© Waserman and Watson; licensee BioMed Central Ltd. 2011
Published: 10 November 2011
Food allergy is defined as an adverse immunologic response to a dietary protein. Food-related reactions are associated with a broad array of signs and symptoms that may involve many bodily systems including the skin, gastrointestinal and respiratory tracts, and cardiovascular system. Food allergy is a leading cause of anaphylaxis and, therefore, referral to an allergist for appropriate and timely diagnosis and treatment is imperative. Diagnosis involves a careful history and diagnostic tests, such as skin prick testing, serum-specific immunoglobulin E (IgE) testing and, if indicated, oral food challenges. Once the diagnosis of food allergy is confirmed, strict elimination of the offending food allergen from the diet is generally necessary. For patients with significant systemic symptoms, the treatment of choice is epinephrine administered by intramuscular injection into the lateral thigh. Although most children “outgrow” allergies to milk, egg, soy and wheat, allergies to peanut, tree nuts, fish and shellfish are often lifelong. This article provides an overview of the epidemiology, pathophysiology, diagnosis, management and prognosis of patients with food allergy.
In recent years, there has been a significant amount of media attention on the subject of food allergy. While the exact prevalence is unknown, recent estimates suggest that 6% of young children and up to 4% of adults in North America are affected by food allergy, and the prevalence of the disorder appears to be rising [1–4].
Food allergy is also a leading cause of anaphylaxis (a severe, potentially fatal allergic reaction; please see Anaphylaxis article in this supplement for more information) presenting to emergency departments . Annually, there are approximately 200 deaths in the United States attributed to food allergy . At present, there are no accurate data regarding food allergy-related deaths in Canada.
Accurate diagnosis and appropriate management of food allergy are critical since accidental exposure to even minute quantities of the food causing the allergic reaction may result in anaphylaxis . This article provides an overview of current literature related to the epidemiology, pathophysiology, diagnosis, and appropriate management of food allergy. This review focuses primarily on immunoglobulin E (IgE)-mediated food-allergic reactions.
The term food allergy is used to describe an adverse immunologic response to a food protein. It is important to distinguish food allergy from other non-immune-mediated adverse reactions to foods, particularly since more than 20% of adults and children alter their diets due to perceived food allergy . Adverse reactions that are not classified as food allergy include food intolerances secondary to metabolic disorders (e.g., lactose intolerance), reactions to toxic contaminants (e.g. histamine produced by scombroid fish contaminated by Salmonella organisms) or pharmacologically active food components (e.g. caffeine in coffee causing jitteriness, tyramine in aged cheeses triggering migraine). Other conditions which are associated with symptoms similar to food allergy include auriculotemporal syndrome (a disorder characterized by facial flushing and salivation that may follow trauma to the parotid gland), and gustatory rhinitis [2–4].
Although food allergy can arise to any food, the allergens responsible for more than 85% of food allergy are: milk, egg, peanut, tree nuts, shellfish, fish, wheat, sesame seed and soy . These are also the “priority” allergens defined by Health Canada. It is the protein component, not the fat or carbohydrate component, of these foods that leads to sensitization and allergy. The allergenic segments or “epitopes” of these proteins tend to be small (10 to 70 kd in size), water-soluble glycoproteins that are generally resistant to denaturation by heat or acid and, therefore, can remain intact even after processing, storage, cooking and digestion [3, 4, 6]. Examples of these glycoproteins include caseins in milk, vicillins in peanut, and ovomucoid in egg. In general, allergies to additives and preservatives are uncommon.
Food-induced allergic disorders are broadly categorized into those mediated by immunoglobulin E (IgE) antibodies or by non-IgE-mediated mechanisms. IgE-mediated allergic responses are the most widely recognized form of food allergy and are characterized by the rapid onset of symptoms after ingestion. During initial “sensitization” to the food, consumption of the allergenic food protein stimulates production of IgE antibodies specific to that food which then bind to tissue basophils and mast cells. When the causal foods are subsequently eaten, they bind to their specific IgE antibodies and trigger the release of mediators, such as histamine, prostaglandins and leukotrienes, causing “clinical reactivity” and allergic symptoms. It is important to note that sensitization can be present without clinical reactivity, meaning that specific IgE to a food is present, but no reaction occurs with exposure [2–4, 7, 8].
Non-IgE-mediated (cell-mediated) food allergy is less common and results from the generation of T cells that respond directly to the protein, leading to the release of mediators that direct certain inflammatory responses (e.g., eosinophilic inflammation) and can cause a variety of subacute and chronic disease states. These types of reactions typically affect the gastrointestinal (GI) tract and skin and include: dietary-protein-induced enterocolitis and proctitis, celiac disease and its related skin disorder dermatitis herpetiformis. Celiac disease is associated with a specific immunoglobulin A (IgA)-mediated sensitivity to gluten (a protein found in wheat, barley, rye and certain other grains), and is associated with chronic inflammation and damage to the villi of the small intestine. Dermatitis herpetiformis is a chronic skin disorder that may occur simultaneously with celiac disease or alone [2–4, 7].
Some disorders are associated with a mixed IgE-/cell-mediated pathophysiology to food, such as atopic dermatitis, eosinophilic gastroenteritis and eosinophilic esophagitis (EoE; see articles on EoE and atopic dermatitis in this supplement). In these disorders, the association with food may not be demonstrated in all patients.
Prevalence estimates for probable food allergy in Canada 
Children with atopic disorders tend to have a higher prevalence of food allergy; approximately 35% of children with moderate-to-severe atopic dermatitis have IgE-mediated food allergy . Studies have also shown that children with atopic dermatitis and food allergy have a higher prevalence of allergic rhinitis and asthma. Approximately 75% of children with atopic dermatitis develop allergic rhinitis and 80% develop asthma .
Signs and symptoms of food allergy.
Angioedema of the lips, tongue, palate
Skin reactions are the most common clinical manifestations of allergic reactions to food and include acute urticaria (hives), angioedema (swelling) and erythema (redness of the skin). Typical respiratory tract symptoms include laryngeal edema, rhinorrhea, and bronchospasm. GI-related signs and symptoms of food allergy include nausea, vomiting, abdominal pain, and diarrhea.
Oral allergy syndrome: cross reaction between proteins in pollen and fresh fruits and vegetables 
• Brazil nut
Anaphylaxis is highly likely when any 1 of the following 3 criteria is fulfilled following exposure to an allergen:
Acute onset of an illness (minutes to several hours) with involvement of the skin, mucosal tissue, or both (e.g., generalized hives, pruritus or flushing, swollen lips-tongue-uvula) and at least 1 of the following:
a. Respiratory compromise (e.g. dyspnea, wheeze, bronchospasm, stridor, reduced PEF, hypoxemia)
b. Reduced BP or associated symptoms of end-organ dysfunction (e.g. hypotonia [collapse], syncope, incontinence)
2 or more of the following that occur rapidly after exposure to a likely allergen for that patient (minutes to several hours):
a. Involvement of the skin-mucosal tissue (e.g., generalized hives, itch-flush, swollen lips-tongue-uvula)
b. Respiratory compromise (e.g., dyspnea, wheeze, bronchospasm, stridor, reduced PEF, hypoxemia)
c. Reduced BP or associated symptoms (e.g., hypotonia [collapse], syncope, incontinence)
d. Persistent GI symptoms (e.g., painful abdominal cramps, vomiting)
Reduced BP after exposure to a known allergen for that patient (minutes to several hours):
a. Infants and children: low systolic BP (age specific) or > 30% decrease in systolic BP*
b. Adults: systolic BP < 90 mmHg or > 30% decrease from that person’s baseline
The diagnosis of a food allergy requires a detailed history and physical examination, and diagnostic tests, such as skin prick tests (SPT) and/or serum-specific IgE testing to foods (ImmunoCAP®). In some cases, oral food challenges may also be required [2–4].
Referral to an allergist is important to confirm the diagnosis of a suspected food allergy. Patients should avoid the food in question until assessment, and an epinephrine auto-injector should be prescribed, even if the diagnosis is uncertain .
It is important to inquire about all suspect foods and to discuss the manner of food preparation (e.g. cooked, raw, added spices or other ingredients). Time of onset of symptoms in relation to food exposure, symptom duration and severity, as well as reproducibility of symptoms in the case of recurrent exposure should be determined. It is also important to ask about factors that can potentiate the allergic reaction, such as exercise or alcohol [2–4].
The primary purpose of the physical examination is to look for supporting evidence of atopy and other allergic diseases (e.g., atopic dermatitis, asthma, and allergic rhinitis) and to rule out the presence of other conditions that may mimic food allergy. The physical examination is also useful for assessing overall nutritional status and growth in children.
In general, diagnostic tests for food allergy (e.g., SPT, serum-specific IgE tests, and oral food challenges) should be performed by an allergist. The SPT is a rapid, safe and sensitive method for diagnosing suspected IgE-mediated food allergy. A positive SPT appears as a wheal and flare reaction when the responsible food is applied to the skin and pricked. A positive SPT has a sensitivity of approximately 90%; however, its specificity is only around 50%. Therefore, a positive SPT alone is not sufficient for diagnosing food allergy; the patient must also have a supportive history. To minimize false positive results, over-testing with SPTs should be avoided. SPT should only be done for those foods that are relevant to the patient’s history. The negative predictive value of a SPT is greater than 95% and, therefore, a negative SPT generally confirms the absence of IgE-mediated reactions [2, 15]. Although less sensitive and more costly than SPTs, serum-specific IgE tests can also be used for diagnosing food allergy, particularly if SPTs cannot be performed or are not available .
If there is still clinical suspicion of food allergy, but the diagnosis is uncertain based on the results of SPT and/or serum-specific IgE testing, than an oral food challenge may be appropriate. Oral food challenges involve gradual feeding of the suspected food with careful, medically-supervised assessment for any symptoms. In the event of symptoms, feeding is discontinued and the patient is treated where approriate. Food challenges should only be conducted in clinics or hospitals equipped with both the personnel and equipment needed to treat anaphylaxis .
Other strategies that can help assist in the diagnosis of food allergy are an elimination diet and food/symptom diaries. The elimination diet can be used for both the diagnosis and treatment of food allergy and requires complete avoidance of suspected foods or groups of foods for a given period of time (usually 1-2 weeks), while monitoring for an associated decrease in symptoms. Success of this approach in the diagnosis of food allergy depends on identifying the correct food allergen and completely eliminating it from the diet. It is limited by potential bias in both patients and physicians, and variable patient compliance with the diet. Food/symptom diaries require the patient to keep a chronological record of all foods eaten and any associated adverse symptoms. These records may be helpful for identifying the food implicated in an adverse reaction; however, they are not usually diagnostic, particularly when symptoms are delayed or infrequent [2–4].
Tests such as applied kinesiology, vega machine testing and serum immunoglobulin G (IgG) blood testing have no role in the diagnosis of food allergy. Again, if food allergy is suspected, the food should be avoided, an epinephrine auto-injector should be prescribed, and the patient should be referred for an allergy assessment.
There is currently no treatment for food allergy, beyond avoidance of the responsible food(s). Once a food allergy is diagnosed, strict elimination of the offending food allergen from the diet is necessary. A properly managed, well-balanced elimination diet can lead to resolution of symptoms while maintaining nutritional status. When the elimination diet is used as treatment, the identified food allergens are removed from the diet indefinitely, unless evidence exists that the food allergy has resolved [2–4].
In the case of accidental exposure, the treatment of choice is epinephrine administered by intramuscular injection into the lateral thigh [2–4]. There are currently two epinephrine auto-injectors available in North America: EpiPen® and Twinject®. Both products come in two dosages (0.15 mg and 0.30 mg), which are prescribed according to weight. The 0.30 mg dosage should be used for those weighing 30 kg or more, and the 0.15 mg dosage for children weighing between 15–30 kg. Certain sources recommend switching to the 0.30 mg dose at 25 kg rather than 30 kg .
These devices should be stored properly (avoiding temperature extremes) and replaced before the expiration date. More information on these auto-injectors is available at http://www.epipen.ca and http://www.twinject.ca. All individuals receiving emergency epinephrine must be transported to hospital immediately (ideally by ambulance) for evaluation and observation .
A concise, written plan for the treatment of allergic reactions resulting from accidental exposure to the food should be developed, and copies made available to the appropriate persons (e.g., daycare providers, teachers, employers). Examples of such a plan, along with other relevant information and materials, can be downloaded at Anaphylaxis Canada (http://www.anaphylaxis.ca) or the Food Allergy and Anaphylaxis Network (http://www.foodallergy.org; a US-based association). Recommendations for the management of anaphylaxis in schools and other community settings  are also available through the Allergy Safe Communities website at http://www.allergysafecommunities.ca.
Patients and their caregivers must also be educated on food avoidance, the identification and treatment of allergic and anaphylactic reactions, the appropriate use of epinephrine auto-injectors, and how to obtain immediate medical assistance (e.g., call 911) (see Anaphylaxis article in this supplement for more information). Individuals should also be instructed to read food labels carefully, watching for hidden ingredients such as “natural flavour” or “spices” that may indicate the presence of allergens, as well as “may contain” warnings. All food-allergic patients should obtain and wear medical identification (such as a MedicAlert® bracelet/necklace) indicating their food allergy .
Recent research has also shown that peanut allergic children can be desensitized to peanut by feeding them increasing amounts of peanut under close supervision . Similar studies have been conducted for egg and milk allergy. Results of these studies are promising; however, they have involved only small numbers of subjects, side effects have been noted, and protocols are still evolving. Therefore, further confirmatory studies in this area are needed.
Strategies for the prevention of food allergy have been extensively studied. Prior recommendations suggesting avoidance of highly allergenic foods in infant diets and the diets of pregnant/breastfeeding mothers have not been shown to decrease the prevalence of food allergy or atopic disease . Recent guidelines from the American Academy of Pediatrics state that “no current convincing evidence exists to recommend specific avoidance of certain foods beyond 4-6 months of age for the prevention of allergy” .
The prognosis of food allergy is complex and dependent on the particular food. As mentioned earlier, most infants and young children outgrow allergies to milk, egg, soy and wheat. Children should be re-evaluated at regular intervals to determine whether clinical tolerance has developed. The natural history of egg and milk allergy appears to be evolving in that an increasing number of children are outgrowing these allergies in their teenaged years [23, 24]. Allergy to peanut, tree nuts, fish, and shellfish is more persistent, and lifelong in most cases.
Food allergy is an important clinical problem of increasing prevalence. Assessment by an allergist is very important for appropriate diagnosis and treatment. Diagnosis currently relies on a careful history and diagnostic tests, such as SPT, serum-specific IgE testing (where appropriate) and, if indicated, oral food challenges. The mainstay of treatment is avoidance of the responsible food(s) and appropriate, prompt response to allergic reactions with epinephrine. Further insights into the pathophysiology of food allergy will lead to the development of improved methods for prevention, diagnosis, and management of the disorder.
Key take-home messages
Food allergy is defined as an adverse immunologic response to a dietary protein.
Referral to an allergist is important for appropriate diagnosis and treatment.
Diagnosis of a food allergy requires a detailed history, diagnostic tests such as skin prick tests (SPT) and/or serum-specific IgE testing to foods and, in some cases, oral food challenges.
Treatment of food allergy involves avoidance of the responsible food(s) and injectable epinephrine.
For patients with significant systemic symptoms, the treatment of choice is epinephrine administered by intramuscular injection into the lateral thigh.
Most children "outgrow" allergies to milk, egg, soy and wheat by school age; allergy to peanut, tree nuts, fish, and shellfish are usually lifelong, although some patients may outgrow peanut allergy.
The authors would like to thank Julie Tasso for her editorial services and assistance in the preparation of this manuscript.
This article has been published as part of Allergy, Asthma & Clinical Immunology Volume 7 Supplement 1, 2011: Practical guide for allergy and immunology in Canada. The full contents of the supplement are available online at http://www.aacijournal.com/supplements/7/S1
- Sicherer SH, Muñoz-Furlong A, Sampson HA: Prevalence of seafood allergy in the United States determined by a random telephone survey. J Allergy Clin Immunol. 2004, 114: 159-165. 10.1016/j.jaci.2004.04.018.View ArticlePubMedGoogle Scholar
- Sampson HA: Update on food allergy. J Allergy Clin Immunol. 2004, 113: 805-819. 10.1016/j.jaci.2004.03.014.View ArticlePubMedGoogle Scholar
- Sicherer SH, Sampson HA: Food allergy. J Allergy Clin Immunol. 2006, 117 (2 Suppl Mini-Primer): S470-475.View ArticlePubMedGoogle Scholar
- Sicherer SH, Sampson HA: Food allergy. J Allergy Clin Immunol. 2010, 125 (2 Suppl 2): S116-125.View ArticlePubMedGoogle Scholar
- The Food Allergy & Anaphylaxis Network. http://www.foodallergy.org. Accessed September 14, 2010
- Connors L, Waserman S: Food allergy — the nuts and bolts. Parkhurst Exchange. 2010, 18-Available at: http://www.parkhurstexchange.com/clinical-reviews/apr10/food-allergy Accessed October 14, 2010Google Scholar
- Sicherer SH: Food allergy. Lancet. 2002, 360: 701-710. 10.1016/S0140-6736(02)09831-8.View ArticlePubMedGoogle Scholar
- Sicherer SH, Muñoz-Furlong A, Murphy R, Wood RA, Sampson HA: Symposium: pediatric food allergy. Pediatrics. 2003, 111: 1591-1594.Google Scholar
- Wood RA: The natural history of food allergy. Pediatrics. 2003, 111 (6 pt 3): 1631-1637.PubMedGoogle Scholar
- Hourihane JO, Roberts SA, Warner JO: Resolution of peanut allergy: case-control study. BMJ. 1998, 316: 1271-1275. 10.1136/bmj.316.7140.1271.PubMed CentralView ArticlePubMedGoogle Scholar
- MacDougall CF, Cast AJ, Colver AF: How dangerous is food allergy in childhood? The incidence of severe and fatal allergic reactions across the UK and Ireland. Arch Dis Child. 2002, 86: 236-239. 10.1136/adc.86.4.236.PubMed CentralView ArticlePubMedGoogle Scholar
- Eigenmann PA, Sicherer SH, Borkowski TA, Cohen BA, Sampson HA: Prevalence of IgE-mediated food allergy among children with atopic dermatitis. Pediatrics. 1998, 101: e8-View ArticlePubMedGoogle Scholar
- Sampson HA: Food allergy. J Allergy Clin Immunol. 2003, 111 (2 Suppl): S540-547.View ArticlePubMedGoogle Scholar
- Ben-Shoshan M, Harrington DW, Soller L, Fragapane J, Joseph L, St Pierre Y, Godefroy SB, Elliot SJ, Clarke AE: A population-based study on peanut, tree nut, fish, shellfish, and sesame allergy prevalence in Canada. J Allergy Clin Immunol. 2010, 125: 1327-35. 10.1016/j.jaci.2010.03.015.View ArticlePubMedGoogle Scholar
- Scurlock AM, Lee LA, Burks AW: Food allergy in children. Immunol Allergy Clin N Am. 2005, 25: 369-388. 10.1016/j.iac.2005.02.005.View ArticleGoogle Scholar
- Sampson HA, Munoz-Furlong A, Campbell RL, Adkinson NF, Bock SA, Branum A, Brown SG, Camargo CA, Cydulka R, Galli SJ, Gidudu J, Gruchalla RS, Harlor AD, Hepner DL, Lewis LM, Lieberman PL, Metcalfe DD, O'Connor R, Muraro A, Rudman A, Schmitt C, Scherrer D, Simons FE, Thomas S, Wood JP, Decker WW: Second symposium on the definition and management of anaphylaxis: summary report – Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium. J Allergy Clin Immunol. 2006, 117: 391-397. 10.1016/j.jaci.2005.12.1303.View ArticlePubMedGoogle Scholar
- Sampson HA, Munoz-Furlong A, Bock SA, Schmitt C, Bass R, Chowdhury BA, Decker WW, Furlong TJ, Galli SJ, Golden DB, Gruchalla RS, Harlor AD, Hepner DL, Howarth M, Kaplan AP, Levy JH, Lewis LM, Lieberman PL, Metcalfe DD, Murphy R, Pollart SM, Pumphrey RS, Rosenwasser LJ, Simons FE, Wood JP, Camargo CA: Symposium on the definition and management of anaphylaxis: summary report. J Allergy Clin Immunol. 2005, 115: 584-591. 10.1016/j.jaci.2005.01.009.View ArticlePubMedGoogle Scholar
- Nowak-Wegrzyn A, Assa’ad AH, Bahna SL, Bock SA, Sicherer SH, Teuber SS, Adverse Reactions to Food Committee of American Academy of Allergy, Asthma & Immunology: Work Group report: oral food challenge testing. J Allergy Clin Immunol. 2009, 123: S365-383. 10.1016/j.jaci.2009.03.042.View ArticlePubMedGoogle Scholar
- Sicherer SH, Simons FE, Section on Allergy and Immunology, American Academy of Pediatrics: Self-injectable epinephrine for first-aid management of anaphylaxis. Pediatrics. 2007, 119: 638-646. 10.1542/peds.2006-3689.View ArticlePubMedGoogle Scholar
- Canadian Society of Allergy and Clinical Immunology: Anaphylaxis in schools & other settings. 2009, CSACI, 2Google Scholar
- Burks A: Peanut allergy. Lancet. 2008, 371: 1538-1546. 10.1016/S0140-6736(08)60659-5.View ArticlePubMedGoogle Scholar
- Greer F, Sicherer S, Burks W, American Academy of Pediatrics Committee on Nutrition, American Academy of Pediatrics, Section on Allergy and Immunology: Effects of early nutritional interventions on the development of atopic disease in infants and children: the role of maternal dietary restriction, breastfeeding, timing of introduction of complementary foods, and hydrolyzed formulas. Pediatrics. 2008, 121: 183-191. 10.1542/peds.2007-3022.View ArticlePubMedGoogle Scholar
- Savage JH, Matsui EC, Skripak JM, Wood RA: The natural history of egg allergy. J Allergy Clin Immunol. 2007, 120: 1413-1417. 10.1016/j.jaci.2007.09.040.View ArticlePubMedGoogle Scholar
- Skripak JM, Matsui EC, Mudd K, Wood RA: The natural history of IgE-mediated cow's milk allergy. J Allergy Clin Immunol. 2007, 120: 1172-1177. 10.1016/j.jaci.2007.08.023.View ArticlePubMedGoogle Scholar
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