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  1. Identification of molecular markers, such as miRNAs is promising for the diagnosis of asthma and its clinical phenotypes. The aim of this study was to examine the changes in the expression of selected microRNA...

    Authors: Mostafa Atashbasteh, Esmaeil Mortaz, Seyed Alireza Mahdaviani, Hamidreza Jamaati and Abdolamir Allameh
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:51
    Content type: Research Published on:

  2. A retrospective review of clinical manifestations and demographic pattern of patients diagnosed as chronic granulomatous disease (CGD) from 7 hospitals in Malaysia. An analysis of the available database would ...

    Authors: Lokman Mohd Noh, Amir Hamzah Abdul Latiff, Intan Hakimah Ismail, Rahim Md Noah, Asrul Abdul Wahab, Intan Juliana Abd. Hamid, Adiratna Mat Ripen, Nasuruddin B. Abdullah, Kamarul Azhar Razali, Norzila Zainudin, Florence Bakon, Long Juan Kok, Adli Ali, Bilkis Banu SAbd Aziz, Hasniah Abdul Latif, Siti Mardhiana Mohamad…
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:50
    Content type: Research Published on:

  3. Kimura’s disease (KD) is a rare chronic inflammatory disease of unknown etiology. Clinically, KD is characterized by nodular subcutaneous masses, that are typically localized to the neck and head. Involvement ...

    Authors: Keisuke Sugimoto, Takuji Enya, Yuichi Morimoto, Rina Oshima, Kohei Miyazaki and Mitsuru Okada
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:48
    Content type: Case Report Published on:

  4. There is a need to identify the asthma inflammatory phenotypes of patients to facilitate personalized asthma treatment. Sputum induction is time-consuming and requires expert clinical technique. This study aim...

    Authors: Bingqing Shi, Wei Li, Yuqiu Hao, Hongna Dong, Wenjing Cao, Jie Guo and Peng Gao
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:47
    Content type: Research Published on:

  5. Worldwide, allergy affects more than one billion people, with particularly rising prevalence in industrialised areas. Specifically, young adults appear to be predominantly targeted for an allergy diagnosis. Al...

    Authors: Hanna Danielewicz, Anna Dębińska, Grzegorz Myszczyszyn, Anna Myszkal, Lidia Hirnle, Anna Drabik-Chamerska, Danuta Kalita and Andrzej Boznański
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:46
    Content type: Research Published on:

  6. Investigating the endotypes of the different asthma phenotypes would help disease monitoring, prognosis determination, and improving asthma management standardization. This study aimed to classify asthma into ...

    Authors: Yi Jiang, Ruoli An, Li Cheng, Qianru Yue, Hanwei Zhang, Yali Zhang, Xiaomei Kong, Hongxia Ma, Fang Chen and Yufeng Guo
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:45
    Content type: Research Published on:

  7. Recent research has pointed out the important roles of epigenetic modifications in the development and persistence of allergic rhinitis (AR), especially in relation to DNA methylation of disease-associated gen...

    Authors: Yu Zhang, Meiyu Tan, Xiaoqiong Qian, Cong Li, Lei Yue, Yuehong Liu and Song Shi
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:44
    Content type: Research Published on:

  8. Intestinal helminths have been proposed to have a protective role against allergic sensitization and atopic diseases. However, consistent data demonstrating this are lacking in Sub-Saharan countries. We aimed ...

    Authors: Dessie Abera, Moges Wordofa, Abiyot Mesfin, Gemechu Tadesse, Mistire Wolde, Kassu Desta, Aster Tsegaye and Bineyam Taye
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:43
    Content type: Research Published on:

  9. Trained immunity is the ability of the innate immune system to form immune memory responses to provide support the formation of appropriate adaptive responses. Allergic airways disease (AAD) is a maladapted im...

    Authors: Husheem Michael, Yuanyi Li, Yufa Wang and Christine T. McCusker
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:42
    Content type: Research Published on:

  10. The epidemiologic impact of hereditary angioedema (HAE) is difficult to quantify, due to misclassification in retrospective studies resulting from non-specific diagnostic coding. The aim of this study was to i...

    Authors: Emily S. Brouwer, Emily W. Bratton, Aimee M. Near, Lynn Sanders and Christina D. Mack
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:41
    Content type: Research Published on:

  11. Hereditary angioedema (HAE) is a rare disease characterized by unpredictable, potentially life-threatening attacks, resulting in significant physical and emotional burdens for patients and families. To optimiz...

    Authors: Konrad Bork, John T. Anderson, Teresa Caballero, Timothy Craig, Douglas T. Johnston, H. Henry Li, Hilary J. Longhurst, Cristine Radojicic and Marc A. Riedl
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:40
    Content type: Review Published on:

  12. Chronic urticaria is a common disorder of the skin, characterised by recurrent skin wheals and angioedema. Recent reports have shown that altered diversity and composition of the gut microbiota may lead to imb...

    Authors: Xiao-Dong Bi, Bao-Zhen Lu, Xin-Xin Pan, Sha Liu and Jiu-Yao Wang
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:39
    Content type: Research Published on:

  13. IL-35 is a newly anti-inflammatory cytokine that belongs to the IL-12 family. Mast cells, as one of the major effector cells in the immune response system, plays an important role in the pathogenesis of chroni...

    Authors: Li-xin Fu, Tao Chen, Qiao-mei Sun, Pei-mei Zhou and Zai-pei Guo
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:38
    Content type: Research Published on:

  14. Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but serious delayed hypersensitivity reaction that can be caused by antibiotic exposure. The reaction typically develops in 2 to 6 weeks....

    Authors: Arun Dhir, Hasandeep Kular, Abdelbaset A. Elzagallaai, Bruce Carleton, Michael J. Rieder, Raymond Mak and Tiffany Wong
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:37
    Content type: Case Report Published on:

  15. Although Japanese radish (Raphanus sativus L.) is a common Japanese ingredient, there are few reports of IgE-mediated immediate food allergy caused by Japanese radish.

    Authors: Sumiko Abe, Jun Ito, Sonoko Harada, Hitoshi Sasano, Shoko Ueda, Yuuki Sandhu, Tomohito Takeshige, Yoko Katsura, Norihiro Harada and Kazuhisa Takahashi
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:36
    Content type: Case Report Published on:

  16. The autoantibody profile of primary biliary cholangitis (PBC) includes antinuclear antibodies (ANA) which are detectable by indirect immunofluorescence in more than 50% of PBC patients. One of the two immunofl...

    Authors: Alessandro Granito, Luigi Muratori, Francesco Tovoli and Paolo Muratori
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:35
    Content type: Letter to the Editor Published on:

  18. The Environmental Exposure Unit (EEU), a controlled allergen exposure model of allergic rhinitis (AR), has traditionally utilized seasonal allergens. We sought to clinically validate the use of house dust mite...

    Authors: Lubnaa Hossenbaccus, Sophia Linton, Jenny Thiele, Lisa Steacy, Terry Walker, Crystal Malone and Anne K. Ellis
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:34
    Content type: Research Published on:

  19. Allergic asthma is an inflammatory disease resulting from continued or intermittent allergen exposure, and allergic rhinitis can be trigger of asthma. The main mechanism of these disease is allergic reaction a...

    Authors: Qixue Du, Wei Meng, Seyyed Shamsadin Athari and Renzhong Wang
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:32
    Content type: Research Published on:

  21. Atopic diseases, such as atopic dermatitis (AD) and food allergy (FA), have increased in prevalence in industrialized countries during the past few decades and pose a significant health burden. They appear to ...

    Authors: Alyssa Sweeney, Vanitha Sampath and Kari C. Nadeau
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:30
    Content type: Review Published on:

  22. Safe and effective vaccines provide the first hope for mitigating the devastating health and economic impacts resulting from coronavirus disease 2019 (COVID-19) and related public health orders. Recent case re...

    Authors: Timothy K. Vander Leek, Edmond S. Chan, Lori Connors, Beata Derfalvi, Anne K. Ellis, Julia E. M. Upton and Elissa M. Abrams
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:29
    Content type: Guidelines Published on:

  23. The impact of childhood food allergy on household costs has not been examined in Canada. The current study sought to examine differences in direct, indirect, and intangible costs among Canadian families with a...

    Authors: Michael A. Golding, Elinor Simons, Elissa M. Abrams, Jennifer Gerdts and Jennifer L. P. Protudjer
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:28
    Content type: Research Published on:

  24. There has been research about the prevalence and risk factors of eczema, hay fever, and asthma in children, but little is known about these conditions in adults in China.

    Authors: Xiaoyan Wang, Yan Zhuang, Yanlei Chen, Hongtian Wang and Xueyan Wang
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:27
    Content type: Research Published on:

  25. Increasingly, social media is a source for information about health and disease self-management. We conducted a content analysis of promotional asthma-related posts on Instagram to understand whether promoted ...

    Authors: Brent Heineman, Marcella Jewell, Michael Moran, Kolbi Bradley, Kerry A. Spitzer and Peter K. Lindenauer
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:26
    Content type: Letter to the Editor Published on:

  26. For a century, epinephrine has been the drug of choice for acute treatment of systemic allergic reactions/anaphylaxis. For 40 years, autoinjectors have been used for the treatment of anaphylaxis. Over the last...

    Authors: Sten Dreborg and Harold Kim
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:25
    Content type: Review Published on:

  28. Studies on the association between vitamin D levels and allergen sensitization have reported conflicting results. We aimed to evaluate the association between low vitamin D levels and sensitization to 59 aeroa...

    Authors: Jee Hye Wee, Sung Woo Cho, Jeong-Whun Kim and Chae-Seo Rhee
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:23
    Content type: Research Published on:

  29. Anaphylactic sting reactions need a prompt management. A structured educational intervention for patients with insect sting allergy has not been implemented so far. The purpose of this study was to analyze the...

    Authors: Lisa-Sophie Schoeben, Nicole Mohr, Corinna Bubak, Astrid Schmieder and Marthe-Lisa Schaarschmidt
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:22
    Content type: Research Published on:

  30. Adolescence, as a transition between childhood and adulthood, is a critical stage for the long-term control of atopic diseases. We aim to determine if sleep characteristics are involved in the increased risk o...

    Authors: Yiting Chen, Qian Yang, Kena Zhao, Zengqiang Wu, Xiaoming Shen and Shenghui Li
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:21
    Content type: Research Published on:

  31. Cefaclor, a second-generation oral cephalosporin, is widely prescribed to treat infectious diseases. Immediate hypersensitivity (HS) reactions to cefaclor have continuously been reported and are expected to in...

    Authors: Hyo-In Rhyou, Go-Eun Doo, Jiwon Yoon, Chae-Yeon Ha, Hee-Joo Nam, Sung-Dae Woo, Youngsoo Lee, Young-Hee Nam and Young-Min Ye
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:20
    Content type: Research Published on:

  32. We conducted a systematic review and meta-analysis to determine the effectiveness of comprehensive community-based interventions with ≥ 2 components in improving asthma outcomes in children.

    Authors: Mei Chan, Melinda Gray, Christine Burns, Louisa Owens, Susan Woolfenden, Raghu Lingam, Adam Jaffe and Nusrat Homaira
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:19
    Content type: Review Published on:

  33. Angiotensin Converting Enzyme Inhibitors (ACEI) are a common cause of Emergency Room presentation for angioedema. Although no treatment guidelines exist, C1 esterase inhibitor concentrate (C1-INH) is used on a...

    Authors: Uliana Kovaltchouk, Boyang Zhang, Vipul Jain and Chrystyna Kalicinsky
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:18
    Content type: Letter to the Editor Published on:

  34. Erythema multiforme (EM) is an acute, immune-mediated mucocutaneous disease, most often preceded by herpes simplex virus (HSV) infection or reactivation. Mycoplasma pneumoniae (Mp) is considered the second major ...

    Authors: Sarah M. Volkers, Christian Meisel, Dorothea Terhorst-Molawi, Guido J. Burbach, Dirk Schürmann, Norbert Suttorp and Leif E. Sander
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:17
    Content type: Case Report Published on:

  35. Asthma is one of the most common diseases amongst children. Blood eosinophil count and neutrophil–lymphocyte ratio (NLR) are known as markers for phenotyping asthma. This study was performed to investigate blo...

    Authors: Hossein Esmaeilzadeh, Fatemeh Nouri, Seyed Hesamodin Nabavizadeh, Soheila Alyasin and Negar Mortazavi
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:16
    Content type: Research Published on:

  37. Common variable immunodeficiency is the most prevalent symptomatic primary immunodeficiency in adults. Affected patients fail to mount an appropriate humoral response against community acquired infectious dise...

    Authors: Luciana C. Ribeiro, Bruno Deltreggia Benites, Raisa G. Ulaf, Thyago A. Nunes, Carolina Costa-Lima, Marcelo Addas-Carvalho, José Luiz Proenca-Modena, Fabiana Granja, Vitor Antonio da Costa, Adriana da Silva Santos Duarte, Audrey Basso Zangirolami, Emerson Clayton Amaro, Eli Mansour, Ricardo L. Zollner and Licio A. Velloso
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:14
    Content type: Case Report Published on:

  38. Although the relationship between allergic sensitization and increased respiratory symptoms of chronic obstructive pulmonary disease (COPD) has been suggested, which allergen has a significant effect on COPD p...

    Authors: Hikaru Toyota, Naoya Sugimoto, Konomi Kobayashi, Yuki Suzuki, Yuri Takeshita, Ayaka Ito, Mariko Ujino, Fuminori Tomyo, Hirokazu Sakasegawa, Yuta Koizumi, Michio Kuramochi, Masao Yamaguchi and Hiroyuki Nagase
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:13
    Content type: Research Published on:

  39. Pediatric food allergy is associated with direct, indirect and intangible costs. However, it remains unclear if intangible costs of pediatric food allergy influence parental career choices. Using data from 63 ...

    Authors: Tara Lynn Mary Frykas, Michael Golding, Elissa M. Abrams, Elinor Simons and Jennifer Lisa Penner Protudjer
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:12
    Content type: Letter to the editor Published on:

  40. Because atopic dermatitis does not heal completely, associated severe atopic keratoconjunctivitis (AKC) and vernal keratoconjunctivitis (VKC) often require long-term treatment. This study aims to evaluate the ...

    Authors: Hiroyuki Yazu, Kazumi Fukagawa, Eisuke Shimizu, Yasunori Sato and Hiroshi Fujishima
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:11
    Content type: Research Published on:

  41. Polyvalent Mechanical Bacterial Lysate (PMBL®) contains antigens of bacteria responsible for respiratory infections. PMBL® has been proven to reduce the number of respiratory infections, and in its use, immuno...

    Authors: Małgorzata Bartkowiak-Emeryk, Andrzej Emeryk, Jacek Roliński, Ewelina Wawryk-Gawda and Ewa Markut-Miotła
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:10
    Content type: Research Published on:

  42. X-linked hypohidrotic ectodermal dysplasia (XLHED) is the most common form of ectodermal dysplasia. Clinical and genetic heterogeneity between different ectodermal dysplasia types and evidence of incomplete pe...

    Authors: Bhavi P. Modi, Kate L. Del Bel, Susan Lin, Mehul Sharma, Phillip A. Richmond, Clara D. M. van Karnebeek, Edmond S. Chan, Vishal Avinashi, Wingfield E. Rehmus, Catherine M. Biggs, Wyeth W. Wasserman and Stuart E. Turvey
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:9
    Content type: Letter to the editor Published on:

  43. Melkersson–Rosenthal syndrome (MRS) is a rare neuro-mucocutaneous disorder of unknown cause, clinically characterized by a triad of recurrent facial palsy, orofacial swelling, and fissured tongue. It is freque...

    Authors: Yared Zenebe Zewde
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:8
    Content type: Case report Published on:

  45. Erdheim-Chester disease (ECD) is a rare non-Langerhans histiocytosis with slow progression over the years that is particularly difficult to diagnose.

    Authors: David Spoerl, Raphaël André, Aurélie Bornand and Jörg D. Seebach
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:6
    Content type: Letter to the editor Published on:

  46. Severe coronavirus disease-19 (COVID-19) presents with progressive dyspnea, which results from acute lung inflammatory edema leading to hypoxia. As with other infectious diseases that affect the respiratory tr...

    Authors: Natália F. Mendes, Carlos P. Jara, Eli Mansour, Eliana P. Araújo and Licio A. Velloso
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:5
    Content type: Short report Published on:

  47. The pathogenetic mechanisms of neutrophilic asthma are not well understood now. Whether T helper (Th)17-mediated immunity contributes to the pathogenesis of neutrophilic asthma in human is still under investig...

    Authors: Qing Wei, Jing Liao, Min Jiang, Jing Liu, Xiuan Liang and Guangmin Nong
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:4
    Content type: Research Published on:

  48. Mepolizumab and benralizumab are biologics approved for severe eosinophilic asthma. Mepolizumab is an anti-interlukin-5 (IL-5) antibody while benralizumab is an anti-interleukin-5 receptor alpha (IL-5Rα) antib...

    Authors: Arian Ghassemian, Jane Jiyoon Park, Michael W. Tsoulis and Harold Kim
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:3
    Content type: Letter to the editor Published on:

  49. Egg allergy is one of the most common food allergies in children. To date, oral immunotherapy (OIT) has been considered as a promising treatment option for egg allergy. However, safety issues remain concerning...

    Authors: Nagatoshi Sagara, Satoshi Fujita, Ryohei Suzuki, Akiko Aota, Kenichi Akashi and Toshio Katsunuma
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:2
    Content type: Case report Published on:

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