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Patient engagement and patient support programs in allergy immunotherapy: a call to action for improving long-term adherence
Allergy, Asthma & Clinical Immunology volume 12, Article number: 34 (2016)
Allergy immunotherapy (AIT) is acknowledged to produce beneficial mid- and long-term clinical and immunologic effects and increased quality of life in patients with allergic respiratory diseases (such as allergic rhinoconjunctivitis and allergic asthma). However, poor adherence to AIT (due to intentional and/or non-intentional factors) is still a barrier to achieving these benefits. There is an urgent need for patient support programs (PSPs) that encompass communication, educational and motivational components. In the field of AIT, a PSP should be capable of (1) improving adherence, (2) boosting patient engagement, (3) explaining how AIT differs from pharmacological allergy treatments; (4) increasing health literacy about chronic, progressive, immunoglobulin-E-mediated immune diseases, (5) helping the patient to understand and manage local or systemic adverse events, and (6) providing and/or predicting local data on aeroallergen levels. We reviewed the literature in this field and have identified a number of practical issues to be addressed when implementing a PSP for AIT: the measurement of adherence, the choice of technologies, reminders, communication channels and content, the use of “push” messaging and social networks, interactivity, and the involvement of caregivers and patient leaders. A key issue is “hi-tech” (i.e. approaches based mainly on information technology) vs. “hi-touch” (based mainly on interaction with humans, i.e. family members, patient mentors and healthcare professionals). We conclude that multistakeholder PSPs (combining patient-, provider and society-based actions) must now be developed and tested with a view to increasing adherence, efficacy and safety in the field of AIT.
Allergy immunotherapy (AIT, either sublingual or subcutaneous) is acknowledged to have beneficial mid- and long-term clinical and immunologic effects on patients with allergic respiratory diseases (such as allergic rhinoconjunctivitis and allergic asthma). In particular, those effects may persist for several years after discontinuation [1–4]. Indeed, long-term efficacy and sustained (post-treatment) efficacy are important parameters in the regulatory approval of AIT formulations in Europe . Even though AIT has a relatively short (intra-season) onset of action  for symptom relief, multi-season or multi-year administration of AIT is required to achieve a long-lasting, disease-modifying effects. Poor adherence to long-term AIT (as with other chronic treatments) is thus a barrier to obtaining allergen tolerance, symptom relief and improved quality of life (QoL).
Adherence to long-term treatment: a key reason for trying to boost patient engagement
Although progress in technology and medicine offers great opportunities for healthy living, successful outcomes are increasingly reliant on the patient’s active participation in his/her treatment. However, one of the main problems in modern medicine—especially in the field of chronic disease—is patient adherence, defined by the World Health Organization as “the extent to which a person’s behavior—taking a medication, following a diet or executing lifestyle changes—corresponds with agreed recommendations from a healthcare provider” . In a quote attributed to the former US Surgeon General Dr. C. Everett Koop, “drugs don’t work in patients who don’t take them”.
Adherence can be broken down into several stages (Fig. 1): (1) initiation (also referred to as acceptance), (2) implementation (also referred to as compliance, i.e. the proportion of the recommended doses of medication actually taken by the patient) and (3) persistence (i.e. not discontinuing the treatment before the end of the recommended period) [7–9]. There are many intentional or non-intentional reasons why a patient may fail to take his/her medication or not follow other healthcare measures prescribed by a physician (Table 1) [10, 11]. However, most (but not all) studies of non-adherence in chronic disease suggest that non-intentional reasons predominate—mainly “I simply forgot” and variants of the latter [12, 13]. In intentional non-adherence, patients often irrationally consider that the risks associated with adherence are greater than the risks associated with non-adherence (Table 1).
Levels of adherence in patients on AIT
It has been estimated that the compliance rate for drug therapy of chronic disease is barely over 50 % ; most of these data have come from studies of patients with diabetes, chronic kidney disease, neurologic disorders, cardiovascular disease or AIDS. In the literature on AIT, the compliance component of adherence ranges from around 25 % to over 90 % . In a recent Italian study of sales data provided by two major manufacturers, more than 50 % of patients discontinued sublingual allergy immunotherapy (SLIT) during the first year, and only 13 % were still on treatment in the second year. This shortfall was independent of the allergen source, administration regimen and, in part, reimbursement status . A German retrospective analysis of renewal rates for grass pollen AIT found that 49 and 64 % of patients did not renew their SLIT or SCIT prescription, respectively, over 2 years . Hence, increasing the adherence rate may be an important way of improving safety, efficacy, quality of life (QoL) and other patient-related outcomes in AIT.
Key factors in improving adherence rates
A multitude of organizational, educational and technological interventions have been developed or proposed with a view to improving adherence and patient outcomes. In a Cochrane review, Haynes et al.  reported that only 26 out of 58 interventions in 49 randomized clinical trials were associated with improved adherence, and that almost all of the interventions with long-term efficacy were complex and multifactorial. Furthermore, it appears to be impossible to predict which interventions will or will not work in a particular setting and over a given timeframe. Behavioral interventions for enhancing medication adherence (when behavioral counselling is directly offered to patients by specifically trained health care professionals) have shown contradictory results . Unfortunately, even the most successful interventions did not produce large improvements in adherence.
Patient education, health literacy, patient-centered care, patient-centered communication, patient activation and patient engagement are related but non-identical approaches that can potentially improve adherence. Firstly, patient education has been variously defined as “any set of planned educational activities designed to improve patients’ health behaviors and health status”  and “a process of assisting consumers of health care to learn how to incorporate health-related behaviors (i.e., knowledge, skills and/or attitudes) into everyday life with the purpose of achieving the goal of optimal health” . Secondly, health literacy is defined by the US Institute of Medicine of the National Academies as “the degree to which individuals have the capacity to obtain, process, and understand basic health information needed to make appropriate health decisions” . Low health literacy is associated with poor adherence and poor outcomes [22–24]. However, most programs based on health education, information, literacy or numeracy alone have failed to improve adherence, even though they do improve the level of knowledge about disease [16, 25].
Lastly, patient engagement—described as “the blockbuster drug of the century” —has been defined as “actions [that] individuals must make to obtain the greatest benefit from the health care services available to them” by the Center for Advancing Health  and “the involvement in their own care by individuals (and others they designate to engage on their behalf), with the goal that they make competent, well-informed decisions about their health and health care and take action to support those decisions” by the Agency for Healthcare Research and Quality . Both these definitions emphasize that even a well-informed, health-literate patient must also be personally committed, motivated and pro-active if he/she is to help prevent, manage and treat his/her disease. It has been reported that in patients with chronic metabolic diseases, empowerment-based self-management interventions have stronger, long-lasting effects than conventional self-management or education, although adherence has not always been assessed in these studies [29–31]. Furthermore, the time that healthcare professionals can dedicate to allergic patients (and their parents, when considering pediatric patients) in the office may modulate the above-mentioned educational and psychological factors. For example, Rolinck-Werninghaus et al.  reported that an individually tailored nurse consultation for parents of children with atopic dermatitis was associated with significant benefits in terms of reduced disease severity and confidence in dealing with the disease. Group educational programs were particularly effective in parents with poor coping abilities at baseline .
Patient engagement and patient support programs (PSPs) in the field of respiratory allergies and AIT
Patient engagement must be kindled and maintained. PSPs (including communication, educational and motivational components) are intended to boost patient engagement, improve adherence (initiation, compliance and persistence), help patients understand and manage their disease, improve QoL and facilitate patient-physician communication, concordance and trust.
In the field of AIT, a PSP will have additional, specific objectives:
Explain the benefits of AIT and how it differs from other allergy treatments: the disease-modifying mode of action vs. symptomatic medication, short- and long-term benefits of AIT, modes of administration, the recommended duration of treatment (3–5 years), the onset of action of AIT (as early as the first season, within 1–4 months of initiation ), reduction in the need for pharmacotherapy, and possible prevention of the progression of the allergic disease such as secondary/tertiary prevention regarding the development of asthma [4, 34].
Increase health literacy about allergic disease (from the diagnosis onwards, if possible), with a focus on chronic, progressive, immunoglobulin-E-mediated immune diseases with health, work and QoL consequences.
Help to understand and manage local or systemic adverse events and those related to the administration route, whether SLIT or subcutaneous allergy immunotherapy (SCIT).
Improve adherence year after year or season after season, in order to obtain the disease-modifying benefits of AIT.
Provide data on and/or predict aeroallergen and pollutant levels on a local basis (for a patient’s place of residence or when travelling), with customized alerts for specified allergen sources. This is essential in pollen-induced allergies, due to the well-known variability of pollen seasons as a function of geographic location and climate. Prediction of the start of a pollen season is less useful in patients following a perennial AIT regimen or a pre- and co-seasonal regimen than is initiated before the start of the season. However, confirmation of the end of a pollen season may be more valuable for highlighting the end date for co-seasonal administration.
Allergists are clearly moving towards patient-centered care and PSPs, as illustrated by the new MASK-rhinitis IT tool (developed as part of the European Innovation Partnership on Active and Healthy Ageing) for diagnosing, stratifying and managing patients with AR and assessing treatment efficacy . The MASK-rhinitis smartphone application for the patient combines e-Allergy screening (for early online diagnosis of allergy and asthma), the daily rating of rhinitis symptoms on a visual analogue scale and an assessment of disease control using the control of allergic rhinitis and asthma test. It is interfaced with a clinical decision support system based on the widely used allergic rhinitis in asthma guidelines . With the rapid growth of mobile Internet use, smartphone apps are inevitably going to be key components of PSPs.
The field of asthma (a condition that is generally but not always allergic) may provide valuable insights for PSPs in AIT of allergic respiratory diseases. Over the last few decades, intense effort has been devoted worldwide to delivering and promoting asthma education, self-management and personal action plans. By way of an example, a recent study has shown that self-monitoring, individualized asthma action plans, information about assessments and correct use of an inhaler do increase adherence and provide clinically useful data on disease control . In another study, an intervention based on a “physician on call patient engagement trial” mobile phone application was associated with improvements in activity, productivity, disease control, disease perception and emotion, although adherence was not assessed . However, systematic reviews of this aspect revealed the absence of a clear clinical trial-based evidence in favor of these asthma interventions. In Coffman et al.’s US-based meta-analysis of the effects of pediatric asthma education on hospitalizations, emergency department visits, and urgent physician visits, 37 trials met the meta-analysis’ inclusion criteria . The researchers concluded that although pediatric asthma education reduced the mean number of hospitalizations and emergency department visits and the likelihood of an emergency department visit, there was no significant effect on the likelihood of hospitalization in general or the mean number of urgent physician visits. Similarly, in a meta-analysis of 37 studies, Pinnock et al.  concluded that only “whole systems approaches” that explicitly and simultaneously addressed patient-, professional- and organization-related factors were associated with consistent improvements in clinical outcomes in asthma, although adherence per se was rarely studies. This approach typically combined (1) direct patient coaching, free resources, patient mentors and/or group activities, (2) continuing professional education and training for specialists and/or primary care physicians, and (3) local and/or national health promotion and awareness programs .
A call to action for PSPs in the field of AIT
A number of practical questions and choices must be considered when implementing a PSP for AIT. We encourage researchers, physicians, other healthcare professionals, learned societies, medical associations and patient organizations to explore and refine the following points.
Levels of adherence should be measured as soon as a patient has been prescribed AIT and then on a regular basis thereafter. Both patients and physicians should be able to display data on changes over time in adherence and engagement. Validated tools exist, such as the 4- or 8-item Morisky Medication Adherence Scale . The PSP interface could also be used to assess disease control in allergic rhinitis or asthma [42, 43]. Ideally, a PSP should be able to identify particular barriers to adherence (see Table 1), characterize non-adherence profiles (poor dosage vs. poor persistence, for example) and adapt actions and content accordingly. For example, a patient suffering from forgetfulness could be invited to view a short video giving behavioral tips on improving self-organization. A PSP should also be able to rapidly detect patients with special communication needs.
Technological choices Modern technology enables the interactive, mass dissemination of customized information. However, the application of technology per se is not a panacea for engagement and adherence; “hi-tech” must be balanced against “hi-touch”—the maintenance of a close personal connection. Mistry et al.  have stated that there are too few high-quality studies to reliably assess the effectiveness of technology-mediated interventions; of 38 studies reviewed, 24 did not find significant effects on both adherence and clinical outcomes. By way of an example, Alesina et al.  recently studied the use of an electronic tablet container (the Memozax) with a programmable daily sound alarm in 261 patients taking a timothy grass pollen sublingual AIT tablet in Italy. The patients were randomized 1:1 to use of the device or not. After 1 year, the compliance rate in the Memozax group was slightly higher (91.7 %) than that in the non-Memozax group (90.3 %) but this difference was not statistically significant. In general, there is a lack of robust, clinical trial data on the efficacy of health information technology tools in the self-management of respiratory disease. Easy access to the Internet and the ease with which apps can be created have disadvantages, too; the same group’s review of 103 apps for asthma in English found that none combined reliable, comprehensive patient information with supportive tools for self-management . In a recent Cochrane Collaboration review, the same group searched for randomized controlled trials on the clinical effectiveness, cost-effectiveness and feasibility of smartphone and tablet apps in the self-management of individuals with asthma. Only two trials (totaling 408 participants) met the inclusion criteria, and neither found a significant effect on adherence .
Reminders, communication channels and content A PSP designed to enhance adherence is likely to feature prominent reminders to take medications, refill prescriptions or contact a healthcare professional. These reminders may be based on phone calls, text messages, e-mail messages, pagers, interactive voice response systems, video calls, “smart” electronic medication containers, or combinations thereof. Furthermore, the use of “push” messaging and social networks in a PSP may be confronted with “information overload” in which messages are not seen or not opened. The optimal frequency of messaging will depend on the disease, the treatment, the symptom burden and, of course, the patient’s personal preference. For example, adherence reminders should probably be issued on a daily basis for the at-home administration of SLIT but much less frequently for patients receiving SCIT. Another question is whether to introduce one technology-based intervention at a time or several simultaneously. A PSP must be able to anticipate and avoid “information fatigue” amongst its users. Lastly, messaging-based reminders may be unidirectional or bidirectional. In the latter situation, participants are encouraged to respond to reminders by giving information on adherence—even though this is usually impossible to verify. A smart, responsive system that takes account of the patient’s replies and redefines the messaging content accordingly may be preferable to “dumb”, alarm-clock-like reminders. Whereas poor adherence will generally trigger encouraging, advisory reminders, the opposite is also valid; congratulatory messages can be used to “reward” good compliance.
Custom platforms or open social media? Mainstream social media platforms are easy to use and extremely wide-ranging but may not be sufficiently trusted and authenticated to convince and motivate patients. Validated, “official” sources of information should be developed in collaboration with patient associations and/or medical associations.
Age-specific content Elderly adults, young adults, teenagers, young children and the latter’s parents have differing communication abilities, styles and habits. A PSP will have to be capable of using an appropriate language style when addressing a particular age group; communication will be totally different.
When in the patient’s journey can or should he/she be contacted by the PSP provider? In AIT, it is probably best to initiate a PSP as soon as the patient has been diagnosed with an allergy because understanding the nature of allergic disease is essential for taking informed treatment decisions thereafter .
Interactivity and data validity Should patients be able to request meetings or interactions with their physician or other health advisors? And if the PSP collects patient-reported data, will these data be reliable enough to be of use in setting or modifying the treatment strategy?
The involvement of “patient leaders” It has been reported that patients with chronic conditions (heart disease, lung disease, stroke, or arthritis) benefit from short self-management courses in which they learn from other patients . Furthermore, some countries have “train the trainers” courses for asthma, eczema or anaphylaxis; this could be extended to AIT.
Caregiver involvement This is essential for pediatric PSPs and even for slightly older populations. For example, research in asthma has shown that caregiver support for adherence is still important in adolescence and young adulthood, even as these patients gain independence in dealing with their illness and treatment [50, 51].
Multicomponent, multichannel, multistakeholder PSPs are needed to trigger patient engagement, increase knowledge about allergic diseases, overcome poor adherence to AIT and, ultimately, improve health outcomes through better patient self-management and stronger physician-patient partnerships which is of high importance especially in the field of AIT. By way of an analogy, the patient is no longer a mere “passenger”; the patient (and not the physician) is sitting in the driver’s seat, and the physician’s role is now to act as a guide and a coach. AIT providers have an important role to play (whether directly or indirectly) in PSPs, with a move towards this new paradigm.
The available evidence suggests that approaches with system-based reminders alone are not sufficiently effective on adherence. It would be interesting to design clinical trials in which adherence is the primary criterion, evaluating “hi-tech” interventions (based mainly on information technology) and “hi-touch” interventions (based mainly on interaction with humans, i.e. family members, patient mentors and healthcare professionals). However, the available evidence suggests that no single approach—whether tech- or human-based—has a significant, lasting impact on adherence; only “whole systems approaches” (combining patient-, provider and society-based actions) might do so .
patient support program
quality of life
subcutaneous allergy immunotherapy
sublingual allergy immunotherapy
Burks AW, Calderon MA, Casale T, Cox L, Demoly P, Jutel M, et al. Update on allergy immunotherapy: American Academy of Allergy, Asthma & Immunology/European Academy of Allergy and Clinical Immunology/PRACTALL consensus report. J Allergy Clin Immunol. 2013;131:1288–96.
Eifan AO, Shamji MH, Durham SR. Long-term clinical and immunological effects of allergen immunotherapy. Curr Opin Allergy Clin Immunol. 2011;11:586–93. doi:10.1097/ACI.0b013e32834cb994.
Demoly P, Calderon MA, Casale TB, Malling HJ, Wahn U. The value of pre- and co-seasonal sublingual immunotherapy in pollen-induced allergic rhinoconjunctivitis. Clin Transl Allergy. 2015;5:18. doi:10.1186/s13601-015-0061-z.
Jutel M, Agache I, Bonini S, Burks AW, Calderon M, et al. International consensus on allergy immunotherapy. J Allergy Clin Immunol. 2015;136(3):556–68.
Committee for Medicinal Products for Human Use at the European Medicines Agency. Guideline on the clinical development of products for specific immunotherapy for the treatment of allergic diseases, Draft CHMP/EWP/18504/2006. London: 2008. http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2009/09/WC500003605.pdf. Accessed 6 Jan 2016.
Horak F, Zieglmayer P, Zieglmayer R, Lemell P, Devillier P, Montagut A, et al. Early onset of action of a 5-grass-pollen 300IR sublingual immunotherapy tablet evaluated in an allergen challenge chamber. J Allergy Clin Immunol. 2009;124:471–7.
World Health Organization. Adherence to long-term therapies: evidence for action. Geneva: WHO; 2003. http://www.who.int/chp/knowledge/publications/adherence_full_report.pdf?ua=1. Accessed 6 Jan 2016.
Vrijens B, Urquhart J. Patient adherence to prescribed antimicrobial drug dosing regimens. J Antimicrob Chemother. 2005;55:616–27.
Vrijens B, De Geest S, Hughes DA, Przemyslaw K, Demonceau J, Ruppar T, et al. ABC project team: a new taxonomy for describing and defining adherence to medications. Br J Clin Pharmacol. 2012;73:691–705. doi:10.1111/j.1365-2125.2012.04167.x.
Braido F, Baiardini I, Menoni S, Brusasco V, Centanni S, Girbino G. Dal Negro R, Canonica GW. Asthma management failure: a flaw in physicians’ behavior or in patients’ knowledge? J Asthma. 2011;48:266–74. doi:10.3109/02770903.2011.555040.
Baiardini I, Puggioni F, Menoni S, Boot JD, Diamant Z, Braido F, Canonica GW. Patient knowledge, perceptions, expectations and satisfaction on allergen-specific immunotherapy: a survey. Respir Med. 2013;107:361–7. doi:10.1016/j.rmed.2012.11.004.
Barfod TS, Sørensen HT, Nielsen H, Rodkjaer L, Obel N. ‘Simply forgot’ is the most frequently stated reason for missed doses of HAART irrespective of degree of adherence. HIV Med. 2006;7:285–90.
Koster ES, Philbert D, de Vries TW, van Dijk L, Bouvy ML. “I just forget to take it”: asthma self-management needs and preferences in adolescents. J Asthma. 2015;52:831–7. doi:10.3109/02770903.2015.1020388.
Passalacqua G, Baiardini I, Senna G, Canonica GW. Adherence to pharmacological treatment and specific immunotherapy in allergic rhinitis. Clin Exp Allergy. 2013;43:22–8. doi:10.1111/j.1365-2222.2012.04052.x.
Senna G, Lombardi C, Canonica GW, Passalacqua G. How adherent to sublingual immunotherapy prescriptions are patients? The manufacturers’ viewpoint. J Allergy Clin Immunol. 2010;126:668–9. doi:10.1016/j.jaci.2010.06.045.
Sieber J, De Geest S, Shah-Hosseini K, Mosges R. Medication persistence with long-term, specific grass pollen immunotherapy measured by prescription renewal rates. Curr Med Res Opin. 2011;27:855–61.
Haynes RB, Ackloo E, Sahota N, McDonald HP, Yao X. Interventions for enhancing medication adherence. Cochrane Database Syst Rev. 2008;2:CD000011. doi:10.1002/14651858.CD000011.pub3.
Costa E, Giardini A, Savin M, Menditto E, Lehane E, Laosa O, Pecorelli S, Monaco A, Marengoni A. Interventional tools to improve medication adherence: review of literature. 2015;9:1303–14. doi:10.2147/PPA.S87551.
Lorig K. Common sense patient education. Ivanhoe: Fraser Publications; 1991.
Bastable SB. Nurse as Educator; principles of teaching and learning for nursing practice. 3rd ed. London: Jones and Bartlett; 2008.
Nielsen-Bohlman L, Panzer AM, Kindig DA. Institute of Medicine Committee on Health Literacy. Health literacy: a prescription to end confusion. Washington, DC: The National Academies Press; 2004.
Gazmararian JA, Baker DW, Williams MV, Parker RM, Scott TL, Green DC, Fehrenbach SN, Ren J, Koplan JP. Health literacy among medicare enrollees in a managed care organization. JAMA. 1999;281:545–51.
Kalichman SC, Ramachandran B, Catz S. Adherence to combination antiretroviral therapies in HIV patients of low health literacy. J Gen Intern Med. 1999;14:267–73.
Berkman ND, Sheridan SL, Donahue KE, Halpern DJ, Crotty K. Low health literacy and health outcomes: an updated systematic review. Ann Intern Med. 2011;155:97–107.
Al-Aqeel S, Al-Sabhan J. Strategies for improving adherence to anti-epileptic drug treatment in patients with epilepsy. Cochrane Database Syst Rev. 2011;1:CD008312.
http://www.kevinmd.com/blog/2013/10/patient-engagement-blockbuster-drug-century.html. Accessed 6 Jan 2016.
http://www.cfah.org/file/CFAH_Engagement_Behavior_Framework_current.pdf. Accessed 6 Jan 2016.
http://www.naqc.org/WhitePaper-PatientEngagement. Accessed 6 Jan 2016.
Kuo CC, Lin CC, Tsai FM. Effectiveness of empowerment-based self-management interventions on patients with chronic metabolic diseases: a systematic review and meta-analysis. Worldviews Evid Based Nurs. 2014;11:301–15. doi:10.1111/wvn.12066.
Anderson RM, Funnell MM, Aikens JE, Krein SL, Fitzgerald JT, Nwankwo R, Tannas CL, Tang TS. Evaluating the efficacy of an empowerment-based self-management consultant intervention: results of a 2-Year randomized controlled trial. Ther Patient Educ. 2009;1:3–11.
McGloin H, Timmins F, Coates V, Boore J. A case study approach to the examination of a telephone-based health coaching intervention in facilitating behaviour change for adults with Type 2 diabetes. J Clin Nurs. 2015;24:1246–57.
Rolinck-Werninghaus C, Trentmann M, Reich A, Lehmann C, Staab D. Improved management of childhood atopic dermatitis after individually tailored nurse consultations: a pilot study. Pediatr Allergy Immunol. 2015;26:805–10. doi:10.1111/pai.12338.
Breuer K, Matterne U, Diepgen TL, Fartasch M, Gieler U, Kupfer J, et al. Predictors of benefit from an atopic dermatitis education programme. Pediatr Allergy Immunol. 2014;25:489–95. doi:10.1111/pai.12249.
Passalacqua G. Specific immunotherapy: beyond the clinical scores. Ann Allergy Asthma Immunol. 2011;107:401–6. doi:10.1016/j.anai.2011.04.017.
Bousquet J, Schunemann HJ, Fonseca J, Samolinski B, Bachert C, Canonica GW, Casale T, et al. MACVIA-ARIA Sentinel network for allergic rhinitis (MASK-rhinitis): the new generation guideline implementation. Allergy. 2015;70:1372–92.
Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy. 2008;63:8–160.
Janson SL, McGrath KW, Covington JK, Cheng SC, Boushey HA. Individualized asthma self-management improves medication adherence and markers of asthma control. J Allergy Clin Immunol. 2009;123:840–6.
Cingi C, Yorgancioglu A, Cingi CC, Oguzulgen K, Muluk NB, Ulusoy S, et al. The “physician on call patient engagement trial” (POPET): measuring the impact of a mobile patient engagement application on health outcomes and quality of life in allergic rhinitis and asthma patients. Int Forum Allergy Rhinol. 2015;5:487–97. doi:10.1002/alr.21468.
Coffman JM, Cabana MD, Halpin HA, Yelin EH. Effects of asthma education on children’s use of acute care services: a meta-analysis. Pediatrics. 2008;121:575–86. doi:10.1542/peds.2007-0113.
Pinnock H, Epiphaniou E, Pearce G, Parke H, Greenhalgh T, Sheikh A, et al. Implementing supported self-management for asthma: a systematic review and suggested hierarchy of evidence of implementation studies. BMC Med. 2015;1(13):127. doi:10.1186/s12916-015-0361-0.
Morisky DE, Green LW, Levine DM. Concurrent and predictive validity of a self-reported measure of medication adherence. Med Care. 1986;24:67–74.
Demoly P, Jankowski R, Chassany O, Bessah Y, Allaert FA. Validation of a self-questionnaire for assessing the control of allergic rhinitis. Clin Exp Allergy. 2011;41:860–8.
Nathan RA, Sorkness CA, Kosinski M, Schatz M, Li JT, Marcus P, et al. Development of the asthma control test: a survey for assessing asthma control. J Allergy Clin Immunol. 2004;113:59–65.
Mistry N, Keepanasseril A, Wilczynski NL, Nieuwlaat R, Ravall M. Haynes RB; Patient Adherence Review Team. Technology-mediated interventions for enhancing medication adherence. J Am Med Inform Assoc. 2015;22:e177–93. doi:10.1093/jamia/ocu047.
Alesina R, Milani M, Pecora S. A multicenter, randomized, parallel-group trial assessing compliance, tolerability, safety, and efficacy to treatment with grass allergy tablets in 261 patients with grass pollen rhinoconjunctivitis. J Allergy (Cairo). 2012;2012:673502. doi:10.1155/2012/673502.
Marcano Belisario JS. Huckvale K, Greenfield G, Car J, Gunn LH. Smartphone and tablet self management apps for asthma. Cochrane Database Syst Rev. 2013;11:CD010013. doi:10.1002/14651858.CD010013.pub2.
Huckvale K, Car M, Morrison C, Car J. Apps for asthma self-management: a systematic assessment of content and tools. BMC Med. 2012;10:144. doi:10.1186/1741-7015-10-144.
Calderon MA, Cox L, Casale TB, Mösges R, Pfaar O, Malling HJ, et al. The effect of a new communication template on anticipated willingness to initiate or resume allergen immunotherapy: an internet-based patient survey. Allergy Asthma Clin Immunol. 2015;11:17. doi:10.1186/s13223-015-0083-z.
Lorig KR, Ritter P, Stewart AL, Sobel DS, Brown BW Jr, Bandura A, et al. Chronic disease self-management program: 2-year health status and health care utilization outcomes. Med Care. 2001;39:1217–23.
Penza-Clyve SM, Mansell C, McQuaid EL. Why don’t children take their asthma medications? A qualitative analysis of children’s perspectives on adherence. J Asthma. 2004;41:189–97.
Costa C, Menesatti P, Brighetti MA, Travaglini A, Rimatori V, Di Rienzo Businco A, Pelosi S, Bianchi A, Matricardi PM, Tripodi S. Pilot study on the short-term prediction of symptoms in children with hay fever monitored with e-Health technology. Eur Ann Allergy Clin Immunol. 2014;46:216–25.
All the authors conceived the review, analyzed the literature and drafted the manuscript. All authors read and approved the final manuscript.
We thank David Fraser D.Phil. (Biotech Communication SARL, Damery, France) for editorial support funded by Stallergenes Greer.
Pascal Demoly is a consultant and a speaker for Stallergenes, Circassia, ALK and Chiesi and was a speaker for Merck, Astra Zeneca, Pierre Fabre Médicaments, Menarini, Allergopharma and GlaxoSmithKline in 2010–2015. Giovanni Passalacqua is a consultant and speaker for Stallergenes, Lofarma, and has been a speaker for Allergopharma, ALK-Abellò, Chiesi, Novartis, GSK. Oliver Pfaar has received research grants for his institution from ALK Abello (Germany/Denmark), Allergopharma (Germany), Stallergenes (Germany/France), HAL Allergy (Germany/the Netherlands), Artu Biologicals (the Netherlands), Allergy Therapeutics/Bencard (UK/Germany), Hartington (Spain), Lofarma (Italy, Germany), Novartis/Leti (Germany/Spain), GlaxoSmithKline (UK/Germany), Essex Pharma (Germany), Cytos (Switzerland), Curalogic (Denmark), Roxall (Germany), Biomay (Austria), Nuvo (Germany), Circassia (UK), European Union (FP-7 Health-2013 Innovation 1), Biotech Tools s.a. (Belgium). He has received personal fees as speaker or as investigator or as consultant for Allergy Therapeutics/Bencard (UK/Germany), HAL Allergy (Germany, the Netherlands), Hartington (Spain), Lofarma (Italy, Germany), Novartis/Leti (Germany/Spain), MEDA (Germany), ALK Abello (Germany/Denmark), Allergopharma (Germany), Anergis (CH), Biotech Tools s.a. (Belgium), GfK Bridgehead (UK), Navigant Consulting (USA), Sanofi (USA), Roxall (Germany), Guidepoint Global Advisors (USA), MCX/GA2LEN (Germany), Thermo Fisher (Germany), Pohl-Boskamp (Germany), GEKA mbh (Germany) and Stallergenes (Germany/France). He has received fees for development of educational presentations from GlaxoSmithKline (Germany), Bencard (Germany), and Novartis (Germany). He is the current chairman of the Immunotherapy Interest Group (IT IG) of the European Academy of Allergy and Clinical Immunology (EAACI) and the secretary of the ENT section of the German Society for Allergology and Clinical Immunology (DGAKI). Joaquín Sastre reports having served as a consultant to Thermofisher, MSD, Novartis, Gennetech, Sanofi, Leti, Roche, FAES FARMA, and GSK; having been paid lecture fees by Novartis, GSK, Stallergenes, LETI and FAES FARMA; as well as having received grant support for research from Thermofisher, GSK, and ALK-Abello. Ulrich Wahn has received consulting fees from Stallergenes Merck, Allergopharma, Danone, Hipp and Novartis, honoraria for lectures from ALK, Allergy Therapeutics, Stallergenes, Allergopharma, Nestle, Nutricia, Novartis, MSD and LETI, and research funding from Stallergenes.
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Demoly, P., Passalacqua, G., Pfaar, O. et al. Patient engagement and patient support programs in allergy immunotherapy: a call to action for improving long-term adherence. Allergy Asthma Clin Immunol 12, 34 (2016). https://doi.org/10.1186/s13223-016-0140-2
- Patient engagement
- Patient support program
- Allergy immunotherapy