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Comparing wheat flour and commercial wheat extract skin prick testing in Wheat Dependent Exercise Induced Anaphylaxis

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Wheat Dependent Exercise Induced Anaphylaxis (WDEIA) is a form of Food Dependent Exercise Induced Anaphylaxis. WDEIA occurs when there is an allergic reaction following the ingestion of wheat, coupled with exercise [1]. The suspected allergen that is responsible for WDEIA is omega- 5- gliadin [2].

We report a series of adult clinical cases of WDEIA recorded between 2006-2009 at Health Sciences Centre (Winnipeg). The purpose of this study was to compare the results of Skin Prick Test (SPT) to commercial wheat extract and wheat flour in patients with WDEIA.

Materials and methods

We preformed a retrospective chart review of 8 patients with WDEIA. We recorded response to SPT for commercial wheat extract (Omega, Allergy Canada) and wheat flour.


The patients were 25-63 years old, 5/8 were female. All patients had histories of wheat consumption followed by exercise (or stress) resulting in allergic reactions. 5/8 cases were SPT negative to commercial wheat extract but positive to wheat flour. 1/8 was SPT negative with both commercial wheat extract and wheat flour, but positive with the wheat product (bun), which by history provoked a reaction. 1/8 was SPT positive to both. 1/8 was positive to wheat extract but SPT to wheat flour was not done. When patients adhered to wheat avoidant diets no reactions occurred.


In the 8 adults reviewed with WDEIA, SPT with wheat flour was much more sensitive than SPT with commercial wheat extract. Therefore, both commercial wheat extract and wheat flour should be used for SPT to diagnose WDEIA.


  1. 1.

    Palosuo K, Alenius H, Varjonen E, Koivuluhta M, Mikkola J, Keskinen H, Kalkkinen N, Reunala T: A novel wheat gliadin as a cause of exercise-induced anaphylaxis. J Allergy Clin Immunol. 1999, 103: 912-917. 10.1016/S0091-6749(99)70438-0.

  2. 2.

    Lee J, Yoon S, Ye Y, Hur G, Kim S, Park H: Gliadin-specific IgE in wheat-dependent exercise-induced anaphylaxis. Allergy Asthma Proc. 2008, 29: 614-21. 10.2500/aap.2008.29.3175.

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Author information

Correspondence to Lana A Rosenfield.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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About this article


  • Public Health
  • Allergic Reaction
  • Chart Review
  • Clinical Case
  • Wheat Flour