Articles

Use of mepolizumab in adult patients with cystic fibrosis and an eosinophilic phenotype: case series

Cystic fibrosis (CF) is characterized by inflammation, progressive lung disease, and respiratory failure. Although the relationship is not well understood, patients with CF are thought to have a higher prevale...

Authors: Lijia Zhang, Larry Borish, Anna Smith, Lindsay Somerville and Dana Albon

Type II acquired cutis laxa associated with recurrent urticarial vasculitis: brief report

Cutis laxa is a connective tissue disease characterized by loose, wrinkled, and redundant skin. It is either inherited or acquired. In most cases, acquired cutis laxa is associated with neoplasms, drugs, and a...

Authors: Amelia Nabatanzi, Siqi Da, Musa Male, Siyuan Chen and Changzheng Huang

Kimura’s disease affecting multiple body parts in a 57-year-old female patient: a case report

Kimura’s disease (KD) is a rare chronic inflammatory disease with unknown etiology. It usually manifests as a painless soft tissue mass or subcutaneous nodule on one side of the patient’s head and/or neck and ...

Authors: Bo Yu, Guoxing Xu, Xiaofan Liu, Wen Yin, Hao Chen and Baoqing Sun

Expression of COX-1, COX-2, 5-LOX and \(\hbox {CysLT}_2\) in nasal polyps and bronchial tissue of patients with aspirin exacerbated airway disease

Aspirin exacerbated respiratory disease (AERD) is a disease of the upper and lower airways. It is characterized by severe asthma, chronic sinusitis with nasal polyps (CRSwNP) and intolerance towards nonsteroid...

Authors: Monique Vorsprach, Christoph Arens, Stephan Knipping, Dörte Jechorek, Sabine Stegemann-Koniszewski, Eva Lücke and Jens Schreiber

Co-exposure to lipopolysaccharide and desert dust causes exacerbation of ovalbumin-induced allergic lung inflammation in mice via TLR4/MyD88-dependent and -independent pathways

Lipopolysaccharide (LPS) often presents in high concentrations in particulate matter (PM), few studies have reported the enhancing effects of both LPS and PM on airway inflammation in mice and the role of toll...

Authors: Yahao Ren, Takamichi Ichinose, Miao He, Seiichi Youshida, Masataka Nishikawa and Guifan Sun

The impact of perennial allergic rhinitis with/without allergic asthma on sleep, work and activity level

Allergic respiratory diseases such as allergic rhinitis (AR) and allergic asthma (AA) are common conditions that can influence sleep and daytime functioning. However, the significance of this impact is unclear...

Authors: Mercedes Rodriguez Romano, Stephanie James, Emily Farrington, Richard Perry and Lisa Elliott

Diagnosis of Vespa affinis venom allergy: use of immunochemical methods and a passive basophil activation test

Allergy to Vespa affinis venom is common in the Asia Pacific region. Venom preparations for diagnosis are not commercially available for this species.

Authors: Peshala Gunasekara, S. M. Handunnetti, Sunil Premawansa, Pradeep Kaluarachchi, Chandima Karunatilake, Indra P. Ratnayake, R. K. S. Dias, G. A. S. Premakumara, W. M. D. K. Dasanayake, Suranjith L. Seneviratne and Rajiva de Silva

Mechanism(s) of prolonged attenuation of allergic responses after modulation of idiotypic regulatory network

We showed previously that allergic reactivity to ovalbumin (OVA) could be regulated in mice following perturbation of immune networks using combinations of an immune Ig along with anti-idiotypic Ig. We have ex...

Authors: R. M. Gorczynski, T. Maqbool and G. Hoffmann

The critical role of histology in distinguishing sarcoidosis from common variable immunodeficiency disorder (CVID) in a patient with hypogammaglobulinemia

Common variable immunodeficiency disorders (CVID) are a rare group of primary immune defects, where the underlying cause is unknown. Approximately 10–20% of patients with typical CVID have a granulomatous vari...

Authors: Rohan Ameratunga, Yeri Ahn, Dominic Tse, See-Tarn Woon, Jennifer Pereira, Sinead McCarthy and Hilary Blacklock

Proteomic features characterization of Hymenoptera venom allergy

Hymenoptera venom allergy is one of the most frequent causes of anaphylaxis. In its most severe form, the reaction to wasp and honey bee stings may be life-threatening. Therefore, immediate and proper diagnosis o...

Authors: Eliza Matuszewska, Joanna Matysiak, Anna Bręborowicz, Katarzyna Olejniczak, Zdzisława Kycler, Zenon J. Kokot and Jan Matysiak

Bronchoscopy-guided bronchial epithelium sampling as a tool for selecting the optimal biologic treatment in a patient with severe asthma: a case report

There are numerous biologics for treating patients with severe asthma. A cost-effective method for selecting the most appropriate biologic therapy for a patient is thus important. Bronchoscopy-guided bronchial...

Authors: Chin-Wei Kuo, Xin-Min Liao, Yi-Ching Huang, Han-Yu Chang and Chi-Chang Shieh

Does unified allergic airway disease impact on lung function and type 2 biomarkers?

The concept of the unified allergic airway disease (UAD) recognises the association between allergic inflammation in the upper and lower airways. Patients with asthma and concomitant allergic rhinitis experien...

Authors: Chris RuiWen Kuo, Rory Chan and Brian Lipworth

Short-term skin problems in infants aged 0–3 months affect food allergies or atopic dermatitis until 2 years of age, among infants of the general population

This study examined whether infants aged 0–3 months exhibited long-term effects of using a moisturizer skincare intervention and whether a short-term skin problem resulted in the subsequent development of food...

Authors: Kaori Yonezawa and Megumi Haruna

Use of a vibrating mesh nebulizer for allergen challenge

Allergen inhalation tests are a valuable research tool. The allergen dose producing an early asthmatic response (EAR) can be predicted from methacholine responsiveness and allergen skin test endpoint (STE). Th...

Authors: Donald W. Cockcroft, Beth E. Davis, Christianne M. Blais, Louis-Philippe Boulet, Marie-Éve Boulay, Hélène Villeneuve, Gail M. Gauvreau, Paul M. O’Byrne, Karen J. Howie and Caitlin D. Obminski

The International/Canadian Hereditary Angioedema Guideline

This is an update to the 2014 Canadian Hereditary Angioedema Guideline with an expanded scope to include the management of hereditary angioedema (HAE) patients worldwide. It is a collaboration of Canadian and ...

Authors: Stephen Betschel, Jacquie Badiou, Karen Binkley, Rozita Borici-Mazi, Jacques Hébert, Amin Kanani, Paul Keith, Gina Lacuesta, Susan Waserman, Bill Yang, Emel Aygören-Pürsün, Jonathan Bernstein, Konrad Bork, Teresa Caballero, Marco Cicardi, Timothy Craig…

Association between methylation in nasal epithelial TSLP gene and chronic rhinosinusitis with nasal polyps

This study was performed to determine whether there was any association between abnormal DNA methylation of a thymic stromal lymphopoietin (TSLP) locus and pathogenesis of chronic rhinosinusitis (CRS).

Authors: Jingyun Li, Jian Jiao, Yunbo Gao, Yuan Zhang and Luo Zhang

Agreement between self-reported asthma symptoms and exhaled nitric oxide levels: impact on inhaled corticosteroid prescribing in general practice. An observational study

The National Review of Asthma Deaths UK highlighted that 46% of deaths could be avoided and recommended that all sufferers receive a structured asthma annual review which assess asthma control. In primary care...

Authors: Raj Gill and E. Mark Williams

Methodological evaluation of human research on asthmagenicity and occupational cleaning: a case study of quaternary ammonium compounds (“quats”)

In this paper, we review methodological approaches used in studies that evaluated the association between occupational exposure to quaternary ammonium compounds (quats) and occupational asthma. This associatio...

Authors: Judy S. LaKind and Michael Goodman

A novel mutation in NCF2 resulting in very-early-onset colitis and juvenile idiopathic arthritis in a patient with chronic granulomatous disease

Chronic granulomatous disease (CGD) is a rare primary immunodeficiency disorder caused by a defect in the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex. The disease primarily presents wit...

Authors: Suzan AlKhater

Whole blood vs PBMC: compartmental differences in gene expression profiling exemplified in asthma

Blood has proven to be a useful resource for molecular analysis in numerous biomedical studies, with peripheral blood mononuclear cells (PBMCs) and whole blood being the major specimen types. However, comparat...

Authors: Daniel He, Chen Xi Yang, Basak Sahin, Amrit Singh, Casey P. Shannon, John-Paul Oliveria, Gail M. Gauvreau and Scott J. Tebbutt

Review of the Manitoba cohort of patients with hereditary angioedema with normal C1 inhibitor

Hereditary angioedema with normal C1 inhibitor (HAE-nC1 INH) is a rare, underappreciated condition characterized by recurrent subcutaneous angioedema. The underlying pathophysiology and diagnostic criteria con...

Authors: Lundy McKibbin, Colin Barber, Chrystyna Kalicinsky and Richard Warrington

Gender differences in asthma perception and its impact on quality of life: a post hoc analysis of the PROXIMA (Patient Reported Outcomes and Xolair^® In the Management of Asthma) study

Gender differences in asthma perception and control have been reported. The PROXIMA observational study assessed these outcomes in a cohort of Italian severe allergic asthma (SAA) patients. This post hoc analy...

Authors: Delia Colombo, Emanuela Zagni, Fabio Ferri and Giorgio Walter Canonica

Differential expression of CCR2 and CX₃CR1 on CD16⁺ monocyte subsets is associated with asthma severity

Monocytes play an important role in immune and inflammatory diseases and monocyte subsets are predictors of disease in certain conditions. Expression of the chemokine receptors, CCR2 and CX₃CR1 on monocyte subset...

Authors: Reem Al-Rashoudi, Gillian Moir, Mohamed S. Al-Hajjaj, Monther M. Al-Alwan, Heather M. Wilson and Isabel J. Crane

Plasma cytokine profiles associated with rhodesiense sleeping sickness and falciparum malaria co-infection in North Eastern Uganda

Immunological Human African Trypanosomiasis (HAT) studies often exclude malaria, although both infections overlap in specific endemic areas. During this co-infection, it is not known whether this parasitic int...

Authors: Julius Nsubuga, Charles Drago Kato, Ann Nanteza, Enock Matovu and Vincent Pius Alibu

The association between caesarean section and childhood asthma: an updated systematic review and meta-analysis

Investigating the association between caesarean section (SC) and childhood asthma has shown contradictory results in different studies. The present study was conducted to determine the association between SC a...

Authors: Behzad Darabi, Shoboo Rahmati, Mohammad Reza HafeziAhmadi, Gholamreza Badfar and Milad Azami

CSACI position statement: Newer generation H₁-antihistamines are safer than first-generation H₁-antihistamines and should be the first-line antihistamines for the treatment of allergic rhinitis and urticaria

Oral H₁-antihistamines (AHs) are the most commonly used therapy to treat allergic rhinitis and chronic urticaria. Older, first-generation AHs (e.g. diphenhydramine, hydroxyzine) have significant and common side e...

Authors: Michael N. Fein, David A. Fischer, Andrew W. O’Keefe and Gord L. Sussman

Oral immunotherapy with peach juice in patients allergic to LTPs

To assess the safety and efficacy of an oral immunotherapy regimen in patients with allergy to lipid transfer proteins (LTPs).

Authors: Begoña Navarro, Eladia Alarcón, Ángela Claver, Mariona Pascal, Araceli Díaz-Perales and Anna Cisteró-Bahima

Haemopoietic stem cell transplantation in Systemic lupus erythematosus: a systematic review

Despite advances in treating Systemic lupus erythematosus (SLE), a proportion of patients continue to face significant morbidity and mortality. Haemopoietic stem cell transplant (HSCT) has been recognized as a...

Authors: Nipun Lakshitha de Silva and Suranjith L. Seneviratne

Serum IL-1β can be a biomarker in children with severe persistent allergic rhinitis

Allergic rhinitis (AR) is one of the most common diseases globally and usually persists throughout life. In the present study, we aimed to determine whether the expression of inflammatory biomarkers has a rela...

Authors: Myung Woul Han, Song Hee Kim, Inbo Oh, Yang Ho Kim and Jiho Lee

Maternal food allergy is associated with daughters’ menarche in early adolescence

Associations between allergic disease and puberty amongst females have been widely studied. However, this association has received less attention in multigenerational populations. To this end, we sought to exa...

Authors: Jennifer Lisa Penner Protudjer, Elissa Michelle Abrams, Anita Luba Kozyrskyj and Allan Barry Becker

Stress, pseudoallergens, autoimmunity, infection and inflammation in chronic spontaneous urticaria

Chronic spontaneous urticaria (CSU) is often associated with organ specific autoimmunity but is rarely caused by food allergy. Colourings and preservatives in pre-packaged foods, so called pseudoallergens, hav...

Authors: Ciara Jade Bansal and Amolak Singh Bansal

Successful management of severe asthma in a young boy with eosinophilic chronic rhinosinusitis who received omalizumab: a case report

The incidence of chronic rhinosinusitis with nasal polyps has recently increased in Japan and other East Asian countries, and this disease is called eosinophilic chronic sinusitis (ECRS) in Japan. ECRS usually...

Authors: Yasuho Shoda, Misa Watanabe, Kota Wada, Takehiko Soutome, Yumiko Komine, Tetsuo Mikami, Tetsuo Nemoto and Akira Ohara

Food allergy-related concerns during the transition to self-management

Compared to non-allergic individuals, food allergic individuals have impaired health-related quality of life (HRQL). However, effects of gender and age are unclear. The objective of our study was to describe a...

Authors: Jennifer Lisa Penner Protudjer, Roelinde Middelveld, Sven-Erik Dahlén and Staffan Ahlstedt

Efficacy of add-on mepolizumab in adolescents with severe eosinophilic asthma

Adolescents (12–17 years of age) with severe eosinophilic asthma experience frequent exacerbations and reduced lung function leading to poor health-related quality of life. Mepolizumab is approved for add-on m...

Authors: Steven W. Yancey, Hector G. Ortega, Oliver N. Keene and Eric S. Bradford

Shared prenatal impacts among childhood asthma, allergic rhinitis and atopic dermatitis: a population-based study

Increasing prevalence of childhood allergic diseases including asthma is a global health concern, and we aimed to investigate prenatal risk factors for childhood asthma and to address the potential shared pren...

Authors: Ching-Heng Lin, Jiun-Long Wang, Hsin-Hua Chen, Jeng-Yuan Hsu and Wen-Cheng Chao

Hypersensitivity reactions to high osmolality Total Parenteral Nutrition: a case report

The full range of allergic reactions to Total Parenteral Nutrition (TPN) remains unknown. Additionally, beyond individual allergens, there may be other factors contributing to TPN hypersensitivity reactions.

Authors: Steph A. Pang, Shaun Eintracht, Jesse M. Schwartz, Belinda Lobo and Elizabeth MacNamara

Structural alterations and markers of endothelial activation in pulmonary and bronchial arteries in fatal asthma

There is interest in better understanding vessel pathology in asthma, given the findings of loss of peripheral vasculature associated with disease severity by imaging and altered markers of endothelial activat...

Authors: Renata Calciolari Rossi, Raquel Anonni, Diogenes Seraphim Ferreira, Luiz Fernando Ferraz da Silva and Thais Mauad

Subcutaneous C1 inhibitor for prevention of attacks of hereditary angioedema: additional outcomes and subgroup analysis of a placebo-controlled randomized study

Hereditary angioedema (HAE) is a debilitating disorder resulting from C1-esterase inhibitor (C1-INH) deficiency. In the COMPACT phase 3 study the prophylactic use of a subcutaneous C1 inhibitor (C1-INH [SC], H...

Authors: H. Henry Li, Bruce Zuraw, Hilary J. Longhurst, Marco Cicardi, Konrad Bork, James Baker, William Lumry, Jonathan Bernstein, Michael Manning, Donald Levy, Marc A. Riedl, Henrike Feuersenger, Subhransu Prusty, Ingo Pragst, Thomas Machnig and Timothy Craig

Short-term pulmonary infiltrate with eosinophilia caused by asthma: a phenotype of severe, eosinophilic asthma? Five cases and a review of the literature

Asthma is often accompanied by peripheral eosinophilia and eosinophilic airway inflammation. This article explores the relationship between asthma and short-term pulmonary infiltrate with eosinophilia, which r...

Authors: Min Song, Shan Cai, Hong Luo, Yi Jiang, Min Yang, Yan Zhang, Hong Peng and Ping Chen

Graft versus host disease and microchimerism in a JAK3 deficient patient

The lymphohematopoietic cells originating from feto-maternal trafficking during pregnancy may cause microchimerism and lead to materno-fetal graft versus host disease (GVHD) in severe combined immunodeficiency...

Authors: Zahra Shahbazi, Nima Parvaneh, Shirin Shahbazi, Hamzeh Rahimi, Mohammad Hamid, Davoud Shahbazi, Samaneh Delavari, Hassan Abolhassani, Asghar Aghamohammadi and Reza Mahdian

Sestrin2 is involved in asthma: a case–control study

Asthma is a chronic disease that seriously harms the health of patients. Oxidative stress is involved in asthma. As an oxidative stress-inducible protein, sestrin2 is elevated in oxidative stress-related disea...

Authors: Yanfang Kang, Chen Chen, Xiaotian Hu, Xiaohua Du, Huifen Zhai, Yan Fang, Xiulin Ye, Weimin Yang and Shibo Sun

Abstracts of 11th C1-inhibitor Deficiency & Angioedema Workshop

Authors:

Endogenous stimulation is responsible for the high frequency of IL-17A-producing neutrophils in patients with rheumatoid arthritis

Neutrophils play an important role in the pathogenesis of rheumatoid arthritis (RA). It has recently been reported that in addition to T helper (Th) 17 cells, other cells, including neutrophils, produce IL-17A...

Authors: Maria Gonzalez-Orozco, Rosa E. Barbosa-Cobos, Paola Santana-Sanchez, Lizbeth Becerril-Mendoza, Leonardo Limon-Camacho, Ana I. Juarez-Estrada, Gustavo E. Lugo-Zamudio, Jose Moreno-Rodriguez and Vianney Ortiz-Navarrete

Epigenome-wide association study of asthma and wheeze characterizes loci within HK1

To identify novel epigenetic markers of adolescent asthma and replicate findings in an independent cohort, then explore whether such markers are detectable at birth, predictive of early-life wheeze, and associ...

Authors: Todd M. Everson, Hongmei Zhang, Gabrielle A. Lockett, Akhilesh Kaushal, Melinda Forthofer, Susan L. Ewart, Kimberley Burrows, Caroline L. Relton, Gemma C. Sharp, A. John Henderson, Veeresh K. Patil, Faisal I. Rezwan, S. Hasan Arshad, John W. Holloway and Wilfried Karmaus

Allergen sensitization pattern of allergic adults and children in southern China: a survey based on real life data

Allergic diseases are increasing yearly. We aimed to evaluate the difference in allergen sensitization pattern between adults and children in southern China by analyzing a large sample size of real-life data, ...

Authors: Wenting Luo, Haisheng Hu, Wangbing Tang, Xiangwei Zou, Huimin Huang, Zhifeng Huang, Yong Liu and Baoqing Sun

Clinical and pulmonary function changes in cough variant asthma with small airway disease

It is known that small airway disease is present across all asthma severities; however, its prevalence and clinical characteristics in cough variant asthma (CVA) have not been fully illuminated.

Authors: Honglei Yuan, Xiaojing Liu, Li Li, Gang Wang, Chunfang Liu, Yuzhen Zeng, Ruolin Mao, Chunling Du and Zhihong Chen

Proceedings of the Canadian Society of Allergy and Clinical Immunology Annual Scientific Meeting 2018: Part Two

Authors:

Maternal diet before and during pregnancy and risk of asthma and allergic rhinitis in children

Consumption of certain foods during pregnancy has been shown to have beneficial effects on childhood asthma and allergic disease development and aggravation. However, most studies provide conflicting results a...

Authors: Nour Baïz, Jocelyne Just, Julie Chastang, Anne Forhan, Blandine de Lauzon-Guillain, Anne-Marie Magnier and Isabella Annesi-Maesano

Inflammatory patterns of antrochoanal polyps in the pediatric age group

The pathogenesis and etiology of antrochoanal polyps (ACPs) remains obscure. This study aimed to characterize the inflammatory profiles and investigate the effect of atopy on the pathogenesis of pediatric ACPs.

Authors: Huiwen Zheng, Lixing Tang, Beibei Song, Xiaojian Yang, Ping Chu, Shujing Han, Pengpeng Wang, Jie Lu, Wentong Ge and Xin Ni

Risk factors and prognosis of recurrent wheezing in Chinese young children: a prospective cohort study

Nearly all the investigations into the risk factors for wheezing and asthma were conducted in developed countries with a high prevalence rate of asthma and allergy, but the studies in developing countries are ...

Authors: Jing Guo, Wenjing Zhu, Huimin Wang, Patrick G. Holt, Guicheng Zhang and Chuanhe Liu