Articles

Serum free IgE guided dose reduction of omalizumab: a case report

Omalizumab is a human IgG1 antibody against IgE used as a therapy for sever asthmatic patients with asthma. According to the guidelines of the Global Initiative for Asthma, omalizumab is an add-on drug at trea...

Authors: Yasuhiro Gon, Reiko Ito, Shuichiro Maruoka, Kenji Mizumura, Yutaka Kozu, Hisato Hiranuma, Yuko Iida, Sotaro Shikano and Shu Hashimoto

Management of chronic spontaneous urticaria (CSU): a treat to target approach using a patient reported outcome

Treat-to-target therapy approaches are established for chronic diseases such as diabetes, hypertension, and more recently rheumatoid arthritis, resulting in improved patient outcomes. These approaches do not u...

Authors: Hermenio Lima, Melinda Gooderham, Jan Dutz, Charles Lynde, Hugo Chapdelaine, Anne Ellis, Martin Gilbert, Vincent Ho, Kim Papp, Yves Poulin and Gordon Sussman

Poor sleep is highly associated with house dust mite allergic rhinitis in adults and children

Sleep disorders are often underreported to physicians by patients with allergies. This study aimed to characterize the sleep disorders associated with respiratory allergy to house dust mites (HDM) at the time ...

Authors: Damien Leger, Bénédicte Bonnefoy, Bernard Pigearias, Bertrand de La Giclais and Antoine Chartier

Protective barrier properties of Rhinosectan^® spray (containing xyloglucan) on an organotypic 3D airway tissue model (MucilAir): results of an in vitro study

To evaluate barrier protective properties of Rhinosectan^® spray, a medical device containing xyloglucan, on nasal epithelial cells (MucilAir).

Authors: Barbara De Servi, Francesco Ranzini and Núria Piqué

Expression of intelectin-1 in bronchial epithelial cells of asthma is correlated with T-helper 2 (Type-2) related parameters and its function

Intelectin-1 (ITLN-1) is secreted by intestinal goblet cells and detectable in blood. Its expression is increased in IL-13-overexpressing mouse airways. However, its expression and function in human airways is...

Authors: Taiji Watanabe, Kazuyuki Chibana, Taichi Shiobara, Rinna Tei, Ryosuke Koike, Yusuke Nakamura, Ryo Arai, Yukiko Horigane, Yasuo Shimizu, Akihiro Takemasa, Takeshi Fukuda, Sally E. Wenzel and Yoshiki Ishii

4-month omalizumab efficacy outcomes for severe allergic asthma: the Dutch National Omalizumab in Asthma Registry

Omalizumab is licensed as add-on therapy for patients with severe allergic asthma. Response is in most studies scored by the physician’s global evaluation of treatment effectiveness (GETE). A good clinical and...

Authors: S. M. Snelder, E. J. M. Weersink and G. J. Braunstahl

Safety of 100 µg venom immunotherapy rush protocols in children compared to adults

There is a paucity of studies examining the safety of venom immunotherapy (VIT) in children. We aimed to assess the incidence of anaphylactic side effects during rush VIT in a cohort of pediatric patients and ...

Authors: Johanna Stoevesandt, Christine Hosp, Andreas Kerstan and Axel Trautmann

Erratum to: Do epinephrine auto-injectors have an unsuitable needle length in children and adolescents at risk for anaphylaxis from food allergy?

Authors: Sten Dreborg, Xia Wen, Laura Kim, Gina Tsai, Immaculate Nevis, Ryan Potts, Jack Chiu, Arunmozhi Dominic and Harold Kim

Breakthrough attacks in patients with hereditary angioedema receiving long-term prophylaxis are responsive to icatibant: findings from the Icatibant Outcome Survey

Patients with hereditary angioedema (HAE) due to C1-inhibitor deficiency (C1-INH-HAE) experience recurrent attacks of cutaneous or submucosal edema that may be frequent and severe; prophylactic treatments can ...

Authors: Werner Aberer, Marcus Maurer, Laurence Bouillet, Andrea Zanichelli, Teresa Caballero, Hilary J. Longhurst, Amandine Perrin and Irmgard Andresen

Asthma pressurised metered dose inhaler performance: propellant effect studies in delivery systems

Current pressurised metered dose asthma inhaler (pMDI) propellants are not inert pharmacologically as were previous chlorofluorocarbons, have smooth muscle relaxant‚ partial pressure effects in the lungs and i...

Authors: William F. S. Sellers

Abstracts from the 10th C1-inhibitor deficiency workshop

Authors: Alvin H. Schmaier, Marco Cicardi, Avner Reshef, Dumitru Moldovan, Attila Mócsai, Margarita López-Trascasa, Alberto López Lera, Nancy J. Brown, Anastasios E. Germenis, Rafael Filippelli-Silva, Diego A. Duarte, Renan P. Martin, Camila L. Veronez, Michel Bouvier, Michael Bader, Claudio M. Costa-Neto…

Angioedema suppressed by a combination of anti-histamine and leukotriene modifier

Angioedema without co-existent urticaria is due to a limited number of causes, including hereditary and acquired C1 esterase inhibitor deficiency, drug-induced angioedema or idiopathic histaminergic or non-his...

Authors: Brendan N. Wong and Peter Vadas

A case series evaluating the serological response of adult asthma patients to the 23-valent pneumococcal polysaccharide vaccine

Asthma is an independent risk factor for invasive pneumococcal disease; however, the immune response of adult asthma patients to pneumococcal vaccination is unknown. We explore the serologic response of patien...

Authors: C. R. Laratta, K. Williams, D. Vethanayagam, M. Ulanova and H. Vliagoftis

Maternal sensitivity and social support protect against childhood atopic dermatitis

Many studies have identified associations between qualities of maternal–child relationships and childhood asthma, but few have examined associations with childhood atopic dermatitis (AD), a common precursor to...

Authors: Nicole L. Letourneau, Anita L. Kozyrskyj, Nela Cosic, Henry N. Ntanda, Lubna Anis, Martha J. Hart, Tavis S. Campbell and Gerald F. Giesbrecht

The relationship between circulating concentrations of interleukin 17 and C reactive protein in chronic spontaneous urticaria

Up-regulation of interleukin 17 (IL-17) family cytokines and acute phase response have been observed in patients with chronic spontaneous urticaria (CSU). It has been demonstrated that IL-17 stimulates C-react...

Authors: A. Grzanka, A. Damasiewicz-Bodzek and A. Kasperska-Zajac

Visual analogue scale (VAS) as a monitoring tool for daily changes in asthma symptoms in adolescents: a prospective study

Success in asthma management hinges on patients’ competency to detect and respond to ever-changing symptom severity. Thus, it is crucial to have reliable, simple, and sustainable methods of symptom monitoring ...

Authors: Hyekyun Rhee, Michael Belyea and Jennifer Mammen

Systemic mastocytosis with KIT V560G mutation presenting as recurrent episodes of vascular collapse: response to disodium cromoglycate and disease outcome

Mastocytosis are rare diseases characterized by an accumulation of clonal mast cells (MCs) in one or multiple organs or tissues. Patients with systemic mastocytosis (SM), whose MCs frequently arbor the activat...

Authors: Iolanda Conde-Fernandes, Rita Sampaio, Filipa Moreno, José Palla-Garcia, Maria dos Anjos Teixeira, Inês Freitas, Esmeralda Neves, Maria Jara-Acevedo, Luis Escribano and Margarida Lima

Preconception allergen sensitization can induce B10 cells in offspring: a potential main role for maternal IgG

The mechanisms through which allergies can be inhibited after preconception immunization with allergens are not fully understood. We aimed to evaluate whether maternal immunization can induce a regulatory B (B...

Authors: Marília Garcia de Oliveira, Luana de Mendonça Oliveira, Aline Aparecida de Lima Lira, Fábio da Ressureição Sgnotto, Alberto José da Silva Duarte, Maria Notomi Sato and Jefferson Russo Victor

Regulation of Th2 responses by different cell types expressing the interleukin-31 receptor

Interleukin-31 (IL-31) is a recently identified cytokine produced by Th2 cells that is involved in the development of atopic dermatitis-induced skin inflammation and pruritus. Its receptor, IL-31RA, is express...

Authors: Saburo Saito, Ayana Aoki, Iwao Arai, Shinya Takaishi, Haruyasu Ito, Nobutake Akiyama and Hiroshi Kiyonari

Canadian Society of Allergy and Clinical Immunology annual scientific meeting 2016

Authors: Mohammad A. Alsayegh, Hanan Alshamali, Mousa Khadada, Amanda Ciccolini, Anne K. Ellis, Diana Quint, William Powley, Laurie Lee, Yahya Fiteih, Shairaz Baksh, Harissios Vliagoftis, Sebastien K. Gerega, Brad Millson, Katia Charland, Stephane Barakat, Xichun Sun…

Efficacy and safety of setipiprant in seasonal allergic rhinitis: results from Phase 2 and Phase 3 randomized, double-blind, placebo- and active-referenced studies

Antagonism of chemoattractant receptor-homologous molecule on T-helper type-2 cells (CRTH2), a G-protein coupled receptor for prostaglandin D2, could be beneficial for treating allergic disorders. We present f...

Authors: Paul Ratner, Charles P. Andrews, Frank C. Hampel, Bruce Martin, Dale E. Mohar, Denis Bourrelly, Parisa Danaietash, Sara Mangialaio, Jasper Dingemanse, Abdel Hmissi and Jay van Bavel

Consumer preferences for food allergen labeling

Food allergen labeling is an important tool to reduce risk of exposure and prevent anaphylaxis for individuals with food allergies. Health Canada released a Canadian food allergen labeling regulation (2008) an...

Authors: Carlo A. Marra, Stephanie Harvard, Maja Grubisic, Jessica Galo, Ann Clarke, Susan Elliott and Larry D. Lynd

Sputum cell counts to manage prednisone-dependent asthma: effects on FEV₁ and eosinophilic exacerbations

Prednisone dependence in asthma is usually described based on clinical and spirometric characteristics. It is generally believed that these patients have frequent exacerbations and lose lung function rapidly b...

Authors: Afia Aziz-Ur-Rehman, Angira Dasgupta, Melanie Kjarsgaard, Frederick E. Hargreave and Parameswaran Nair

Nasal nitric oxide in allergic rhinitis in children and its relationship to severity and treatment

Nasal nitrous oxide (nNO) is increased in allergic rhinitis (AR), but not in asthma, and is a non-invasive marker for inflammation in the nasal passages.

Authors: Peng-peng Wang, Gui-xiang Wang, Wen-tong Ge, Li-xing Tang, Jie Zhang and Xin Ni

Elevated expression of TIGIT on CD3⁺CD4⁺ T cells correlates with disease activity in systemic lupus erythematosus

It is well-known that lymphocytes play an important role in systemic lupus erythematosus (SLE). T cell immunoreceptor with Ig and immunoreceptor tyrosine-based inhibitory domains (TIGIT) is one of immunosuppre...

Authors: Qing Luo, Jianqing Ye, Lulu Zeng, Xue Li, Le Fang, Beihua Ju, Zikun Huang and Junming Li

Dietary intake is associated with respiratory health outcomes and DNA methylation in children with asthma

Asthma is an increasingly common chronic disease among children, and data point toward a complex mechanism involving genetic, environmental and epigenetic factors. Epigenetic modifications such as DNA hypo- or...

Authors: L. Montrose, T. J. Ward, E. O. Semmens, Y. H. Cho, B. Brown and C. W. Noonan

Gene therapy for primary immune deficiencies: a Canadian perspective

The use of gene therapy (GT) for the treatment of primary immune deficiencies (PID) including severe combined immune deficiency (SCID) has progressed significantly in the recent years. In particular, long-term...

Authors: Xiaobai Xu, Chetankumar S. Tailor and Eyal Grunebaum

An avoidable cause of thymoglobulin anaphylaxis

Thymoglobulin® (anti-thymocyte globulin [rabbit]) is a purified pasteurised, gamma immune globulin obtained by immunisation of rabbits with human thymocytes. Anaphylactic allergic reactions to a first injectio...

Authors: S. Brabant, A. Facon, F. Provôt, M. Labalette, B. Wallaert and C. Chenivesse

Allergic rhinitis: the eligible candidate to mite immunotherapy in the real world

As standard drug treatment of allergic rhinitis (AR) is not completely satisfactory, allergen immunotherapy (AIT) represents the only current treatment with the potential to modify the natural history. House d...

Authors: Giorgio Ciprandi, Valentina Natoli, Paola Puccinelli and Cristoforo Incorvaia

Prediction of clinical peanut allergy status among children in Hamilton, Ontario using chart review data collected during 2012–2015

Peanut sensitization does not necessarily indicate clinical peanut allergy, and uncertainty as to whether or not there is true peanut allergy can lead to increased anxiety and decreased quality of life for pat...

Authors: Elizabeth Simms, Gary Foster, Katherine Arias, Mark Larché, Tosha Freitag, Tina Walker, Susanna Goncharova, Andrea Marrin, Andreas Freitag, Manel Jordana and Susan Waserman

Day-time variation of serum periostin in asthmatic adults treated with ICS/LABA and adults without asthma

We aimed to determine the effect of sampling time during the day on serum periostin levels in adult participants with and without asthma.

Authors: Rachel Caswell-Smith, Terrianne Cripps, Thom Charles, Alexander Hosking, Meghana Handigol, Cecile Holweg, John Matthews, Mark Holliday, Corentin Maillot, James Fingleton, Mark Weatherall, Richard Beasley and Irene Braithwaite

Prevalence of allergen sensitization in 1000 adults in Saskatchewan

The prevalence of sensitization varies geographically based on multiple environmental factors including humidity. The aim of this study was to determine the prevalence of atopy in symptomatic adults. More impo...

Authors: Stacey D. Lok, Beth E. Davis and Donald W. Cockcroft

Primum non nocere—first do no harm. And then feed peanut

The Addendum Guidelines for the Prevention of Peanut Allergy in the United States—Report of the NIAID-Sponsored Expert Panel were developed to build on previous food allergy guidelines after several key studies d...

Authors: Kyla Jade Hildebrand, Elissa Michele Abrams, Timothy K. Vander Leek, Julia Elizabeth Mainwaring Upton, Douglas P. Mack, Linda Kirste, Christine McCusker and Sandeep Kapur

Atopic keratoconjunctivitis complicated by Kocuria koreensis keratitis: the first case

Patients with atopic dermatitis have a predisposition to Staphylococcus aureus and a Herpes simplex virus infection. The treatment of atopic diseases with steroid and immunosuppressive agents induces opportunisti...

Authors: Noriko Inada, Jun Shoji and Satoru Yamagami

High rate of house dust mite sensitization in a shrimp allergic southern Ontario population

Shrimp and house dust mite (HDM) allergies are common in Canadians. Often, both of these allergies occur in the same patient. This may be due to homology of tropomyosin or other potentially shared proteins. Th...

Authors: Lana Rosenfield, Michael William Tsoulis, Kirolos Milio, Meghan Schnittke and Harold Kim

Hereditary angioedema: health-related quality of life in Canadian patients as measured by the SF-36

Hereditary angioedema (HAE) is a rare but serious condition characterized by recurrent spontaneous attacks of angioedema affecting superficial tissues of upper respiratory and gastrointestinal tracts. The pote...

Authors: Nina Lakhani Jindal, Elaine Harniman, Nieves Prior, Elia Perez-Fernandez, Teresa Caballero and Stephen Betschel

Asthma and the microbiome: defining the critical window in early life

Asthma is a chronic inflammatory immune disorder of the airways affecting one in ten children in westernized countries. The geographical disparity combined with a generational rise in prevalence, emphasizes th...

Authors: Leah T. Stiemsma and Stuart E. Turvey

Addendum guidelines for the prevention of peanut allergy in the United States: report of the National Institute of Allergy and Infectious Diseases-sponsored expert panel

Food allergy is an important public health problem because it affects children and adults, can be severe and even life-threatening, and may be increasing in prevalence. Beginning in 2008, the National Institut...

Authors: Alkis Togias, Susan F. Cooper, Maria L. Acebal, Amal Assa’ad, James R. Baker, Lisa A. Beck, Julie Block, Carol Byrd-Bredbenner, Edmond S. Chan, Lawrence F. Eichenfield, David M. Fleischer, George J. Fuchs III, Glenn T. Furuta, Matthew J. Greenhawt, Ruchi S. Gupta, Michele Habich…

Airway autoimmune responses in severe eosinophilic asthma following low-dose Mepolizumab therapy

Anti-interleukin (IL)-5 monoclonal antibodies as an eosinophil-depleting strategy is well established, with Mepolizumab being the first biologic approved as an adjunct treatment for severe eosinophilic asthma.

Authors: Manali Mukherjee, Hui Fang Lim, Sruthi Thomas, Douglas Miller, Melanie Kjarsgaard, Bruce Tan, Roma Sehmi, Nader Khalidi and Parameswaran Nair

Anaphylaxis to supplemental oral lactase enzyme

Anaphylactic reactions involving IgE mediated hypersensitivity have been frequently reported for a number of uncommon foods. However, cases of anaphylaxis to over the counter vitamins and oral supplements have...

Authors: M. R. Voisin and R. Borici-Mazi

Polyethylene glycol as a cause of anaphylaxis

Polyethylene glycols (PEGs) or macrogols are polyether compounds and are widely used as additives in pharmaceuticals, cosmetics, and food.

Authors: Katharina Wylon, Sabine Dölle and Margitta Worm

AllerGen’s 8th research conference

Authors: Marie-Claire Arrieta, Andrea Arevalos, Leah Stiemsma, Marta E. Chico, Carlos Sandoval, Minglian Jin, Jens Walter, Phil Cooper, Brett Finlay, Emilie Bernatchez, Matthew J. Gold, Anick Langlois, Pascale Blais-Lecours, Caroline Duchaine, David Marsolais, Kelly M. McNagny…

Comprehensive genetic testing for primary immunodeficiency disorders in a tertiary hospital: 10-year experience in Auckland, New Zealand

New Zealand is a developed geographically isolated country in the South Pacific with a population of 4.4 million. Genetic diagnosis is the standard of care for most patients with primary immunodeficiency disor...

Authors: See-Tarn Woon and Rohan Ameratunga

Aspergillus march: from ABPA to aspergilloma to subacute invasive aspergillosis

Aspergillus is a ubiquitous fungus responsible for allergic as well as saprophytic and invasive manifestations depending on host’s immune status. The following case report demonstrates...

Authors: Vikas Dogra, Ankit Kumar Sinha, Rajat Saxena and Deepak Talwar

Gene mutations responsible for primary immunodeficiency disorders: A report from the first primary immunodeficiency biobank in Iran

Primary immunodeficiency (PID) is a heterogeneous group of inheritable genetic disorders with increased susceptibility to infections, autoimmunity, uncontrolled inflammation and malignancy. Timely precise diag...

Authors: Saba Sheikhbahaei, Roya Sherkat, Dirk Roos, Majid Yaran, Somayeh Najafi and Alireza Emami

Analysis of feline and canine allergen components in patients sensitized to pets

Component resolved allergen diagnosis allows for a precise evaluation of the sensitization profiles of patients sensitized to felines and canines. An accurate interpretation of these results allows better insi...

Authors: Natalia Ukleja-Sokołowska, Ewa Gawrońska-Ukleja, Magdalena Żbikowska-Gotz, Ewa Socha, Kinga Lis, Łukasz Sokołowski, Andrzej Kuźmiński and Zbigniew Bartuzi

Lymphocyte Kv1.3-channels in the pathogenesis of chronic obstructive pulmonary disease: novel therapeutic implications of targeting the channels by commonly used drugs

In patients with chronic obstructive pulmonary disease (COPD), over-activated T-lymphocytes produce pro-inflammatory cytokines and proliferate in situ in the lower airways and pulmonary parenchyma, contributin...

Authors: Itsuro Kazama and Tsutomu Tamada

Prevalence of beta-lactam allergy: a retrospective chart review of drug allergy assessment in a predominantly pediatric population

Research suggests that 90% of patients labeled beta-lactam allergic are able to tolerate penicillins following further assessment. This study aims to define and describe the frequency of true beta-lactam aller...

Authors: Elissa M. Abrams, Andrew Wakeman, Tom V. Gerstner, Richard J. Warrington and Alexander G. Singer

Usefulness of component resolved analysis of cat allergy in routine clinical practice

Cat allergy is of great importance, and its prevalence is increasing worldwide. Cat allergens and house dust mite allergens represent the major indoor allergens; however, they are ubiquitous. Cat sensitization...

Authors: Katharina Eder, Sven Becker, Marion San Nicoló, Alexander Berghaus and Moritz Gröger

Erratum to: Two-weeks-sustained unresponsiveness by oral immunotherapy using microwave heated cow’s milk for children with cow’s milk allergy

Authors: Masaya Takahashi, Shoichiro Taniuchi, Kazuhiko Soejima, Yasuko Hatano, Sohsaku Yamanouchi and Kazuanri Kaneko