Volume 10 Supplement 1
Systematic review of outcome measures in randomised controlled trials of pediatric eosinophilic esophagitis (EoE) treatment
© Rubin et al; licensee BioMed Central Ltd. 2014
Published: 3 March 2014
Heterogeneity has been noted in the selection and reporting of disease-specific pediatric outcomes in randomized controlled trials (RCTs) . The consequence may be invalid results from RCTs, or difficulty in comparing results across trials [2, 3]. The primary objective of this systematic review was to assess the heterogeneity of outcome measures selection and reporting in recent pediatric EoE treatment trials. As secondary objectives, we assessed the heterogeneity of disease definition and resolution across studies compared to established concensus guidelines, as well as the evidence for current EoE treatments.
We searched MEDLINE, EMBASE, The Cochrane Library, Cochrane Central Register of Controlled Trials (CENTRAL), and CINAHL from the last ten years, including randomized controlled trials of EoE treatment in patients 0-18 years. Two authors independently assessed articles for inclusion.
The results of this study confirm the need for universally reported, pediatric-specific, standardized outcome measures in EoE trials. Adherence to standardized disease definitions will enhance the utility of outcome measures. Consistent disease definition and standardized outcome reporting will allow for meta-analyses across similar trials and thus inform future clinical decision-making in pediatric EoE.
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