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  1. Dupilumab is a receptor antagonist binding to the alpha subunit of the interleukin-4 receptor. Through binding to it, dupilumab inhibits signaling of both IL-4 and IL-13, the representative Th2 biomarkers. Rec...

    Authors: Dong Hyek Jang, Jae In Lee, Joo Yoon Bae, Hye Jung Jung, Mi Yeon Park and Jiyoung Ahn

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:60

    Content type: Case report

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  2. Mycobacterium vaccae nebulization imparted protective effect against allergic asthma in a mouse model. The TGF-β/Smad signal transduction pathway plays an important role in allergic bronchial asthma. However, the...

    Authors: Xiao-hong Jiang, Chao-qian Li, Guang-yi Feng, Ming-jie Luo and Qi-xiang Sun

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:59

    Content type: Research

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  3. The prevalence of allergic rhinitis (AR), an environment- and lifestyle-dependent condition, has been constantly increasing in Korea. Although the environment and lifestyle of the Korean people have recently u...

    Authors: Ji Heui Kim, Shin Ae Kim, Ja Yoon Ku, Won Ki Cho and Chol Ho Shin

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:58

    Content type: Research

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  4. Current recommendations for the management of penicillin allergy are to perform penicillin skin testing (PST) with penicilloyl-polylysine (PPL) and benzylpenicillin (BP) prior to drug challenge with amoxicilli...

    Authors: Roxane Labrosse, Louis Paradis, Kathryn Samaan, Jonathan Lacombe-Barrios, Jean Paradis, Philippe Bégin and Anne Des Roches

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:57

    Content type: Letter to the editor

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  5. Allergic bronchopulmonary aspergillosis (ABPA) is a severe hypersensitivity reaction to aspergillus species colonizing the airways of patients with asthma or cystic fibrosis. Biologics including anti-IgE and a...

    Authors: Carlo Mümmler, Bernd Kemmerich, Jürgen Behr, Nikolaus Kneidinger and Katrin Milger

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:55

    Content type: Case report

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  6. Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency and has a broad spectrum of clinical manifestations. Among non-infectious complications, an increased incidence o...

    Authors: Veronica Pedini, Jacopo Umberto Verga, Irene Terrenato, Denise Menghini, Cristina Mezzanotte and Maria Giovanna Danieli

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:54

    Content type: Research

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  7. The role and importance of skin barrier as an immunologic organ and as a potent way of sensitization is well known. However, antibiotics anaphylaxis following skin sensitization has not been reported.

    Authors: N. Paradis, L. Marois, L. Paradis, F. Graham, P. Bégin and A. Des Roches

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:51

    Content type: Case report

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  8. Neutrophils, eosinophils and inflammatory cells contribute to asthmatic inflammation. The anti-bactericidal/permeability-increasing protein (BPI), produced by neutrophils, peripheral blood monocytes or epithel...

    Authors: Chen Xingyuan and Qiu Chen

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:50

    Content type: Research

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  9. Omalizumab is approved for treating severe allergic asthma from age 6, but the definition of severe asthma including a systematic assessment to rule out difficult-to-treat asthma has changed since the drug was...

    Authors: Daniel P. Henriksen, Uffe Bodtger, Kirsten Sidenius, Niels Maltbaek, Lars Pedersen, Hanne Madsen, Ehm A. Andersson, Ole Norgaard, Louise K. Madsen and Bo L. Chawes

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:49

    Content type: Review

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  10. Omalizumab, mepolizumab, benralizumab, and dupilumab are the currently available biologics used to treat asthma in Japan. Anaphylaxis following treatment with mepolizumab or benralizumab is considered rare.

    Authors: Koichi Jingo, Norihiro Harada, Toshihiko Nishioki, Masahiro Torasawa, Tomoko Yamada, Tetsuhiko Asao, Haruhi Takagi, Tomohito Takeshige, Jun Ito and Kazuhisa Takahashi

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:46

    Content type: Case report

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  11. MP-AzeFlu is relatively new a pharmaceutical drug used in the treatment of allergic rhinitis. It is comprised of azelastine hydrochloride (AZE), a potent histamine-H1-receptor antagonist and fluticasone propio...

    Authors: Sandra Ekstedt, Susanna Kumlien Georén and Lars Olaf Cardell

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:45

    Content type: Letter to the editor

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  12. Several epidemiological studies have examined the possibility of a relationship between season of birth and atopic dermatitis (AD) and food allergy (FA), yet their results are contradictory. We investigated th...

    Authors: Yu Kuwabara, Ritsue Nii, Keiko Tanaka, Eiichi Ishii, Mizuho Nagao and Takao Fujisawa

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:44

    Content type: Research

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  13. Rare tonsillar granulomas may be caused for example by infections, malignancies or sarcoidosis. Granulomas also occur in inborn errors of immunity (IEI) such as common variable immunodeficiency (CVID) with B c...

    Authors: Aleksi Laajala, Outi Kuismin, Mikko Tastula, Leena Tiitto, Saila Kauppila, Anna Salo, Pirjo Åström, Antti Nissinen, Virpi Glumoff, Mikko R. J. Seppänen and Timo Hautala

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:43

    Content type: Case report

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  14. In this letter to the editor, we present results of claims data analysis. This claims data analysis supports a hypothesis that in patients with hereditary angioedema due to C1-esterase inhibitor (C1-INH) defic...

    Authors: Henriette Farkas, Donald Levy, Dylan Supina, Melvin Berger, Subhransu Prusty and Moshe Fridman

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:42

    Content type: Letter to the editor

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  15. Hereditary angioedema (HAE) is caused by a SERPING1 gene defect resulting in decreased (Type I) or dysfunctional (Type II) C1 esterase inhibitor (C1-INH). The prevalence of autoimmune diseases (ADs) in patient...

    Authors: Donald Levy, Timothy Craig, Paul K. Keith, Girishanthy Krishnarajah, Rachel Beckerman and Subhransu Prusty

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:41

    Content type: Research

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  16. Mucus hypersecretion and goblet cell upregulation are common features of chronic rhinosinusitis with nasal polyps (CRSwNP). Although epidermal growth factor (EGF) has been reported to stimulate the expression ...

    Authors: Jian Jiao, Tao Zhang, Yu Zhang, Jingyun Li, Min Wang, Ming Wang, Ying Li, Xiangdong Wang and Luo Zhang

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:40

    Content type: Research

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  17. Allergic rhinitis (AR) is an inflammatory disease of the nasal mucosa impacting up to 25% of Canadians. The standard of care for AR includes a treatment plan that takes into account patient preferences, the se...

    Authors: Lubnaa Hossenbaccus, Sophia Linton, Sarah Garvey and Anne K. Ellis

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:39

    Content type: Review

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  18. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Alexandra Langlois, Marie-Hélène Lavergne, Hélène Leroux, Kerstin Killer, Pauline Azzano, Louis Paradis, Kathryn Samaan, Jonathan Lacombe-Barrios, Thomas Eiwegger, Julia Upton, Gordon Sussman, Thomas Poder, Benoît Mâsse, Anne Des Roches and Philippe Bégin

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:38

    Content type: Correction

    Published on:

    The original article was published in Allergy, Asthma & Clinical Immunology 2020 16:25

  19. Ulcerative colitis (UC) is a chronic, non-specific inflammatory bowel disease (IBD) with unknown etiology. The lack of specific clinical manifestations, standard diagnostic criteria, objective and accurate ind...

    Authors: Yanhua Pang, Huijie Ruan, Dongfang Wu, Yanfei Lang, Ke Sun and Cuiping Xu

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:37

    Content type: Research

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  20. Quercetin is a naturally occurring polyphenol flavonoid which is rich in antioxidants. It has anti-allergic functions that are known for inhibiting histamine production and pro-inflammatory mediators. Querceti...

    Authors: Morteza Jafarinia, Mahnaz Sadat Hosseini, Neda kasiri, Niloofar Fazel, Farshid Fathi, Mazdak Ganjalikhani Hakemi and Nahid Eskandari

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:36

    Content type: Review

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  21. Antibiotics cause dramatic changes to the human microbiome. The composition of the microbiome has been associated with changes in the immune system and these changes are beginning to be linked to immune diseas...

    Authors: Rod A. Herman

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:35

    Content type: Letter to the editor

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  22. Both intravenous and subcutaneous human immune globin G (IgG) replacement (IVIG and SCIG, respectively) reduce severe infection and increase serum IgG levels in primary immune deficiency disorder (PIDD) patien...

    Authors: Graham Walter, Chrystyna Kalicinsky, Richard Warrington, Marianne Miguel, Jeannette Reyes and Tamar S. Rubin

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:34

    Content type: Research

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  23. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Stephen Betschel, Jacquie Badiou, Karen Binkley, Rozita Borici-Mazi, Jacques Hébert, Amin Kanani, Paul Keith, Gina Lacuesta, Susan Waserman, Bill Yang, Emel Aygören-Pürsün, Jonathan Bernstein, Konrad Bork, Teresa Caballero, Marco Cicardi, Timothy Craig…

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:33

    Content type: Correction

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    The original article was published in Allergy, Asthma & Clinical Immunology 2019 15:72

  24. We report a case of IgE-mediated hypersensitivity to lemon seed. We demonstrate for the first time a pattern of cross-sensitisation between seeds of citrus hybrid species from similar ancestral species origins.

    Authors: O. Stephanie Kayode, Nuevalynne Prado, David J. Thursfield, Stephen J. Till and Leonard Q. C. Siew

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:32

    Content type: Case report

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  25. Allergen specific IgG4 levels have been monitored as a surrogate marker for the tolerance inducing effect of subcutaneous immunotherapy (SCIT) in many studies. Its accuracy at group level has been well establi...

    Authors: Dan Weinfeld, Ulla Westin, Laila Hellkvist, Ulf-Henrik Mellqvist, Ingvar Jacobsson and Lars-Olaf Cardell

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:31

    Content type: Research

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  26. Chronic rhinosinusitis (CRS) describes an inflammatory condition affecting the sinonasal mucosa. As the immune system players such as immunoglobulins play prominent roles in the development of CRS, we aimed to...

    Authors: Hossein Aazami, Farhad Seif, Babak Ghalehbaghi, Pegah Babaheidarian, Alireza Mohebbi, Aslan Ahmadi, Majid Khoshmirsafa, Sahand Ghalehbaghi, Babak Behnam, Kobra Zinat Entezami, Zahra Madjd and Reza Falak

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:30

    Content type: Research

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  27. The clinical efficacy of rupatadine in terms of responders has not been previously explored in perennial allergic rhinitis (PAR).

    Authors: Antonio Valero, Iñaki Izquierdo, Marek L. Kowalski, Glenis K. Scadding, Jean Bousquet and Joaquim Mullol

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:29

    Content type: Research

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  28. Mepolizumab (MEP) is the first anti Interleukin (IL)-5 add-on therapy approved for the treatment of severe refractory eosinophilic asthma.

    Authors: C. Caruso, S. Colantuono, D. Pugliese, C. Di Mario, B. Tolusso, E. Gremese, G. Papparella, F. Castrì, A. Gasbarrini, A. Romano and A. Armuzzi

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:27

    Content type: Case report

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  29. A post hoc analysis of two randomized, placebo–controlled, Phase 3 trials of intravenous reslizumab, an anti-interleukin-5 (IL-5) biologic for severe eosinophilic asthma.

    Authors: J. Christian Virchow, Lisa Hickey, Evelyn Du and Margaret Garin

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:26

    Content type: Short report

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  30. Previous proof-of-concept studies have shown that a short course of omalizumab can safely accelerate the oral immunotherapy schedule for multiple allergens simultaneously. Considering the high cost of medicati...

    Authors: Alexandra Langlois, Marie-Hélène Lavergne, Hélène Leroux, Kerstin Killer, Pauline Azzano, Louis Paradis, Kathryn Samaan, Jonathan Lacombe-Barrios, Thomas Eiwegger, Julia Upton, Gordon Sussman, Thomas Poder, Benoît Mâsse, Anne Des Roches and Philippe Bégin

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:25

    Content type: Research

    Published on:

    The Correction to this article has been published in Allergy, Asthma & Clinical Immunology 2020 16:38

  31. This paper presents a peculiar first case of an allergy to Silybum marianum (milk thistle) and Eragrostis tef (teff). Both teff and milk thistle have been presented in the literature (both domestic and foreign...

    Authors: O. Wojas, E. Krzych-Fałta, P. Samel-Kowalik, M. Żalikowska-Gardocka, E. Majsiak, A. Mari and B. Samoliński

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:23

    Content type: Case report

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  32. Activated PI3K delta syndrome (APDS) belongs to the heterogeneous group of primary immunodeficiency disorders (PIDs). Progress in next-generation sequencing (NGS) enabled identification of gain-of-function mut...

    Authors: Marlena Ewertowska, Elżbieta Grześk, Anna Urbańczyk, Anna Dąbrowska, Katarzyna Bąbol-Pokora, Monika Łęcka and Sylwia Kołtan

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:22

    Content type: Case report

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  33. Fatigue, sleep disturbance and altered mood are frequently reported in patients with primary antibody deficiency syndrome (PADS) on adequate immunoglobulin replacement therapy. This study aimed to determine th...

    Authors: Rhea A. Bansal, Susan Tadros and Amolak S. Bansal

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:21

    Content type: Research

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  34. Oral immunotherapy (OIT) is an emerging approach to the treatment of patients with IgE-mediated food allergy and is in the process of transitioning to clinical practice.

    Authors: P. Bégin, E. S. Chan, H. Kim, M. Wagner, M. S. Cellier, C. Favron-Godbout, E. M. Abrams, M. Ben-Shoshan, S. B. Cameron, S. Carr, D. Fischer, A. Haynes, S. Kapur, M. N. Primeau, J. Upton, T. K. Vander Leek…

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:20

    Content type: Review

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  35. Biomarkers of clinical efficacy for subcutaneous immunotherapy (SCIT) on allergic rhinitis (AR) have not been identified yet. This study aims to assess the clinical relevance of serum inhibitory activity for I...

    Authors: Wenping Wang, Jinshu Yin, Xueyan Wang, Tingting Ma, Tianfei Lan, Qingkun Song and Yifan Guo

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:18

    Content type: Research

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  36. Food allergy is a growing global health concern, with limited studies conducted in developing countries. High-risk behavior regarding allergies is common among young adults, making them prone to severe allergi...

    Authors: Ali Hassan, Amna Alsaihati, Malak Al Shammari, Haitham Alaithan, Wejdan Al-Johani, Nouf AlShamlan and Salman Aljubran

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:17

    Content type: Research

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  37. The problem of nonadherence to therapy is a key reason of insufficient asthma control. Evaluating the beliefs about asthma medication, cognitive and emotional perceptions may help to identify patients with poo...

    Authors: Dins Smits, Girts Brigis, Jana Pavare, Inga Urtane, Sandis Kovalovs and Noël Christopher Barengo

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:16

    Content type: Research

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  38. The Allergy Patient Identification for Immunotherapy (AsPIRe) program was a parallel physician and patient survey. The objectives were to examine physician and patient perceptions of seasonal allergy symptoms ...

    Authors: Anne K. Ellis, Jean Boursiquot, Stuart Carr, François Graham and Marie-Soleil Masse

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:15

    Content type: Research

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  39. Direct inhalation challenges (e.g. methacholine) are stated to be more sensitive and less specific for a diagnosis of asthma than are indirect challenges (e.g. exercise, non-isotonic aerosols, mannitol, etc.)....

    Authors: Donald W. Cockcroft, Beth E. Davis and Christianne M. Blais

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:14

    Content type: Review

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  40. Allergic rhinitis (AR) is believed to be a complex genetic disease. The last decade has been marked by the publication of more than 20 genome-wide association studies (GWASs) of AR and associated allergic phen...

    Authors: Yunbo Gao, Jingyun Li, Yuan Zhang and Luo Zhang

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:13

    Content type: Research

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  41. The first and corresponding author was unfortunately presented as Mercedes Rodriguez Romano. The correct author name is Mercedes Romano.

    Authors: Mercedes Romano, Stephanie James, Emily Farrington, Richard Perry and Lisa Elliott

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:12

    Content type: Correction

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    The original article was published in Allergy, Asthma & Clinical Immunology 2019 15:81

  42. Women with hereditary angioedema due to C1-inhibitor deficiency (HAE-C1INH) experience more frequent and severe angioedema attacks compared with men. Fluctuations in female sex hormones can influence HAE attac...

    Authors: Donald S. Levy, Henriette Farkas, Marc A. Riedl, Florence Ida Hsu, Joel P. Brooks, Marco Cicardi, Henrike Feuersenger, Ingo Pragst and Avner Reshef

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:8

    Content type: Research

    Published on:

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