Volume 10 Supplement 1

Canadian Society of Allergy and Clinical Immunology Annual Scientific Meeting 2013

Open Access

Systematic review of outcome measures in trials of pediatric anaphylaxis treatment

  • Tamar Rubin1,
  • Jacqueline Clayton1,
  • Denise Adams1, 2,
  • Hsing Jou1, 2 and
  • Sunita Vohra1, 2, 3Email author
Allergy, Asthma & Clinical Immunology201410(Suppl 1):A36

https://doi.org/10.1186/1710-1492-10-S1-A36

Published: 3 March 2014

Background

Considerable heterogeneity has been observed in the selection and reporting of disease-specific pediatric outcome measures in randomized controlled trials (RCTs) [1]. This makes interpretation of results and comparison across trials challenging [2]. Outcome measures in pediatric anaphylaxis trials have never previously been systematically assessed [3]. This systematic review (SR) will identify and assess outcome measures used in RCTs of anaphylaxis treatment in children. As a secondary objective, this SR will assess the evidence for current treatment modalities for anaphylaxis in the pediatric population.

Methods

We searched MEDLINE, EMBASE, The Cochrane Library, Cochrane Central Register of Controlled Trials (CENTRAL), and CINAHL from 2001 until December 2012. We also searched websites listing ongoing trials. We included randomized and controlled trials of anaphylaxis treatment in patients 0-18 years of age. Two authors independently assessed articles for inclusion.

Results

No published studies fulfilled the inclusion criteria (Fig 1).
Figure 1

Search Flow Diagram

Conclusions

There is an alarming absence of RCTs evaluating the treatments for anaphylaxis in children. High quality studies are needed and are possible to design, despite the severe and acute nature of this condition. Consensus about the selection and validation of appropriate outcome measures will enhance the quality of research and improve the care of children with anaphylaxis.

Systematic review registration

CRD42012002685

Authors’ Affiliations

(1)
Department of Pediatrics, University of Alberta
(2)
CARE Program, University of Alberta
(3)
Department of Public Health Sciences, University of Alberta

References

  1. Clarke M: Standardising outcomes for clinical trials and systematic reviews. Trials. 2007, 8: 39-10.1186/1745-6215-8-39.PubMed CentralView ArticlePubMedGoogle Scholar
  2. Williamson PR, Gamble C, Altman DG, Hutton JL: Outcome selection bias in meta-analysis. Stat Methods Med Res. 2005, 14: 515-524. 10.1191/0962280205sm415oa.View ArticlePubMedGoogle Scholar
  3. Sinha I, Jones L, Smith RL, Williamson PR: A systematic review of studies that aim to determine which outcomes to measure in clinical trials in children. PLoS Med. 2008, 5 (4): e96-10.1371/journal.pmed.0050096.PubMed CentralView ArticlePubMedGoogle Scholar

Copyright

© Rubin et al; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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