The official journal of CSACI
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Citation: Allergy, Asthma & Clinical Immunology 2022 18(Suppl 1):11
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Comparison of circulating fibrocytes from non-asthmatic patients with seasonal allergic rhinitis between in and out of pollen season samples
Allergic rhinitis is a risk factor for asthma development. In asthma, fibroblast progenitors, fibrocytes, are increased in the blood and bronchial mucosa following allergen exposure. These cells may play a rol...
Citation: Allergy, Asthma & Clinical Immunology 2022 18:24 -
Intravenous immunoglobulins improve live birth rate among women with underlying immune conditions and recurrent pregnancy loss: a systematic review and meta-analysis
Intravenous immunoglobulin (IVIG) is increasingly used as a treatment for recurrent pregnancy loss (RPL) despite lack of clear evidence on efficacy. Recent data suggest IVIG might be more effective in a subgro...
Citation: Allergy, Asthma & Clinical Immunology 2022 18:23 -
AstraZeneca ChAdOx1-S COVID-19 vaccine can be safely administered in patients with EDTA allergy
Immediate hypersensitivity reactions to COVID-19 vaccines have been postulated to be linked to their excipients, such as polyethylene glycol (PEG) in Pfizer Comirnaty, or polysorbate 80 and ethylenediaminetetr...
Citation: Allergy, Asthma & Clinical Immunology 2022 18:22 -
Monitoring patients with uncomplicated common variable immunodeficiency: a systematic review
Non-infectious complications have become a major cause of morbidity and mortality in patients with Common Variable Immunodeficiency (CVID). The monitoring of patients with CVID prior to the development of non-...
Citation: Allergy, Asthma & Clinical Immunology 2022 18:21 -
Identification of gene biomarkers with expression profiles in patients with allergic rhinitis
Allergic rhinitis (AR) is an upper respiratory tract inflammation disease caused by IgE-mediated reactions against inhaled allergens. The incidence of AR is significantly increasing throughout the world. Hence...
Citation: Allergy, Asthma & Clinical Immunology 2022 18:20 -
Growth in diagnosis and treatment of primary immunodeficiency within the global Jeffrey Modell Centers Network
Primary immunodeficiencies (PI), which include more than 450 single-gene inborn errors of immunity and may affect up to 1% of the population, are genetic disorders that impair the immune system. If not properly i...
Citation: Allergy, Asthma & Clinical Immunology 2022 18:19 -
Rituximab and dupilumab improve eosinophilic granulomatosis with polyangiitis with multiple pulmonary thrombi
Eosinophilic granulomatosis with polyangiitis (EGPA) is characterized by a necrotizing vasculitis with tissue and peripheral blood eosinophilia affecting small and medium-sized arteries, capillaries, and veins...
Citation: Allergy, Asthma & Clinical Immunology 2022 18:18 -
Prolidase deficiency, a rare inborn error of immunity, clinical phenotypes, immunological features, and proposed treatments in twins
Prolidase deficiency (PD) is an autosomal recessive inborn multisystemic disease caused by mutations in the PEPD gene encoding the enzyme prolidase D, leading to defects in turnover of proline-containing proteins...
Citation: Allergy, Asthma & Clinical Immunology 2022 18:17 -
Telemedicine in allergy/immunology in the era of COVID-19: a Canadian perspective
In the era of COVID-19, utilization of telemedicine has dramatically increased. In addition to reduced travel times, patient expenses, and work or school days missed, telemedicine allows clinicians to provide ...
Citation: Allergy, Asthma & Clinical Immunology 2022 18:16 -
Activated phosphoinositide 3-kinase δ syndrome associated with nephromegaly, growth hormone deficiency, bronchiectasis: a case report
Activated phosphoinositide 3-kinase (PI3K) δ syndrome (APDS) is a rare form of primary immunodeficiency with 243 known cases reported in the literature. Known findings associated with the condition include rec...
Citation: Allergy, Asthma & Clinical Immunology 2022 18:15 -
Improvement of peripheral neuropathy in a patient with antineutrophil cytoplasmic antibody-negative eosinophilic granulomatosis with polyangiitis by additional mepolizumab
Eosinophilic granulomatosis with polyangiitis (EGPA) is a vasculitis characterized by abnormally high eosinophils and frequent peripheral neuropathy. Mepolizumab is an approved therapy for EGPA, but its effica...
Citation: Allergy, Asthma & Clinical Immunology 2022 18:14 -
Stellate ganglion block as an intervention in refractory eosinophilic granulomatosis with polyangiitis: a case report
Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare vasculitis. Although glucocorticoid therapy with or without immunosuppressants leads to remission in the majority of cases, most EGPA patients rem...
Citation: Allergy, Asthma & Clinical Immunology 2022 18:13 -
The STAT6 inhibitor AS1517499 reduces the risk of asthma in mice with 2,4-dinitrochlorobenzene-induced atopic dermatitis by blocking the STAT6 signaling pathway
Epidemiological studies have revealed a link between atopic dermatitis (AD) and asthma. AS1517499, a selective signal transducer and activation of transcription 6 (STAT6) inhibitor, has been shown to effective...
Citation: Allergy, Asthma & Clinical Immunology 2022 18:12 -
Allergic rhinitis, allergic contact dermatitis and disease comorbidity belong to separate entities with distinct composition of T-cell subsets, cytokines, immunoglobulins and autoantibodies
Allergic rhinitis (AR) and allergic contact dermatitis (ACD) are prevalent allergic diseases and have significant impacts on patients’ daily life. Despite many studies on AR or ACD have been conducted separate...
Citation: Allergy, Asthma & Clinical Immunology 2022 18:10 -
The use of dupilumab in severe atopic dermatitis during pregnancy: a case report
Atopic dermatitis is a common chronic skin disease that can occur in pregnancy. Current treatments include topical and systemic glucocorticoids and cyclosporine. Presently, the only biologic approved for atopi...
Citation: Allergy, Asthma & Clinical Immunology 2022 18:9 -
Modified oral food challenge protocol approach in the diagnosis of Food Protein-Induced Enterocolitis Syndrome
Food Protein-Induced Enterocolitis Syndrome (FPIES) is a non-IgE mediated food allergy most commonly presenting in infants. The most common food triggers include soy, cow’s milk and grains. Symptoms may includ...
Citation: Allergy, Asthma & Clinical Immunology 2022 18:8 -
Lessons learned in allergy and immunology training: a survey analysis
There is currently little Canadian data to assess how well traditional time-based residency training programs have prepared residents for careers in Clinical Immunology and Allergy (CIA). This study aims to id...
Citation: Allergy, Asthma & Clinical Immunology 2022 18:7 -
Differences between Staphylococcus aureus nasal carriage and IgE-sensitization to Staphylococcus aureus enterotoxin on risk factors and effects in adult population
Staphylococcus aureus (SA) nasal carriage (SA carriage) and IgE-sensitization to SA enterotoxin (SE IgE-sensitization) are known to be associated with chronic airway disease.
Citation: Allergy, Asthma & Clinical Immunology 2022 18:6 -
The frequencies of peripheral blood CD5+CD19+ B cells, CD3−CD16+CD56+ NK, and CD3+CD56+ NKT cells and serum interleukin-10 in patients with multiple sclerosis and neuromyelitis optica spectrum disorder
Multiple sclerosis (MS) and neuromyelitis optica syndrome disease (NMOSD) are inflammatory diseases of the central nervous system. The pathogenesis and treatments for these two conditions are very different. N...
Citation: Allergy, Asthma & Clinical Immunology 2022 18:5 -
Attenuated androgen discontinuation in patients with hereditary angioedema: a commented case series
Hereditary angioedema (HAE) is characterized by potentially severe and life-threatening attacks of localized swelling. Prophylactic therapies are available, including attenuated androgens. Efficacy of attenuat...
Citation: Allergy, Asthma & Clinical Immunology 2022 18:4 -
Role of airway smooth muscle cell phenotypes in airway tone and obstruction in guinea pig asthma model
Airway obstruction (AO) in asthma is driven by airway smooth muscle (ASM) contraction. AO can be induced extrinsically by direct stimulation of ASM with contractile agonists as histamine, or by indirect provoc...
Citation: Allergy, Asthma & Clinical Immunology 2022 18:3 -
Fatal liver mass rupture in a common-variable-immunodeficiency patient with probable nodular regenerating hyperplasia
Nodular regenerating hyperplasia (NRH) is the most common liver involvement in common variable immunodeficiency (CVID). Most patients are asymptomatic with gradually increasing alkaline phosphatase (ALP) and mild...
Citation: Allergy, Asthma & Clinical Immunology 2022 18:2 -
What is the impact of birth weight corrected for gestational age on later onset asthma: a meta-analysis
Asthma is a common multifactorial disease affecting millions worldwide. The Barker hypothesis postulates an association between later onset disease risk and energy exposure in utero. Birth weight corrected for...
Citation: Allergy, Asthma & Clinical Immunology 2022 18:1 -
Hereditary angioedema due to C1 inhibitor deficiency: real-world experience from the Icatibant Outcome Survey in Spain
The Icatibant Outcome Survey (IOS) is an international registry monitoring the use of icatibant, a bradykinin B2 receptor antagonist indicated for the acute treatment of hereditary angioedema (HAE) attacks. Our g...
Citation: Allergy, Asthma & Clinical Immunology 2021 17:137 -
Failure of a single day metronidazole desensitization protocol, and success of a modified two-day protocol in an outpatient setting
True allergy to metronidazole, a common anti-infective in clinical practice, is rarely reported in the literature. In the case of Trichomonas, there are few alternatives to the nitrimidazole class of drugs, and t...
Citation: Allergy, Asthma & Clinical Immunology 2021 17:136 -
The association between allergy and sinusitis: a cross-sectional study based on NHANES 2005–2006
The relationship between allergies and sinusitis, though extensively studied, remains poorly defined. While several studies proposed a cause-and-effect relationship between allergy and chronic sinusitis, sever...
Citation: Allergy, Asthma & Clinical Immunology 2021 17:135 -
Malignancy and immune disorders in patients with hereditary angioedema
Hereditary angioedema (HAE) is an inherited condition manifesting as recurrent angioedema episodes which is caused by deficiency or dysfunction of C1 inhibitor. Although complement dysregulation has historical...
Citation: Allergy, Asthma & Clinical Immunology 2021 17:134 -
Impact of comorbidities on risk of angioedema without urticaria in elderly patients
Angioedema without urticaria (AWU) is a disease found in the elderly population but is still poorly studied. The aim of this study was to investigate potential factors, especially comorbidities, that may affec...
Citation: Allergy, Asthma & Clinical Immunology 2021 17:133 -
Can fecal calprotectin levels be used to monitor infant milk protein allergies?
Milk protein allergy is one of the most common food allergies in infants. We aimed to test whether fecal calprotectin can be used to monitor food allergies in infants by comparing the fecal calprotectin levels...
Citation: Allergy, Asthma & Clinical Immunology 2021 17:132 -
Characterizing telemedicine use in clinical immunology and allergy in Canada before the COVID-19 pandemic
There exists a geographic barrier to access CIA care for patients who live in rural communities; telemedicine may bridge this gap in care. Herein we characterized the use of telemedicine in CIA at a population...
Citation: Allergy, Asthma & Clinical Immunology 2021 17:131 -
CSACI position statement: transition recommendations on existing epinephrine autoinjectors
Epinephrine is the first line treatment for anaphylaxis, an acute potentially life-threatening allergic reaction. It is typically administered intramuscularly in the anterolateral thigh at a dose of 0.01 mg/kg...
Citation: Allergy, Asthma & Clinical Immunology 2021 17:130 -
Tiotropium bromide as adjunct therapy in children with asthma: a clinical experience
The Global Initiative for Asthma has only recently added tiotropium bromide as adjunct controller therapy in severe asthma (Step 4 or 5) in adults (2015) and children (2019). Although not yet approved for pedi...
Citation: Allergy, Asthma & Clinical Immunology 2021 17:129 -
Successful treatment of refractory status asthmaticus with omalizumab: a case report
Refractory status asthmaticus is the cause of rare cases of in-hospital death due to acute bronchial asthma. The most severe cases unresponsive to first, second and next line treatment may be fatal despite agg...
Citation: Allergy, Asthma & Clinical Immunology 2021 17:128 -
Randomized controlled trial of ragweed sublingual immunotherapy tablet in the subpopulation of Canadian children and adolescents with allergic rhinoconjunctivitis
Post hoc analyses of randomized placebo-controlled trials have demonstrated efficacy and tolerability of the ragweed sublingual immunotherapy (SLIT)-tablet in Canadian adults with ragweed pollen-induced allerg...
Citation: Allergy, Asthma & Clinical Immunology 2021 17:127 -
First patient in the Iranian Registry with novel DOCK2 gene mutation, presenting with skeletal tuberculosis, and review of literature
Dedicator of cytokinesis 2 (DOCK2) deficiency is an inborn error of immunity characterized by cellular and humoral immunological abnormalities leading to early-onset infections.
Citation: Allergy, Asthma & Clinical Immunology 2021 17:126 -
Rupatadine to prevent local allergic reactions to sublingual allergy immunotherapy: a case series
Sublingual immunotherapy tablets (SLIT-T) are an effective treatment for allergic rhinitis (AR), but some patients experience local allergic reactions (LAR) in the first few weeks of treatment that can lead to...
Citation: Allergy, Asthma & Clinical Immunology 2021 17:125 -
Novel pediatric granulomatosis with polyangiitis with a marked bloody pericardial effusion and bloody stool: a case report
Granulomatosis with polyangiitis (GPA) is a syndrome of refractory vasculitis involving the upper respiratory tract, lungs, kidneys, and systemic small and medium-sized arteries that affects all age groups. No...
Citation: Allergy, Asthma & Clinical Immunology 2021 17:124 -
MiRNA-221-5p suppressed the Th17/Treg ratio in asthma via RORγt/Foxp3 by targeting SOCS1
This study was designed to investigate the mechanism and effects of miRNA-221-5p on the T-helper 17 (Th17)/T-regulatory (Treg) ratio in asthma.
Citation: Allergy, Asthma & Clinical Immunology 2021 17:123 -
Characteristics of older adult hospitalized patients with bronchial asthma: a retrospective study
Bronchial asthma is a chronic inflammation of the airways. Older adult patients with bronchial asthma are defined as patients older than 65 and with a previous or current clear diagnosis of asthma. The purpose...
Citation: Allergy, Asthma & Clinical Immunology 2021 17:122 -
Volatile organic breath components and exercise induced bronchoconstriction in asthmatic children
Asthma is one of the most common chronic diseases in childhood and is generally characterized by exercise induced bronchoconstriction (EIB). Assessing EIB is time consuming and expensive as it requires a fully...
Citation: Allergy, Asthma & Clinical Immunology 2021 17:121 -
Associations of Helicobacter pylori and hepatitis A seropositivity with asthma in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL): addressing the hygiene hypothesis
The hygiene hypothesis posits that microbial exposure reduces risk of asthma and other respiratory-related diseases. Helicobacter pylori and hepatitis A virus (HAV) are common fecal–oral infections. Our study aim...
Citation: Allergy, Asthma & Clinical Immunology 2021 17:120 -
Atopy in Kashmir-validation from a case control study with respect to IgE and Interleukin genes
Increased levels of serum Immunoglobulin-E (IgE) and different genetic variants of cytokines are common biochemical manifestation in Allergy. The current study was aimed to study the association of IgE and dif...
Citation: Allergy, Asthma & Clinical Immunology 2021 17:119 -
Pulmonary eosinophilia may indicate onset stage of allergic bronchopulmonary aspergillosis
Allergic bronchopulmonary aspergillosis (ABPA) and chronic eosinophilic pneumonia (CEP) both display peripheral eosinophilia as well as pulmonary infiltration, together described as pulmonary eosinophilia, and...
Citation: Allergy, Asthma & Clinical Immunology 2021 17:118 -
Successful induction treatment of bullous pemphigoid using reslizumab: a case report
Bullous pemphigoid (BP) is a potentially life-threatening autoimmune blistering disease which is characterized by autoantibodies against hemidesmosomal proteins of the skin and mucous membranes. In recent year...
Citation: Allergy, Asthma & Clinical Immunology 2021 17:117 -
Induction of remission in chronic urticaria by immunotherapy using immunoglobulin/histamine complex (Histobulin™): a case report
Symptom control is a major concern in chronic urticaria. Histobulin™ is a histamine/immunoglobulin complex that has been approved for allergic rhinitis, bronchial asthma and chronic urticaria in some countries...
Citation: Allergy, Asthma & Clinical Immunology 2021 17:116 -
Neonatal abstinence syndrome is a potential cause of low TREC copy number
Severe combined immunodeficiency (SCID) is a rare genetic condition characterized by significant T cell lymphopenia and impaired T cell function. Many jurisdictions use the quantitation of T cell receptor exci...
Citation: Allergy, Asthma & Clinical Immunology 2021 17:115 -
The first reported case of Blaptica dubia cockroach allergy
Periplaneta americana and Blattella germanica cockroaches are widespread, and risk of sensitization increases in urban environments where these roaches thrive as household pests. There are no prior reports of Bla...
Citation: Allergy, Asthma & Clinical Immunology 2021 17:114 -
Fexofenadine: review of safety, efficacy and unmet needs in children with allergic rhinitis
Allergic rhinitis (AR) is the most common undiagnosed chronic condition in children. Moderate/severe AR symptoms significantly impair quality of life, and cause sleep disruption, absenteeism and decreased prod...
Citation: Allergy, Asthma & Clinical Immunology 2021 17:113 -
Aplastic anemia secondary to dual cancer immunotherapies a physician nightmare: case report and literature review
Treatment with immune checkpoint inhibitors has revolutionized cancer treatment over the past several years. Despite their clinical benefits, a wide range of immune-mediated toxicities can be observed includin...
Citation: Allergy, Asthma & Clinical Immunology 2021 17:112
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