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  1. Eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP) exhibits a poorer outcome compared with non-eosinophilic chronic rhinosinusitis with nasal polyps (nonECRSwNP), so it is significant to identify ...

    Authors: Zhuoping Liang, Bing Yan, Chang Liu, Ruyu Tan, Chengshuo Wang and Luo Zhang

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:82

    Content type: Research

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  2. Omalizumab is an efficient drug for patients with uncontrolled severe allergic asthma (SAA). However, little is known about the differences in omalizumab treatment outcomes among patients with different types ...

    Authors: Petr Vaník, Jakub Novosad, Olga Kirchnerová, Irena Krčmová and Milan Teřl

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:81

    Content type: Research

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  3. Primary immunodeficiencies (PID) constitute a heterogeneous group of more than 350 monogenetic diseases. PID patients with antibody impairment require lifelong administration of immunoglobulin G replacement th...

    Authors: Viviana Moschese, Clementina Canessa, Antonino Trizzino, Baldassarre Martire, Giorgio Maria Boggia and Simona Graziani

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:80

    Content type: Short report

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  4. Penicillin allergy is frequently reported in adults and children. Recent studies suggest that microbiota plays a key role in the development and progression of allergy. In this study, the relationship between ...

    Authors: Xiaohua Li, Jun Luo, Chuan Nie, Qingxia Li, Xiaofeng Sun, Hongping Li and Yong Zhang

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:79

    Content type: Research

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  5. Allergic bronchopulmonary aspergillosis (ABPA) reflects hypersensitivity and an exaggerated immune response to Aspergillus fumigatus. ABPA typically occurs in individuals with airway diseases such as asthma or cy...

    Authors: Kevin S. K. Lau, Chantane Yeung and Chris Carlsten

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:78

    Content type: Research

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  6. Interferon-stimulated gene 15 (ISG15) was the first ubiquitin-like modifier protein identified that acts by protein conjugation (ISGylation) and is thought to modulate IFN-induced inflammation. Here, we report a ...

    Authors: Guadalupe Buda, Rita María Valdez, German Biagioli, Federico A. Olivieri, Nicolás Affranchino, Carolina Bouso, Vanesa Lotersztein, Dusan Bogunovic, Jacinta Bustamante and Marcelo A. Martí

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:77

    Content type: Letter to the editor

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  7. “Immune boosting” is a trending topic during the COVID-19 pandemic. The concept of “immune boosting” is scientifically misleading and often used to market unproven products and therapies. This paper presents a...

    Authors: Darren N. Wagner, Alessandro R. Marcon and Timothy Caulfield

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:76

    Content type: Letter to the editor

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  8. Asthma is a common chronic disease characterized by episodic or persistent respiratory symptoms and airflow limitation. Asthma treatment is based on a stepwise and control-based approach that involves an itera...

    Authors: Alberto Papi, Francesco Blasi, Giorgio Walter Canonica, Luca Morandi, Luca Richeldi and Andrea Rossi

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:75

    Content type: Review

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  9. Despite the clinical importance of pollen allergens among Filipinos, few studies delve into the sensitization profiles of Filipinos against pollen allergens. This study determined the sensitization profile of ...

    Authors: Maureen Sabit, Cecil Wong, Agnes Andaya and John Donnie Ramos

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:74

    Content type: Research

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  10. Work-related asthma (WRA) accounts for up to 25% of all adults with asthma. Early diagnosis is key for optimal management as delays in diagnosis are associated with worse outcomes. However, WRA is significantl...

    Authors: Madison MacKinnon, Teresa To, Clare Ramsey, Catherine Lemière and M. Diane Lougheed

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:73

    Content type: Review

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  11. Non-communicable diseases, such as allergies, are influenced by both genetic and epigenetic factors. Perinatal determinants conceivably modify the epigenetic makeup of the developing fetal immune system preven...

    Authors: Samuel Schäfer, Anthony Liu, Dianne Campbell and Ralph Nanan

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:71

    Content type: Research

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  12. We present a case of the patient, who developed hypersensitivity reaction during the treatment of chronic lymphocytic leukemia. Bendamustine was suspected as a culprit agent. The patient as well as 3 controls ...

    Authors: Laura Malinauskiene, Kestutis Cerniauskas, Kotryna Linauskiene, Linas Griguola, Anzelika Chomiciene and Audra Blaziene

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:70

    Content type: Letter to the editor

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  13. Substantial experimental studies suggest a role for helminthes infections in the pathogenesis of allergies, but epidemiologic data have been inconsistent. Unlike to asthma, the association between helminthes i...

    Authors: Iraj Mohammadzadeh, Sorena Darvish, Seyed Mohammad Riahi, Solmaz Alizadeh Moghaddam, Mohammad Pournasrollah, Mousa Mohammadnia-Afrozi and Ali Rostami

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:69

    Content type: Research

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  14. Adherence to asthma treatment among children is usually poor. We sought to explore whether electronic adherence monitoring combined with weekly feedback regarding adherence along with a reminder to use inhaled...

    Authors: Jiande Chen, Juan Xu, Liebin Zhao, Jing Zhang, Yong Yin and Fen Zhang

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:68

    Content type: Research

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  15. Human microbiota plays a fundamental role in modulating the immune response. Western environment and lifestyle are envisaged to alter the human microbiota with a new microbiome profile established in Chinese i...

    Authors: Jing Guo, Xiaoping Zhang, Aarti Saiganesh, Christopher Peacock, Shu Chen, Gary A. Dykes, Belinda J. Hales, Peter N. Le Souëf and Guicheng Zhang

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:67

    Content type: Research

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  16. Asthma is a disease characterised by hyper responsiveness and bronchoconstriction of airways, and is a major health burden globally. A dysfunction of the oxidant-antioxidant balance, termed oxidative stress, h...

    Authors: Yenuli Fernando, Pujitha Wickramasinghe, Udani De Silva, Malintha Alahakoon, K. W. D. A. Anuradha and Shiroma Handunnetti

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:66

    Content type: Research

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  17. Loss-of-function (LOF) mutations in signal transducer and activator of transcription 3 (STAT3) is one of the causes of STAT3 hyperimmunoglobulin E (IgE) syndrome (STAT3-HIES), while gain-of-function (GOF) muta...

    Authors: Li Lin, Ying Wang, Bijun Sun, Luyao Liu, Wenjing Ying, Wenjie Wang, Qinhua Zhou, Jia Hou, Haili Yao, Liyuan Hu, Jinqiao Sun and Xiaochuan Wang

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:65

    Content type: Research

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  18. Peanut allergy affects 3% of Australian children and has a higher risk of anaphylaxis than most food allergies. Predicting who is likely to develop anaphylaxis is still an inexact science. The fraction of exha...

    Authors: Elizabeth Percival, Rani Bhatia, Kahn Preece, Mark McEvoy, Adam Collison and Joerg Mattes

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:64

    Content type: Research

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  19. Although the diagnosis and management of chronic spontaneous urticaria (CSU) is well documented in the literature, some aspects of the disease remain unclear. We aimed to further describe the natural history, ...

    Authors: Peter Stepaniuk, Manstein Kan and Amin Kanani

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:63

    Content type: Research

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  20. Vitamin D deficiency or insufficiency, has been associated with atopy and lack of asthma control. Our objective was to investigate associations between variants in genes of vitamin D pathway with serum levels ...

    Authors: Alana Alcântara Galvão, Flávia de Araújo Sena, Emília Maria Medeiros de Andrade Belitardo, Maria Borges Rabelo de Santana, Gustavo Nunes de Oliveira Costa, Álvaro Augusto Cruz, Maurício Lima Barreto, Ryan dos Santos Costa, Neuza Maria Alcantara-Neves and Camila Alexandrina Figueiredo

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:62

    Content type: Research

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  21. The differentiation of CD4+ lymphocytes Th17/regulatory T cells (Treg) and indoleamine 2,3-dioxygenase (IDO) is associated with the pathogenesis of allergic asthma. Basic research has shown that IDO is likely ...

    Authors: Ying Hu, Zhiqiang Chen, Jing Zeng, Shouyan Zheng, Liujuan Sun, Li Zhu and Wei Liao

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:61

    Content type: Research

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  22. Dupilumab is a receptor antagonist binding to the alpha subunit of the interleukin-4 receptor. Through binding to it, dupilumab inhibits signaling of both IL-4 and IL-13, the representative Th2 biomarkers. Rec...

    Authors: Dong Hyek Jang, Jae In Lee, Joo Yoon Bae, Hye Jung Jung, Mi Yeon Park and Jiyoung Ahn

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:60

    Content type: Case report

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  23. Mycobacterium vaccae nebulization imparted protective effect against allergic asthma in a mouse model. The TGF-β/Smad signal transduction pathway plays an important role in allergic bronchial asthma. However, the...

    Authors: Xiao-hong Jiang, Chao-qian Li, Guang-yi Feng, Ming-jie Luo and Qi-xiang Sun

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:59

    Content type: Research

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  24. The prevalence of allergic rhinitis (AR), an environment- and lifestyle-dependent condition, has been constantly increasing in Korea. Although the environment and lifestyle of the Korean people have recently u...

    Authors: Ji Heui Kim, Shin Ae Kim, Ja Yoon Ku, Won Ki Cho and Chol Ho Shin

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:58

    Content type: Research

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  25. Current recommendations for the management of penicillin allergy are to perform penicillin skin testing (PST) with penicilloyl-polylysine (PPL) and benzylpenicillin (BP) prior to drug challenge with amoxicilli...

    Authors: Roxane Labrosse, Louis Paradis, Kathryn Samaan, Jonathan Lacombe-Barrios, Jean Paradis, Philippe Bégin and Anne Des Roches

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:57

    Content type: Letter to the editor

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  26. Allergic bronchopulmonary aspergillosis (ABPA) is a severe hypersensitivity reaction to aspergillus species colonizing the airways of patients with asthma or cystic fibrosis. Biologics including anti-IgE and a...

    Authors: Carlo Mümmler, Bernd Kemmerich, Jürgen Behr, Nikolaus Kneidinger and Katrin Milger

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:55

    Content type: Case report

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  27. Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency and has a broad spectrum of clinical manifestations. Among non-infectious complications, an increased incidence o...

    Authors: Veronica Pedini, Jacopo Umberto Verga, Irene Terrenato, Denise Menghini, Cristina Mezzanotte and Maria Giovanna Danieli

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:54

    Content type: Research

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  28. The role and importance of skin barrier as an immunologic organ and as a potent way of sensitization is well known. However, antibiotics anaphylaxis following skin sensitization has not been reported.

    Authors: N. Paradis, L. Marois, L. Paradis, F. Graham, P. Bégin and A. Des Roches

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:51

    Content type: Case report

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  29. Neutrophils, eosinophils and inflammatory cells contribute to asthmatic inflammation. The anti-bactericidal/permeability-increasing protein (BPI), produced by neutrophils, peripheral blood monocytes or epithel...

    Authors: Chen Xingyuan and Qiu Chen

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:50

    Content type: Research

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  30. Omalizumab is approved for treating severe allergic asthma from age 6, but the definition of severe asthma including a systematic assessment to rule out difficult-to-treat asthma has changed since the drug was...

    Authors: Daniel P. Henriksen, Uffe Bodtger, Kirsten Sidenius, Niels Maltbaek, Lars Pedersen, Hanne Madsen, Ehm A. Andersson, Ole Norgaard, Louise K. Madsen and Bo L. Chawes

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:49

    Content type: Review

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  31. Omalizumab, mepolizumab, benralizumab, and dupilumab are the currently available biologics used to treat asthma in Japan. Anaphylaxis following treatment with mepolizumab or benralizumab is considered rare.

    Authors: Koichi Jingo, Norihiro Harada, Toshihiko Nishioki, Masahiro Torasawa, Tomoko Yamada, Tetsuhiko Asao, Haruhi Takagi, Tomohito Takeshige, Jun Ito and Kazuhisa Takahashi

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:46

    Content type: Case report

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  32. MP-AzeFlu is relatively new a pharmaceutical drug used in the treatment of allergic rhinitis. It is comprised of azelastine hydrochloride (AZE), a potent histamine-H1-receptor antagonist and fluticasone propio...

    Authors: Sandra Ekstedt, Susanna Kumlien Georén and Lars Olaf Cardell

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:45

    Content type: Letter to the editor

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  33. Several epidemiological studies have examined the possibility of a relationship between season of birth and atopic dermatitis (AD) and food allergy (FA), yet their results are contradictory. We investigated th...

    Authors: Yu Kuwabara, Ritsue Nii, Keiko Tanaka, Eiichi Ishii, Mizuho Nagao and Takao Fujisawa

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:44

    Content type: Research

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  34. Rare tonsillar granulomas may be caused for example by infections, malignancies or sarcoidosis. Granulomas also occur in inborn errors of immunity (IEI) such as common variable immunodeficiency (CVID) with B c...

    Authors: Aleksi Laajala, Outi Kuismin, Mikko Tastula, Leena Tiitto, Saila Kauppila, Anna Salo, Pirjo Åström, Antti Nissinen, Virpi Glumoff, Mikko R. J. Seppänen and Timo Hautala

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:43

    Content type: Case report

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  35. In this letter to the editor, we present results of claims data analysis. This claims data analysis supports a hypothesis that in patients with hereditary angioedema due to C1-esterase inhibitor (C1-INH) defic...

    Authors: Henriette Farkas, Donald Levy, Dylan Supina, Melvin Berger, Subhransu Prusty and Moshe Fridman

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:42

    Content type: Letter to the editor

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  36. Hereditary angioedema (HAE) is caused by a SERPING1 gene defect resulting in decreased (Type I) or dysfunctional (Type II) C1 esterase inhibitor (C1-INH). The prevalence of autoimmune diseases (ADs) in patient...

    Authors: Donald Levy, Timothy Craig, Paul K. Keith, Girishanthy Krishnarajah, Rachel Beckerman and Subhransu Prusty

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:41

    Content type: Research

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  37. Mucus hypersecretion and goblet cell upregulation are common features of chronic rhinosinusitis with nasal polyps (CRSwNP). Although epidermal growth factor (EGF) has been reported to stimulate the expression ...

    Authors: Jian Jiao, Tao Zhang, Yu Zhang, Jingyun Li, Min Wang, Ming Wang, Ying Li, Xiangdong Wang and Luo Zhang

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:40

    Content type: Research

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  38. Allergic rhinitis (AR) is an inflammatory disease of the nasal mucosa impacting up to 25% of Canadians. The standard of care for AR includes a treatment plan that takes into account patient preferences, the se...

    Authors: Lubnaa Hossenbaccus, Sophia Linton, Sarah Garvey and Anne K. Ellis

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:39

    Content type: Review

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  39. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Alexandra Langlois, Marie-Hélène Lavergne, Hélène Leroux, Kerstin Killer, Pauline Azzano, Louis Paradis, Kathryn Samaan, Jonathan Lacombe-Barrios, Thomas Eiwegger, Julia Upton, Gordon Sussman, Thomas Poder, Benoît Mâsse, Anne Des Roches and Philippe Bégin

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:38

    Content type: Correction

    Published on:

    The original article was published in Allergy, Asthma & Clinical Immunology 2020 16:25

  40. Ulcerative colitis (UC) is a chronic, non-specific inflammatory bowel disease (IBD) with unknown etiology. The lack of specific clinical manifestations, standard diagnostic criteria, objective and accurate ind...

    Authors: Yanhua Pang, Huijie Ruan, Dongfang Wu, Yanfei Lang, Ke Sun and Cuiping Xu

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:37

    Content type: Research

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  41. Quercetin is a naturally occurring polyphenol flavonoid which is rich in antioxidants. It has anti-allergic functions that are known for inhibiting histamine production and pro-inflammatory mediators. Querceti...

    Authors: Morteza Jafarinia, Mahnaz Sadat Hosseini, Neda kasiri, Niloofar Fazel, Farshid Fathi, Mazdak Ganjalikhani Hakemi and Nahid Eskandari

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:36

    Content type: Review

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  42. Antibiotics cause dramatic changes to the human microbiome. The composition of the microbiome has been associated with changes in the immune system and these changes are beginning to be linked to immune diseas...

    Authors: Rod A. Herman

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:35

    Content type: Letter to the editor

    Published on:

  43. Both intravenous and subcutaneous human immune globin G (IgG) replacement (IVIG and SCIG, respectively) reduce severe infection and increase serum IgG levels in primary immune deficiency disorder (PIDD) patien...

    Authors: Graham Walter, Chrystyna Kalicinsky, Richard Warrington, Marianne Miguel, Jeannette Reyes and Tamar S. Rubin

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:34

    Content type: Research

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  44. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Stephen Betschel, Jacquie Badiou, Karen Binkley, Rozita Borici-Mazi, Jacques Hébert, Amin Kanani, Paul Keith, Gina Lacuesta, Susan Waserman, Bill Yang, Emel Aygören-Pürsün, Jonathan Bernstein, Konrad Bork, Teresa Caballero, Marco Cicardi, Timothy Craig…

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:33

    Content type: Correction

    Published on:

    The original article was published in Allergy, Asthma & Clinical Immunology 2019 15:72

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