts, Kristopher Kang, Kyla J. Hildebrand and Tiffany Wong

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:103

    Content type: Letter to the editor

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  33. Penicillins and other β-lactam antibiotics are the most common elicitors of allergic drug reaction. However, data on the pattern of clinical reaction types elicited by specific β-lactams are scarce and inconsi...

    Authors: Philipp Schrüfer, Knut Brockow, Johanna Stoevesandt and Axel Trautmann

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:102

    Content type: Research

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  34. Femtosecond laser corneal refractive surgery is generally considered safe and effective; however, this procedure is rarely associated with severe allergic reactions. We reported a rare case of hypersensitivity...

    Authors: Jiaonan Ma, Lin Zhang, Mengdi Li and Yan Wang

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:101

    Content type: Case report

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  35. Olaparib is a revolutionary treatment for patients with ovarian and breast cancer. Currently, there is no established 1-day drug desensitization protocol for patients with olaparib type-1 hypersensitivity reac...

    Authors: Rongbo Zhu, Stephen Welch and Hannah Roberts

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:100

    Content type: Case report

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  36. Food protein-induced enterocolitis (FPIES), an entity previously thought to only affect children, has been increasingly described in adults. In this study, we report a Canadian cohort of 19 adolescents and adu...

    Authors: Daniel H. Li, Andrew Wong-Pack, Andrea Leilani Macikunas and Harold Kim

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:99

    Content type: Research

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  37. The study aimed to determine the prevalence and risk factors of allergic rhinitis and related comorbidities in school-age children in Budapest, capital of Hungary. Data and epidemiological studies on this dise...

    Authors: Monika Sultész, Alpár Horváth, Dávid Molnár, Gábor Katona, Györgyi Mezei, Andor Hirschberg and Gabriella Gálffy

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:98

    Content type: Research

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  38. This is a retrospective review of the Winnipeg Regional Health Authority’s (WRHA) angioedema patients who were dispensed icatibant in hospital. Icatibant is a bradykinin B2 receptor antagonist indicated for He...

    Authors: George Cai, Colin Barber and Chrystyna Kalicinsky

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:96

    Content type: Research

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  39. The vast majority of individuals labelled as allergic are not deemed truly allergic upon appropriate assessment by an allergist. A label of beta-lactam allergy carries important risks for individual and public...

    Authors: Samira Jeimy, Moshe Ben-Shoshan, Elissa M. Abrams, Anne K. Ellis, Lori Connors and Tiffany Wong

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:95

    Content type: Review

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  40. Asthma has been shown to be related to an increased risk of invasive pneumococcal disease (IPD), although the results remain inconclusive. Therefore, we performed a meta-analysis to determine whether asthma in...

    Authors: Lingling Li, Yusheng Cheng, Xiongwen Tu, Jie Yang, Chenghui Wang, Min Zhang and Zhiwei Lu

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:94

    Content type: Review

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  41. This differential diagnosis of allergic vs non-allergic asthma is typically made on the basis of sensitization to allergens, such that absence of sensitization could result in a patient being managed as having...

    Authors: Dirk Koschel, Claudia Mailänder, Inessa Schwab Sauerbeck and Jens Schreiber

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:92

    Content type: Research

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