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  1. Content type: Case report

    Omalizumab is a human IgG1 antibody against IgE used as a therapy for sever asthmatic patients with asthma. According to the guidelines of the Global Initiative for Asthma, omalizumab is an add-on drug at trea...

    Authors: Yasuhiro Gon, Reiko Ito, Shuichiro Maruoka, Kenji Mizumura, Yutaka Kozu, Hisato Hiranuma, Yuko Iida, Sotaro Shikano and Shu Hashimoto

    Citation: Allergy, Asthma & Clinical Immunology 2017 13:39

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  2. Content type: Short Report

    Treat-to-target therapy approaches are established for chronic diseases such as diabetes, hypertension, and more recently rheumatoid arthritis, resulting in improved patient outcomes. These approaches do not u...

    Authors: Hermenio Lima, Melinda Gooderham, Jan Dutz, Charles Lynde, Hugo Chapdelaine, Anne Ellis, Martin Gilbert, Vincent Ho, Kim Papp, Yves Poulin and Gordon Sussman

    Citation: Allergy, Asthma & Clinical Immunology 2017 13:38

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  3. Content type: Research

    Sleep disorders are often underreported to physicians by patients with allergies. This study aimed to characterize the sleep disorders associated with respiratory allergy to house dust mites (HDM) at the time ...

    Authors: Damien Leger, Bénédicte Bonnefoy, Bernard Pigearias, Bertrand de La Giclais and Antoine Chartier

    Citation: Allergy, Asthma & Clinical Immunology 2017 13:36

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  4. Content type: Research

    To evaluate barrier protective properties of Rhinosectan® spray, a medical device containing xyloglucan, on nasal epithelial cells (MucilAir).

    Authors: Barbara De Servi, Francesco Ranzini and Núria Piqué

    Citation: Allergy, Asthma & Clinical Immunology 2017 13:37

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  5. Content type: Research

    Intelectin-1 (ITLN-1) is secreted by intestinal goblet cells and detectable in blood. Its expression is increased in IL-13-overexpressing mouse airways. However, its expression and function in human airways is...

    Authors: Taiji Watanabe, Kazuyuki Chibana, Taichi Shiobara, Rinna Tei, Ryosuke Koike, Yusuke Nakamura, Ryo Arai, Yukiko Horigane, Yasuo Shimizu, Akihiro Takemasa, Takeshi Fukuda, Sally E. Wenzel and Yoshiki Ishii

    Citation: Allergy, Asthma & Clinical Immunology 2017 13:35

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  6. Content type: Research

    Omalizumab is licensed as add-on therapy for patients with severe allergic asthma. Response is in most studies scored by the physician’s global evaluation of treatment effectiveness (GETE). A good clinical and...

    Authors: S. M. Snelder, E. J. M. Weersink and G. J. Braunstahl

    Citation: Allergy, Asthma & Clinical Immunology 2017 13:34

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  7. Content type: Research

    There is a paucity of studies examining the safety of venom immunotherapy (VIT) in children. We aimed to assess the incidence of anaphylactic side effects during rush VIT in a cohort of pediatric patients and ...

    Authors: Johanna Stoevesandt, Christine Hosp, Andreas Kerstan and Axel Trautmann

    Citation: Allergy, Asthma & Clinical Immunology 2017 13:32

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  8. Content type: Research

    Patients with hereditary angioedema (HAE) due to C1-inhibitor deficiency (C1-INH-HAE) experience recurrent attacks of cutaneous or submucosal edema that may be frequent and severe; prophylactic treatments can ...

    Authors: Werner Aberer, Marcus Maurer, Laurence Bouillet, Andrea Zanichelli, Teresa Caballero, Hilary J. Longhurst, Amandine Perrin and Irmgard Andresen

    Citation: Allergy, Asthma & Clinical Immunology 2017 13:31

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  9. Content type: Meeting abstracts

    Authors: Alvin H. Schmaier, Marco Cicardi, Avner Reshef, Dumitru Moldovan, Attila Mócsai, Margarita López-Trascasa, Alberto López Lera, Nancy J. Brown, Anastasios E. Germenis, Rafael Filippelli-Silva, Diego A. Duarte, Renan P. Martin, Camila L. Veronez, Michel Bouvier, Michael Bader, Claudio M. Costa-Neto…

    Citation: Allergy, Asthma & Clinical Immunology 2017 13(Suppl 2):29

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    This article is part of a Supplement: Volume 13 Supplement 2

  10. Content type: Research

    Asthma is an independent risk factor for invasive pneumococcal disease; however, the immune response of adult asthma patients to pneumococcal vaccination is unknown. We explore the serologic response of patien...

    Authors: C. R. Laratta, K. Williams, D. Vethanayagam, M. Ulanova and H. Vliagoftis

    Citation: Allergy, Asthma & Clinical Immunology 2017 13:27

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  11. Content type: Research

    Many studies have identified associations between qualities of maternal–child relationships and childhood asthma, but few have examined associations with childhood atopic dermatitis (AD), a common precursor to...

    Authors: Nicole L. Letourneau, Anita L. Kozyrskyj, Nela Cosic, Henry N. Ntanda, Lubna Anis, Martha J. Hart, Tavis S. Campbell and Gerald F. Giesbrecht

    Citation: Allergy, Asthma & Clinical Immunology 2017 13:26

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  12. Content type: Research

    Up-regulation of interleukin 17 (IL-17) family cytokines and acute phase response have been observed in patients with chronic spontaneous urticaria (CSU). It has been demonstrated that IL-17 stimulates C-react...

    Authors: A. Grzanka, A. Damasiewicz-Bodzek and A. Kasperska-Zajac

    Citation: Allergy, Asthma & Clinical Immunology 2017 13:25

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  13. Content type: Research

    Success in asthma management hinges on patients’ competency to detect and respond to ever-changing symptom severity. Thus, it is crucial to have reliable, simple, and sustainable methods of symptom monitoring ...

    Authors: Hyekyun Rhee, Michael Belyea and Jennifer Mammen

    Citation: Allergy, Asthma & Clinical Immunology 2017 13:24

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  14. Content type: Case Report

    Mastocytosis are rare diseases characterized by an accumulation of clonal mast cells (MCs) in one or multiple organs or tissues. Patients with systemic mastocytosis (SM), whose MCs frequently arbor the activat...

    Authors: Iolanda Conde-Fernandes, Rita Sampaio, Filipa Moreno, José Palla-Garcia, Maria dos Anjos Teixeira, Inês Freitas, Esmeralda Neves, Maria Jara-Acevedo, Luis Escribano and Margarida Lima

    Citation: Allergy, Asthma & Clinical Immunology 2017 13:21

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  15. Content type: Research

    The mechanisms through which allergies can be inhibited after preconception immunization with allergens are not fully understood. We aimed to evaluate whether maternal immunization can induce a regulatory B (B...

    Authors: Marília Garcia de Oliveira, Luana de Mendonça Oliveira, Aline Aparecida de Lima Lira, Fábio da Ressureição Sgnotto, Alberto José da Silva Duarte, Maria Notomi Sato and Jefferson Russo Victor

    Citation: Allergy, Asthma & Clinical Immunology 2017 13:22

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  16. Content type: Research

    Interleukin-31 (IL-31) is a recently identified cytokine produced by Th2 cells that is involved in the development of atopic dermatitis-induced skin inflammation and pruritus. Its receptor, IL-31RA, is express...

    Authors: Saburo Saito, Ayana Aoki, Iwao Arai, Shinya Takaishi, Haruyasu Ito, Nobutake Akiyama and Hiroshi Kiyonari

    Citation: Allergy, Asthma & Clinical Immunology 2017 13:23

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  17. Content type: Meeting abstracts

    Authors: Mohammad A. Alsayegh, Hanan Alshamali, Mousa Khadada, Amanda Ciccolini, Anne K. Ellis, Diana Quint, William Powley, Laurie Lee, Yahya Fiteih, Shairaz Baksh, Harissios Vliagoftis, Sebastien K. Gerega, Brad Millson, Katia Charland, Stephane Barakat, Xichun Sun…

    Citation: Allergy, Asthma & Clinical Immunology 2017 13(Suppl 1):16

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    This article is part of a Supplement: Volume 13 Supplement 1

  18. Content type: Research

    Antagonism of chemoattractant receptor-homologous molecule on T-helper type-2 cells (CRTH2), a G-protein coupled receptor for prostaglandin D2, could be beneficial for treating allergic disorders. We present f...

    Authors: Paul Ratner, Charles P. Andrews, Frank C. Hampel, Bruce Martin, Dale E. Mohar, Denis Bourrelly, Parisa Danaietash, Sara Mangialaio, Jasper Dingemanse, Abdel Hmissi and Jay van Bavel

    Citation: Allergy, Asthma & Clinical Immunology 2017 13:18

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  19. Content type: Research

    Food allergen labeling is an important tool to reduce risk of exposure and prevent anaphylaxis for individuals with food allergies. Health Canada released a Canadian food allergen labeling regulation (2008) an...

    Authors: Carlo A. Marra, Stephanie Harvard, Maja Grubisic, Jessica Galo, Ann Clarke, Susan Elliott and Larry D. Lynd

    Citation: Allergy, Asthma & Clinical Immunology 2017 13:19

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  20. Content type: Research

    Prednisone dependence in asthma is usually described based on clinical and spirometric characteristics. It is generally believed that these patients have frequent exacerbations and lose lung function rapidly b...

    Authors: Afia Aziz-Ur-Rehman, Angira Dasgupta, Melanie Kjarsgaard, Frederick E. Hargreave and Parameswaran Nair

    Citation: Allergy, Asthma & Clinical Immunology 2017 13:17

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  21. Content type: Research

    It is well-known that lymphocytes play an important role in systemic lupus erythematosus (SLE). T cell immunoreceptor with Ig and immunoreceptor tyrosine-based inhibitory domains (TIGIT) is one of immunosuppre...

    Authors: Qing Luo, Jianqing Ye, Lulu Zeng, Xue Li, Le Fang, Beihua Ju, Zikun Huang and Junming Li

    Citation: Allergy, Asthma & Clinical Immunology 2017 13:15

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  22. Content type: Research

    Asthma is an increasingly common chronic disease among children, and data point toward a complex mechanism involving genetic, environmental and epigenetic factors. Epigenetic modifications such as DNA hypo- or...

    Authors: L. Montrose, T. J. Ward, E. O. Semmens, Y. H. Cho, B. Brown and C. W. Noonan

    Citation: Allergy, Asthma & Clinical Immunology 2017 13:12

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  23. Content type: Review

    The use of gene therapy (GT) for the treatment of primary immune deficiencies (PID) including severe combined immune deficiency (SCID) has progressed significantly in the recent years. In particular, long-term...

    Authors: Xiaobai Xu, Chetankumar S. Tailor and Eyal Grunebaum

    Citation: Allergy, Asthma & Clinical Immunology 2017 13:14

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  24. Content type: Case Report

    Thymoglobulin® (anti-thymocyte globulin [rabbit]) is a purified pasteurised, gamma immune globulin obtained by immunisation of rabbits with human thymocytes. Anaphylactic allergic reactions to a first injectio...

    Authors: S. Brabant, A. Facon, F. Provôt, M. Labalette, B. Wallaert and C. Chenivesse

    Citation: Allergy, Asthma & Clinical Immunology 2017 13:13

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  25. Content type: Letter to the editor

    As standard drug treatment of allergic rhinitis (AR) is not completely satisfactory, allergen immunotherapy (AIT) represents the only current treatment with the potential to modify the natural history. House d...

    Authors: Giorgio Ciprandi, Valentina Natoli, Paola Puccinelli and Cristoforo Incorvaia

    Citation: Allergy, Asthma & Clinical Immunology 2017 13:11

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  26. Content type: Research

    Peanut sensitization does not necessarily indicate clinical peanut allergy, and uncertainty as to whether or not there is true peanut allergy can lead to increased anxiety and decreased quality of life for pat...

    Authors: Elizabeth Simms, Gary Foster, Katherine Arias, Mark Larché, Tosha Freitag, Tina Walker, Susanna Goncharova, Andrea Marrin, Andreas Freitag, Manel Jordana and Susan Waserman

    Citation: Allergy, Asthma & Clinical Immunology 2017 13:10

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  27. Content type: Research

    We aimed to determine the effect of sampling time during the day on serum periostin levels in adult participants with and without asthma.

    Authors: Rachel Caswell-Smith, Terrianne Cripps, Thom Charles, Alexander Hosking, Meghana Handigol, Cecile Holweg, John Matthews, Mark Holliday, Corentin Maillot, James Fingleton, Mark Weatherall, Richard Beasley and Irene Braithwaite

    Citation: Allergy, Asthma & Clinical Immunology 2017 13:8

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  28. Content type: Research

    The prevalence of sensitization varies geographically based on multiple environmental factors including humidity. The aim of this study was to determine the prevalence of atopy in symptomatic adults. More impo...

    Authors: Stacey D. Lok, Beth E. Davis and Donald W. Cockcroft

    Citation: Allergy, Asthma & Clinical Immunology 2017 13:9

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  29. Content type: Letter to the editor

    The Addendum Guidelines for the Prevention of Peanut Allergy in the United StatesReport of the NIAID-Sponsored Expert Panel were developed to build on previous food allergy guidelines after several key studies d...

    Authors: Kyla Jade Hildebrand, Elissa Michele Abrams, Timothy K. Vander Leek, Julia Elizabeth Mainwaring Upton, Douglas P. Mack, Linda Kirste, Christine McCusker and Sandeep Kapur

    Citation: Allergy, Asthma & Clinical Immunology 2017 13:7

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  30. Content type: Research

    Shrimp and house dust mite (HDM) allergies are common in Canadians. Often, both of these allergies occur in the same patient. This may be due to homology of tropomyosin or other potentially shared proteins. Th...

    Authors: Lana Rosenfield, Michael William Tsoulis, Kirolos Milio, Meghan Schnittke and Harold Kim

    Citation: Allergy, Asthma & Clinical Immunology 2017 13:5

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  31. Content type: Short report

    Hereditary angioedema (HAE) is a rare but serious condition characterized by recurrent spontaneous attacks of angioedema affecting superficial tissues of upper respiratory and gastrointestinal tracts. The pote...

    Authors: Nina Lakhani Jindal, Elaine Harniman, Nieves Prior, Elia Perez-Fernandez, Teresa Caballero and Stephen Betschel

    Citation: Allergy, Asthma & Clinical Immunology 2017 13:4

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  32. Content type: Position article and guidelines

    Food allergy is an important public health problem because it affects children and adults, can be severe and even life-threatening, and may be increasing in prevalence. Beginning in 2008, the National Institut...

    Authors: Alkis Togias, Susan F. Cooper, Maria L. Acebal, Amal Assa’ad, James R. Baker, Lisa A. Beck, Julie Block, Carol Byrd-Bredbenner, Edmond S. Chan, Lawrence F. Eichenfield, David M. Fleischer, George J. Fuchs III, Glenn T. Furuta, Matthew J. Greenhawt, Ruchi S. Gupta, Michele Habich…

    Citation: Allergy, Asthma & Clinical Immunology 2017 13:1

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  33. Content type: Case report

    Anti-interleukin (IL)-5 monoclonal antibodies as an eosinophil-depleting strategy is well established, with Mepolizumab being the first biologic approved as an adjunct treatment for severe eosinophilic asthma.

    Authors: Manali Mukherjee, Hui Fang Lim, Sruthi Thomas, Douglas Miller, Melanie Kjarsgaard, Bruce Tan, Roma Sehmi, Nader Khalidi and Parameswaran Nair

    Citation: Allergy, Asthma & Clinical Immunology 2017 13:2

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  34. Content type: Case report

    Anaphylactic reactions involving IgE mediated hypersensitivity have been frequently reported for a number of uncommon foods. However, cases of anaphylaxis to over the counter vitamins and oral supplements have...

    Authors: M. R. Voisin and R. Borici-Mazi

    Citation: Allergy, Asthma & Clinical Immunology 2016 12:66

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  35. Content type: Case report

    Polyethylene glycols (PEGs) or macrogols are polyether compounds and are widely used as additives in pharmaceuticals, cosmetics, and food.

    Authors: Katharina Wylon, Sabine Dölle and Margitta Worm

    Citation: Allergy, Asthma & Clinical Immunology 2016 12:67

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  36. Content type: Meeting abstracts

    Authors: Marie-Claire Arrieta, Andrea Arevalos, Leah Stiemsma, Marta E. Chico, Carlos Sandoval, Minglian Jin, Jens Walter, Phil Cooper, Brett Finlay, Emilie Bernatchez, Matthew J. Gold, Anick Langlois, Pascale Blais-Lecours, Caroline Duchaine, David Marsolais, Kelly M. McNagny…

    Citation: Allergy, Asthma & Clinical Immunology 2016 12(Suppl 2):63

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    This article is part of a Supplement: Volume 12 Supplement 2

  37. Content type: Research

    New Zealand is a developed geographically isolated country in the South Pacific with a population of 4.4 million. Genetic diagnosis is the standard of care for most patients with primary immunodeficiency disor...

    Authors: See-Tarn Woon and Rohan Ameratunga

    Citation: Allergy, Asthma & Clinical Immunology 2016 12:65

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  38. Content type: Research

    Primary immunodeficiency (PID) is a heterogeneous group of inheritable genetic disorders with increased susceptibility to infections, autoimmunity, uncontrolled inflammation and malignancy. Timely precise diag...

    Authors: Saba Sheikhbahaei, Roya Sherkat, Dirk Roos, Majid Yaran, Somayeh Najafi and Alireza Emami

    Citation: Allergy, Asthma & Clinical Immunology 2016 12:62

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  39. Content type: Research

    Component resolved allergen diagnosis allows for a precise evaluation of the sensitization profiles of patients sensitized to felines and canines. An accurate interpretation of these results allows better insi...

    Authors: Natalia Ukleja-Sokołowska, Ewa Gawrońska-Ukleja, Magdalena Żbikowska-Gotz, Ewa Socha, Kinga Lis, Łukasz Sokołowski, Andrzej Kuźmiński and Zbigniew Bartuzi

    Citation: Allergy, Asthma & Clinical Immunology 2016 12:61

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  40. Content type: Review

    In patients with chronic obstructive pulmonary disease (COPD), over-activated T-lymphocytes produce pro-inflammatory cytokines and proliferate in situ in the lower airways and pulmonary parenchyma, contributin...

    Authors: Itsuro Kazama and Tsutomu Tamada

    Citation: Allergy, Asthma & Clinical Immunology 2016 12:60

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  41. Content type: Research

    Research suggests that 90% of patients labeled beta-lactam allergic are able to tolerate penicillins following further assessment. This study aims to define and describe the frequency of true beta-lactam aller...

    Authors: Elissa M. Abrams, Andrew Wakeman, Tom V. Gerstner, Richard J. Warrington and Alexander G. Singer

    Citation: Allergy, Asthma & Clinical Immunology 2016 12:59

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  42. Content type: Research

    Cat allergy is of great importance, and its prevalence is increasing worldwide. Cat allergens and house dust mite allergens represent the major indoor allergens; however, they are ubiquitous. Cat sensitization...

    Authors: Katharina Eder, Sven Becker, Marion San Nicoló, Alexander Berghaus and Moritz Gröger

    Citation: Allergy, Asthma & Clinical Immunology 2016 12:58

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