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  1. Content type: Research

    MP-AzeFlu, intranasal formulation of azelastine hydrochloride (AZE) and fluticasone propionate (FP), is superior to AZE or FP alone for treatment of allergic rhinitis (AR). However, the precise anti-inflammato...

    Authors: Jordi Roca-Ferrer, Laura Pujols, Maria Pérez-González, Isam Alobid, Borja Callejas, Sònia Vicens-Artés, Mireya Fuentes, Antonio Valero, César Picado, Dennis Castor, DucTung Nguyen and Joaquim Mullol

    Citation: Allergy, Asthma & Clinical Immunology 2018 14:86

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  2. Content type: Research

    Periostin has been shown to be a marker of Type 2 airway inflammation, associated with airway eosinophilia. It has a potential role in identifying asthmatics who may be responsive to treatment with monoclonal ...

    Authors: Evan Tan, Rachel Varughese, Ruth Semprini, Barney Montgomery, Cecile Holweg, Julie Olsson, Rachel Caswell-Smith, James Fingleton, Mark Weatherall, Richard Beasley and Irene Braithwaite

    Citation: Allergy, Asthma & Clinical Immunology 2018 14:87

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  3. Content type: Research

    Exposure to agrochemicals is one of the many aetiological agents, postulated to cause allergic diseases. In this study, we have compared the prevalence of allergic diseases among preschool children growing in ...

    Authors: Sanath Thushara Kudagammana and Keerthi Mohotti

    Citation: Allergy, Asthma & Clinical Immunology 2018 14:84

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  4. Content type: Short report

    Based on immunologic phenotypes underlying asthma, use of monoclonal antibody based therapies is becoming the new standard of care for severe, corticosteroid refractory clinical symptoms. Patients may qualify ...

    Authors: Samira Jeimy, Michael William Tsoulis, Julie Hachey and Harold Kim

    Citation: Allergy, Asthma & Clinical Immunology 2018 14:68

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  5. Content type: Research

    Hereditary angioedema due to C1 inhibitor deficiency (C1-INH-HAE) is an autosomal dominant disease resulting in random and unpredictable attacks of swelling. The swelling in C1-INH-HAE is a result of impaired ...

    Authors: Xavier Charest-Morin, Stephen Betschel, Rozita Borici-Mazi, Amin Kanani, Gina Lacuesta, Georges-Étienne Rivard, Eric Wagner, Susan Wasserman, Bill Yang and Christian Drouet

    Citation: Allergy, Asthma & Clinical Immunology 2018 14:83

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  6. Content type: Research

    Most epidemiologic studies reporting prevalence of allergic rhinitis (AR) and nonallergic rhinitis (NAR) have assessed solely self-reported prevalence, without confirmation by objective measures. Furthermore, ...

    Authors: Yanran Huang, Yuan Zhang and Luo Zhang

    Citation: Allergy, Asthma & Clinical Immunology 2018 14:77

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  7. Content type: Research

    The SNAPSHOT program provides current data on the allergic rhinitis burden in the adult general population of five Middle Eastern countries (Egypt, Turkey, Kuwait, Saudi Arabia and the United Arab Emirates, th...

    Authors: Ahmed Al-Digheari, Bassam Mahboub, Hesham Tarraf, Taskin Yucel, Isabella Annesi-Maesano, Adam Doble, Aaicha Lahlou, Luqman Tariq, Fayaz Aziz and Abdelkader El Hasnaoui

    Citation: Allergy, Asthma & Clinical Immunology 2018 14:63

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  8. Content type: Research

    Extracellular matrix proteins tenascin-C (TNC) and periostin, which were identified as T-helper cell type 2 cytokine-induced genes in human bronchial epithelial cells, accumulate in the airway basement membran...

    Authors: Mina Yasuda, Norihiro Harada, Sonoko Harada, Ayako Ishimori, Yoko Katsura, Yukinari Itoigawa, Kei Matsuno, Fumihiko Makino, Jun Ito, Junya Ono, Kazunori Tobino, Hisaya Akiba, Ryo Atsuta, Kenji Izuhara and Kazuhisa Takahashi

    Citation: Allergy, Asthma & Clinical Immunology 2018 14:72

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  9. Content type: Research

    Chorioamnionitis is a risk factor for future asthma development. Animal models of chorioamnionitis demonstrate increased TH17-to-Treg ratios associated with proinflammatory cytokine elevations. The association of...

    Authors: Anne Marie Singh, Michael G. Sherenian, Kwang-Youn Kim, Kristin A. Erickson, Amy Yang, Karen Mestan, Linda M. Ernst and Rajesh Kumar

    Citation: Allergy, Asthma & Clinical Immunology 2018 14:66

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  10. Content type: Research

    Specific subcutaneous immunotherapy (SCIT) can achieve long-term remission in patients with allergic rhinitis (AR) through complex and still unknown mechanisms. The aim of this study is to evaluate the effect ...

    Authors: Letícia Sousa, Carmen Martín-Sierra, Celso Pereira, Graça Loureiro, Beatriz Tavares, Susana Pedreiro, António Martinho and Artur Paiva

    Citation: Allergy, Asthma & Clinical Immunology 2018 14:45

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  11. Content type: Research

    Upper airway inflammatory diseases are associated with abnormal expression of nasal epithelial forkhead-box J1 (FOXJ1) which regulates motile cilia formation. We sought to investigate whether aberrant FOXJ1 lo...

    Authors: Yang Peng, Wei-jie Guan, Kai Sen Tan, Zhenchao Zhu, Zhuo Chen, Haiyu Hong, Zhaoni Wang, Tengfei Tian, Xiaoxue Zi, Yew Kwang Ong, Mark Thong, Li Shi, Qintai Yang, Qianhui Qiu and De-Yun Wang

    Citation: Allergy, Asthma & Clinical Immunology 2018 14:71

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  12. Content type: Case report

    X-linked lymphoproliferative disease type 1 (XLP1) is a rare primary immune deficiency, which is caused by SH2D1A gene mutations. XLP1 is commonly associated with Epstein–Barr virus (EBV)-associated hemophagocyti...

    Authors: Akihiro Tamura, Suguru Uemura, Nobuyuki Yamamoto, Atsuro Saito, Aiko Kozaki, Kenji Kishimoto, Toshiaki Ishida, Daiichiro Hasegawa, Haruka Hiroki, Tsubasa Okano, Kohsuke Imai, Tomohiro Morio, Hirokazu Kanegane and Yoshiyuki Kosaka

    Citation: Allergy, Asthma & Clinical Immunology 2018 14:82

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  13. Content type: Research

    Sensitization to ash pollen is underestimated in various regions. The prevalence in Germany is about 10%. However, allergy to ash pollen is widely overlooked by allergists, since the pollination period of ash ...

    Authors: Katharina Eder, Donata Gellrich, Catalina Meßmer, Martin Canis and Moritz Gröger

    Citation: Allergy, Asthma & Clinical Immunology 2018 14:76

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  14. Content type: Case report

    Sweet syndrome is a rare skin condition characterised by fever, neutrophilia, and tender erythematous skin lesions and has been reported to occur in association with anti-neutrophil cytoplasmic antibodies (ANC...

    Authors: A. U. Arun Kumar, Mohamed E. Elsayed, Ahmed Alghali, Alaa A. Ali, Husham Mohamed, Wael Hussein, Catriona Hackett, Niamh Leonard and Austin G. Stack

    Citation: Allergy, Asthma & Clinical Immunology 2018 14:46

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  15. Content type: Research

    The aetiology of anaphylaxis differs according to types of foods consumed, fauna and foliage and cultural practices. Although the aetiology of anaphylaxis in Western countries are well known, the causes in Sou...

    Authors: Nilhan Rajiva de Silva, W. M. D. K. Dasanayake, Chandima Karunatilake, Geethani Devika Wickramasingha, B. D. De Silva and Gathsauri Neelika Malavige

    Citation: Allergy, Asthma & Clinical Immunology 2018 14:81

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  16. Content type: Review

    Aluminium salts are by far the most commonly used adjuvants in vaccines. There are only two aluminium salts which are used in clinically-approved vaccines, Alhydrogel® and AdjuPhos®, while the novel aluminium adj...

    Authors: Emma Shardlow, Matthew Mold and Christopher Exley

    Citation: Allergy, Asthma & Clinical Immunology 2018 14:80

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  17. Content type: Case report

    Oral vancomycin is a first-line treatment for severe Clostridium difficile colitis. Oral vancomycin is perceived to lack systemic absorption or systemic adverse effects; however, a few cases of hypersensitivity t...

    Authors: Jeremy Barron, Adolfo Lattes and Esther-Lee Marcus

    Citation: Allergy, Asthma & Clinical Immunology 2018 14:73

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  18. Content type: Case report

    Ginseng is a perennial herb used in traditional Chinese medicine, which has become increasingly popular world-wide due to its proposed medicinal effects. There are two major species of ginseng, Panax ginseng (Kor...

    Authors: Stephanie C. Erdle, Edmond S. Chan, Hyungjun Yang, Bruce A. Vallance, Christopher Mill and Tiffany Wong

    Citation: Allergy, Asthma & Clinical Immunology 2018 14:79

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  19. Content type: Case report

    Hyper IgE recurrent infection syndrome (HIES) is a rare immune deficiency, characterized by recurrent staphylococcal skin and lung abscesses, pneumonia and increased IgE levels. The majority of autosomal domin...

    Authors: Rajiva de Silva, Dhanushka Dasanayake, Manouri Senanayake, Ramya Ediriweera, Savithri Dias, Chandima Karunatilleke, Karen Brocas, Fariba Tahami and Suranjith Seneviratne

    Citation: Allergy, Asthma & Clinical Immunology 2018 14:70

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  20. Content type: Research

    Accumulating evidence suggests that the gut microbiota shapes developmental processes within the immune system. Early life antibiotic use is one factor which may contribute to immune dysfunction and the recent...

    Authors: Rozlyn C. T. Boutin, Zach Dwyer, Kyle Farmer, Chris Rudyk, Mark R. Forbes and Shawn Hayley

    Citation: Allergy, Asthma & Clinical Immunology 2018 14:42

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  21. Content type: Case report

    An allergy to mango is extremely rare. The antigenic composition of the fruit is not fully known. Profilin from mango has a structure similar to birch tree profiling: it is responsible for cross-reactions betw...

    Authors: Natalia Ukleja-Sokołowska, Ewa Gawrońska-Ukleja, Kinga Lis, Magdalena Żbikowska-Gotz, Łukasz Sokołowski and Zbigniew Bartuzi

    Citation: Allergy, Asthma & Clinical Immunology 2018 14:78

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  22. Content type: Case report

    Lupine is a member of the legume family and is often used in many food products in Europe (e.g. pasta, pizza, sauces, etc.) as a wheat or soy substitute. Lupine cross-reacts with peanut, and cases of allergic ...

    Authors: Lianne Soller, Sebastien La Vieille and Edmond S. Chan

    Citation: Allergy, Asthma & Clinical Immunology 2018 14:64

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  23. Content type: Case report

    Bronchial thermoplasty (BT) is a bronchoscopic treatment that can ameliorate the symptoms of severe asthma. However, little is known about the mechanism by which BT improves exertional dyspnea without signific...

    Authors: Keisuke Miki, Mari Miki, Kenji Yoshimura, Kazuyuki Tsujino, Hiroyuki Kagawa, Yohei Oshitani, Yuko Ohara, Yuki Hosono, Ryuya Edahiro, Hiroyuki Kurebe and Seigo Kitada

    Citation: Allergy, Asthma & Clinical Immunology 2018 14:74

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  24. Content type: Case report

    Hereditary angioedema due to C1 inhibitor deficiency (C1-INH-HAE) is a rare autosomal dominant disease characterized by episodes of acute subcutaneous swelling, and/or recurrent severe abdominal pain. The dise...

    Authors: Anna Valerieva, Marco Cicardi, James Baraniuk and Maria Staevska

    Citation: Allergy, Asthma & Clinical Immunology 2018 14:75

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  25. Content type: Case report

    Angioedema due to acquired deficiency of C1-inhibitor (C1-INH-AAE) is a rare disease sharing some clinical and laboratory similarities with hereditary angioedema, but with late onset and no positive family his...

    Authors: Polliana Mihaela Leru, Vlad Florin Anton and Horia Bumbea

    Citation: Allergy, Asthma & Clinical Immunology 2018 14:69

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  26. Content type: Research

    Hereditary angioedema (HAE) due to C1 esterase inhibitor (C1-INH) deficiency is characterized by recurrent swelling attacks that can be life-threatening if left untreated. Prompt treatment is vital during acut...

    Authors: John Dempster

    Citation: Allergy, Asthma & Clinical Immunology 2018 14:44

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  27. Content type: Review

    There is ongoing controversy surrounding the appropriate standards and limits of accommodation of children with food allergies in schools. We identify and explain how relevant Canadian common law, legislation,...

    Authors: Blake Murdoch, Eric M. Adams and Timothy Caulfield

    Citation: Allergy, Asthma & Clinical Immunology 2018 14:67

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  28. Content type: Case report

    Daclizumab is a humanized monoclonal antibody that blocks CD25, the high affinity alpha subunit of the interleukin-2 receptor. Daclizumab therapy targets T regulatory cell and activated effector T cell prolife...

    Authors: Leisa Rebecca Watson, Charlotte A. Slade, Samar Ojaimi, Sara Barnes, Pasquale Fedele, Prudence Smith, Justine Marum, Sebastian Lunke, Zornitza Stark, Matthew F. Hunter, Vanessa L. Bryant and Michael Sze Yuan Low

    Citation: Allergy, Asthma & Clinical Immunology 2018 14:65

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  29. Content type: Research

    Allergen-specific immunotherapy (ASIT) has the potential to modify allergic diseases, and it is also considered a potential therapy for allergic asthma. House dust mite (HDM) allergens, a common source of airb...

    Authors: Yao-Tung Wang, Hsu-Chung Liu, Hui-Chen Chen, Yen-Ching Lee, Tung-Chou Tsai, Hsiao-Ling Chen, Hueng-Chuen Fan and Chuan-Mu Chen

    Citation: Allergy, Asthma & Clinical Immunology 2018 14:43

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  30. Content type: Correction

    Upon publication of the original article [1], the authors reported the following funding information was omitted: Publication supported by Wroclaw Centre of Biotechnology, programme The Leading National Resear...

    Authors: Przemyslaw Zdziarski, Andrzej Gamian, Jacek Majda and Agnieszka Korzeniowska‑Kowal

    Citation: Allergy, Asthma & Clinical Immunology 2018 14:62

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    The original article was published in Allergy, Asthma & Clinical Immunology 2017 13:41

  31. Content type: Research

    Asthma exacerbations are associated with the recruitment of neutrophils to the lungs. These cells release proteases and mediators, many of which act at G protein-coupled receptors (GPCRs) that couple via Gq to...

    Authors: Tresa George, Mainak Chakraborty, Mark A. Giembycz and Robert Newton

    Citation: Allergy, Asthma & Clinical Immunology 2018 14:40

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  32. Content type: Research

    Allergic rhinitis affects around one quarter of the Western European population. Prophylactic allergen immunotherapy may be useful to reduce the risk of acute symptomatic attacks (hayfever). A five-grass polle...

    Authors: Patrick Blin, Pascal Demoly, Martine Drouet, Bruno Falissard, Séverine Lignot-Maleyran, Hélène Maizi, Simon Lorrain, Régis Lassalle, Cécile Droz-Perroteau, Nicholas Moore and Mathieu Molimard

    Citation: Allergy, Asthma & Clinical Immunology 2018 14:38

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  33. Content type: Research

    Chronic granulomatous disease (CGD) is a rare primary immunodeficiency of the phagocytic cells, which results in absent or diminished levels of microbicidal reactive oxygen species. The disease occurs due to g...

    Authors: Shalinda Jude Arjuna Fernando, Noorul Mifra Faiz, Shiroma Mangaika Handunnetti, Aruna Dharshan De Silva, Wasala Mudiyanselage Dhanushka Kumari Dasanayake, Geethani Devika Wickramasinghe, Rathnayake Mudiyanselage Chandima Hasanthi Karunatilake and Nilhan Rajiva de Silva

    Citation: Allergy, Asthma & Clinical Immunology 2018 14:37

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  34. Content type: Review

    Allergen-specific immunotherapy is a potentially disease-modifying therapy that is effective for the treatment of allergic rhinitis/conjunctivitis, allergic asthma and stinging insect hypersensitivity. However...

    Authors: William Moote, Harold Kim and Anne K. Ellis

    Citation: Allergy, Asthma & Clinical Immunology 2018 14(Suppl 2):53

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    This article is part of a Supplement: Volume 14 Supplement 2

  35. Content type: Review

    Eosinophilic esophagitis (EoE) is an atopic condition of the esophagus that has become increasingly recognized over the last 15 years. Diagnosis of the disorder is dependent on the patient’s clinical manifesta...

    Authors: Stuart Carr, Edmond S. Chan and Wade Watson

    Citation: Allergy, Asthma & Clinical Immunology 2018 14(Suppl 2):58

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    This article is part of a Supplement: Volume 14 Supplement 2

  36. Content type: Review

    Drug allergy encompasses a spectrum of immunologically-mediated hypersensitivity reactions with varying mechanisms and clinical presentations. This type of adverse drug reaction not only affects patient qualit...

    Authors: Richard Warrington, Fanny Silviu-Dan and Tiffany Wong

    Citation: Allergy, Asthma & Clinical Immunology 2018 14(Suppl 2):60

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    This article is part of a Supplement: Volume 14 Supplement 2

  37. Content type: Review

    Food allergy is defined as an adverse immunologic response to a food protein. Food-related reactions are associated with a broad range of signs and symptoms that may involve any body system, including the skin...

    Authors: Susan Waserman, Philippe Bégin and Wade Watson

    Citation: Allergy, Asthma & Clinical Immunology 2018 14(Suppl 2):55

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    This article is part of a Supplement: Volume 14 Supplement 2

  38. Content type: Review

    Atopic dermatitis (AD) is a common, chronic skin disorder that can significantly impact the quality of life of affected individuals as well as their families. Although the pathogenesis of the disorder is not c...

    Authors: Sandeep Kapur, Wade Watson and Stuart Carr

    Citation: Allergy, Asthma & Clinical Immunology 2018 14(Suppl 2):52

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    This article is part of a Supplement: Volume 14 Supplement 2

  39. Content type: Review

    Food allergy is a growing public health problem, and in many affected individuals, the food allergy begins early in life and persists as a lifelong condition (e.g., peanut allergy). Although early clinical pra...

    Authors: Edmond S. Chan, Elissa M. Abrams, Kyla J. Hildebrand and Wade Watson

    Citation: Allergy, Asthma & Clinical Immunology 2018 14(Suppl 2):57

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    This article is part of a Supplement: Volume 14 Supplement 2

  40. Content type: Review

    Primary immunodeficiency disorder (PID) refers to a large heterogeneous group of disorders that result from defects in immune system development and/or function. PIDs are broadly classified as disorders of ada...

    Authors: Christine McCusker, Julia Upton and Richard Warrington

    Citation: Allergy, Asthma & Clinical Immunology 2018 14(Suppl 2):61

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    This article is part of a Supplement: Volume 14 Supplement 2

  41. Content type: Review

    Asthma is the most common respiratory disorder in Canada. Despite significant improvement in the diagnosis and management of this disorder, the majority of Canadians with asthma remain poorly controlled. In mo...

    Authors: Jaclyn Quirt, Kyla J. Hildebrand, Jorge Mazza, Francisco Noya and Harold Kim

    Citation: Allergy, Asthma & Clinical Immunology 2018 14(Suppl 2):50

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    This article is part of a Supplement: Volume 14 Supplement 2

  42. Content type: Review

    Urticaria (hives) is a common disorder that often presents with angioedema (swelling that occurs beneath the skin). It is generally classified as acute or chronic. Second-generation, non-sedating, non-impairin...

    Authors: Amin Kanani, Stephen D. Betschel and Richard Warrington

    Citation: Allergy, Asthma & Clinical Immunology 2018 14(Suppl 2):59

    Published on:

    This article is part of a Supplement: Volume 14 Supplement 2

  43. Content type: Review

    Allergic rhinitis is a common disorder that is strongly linked to asthma and conjunctivitis. It is usually a long-standing condition that often goes undetected in the primary-care setting. The classic symptoms...

    Authors: Peter Small, Paul K. Keith and Harold Kim

    Citation: Allergy, Asthma & Clinical Immunology 2018 14(Suppl 2):51

    Published on:

    This article is part of a Supplement: Volume 14 Supplement 2

  44. Content type: Review

    Non-immunoglobulin E (IgE)-mediated food hypersensitivity includes a spectrum of disorders that predominantly affect the gastrointestinal tract. This review will focus on the following more common non-IgE-medi...

    Authors: Lori Connors, Andrew O’Keefe, Lana Rosenfield and Harold Kim

    Citation: Allergy, Asthma & Clinical Immunology 2018 14(Suppl 2):56

    Published on:

    This article is part of a Supplement: Volume 14 Supplement 2

  45. Content type: Review

    Beyond structural and chemical barriers to pathogens, the immune system has two fundamental lines of defense: innate immunity and adaptive immunity. Innate immunity is the first immunological mechanism for fig...

    Authors: Jean S. Marshall, Richard Warrington, Wade Watson and Harold L. Kim

    Citation: Allergy, Asthma & Clinical Immunology 2018 14(Suppl 2):49

    Published on:

    This article is part of a Supplement: Volume 14 Supplement 2

  46. Content type: Review

    Anaphylaxis is an acute, potentially fatal systemic allergic reaction with varied mechanisms and clinical presentations. Although prompt recognition and treatment of anaphylaxis are imperative, both patients a...

    Authors: David Fischer, Timothy K. Vander Leek, Anne K. Ellis and Harold Kim

    Citation: Allergy, Asthma & Clinical Immunology 2018 14(Suppl 2):54

    Published on:

    This article is part of a Supplement: Volume 14 Supplement 2

  47. Content type: Research

    Although several aspects of asthma care have been identified as being sub-optimal in Canada, such as patient education, practice guideline adoption, and access to care, there remains a need to determine the ex...

    Authors: Suzanne Murray, Sara Labbé, Alan Kaplan, Kristine Petrasko and Susan Waserman

    Citation: Allergy, Asthma & Clinical Immunology 2018 14:36

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