Articles

Effect of individual allergen sensitization on omalizumab treatment outcomes in patients with severe allergic asthma determined using data from the Czech Anti-IgE Registry

Omalizumab is an efficient drug for patients with uncontrolled severe allergic asthma (SAA). However, little is known about the differences in omalizumab treatment outcomes among patients with different types ...

Authors: Petr Vaník, Jakub Novosad, Olga Kirchnerová, Irena Krčmová and Milan Teřl

Pediatric subset of primary immunodeficiency patients treated with SCIG: post hoc analysis of SHIFT and IBIS pooled data

Primary immunodeficiencies (PID) constitute a heterogeneous group of more than 350 monogenetic diseases. PID patients with antibody impairment require lifelong administration of immunoglobulin G replacement th...

Authors: Viviana Moschese, Clementina Canessa, Antonino Trizzino, Baldassarre Martire, Giorgio Maria Boggia and Simona Graziani

Altered vaginal microbiome and relative co-abundance network in pregnant women with penicillin allergy

Penicillin allergy is frequently reported in adults and children. Recent studies suggest that microbiota plays a key role in the development and progression of allergy. In this study, the relationship between ...

Authors: Xiaohua Li, Jun Luo, Chuan Nie, Qingxia Li, Xiaofeng Sun, Hongping Li and Yong Zhang

Stability of serum precipitins to Aspergillus fumigatus for the diagnosis of allergic bronchopulmonary aspergillosis

Allergic bronchopulmonary aspergillosis (ABPA) reflects hypersensitivity and an exaggerated immune response to Aspergillus fumigatus. ABPA typically occurs in individuals with airway diseases such as asthma or cy...

Authors: Kevin S. K. Lau, Chantane Yeung and Chris Carlsten

Inflammatory cutaneous lesions and pulmonary manifestations in a new patient with autosomal recessive ISG15 deficiency case report

Interferon-stimulated gene 15 (ISG15) was the first ubiquitin-like modifier protein identified that acts by protein conjugation (ISGylation) and is thought to modulate IFN-induced inflammation. Here, we report a ...

Authors: Guadalupe Buda, Rita María Valdez, German Biagioli, Federico A. Olivieri, Nicolás Affranchino, Carolina Bouso, Vanesa Lotersztein, Dusan Bogunovic, Jacinta Bustamante and Marcelo A. Martí

“Immune Boosting” in the time of COVID: selling immunity on Instagram

“Immune boosting” is a trending topic during the COVID-19 pandemic. The concept of “immune boosting” is scientifically misleading and often used to market unproven products and therapies. This paper presents a...

Authors: Darren N. Wagner, Alessandro R. Marcon and Timothy Caulfield

Treatment strategies for asthma: reshaping the concept of asthma management

Asthma is a common chronic disease characterized by episodic or persistent respiratory symptoms and airflow limitation. Asthma treatment is based on a stepwise and control-based approach that involves an itera...

Authors: Alberto Papi, Francesco Blasi, Giorgio Walter Canonica, Luca Morandi, Luca Richeldi and Andrea Rossi

Pollen allergen skin test and specific IgE reactivity among Filipinos: a community-based study

Despite the clinical importance of pollen allergens among Filipinos, few studies delve into the sensitization profiles of Filipinos against pollen allergens. This study determined the sensitization profile of ...

Authors: Maureen Sabit, Cecil Wong, Agnes Andaya and John Donnie Ramos

Improving detection of work-related asthma: a review of gaps in awareness, reporting and knowledge translation

Work-related asthma (WRA) accounts for up to 25% of all adults with asthma. Early diagnosis is key for optimal management as delays in diagnosis are associated with worse outcomes. However, WRA is significantl...

Authors: Madison MacKinnon, Teresa To, Clare Ramsey, Catherine Lemière and M. Diane Lougheed

Presence of positive skin prick tests to inhalant allergens and markers of T2 inflammation in subjects with chronic spontaneous urticaria (CSU): a systematic literature review

Current guidelines do not recommend performing aeroallergen skin prick testing (SPT) in chronic spontaneous urticaria (CSU).

Authors: Melanie Mitsui Wong and Paul Kevin Keith

Analysis of maternal and perinatal determinants of allergic sensitization in childhood

Non-communicable diseases, such as allergies, are influenced by both genetic and epigenetic factors. Perinatal determinants conceivably modify the epigenetic makeup of the developing fetal immune system preven...

Authors: Samuel Schäfer, Anthony Liu, Dianne Campbell and Ralph Nanan

Skin testing with bendamustine: what concentration should be used?

We present a case of the patient, who developed hypersensitivity reaction during the treatment of chronic lymphocytic leukemia. Bendamustine was suspected as a culprit agent. The patient as well as 3 controls ...

Authors: Laura Malinauskiene, Kestutis Cerniauskas, Kotryna Linauskiene, Linas Griguola, Anzelika Chomiciene and Audra Blaziene

Exposure to Toxocara spp. and Ascaris lumbricoides infections and risk of allergic rhinitis in children

Substantial experimental studies suggest a role for helminthes infections in the pathogenesis of allergies, but epidemiologic data have been inconsistent. Unlike to asthma, the association between helminthes i...

Authors: Iraj Mohammadzadeh, Sorena Darvish, Seyed Mohammad Riahi, Solmaz Alizadeh Moghaddam, Mohammad Pournasrollah, Mousa Mohammadnia-Afrozi and Ali Rostami

The effect of electronic monitoring combined with weekly feedback and reminders on adherence to inhaled corticosteroids in infants and younger children with asthma: a randomized controlled trial

Adherence to asthma treatment among children is usually poor. We sought to explore whether electronic adherence monitoring combined with weekly feedback regarding adherence along with a reminder to use inhaled...

Authors: Jiande Chen, Juan Xu, Liebin Zhao, Jing Zhang, Yong Yin and Fen Zhang

Linking the westernised oropharyngeal microbiome to the immune response in Chinese immigrants

Human microbiota plays a fundamental role in modulating the immune response. Western environment and lifestyle are envisaged to alter the human microbiota with a new microbiome profile established in Chinese i...

Authors: Jing Guo, Xiaoping Zhang, Aarti Saiganesh, Christopher Peacock, Shu Chen, Gary A. Dykes, Belinda J. Hales, Peter N. Le Souëf and Guicheng Zhang

Differences in serum markers of oxidative stress in well controlled and poorly controlled asthma in Sri Lankan children: a pilot study

Asthma is a disease characterised by hyper responsiveness and bronchoconstriction of airways, and is a major health burden globally. A dysfunction of the oxidant-antioxidant balance, termed oxidative stress, h...

Authors: Yenuli Fernando, Pujitha Wickramasinghe, Udani De Silva, Malintha Alahakoon, K. W. D. A. Anuradha and Shiroma Handunnetti

The clinical, immunological and genetic features of 12 Chinese patients with STAT3 mutations

Loss-of-function (LOF) mutations in signal transducer and activator of transcription 3 (STAT3) is one of the causes of STAT3 hyperimmunoglobulin E (IgE) syndrome (STAT3-HIES), while gain-of-function (GOF) muta...

Authors: Li Lin, Ying Wang, Bijun Sun, Luyao Liu, Wenjing Ying, Wenjie Wang, Qinhua Zhou, Jia Hou, Haili Yao, Liyuan Hu, Jinqiao Sun and Xiaochuan Wang

Change in exhaled nitric oxide during peanut challenge is related to severity of reaction

Peanut allergy affects 3% of Australian children and has a higher risk of anaphylaxis than most food allergies. Predicting who is likely to develop anaphylaxis is still an inexact science. The fraction of exha...

Authors: Elizabeth Percival, Rani Bhatia, Kahn Preece, Mark McEvoy, Adam Collison and Joerg Mattes

Natural history, prognostic factors and patient perceived response to treatment in chronic spontaneous urticaria

Although the diagnosis and management of chronic spontaneous urticaria (CSU) is well documented in the literature, some aspects of the disease remain unclear. We aimed to further describe the natural history, ...

Authors: Peter Stepaniuk, Manstein Kan and Amin Kanani

Genetic polymorphisms in vitamin D pathway influence 25(OH)D levels and are associated with atopy and asthma

Vitamin D deficiency or insufficiency, has been associated with atopy and lack of asthma control. Our objective was to investigate associations between variants in genes of vitamin D pathway with serum levels ...

Authors: Alana Alcântara Galvão, Flávia de Araújo Sena, Emília Maria Medeiros de Andrade Belitardo, Maria Borges Rabelo de Santana, Gustavo Nunes de Oliveira Costa, Álvaro Augusto Cruz, Maurício Lima Barreto, Ryan dos Santos Costa, Neuza Maria Alcantara-Neves and Camila Alexandrina Figueiredo

Th17/Treg imbalance is associated with reduced indoleamine 2,3 dioxygenase activity in childhood allergic asthma

The differentiation of CD4+ lymphocytes Th17/regulatory T cells (Treg) and indoleamine 2,3-dioxygenase (IDO) is associated with the pathogenesis of allergic asthma. Basic research has shown that IDO is likely ...

Authors: Ying Hu, Zhiqiang Chen, Jing Zeng, Shouyan Zheng, Liujuan Sun, Li Zhu and Wei Liao

Facial erythema after the treatment of dupilumab in SLE patient

Dupilumab is a receptor antagonist binding to the alpha subunit of the interleukin-4 receptor. Through binding to it, dupilumab inhibits signaling of both IL-4 and IL-13, the representative Th2 biomarkers. Rec...

Authors: Dong Hyek Jang, Jae In Lee, Joo Yoon Bae, Hye Jung Jung, Mi Yeon Park and Jiyoung Ahn

Inhalation of nebulized Mycobacterium vaccae can protect against allergic bronchial asthma in mice by regulating the TGF-β/Smad signal transduction pathway

Mycobacterium vaccae nebulization imparted protective effect against allergic asthma in a mouse model. The TGF-β/Smad signal transduction pathway plays an important role in allergic bronchial asthma. However, the...

Authors: Xiao-hong Jiang, Chao-qian Li, Guang-yi Feng, Ming-jie Luo and Qi-xiang Sun

Comparison of allergens and symptoms in patients with allergic rhinitis between 1990s and 2010s

The prevalence of allergic rhinitis (AR), an environment- and lifestyle-dependent condition, has been constantly increasing in Korea. Although the environment and lifestyle of the Korean people have recently u...

Authors: Ji Heui Kim, Shin Ae Kim, Ja Yoon Ku, Won Ki Cho and Chol Ho Shin

Sensitivity and specificity of double-blinded penicillin skin testing in relation to oral provocation with amoxicillin in children

Current recommendations for the management of penicillin allergy are to perform penicillin skin testing (PST) with penicilloyl-polylysine (PPL) and benzylpenicillin (BP) prior to drug challenge with amoxicilli...

Authors: Roxane Labrosse, Louis Paradis, Kathryn Samaan, Jonathan Lacombe-Barrios, Jean Paradis, Philippe Bégin and Anne Des Roches

Type I allergic reaction to rituximab upon first lifetime exposure: a case report

While drug reactions to rituximab have been commonly reported in the literature, a type I allergic reaction to rituximab after first lifetime exposure has never been reported.

Authors: V. Polito, A. Barbacki and G. Isabwe

Differential response to biologics in a patient with severe asthma and ABPA: a role for dupilumab?

Allergic bronchopulmonary aspergillosis (ABPA) is a severe hypersensitivity reaction to aspergillus species colonizing the airways of patients with asthma or cystic fibrosis. Biologics including anti-IgE and a...

Authors: Carlo Mümmler, Bernd Kemmerich, Jürgen Behr, Nikolaus Kneidinger and Katrin Milger

Incidence of malignancy in patients with common variable immunodeficiency according to therapeutic delay: an Italian retrospective, monocentric cohort study

Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency and has a broad spectrum of clinical manifestations. Among non-infectious complications, an increased incidence o...

Authors: Veronica Pedini, Jacopo Umberto Verga, Irene Terrenato, Denise Menghini, Cristina Mezzanotte and Maria Giovanna Danieli

An emerging allergen: Cannabis sativa allergy in a climate of recent legalization

Considering its recent legalization in Canada, the health implications of Cannabis sativa exposure, including allergy, are coming to the forefront of medical study and interest. C. sativa allergy is an issue that...

Authors: Bradley Jackson, Erica Cleto and Samira Jeimy

Proceedings of the Canadian Society of Allergy and Clinical Immunology Annual Scientific Meeting 2019

Authors:

Asthma increases the risk of herpes zoster: a nested case–control study using a national sample cohort

This study aimed to complement previous studies on the risk of herpes zoster in the asthmatic adult population.

Authors: So Young Kim, Dong Jun Oh and Hyo Geun Choi

Anaphylaxis to clindamycin following cutaneous exposure

The role and importance of skin barrier as an immunologic organ and as a potent way of sensitization is well known. However, antibiotics anaphylaxis following skin sensitization has not been reported.

Authors: N. Paradis, L. Marois, L. Paradis, F. Graham, P. Bégin and A. Des Roches

Serum BPI as a novel biomarker in asthma

Neutrophils, eosinophils and inflammatory cells contribute to asthmatic inflammation. The anti-bactericidal/permeability-increasing protein (BPI), produced by neutrophils, peripheral blood monocytes or epithel...

Authors: Chen Xingyuan and Qiu Chen

Efficacy of omalizumab in children, adolescents, and adults with severe allergic asthma: a systematic review, meta-analysis, and call for new trials using current guidelines for assessment of severe asthma

Omalizumab is approved for treating severe allergic asthma from age 6, but the definition of severe asthma including a systematic assessment to rule out difficult-to-treat asthma has changed since the drug was...

Authors: Daniel P. Henriksen, Uffe Bodtger, Kirsten Sidenius, Niels Maltbaek, Lars Pedersen, Hanne Madsen, Ehm A. Andersson, Ole Norgaard, Louise K. Madsen and Bo L. Chawes

A rare case of anaphylaxis to Indian jujube (Ziziphus Mauritiana Lam)

Indian jujube (Ziziphus Mauritiana Lam) is a sweet fruit from a tree native to tropical and subtropical regions of Asia and India. A few case reports have implicated Indian jujube to cause latex-fruit syndrome. W...

Authors: Babak Aberumand and Rozita Borici-Mazi

Anaphylaxis to three humanized antibodies for severe asthma: a case study

Omalizumab, mepolizumab, benralizumab, and dupilumab are the currently available biologics used to treat asthma in Japan. Anaphylaxis following treatment with mepolizumab or benralizumab is considered rare.

Authors: Koichi Jingo, Norihiro Harada, Toshihiko Nishioki, Masahiro Torasawa, Tomoko Yamada, Tetsuhiko Asao, Haruhi Takagi, Tomohito Takeshige, Jun Ito and Kazuhisa Takahashi

Effects of MP-AzeFlu enhanced by activation of bitter taste receptor TAS2R

MP-AzeFlu is relatively new a pharmaceutical drug used in the treatment of allergic rhinitis. It is comprised of azelastine hydrochloride (AZE), a potent histamine-H1-receptor antagonist and fluticasone propio...

Authors: Sandra Ekstedt, Susanna Kumlien Georén and Lars Olaf Cardell

Season of birth is associated with increased risk of atopic dermatitis in Japanese infants: a retrospective cohort study

Several epidemiological studies have examined the possibility of a relationship between season of birth and atopic dermatitis (AD) and food allergy (FA), yet their results are contradictory. We investigated th...

Authors: Yu Kuwabara, Ritsue Nii, Keiko Tanaka, Eiichi Ishii, Mizuho Nagao and Takao Fujisawa

Tonsillar granuloma associated with hypogammaglobulinemia

Rare tonsillar granulomas may be caused for example by infections, malignancies or sarcoidosis. Granulomas also occur in inborn errors of immunity (IEI) such as common variable immunodeficiency (CVID) with B c...

Authors: Aleksi Laajala, Outi Kuismin, Mikko Tastula, Leena Tiitto, Saila Kauppila, Anna Salo, Pirjo Åström, Antti Nissinen, Virpi Glumoff, Mikko R. J. Seppänen and Timo Hautala

Hereditary angioedema C1-esterase inhibitor replacement therapy and coexisting autoimmune disorders: findings from a claims database

In this letter to the editor, we present results of claims data analysis. This claims data analysis supports a hypothesis that in patients with hereditary angioedema due to C1-esterase inhibitor (C1-INH) defic...

Authors: Henriette Farkas, Donald Levy, Dylan Supina, Melvin Berger, Subhransu Prusty and Moshe Fridman

Co-occurrence between C1 esterase inhibitor deficiency and autoimmune disease: a systematic literature review

Hereditary angioedema (HAE) is caused by a SERPING1 gene defect resulting in decreased (Type I) or dysfunctional (Type II) C1 esterase inhibitor (C1-INH). The prevalence of autoimmune diseases (ADs) in patient...

Authors: Donald Levy, Timothy Craig, Paul K. Keith, Girishanthy Krishnarajah, Rachel Beckerman and Subhransu Prusty

Epidermal growth factor upregulates expression of MUC5AC via TMEM16A, in chronic rhinosinusitis with nasal polyps

Mucus hypersecretion and goblet cell upregulation are common features of chronic rhinosinusitis with nasal polyps (CRSwNP). Although epidermal growth factor (EGF) has been reported to stimulate the expression ...

Authors: Jian Jiao, Tao Zhang, Yu Zhang, Jingyun Li, Min Wang, Ming Wang, Ying Li, Xiangdong Wang and Luo Zhang

Towards definitive management of allergic rhinitis: best use of new and established therapies

Allergic rhinitis (AR) is an inflammatory disease of the nasal mucosa impacting up to 25% of Canadians. The standard of care for AR includes a treatment plan that takes into account patient preferences, the se...

Authors: Lubnaa Hossenbaccus, Sophia Linton, Sarah Garvey and Anne K. Ellis

Correction to: Protocol for a double-blind, randomized controlled trial on the dose-related efficacy of omalizumab in multi-food oral immunotherapy

An amendment to this paper has been published and can be accessed via the original article.

Authors: Alexandra Langlois, Marie-Hélène Lavergne, Hélène Leroux, Kerstin Killer, Pauline Azzano, Louis Paradis, Kathryn Samaan, Jonathan Lacombe-Barrios, Thomas Eiwegger, Julia Upton, Gordon Sussman, Thomas Poder, Benoît Mâsse, Anne Des Roches and Philippe Bégin

Assessment of clinical activity and severity using serum ANCA and ASCA antibodies in patients with ulcerative colitis

Ulcerative colitis (UC) is a chronic, non-specific inflammatory bowel disease (IBD) with unknown etiology. The lack of specific clinical manifestations, standard diagnostic criteria, objective and accurate ind...

Authors: Yanhua Pang, Huijie Ruan, Dongfang Wu, Yanfei Lang, Ke Sun and Cuiping Xu

Quercetin with the potential effect on allergic diseases

Quercetin is a naturally occurring polyphenol flavonoid which is rich in antioxidants. It has anti-allergic functions that are known for inhibiting histamine production and pro-inflammatory mediators. Querceti...

Authors: Morteza Jafarinia, Mahnaz Sadat Hosseini, Neda kasiri, Niloofar Fazel, Farshid Fathi, Mazdak Ganjalikhani Hakemi and Nahid Eskandari

Increasing allergy: are antibiotics the elephant in the room?

Antibiotics cause dramatic changes to the human microbiome. The composition of the microbiome has been associated with changes in the immune system and these changes are beginning to be linked to immune diseas...

Authors: Rod A. Herman

Delivery of subcutaneous immunoglobulin by rapid “push” infusion for primary immunodeficiency patients in Manitoba: a retrospective review

Both intravenous and subcutaneous human immune globin G (IgG) replacement (IVIG and SCIG, respectively) reduce severe infection and increase serum IgG levels in primary immune deficiency disorder (PIDD) patien...

Authors: Graham Walter, Chrystyna Kalicinsky, Richard Warrington, Marianne Miguel, Jeannette Reyes and Tamar S. Rubin

Correction to: The International/Canadian Hereditary Angioedema Guideline

An amendment to this paper has been published and can be accessed via the original article.

Authors: Stephen Betschel, Jacquie Badiou, Karen Binkley, Rozita Borici-Mazi, Jacques Hébert, Amin Kanani, Paul Keith, Gina Lacuesta, Susan Waserman, Bill Yang, Emel Aygören-Pürsün, Jonathan Bernstein, Konrad Bork, Teresa Caballero, Marco Cicardi, Timothy Craig…

Lemon seed allergy: a case presentation

We report a case of IgE-mediated hypersensitivity to lemon seed. We demonstrate for the first time a pattern of cross-sensitisation between seeds of citrus hybrid species from similar ancestral species origins.

Authors: O. Stephanie Kayode, Nuevalynne Prado, David J. Thursfield, Stephen J. Till and Leonard Q. C. Siew