Parental inheritance and perinatal tobacco smoke exposure increase the gender-dependent risk of physician diagnosed asthma at preschool age

Table 1 TSE and parental allergic history had synergistic influence on the physician diagnosed asthma ever in the 6 years of life. This synergistic influence was significant in girls, rather than boys

All	physician diagnosed asthma		OR	95%CI	p (compared with A)
parent allergic disorder -, TSE- (A)	30/161	18.60%	1
parent allergic disorder +, TSE-	97/396	24.00%	1.417	0.896-2.240	0.135
parent allergic disorder -, TSE+	13/56	23.20%	1.32	0.632-2.757	0.459
parent allergic disorder +, TSE+	46/135	34.10%	2.257	1.325-3.846	0.002
Girls					p (compared with A1)
parent allergic disorder -, TSE- (A1)	4/72	5.60%	1
parent allergic disorder +, TSE-	38/196	19.40%	4.089	1.404-11.905	0.006
parent allergic disorder -, TSE+	3/23	13.00%	2.55	0.526-12.353	0.231
parent allergic disorder +, TSE+	20/61	32.80%	8.293	2.649-25.964	<0.001
Boys					p (compared with A2)
parent allergic disorder -, TSE- (A2)	28/89	29.20%	1
parent allergic disorder +, TSE-	59/200	29.50%	1.014	0.586-1.755	0.961
parent allergic disorder -, TSE+	10/33	30.30%	1.054	0.441-2.519	0.907
parent allergic disorder +, TSE+	26/74	35.10%	1.313	0.678-2.541	0.419

ISSN: 1710-1492